New Synaptic and Molecular Targets for Neuroprotection in Parkinson’s Disease
Identifieur interne : 000175 ( Pmc/Checkpoint ); précédent : 000174; suivant : 000176New Synaptic and Molecular Targets for Neuroprotection in Parkinson’s Disease
Auteurs : Paolo Calabresi [Italie] ; Massimiliano Di Filippo [Italie] ; Antongiulio Gallina [Italie] ; Yingfei Wang [États-Unis] ; Jeannette N. Stankowski [États-Unis] ; Barbara Picconi [Italie] ; Valina L. Dawson [États-Unis] ; Ted M. Dawson [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.
Abstract
The defining anatomical feature of Parkinson’s disease (PD) is the degeneration of substantia nigra pars compacta (SNc) neurons, resulting in striatal dopamine (DA) deficiency and in the subsequent alteration of basal ganglia physiology. Treatments targeting the dopaminergic system alleviate PD symptoms but are not able to slow the neurodegenerative process that underlies PD progression. The nucleus striatum comprises a complex network of projecting neurons and interneurons that integrates different neural signals to modulate the activity of the basal ganglia circuitry. In this review we describe new potential molecular and synaptic striatal targets for the development of both symptomatic and neuroprotective strategies for PD. In particular, we focus on the interaction between adenosine A2A receptors and dopamine D2 receptors, on the role of a correct assembly of NMDA receptors, and on the sGC/cGMP/PKG pathway. Moreover, we also discuss the possibility to target the cell death program parthanatos and the kinase LRRK2 in order to develop new putative neuroprotective agents for PD acting on dopaminergic nigral neurons as well as on other basal ganglia structures.
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DOI: 10.1002/mds.25096
PubMed: 22927178
PubMed Central: 4161019
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Dawson</name><affiliation wicri:level="2"><nlm:aff id="A3">Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22927178</idno><idno type="pmc">4161019</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161019</idno><idno type="RBID">PMC:4161019</idno><idno type="doi">10.1002/mds.25096</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000285</idno><idno type="wicri:Area/Pmc/Curation">000285</idno><idno type="wicri:Area/Pmc/Checkpoint">000175</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">New Synaptic and Molecular Targets for Neuroprotection in Parkinson’s Disease</title><author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name><affiliation wicri:level="1"><nlm:aff id="A1">Clinical Neurology, University of Perugia, Perugia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Neurology, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">IRCCS, Santa Lucia Foundation, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS, Santa Lucia Foundation, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Di Filippo, Massimiliano" sort="Di Filippo, Massimiliano" uniqKey="Di Filippo M" first="Massimiliano" last="Di Filippo">Massimiliano Di Filippo</name><affiliation wicri:level="1"><nlm:aff id="A1">Clinical Neurology, University of Perugia, Perugia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Neurology, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">IRCCS, Santa Lucia Foundation, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS, Santa Lucia Foundation, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Gallina, Antongiulio" sort="Gallina, Antongiulio" uniqKey="Gallina A" first="Antongiulio" last="Gallina">Antongiulio Gallina</name><affiliation wicri:level="1"><nlm:aff id="A1">Clinical Neurology, University of Perugia, Perugia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Neurology, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yingfei" sort="Wang, Yingfei" uniqKey="Wang Y" first="Yingfei" last="Wang">Yingfei Wang</name><affiliation wicri:level="2"><nlm:aff id="A3">Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Stankowski, Jeannette N" sort="Stankowski, Jeannette N" uniqKey="Stankowski J" first="Jeannette N." last="Stankowski">Jeannette N. Stankowski</name><affiliation wicri:level="2"><nlm:aff id="A3">Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Picconi, Barbara" sort="Picconi, Barbara" uniqKey="Picconi B" first="Barbara" last="Picconi">Barbara Picconi</name><affiliation wicri:level="1"><nlm:aff id="A1">Clinical Neurology, University of Perugia, Perugia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Neurology, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">IRCCS, Santa Lucia Foundation, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS, Santa Lucia Foundation, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Dawson, Valina L" sort="Dawson, Valina L" uniqKey="Dawson V" first="Valina L." last="Dawson">Valina L. Dawson</name><affiliation wicri:level="2"><nlm:aff id="A3">Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M." last="Dawson">Ted M. Dawson</name><affiliation wicri:level="2"><nlm:aff id="A3">Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The defining anatomical feature of Parkinson’s disease (PD) is the degeneration of substantia nigra pars compacta (SNc) neurons, resulting in striatal dopamine (DA) deficiency and in the subsequent alteration of basal ganglia physiology. Treatments targeting the dopaminergic system alleviate PD symptoms but are not able to slow the neurodegenerative process that underlies PD progression. The nucleus striatum comprises a complex network of projecting neurons and interneurons that integrates different neural signals to modulate the activity of the basal ganglia circuitry. In this review we describe new potential molecular and synaptic striatal targets for the development of both symptomatic and neuroprotective strategies for PD. In particular, we focus on the interaction between adenosine A2A receptors and dopamine D2 receptors, on the role of a correct assembly of NMDA receptors, and on the sGC/cGMP/PKG pathway. Moreover, we also discuss the possibility to target the cell death program parthanatos and the kinase LRRK2 in order to develop new putative neuroprotective agents for PD acting on dopaminergic nigral neurons as well as on other basal ganglia structures.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22927178</article-id><article-id pub-id-type="pmc">4161019</article-id><article-id pub-id-type="doi">10.1002/mds.25096</article-id><article-id pub-id-type="manuscript">NIHMS621433</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>New Synaptic and Molecular Targets for Neuroprotection in Parkinson’s Disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Calabresi</surname><given-names>Paolo</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Di Filippo</surname><given-names>Massimiliano</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Gallina</surname><given-names>Antongiulio</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yingfei</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Stankowski</surname><given-names>Jeannette N.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Picconi</surname><given-names>Barbara</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dawson</surname><given-names>Valina L.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Dawson</surname><given-names>Ted M.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Clinical Neurology, University of Perugia, Perugia, Italy</aff><aff id="A2"><label>2</label>IRCCS, Santa Lucia Foundation, Rome, Italy</aff><aff id="A3"><label>3</label>Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</aff><author-notes><corresp id="cor1"><label>*</label><bold>Correspondence to:</bold> Professor Paolo Calabresi, Clinica Neurologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, 06156 Perugia, Italy; <email>calabre@unipg.it</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>30</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>23</day><month>8</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>9</month><year>2014</year></pub-date><volume>28</volume><issue>1</issue><fpage>51</fpage><lpage>60</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.25096</pmc-comment>
<permissions><copyright-statement>© 2012 <italic>Movement</italic> Disorder Society</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p id="P1">The defining anatomical feature of Parkinson’s disease (PD) is the degeneration of substantia nigra pars compacta (SNc) neurons, resulting in striatal dopamine (DA) deficiency and in the subsequent alteration of basal ganglia physiology. Treatments targeting the dopaminergic system alleviate PD symptoms but are not able to slow the neurodegenerative process that underlies PD progression. The nucleus striatum comprises a complex network of projecting neurons and interneurons that integrates different neural signals to modulate the activity of the basal ganglia circuitry. In this review we describe new potential molecular and synaptic striatal targets for the development of both symptomatic and neuroprotective strategies for PD. In particular, we focus on the interaction between adenosine A2A receptors and dopamine D2 receptors, on the role of a correct assembly of NMDA receptors, and on the sGC/cGMP/PKG pathway. Moreover, we also discuss the possibility to target the cell death program parthanatos and the kinase LRRK2 in order to develop new putative neuroprotective agents for PD acting on dopaminergic nigral neurons as well as on other basal ganglia structures.</p></abstract><kwd-group><kwd>synaptic plasticity</kwd><kwd>dopamine receptors</kwd><kwd>NMDA receptors</kwd><kwd>LRRK2</kwd><kwd>Parthanatos</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Italie</li><li>États-Unis</li></country><region><li>Latium</li><li>Maryland</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name></noRegion><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name><name sortKey="Di Filippo, Massimiliano" sort="Di Filippo, Massimiliano" uniqKey="Di Filippo M" first="Massimiliano" last="Di Filippo">Massimiliano Di Filippo</name><name sortKey="Di Filippo, Massimiliano" sort="Di Filippo, Massimiliano" uniqKey="Di Filippo M" first="Massimiliano" last="Di Filippo">Massimiliano Di Filippo</name><name sortKey="Gallina, Antongiulio" sort="Gallina, Antongiulio" uniqKey="Gallina A" first="Antongiulio" last="Gallina">Antongiulio Gallina</name><name sortKey="Picconi, Barbara" sort="Picconi, Barbara" uniqKey="Picconi B" first="Barbara" last="Picconi">Barbara Picconi</name><name sortKey="Picconi, Barbara" sort="Picconi, Barbara" uniqKey="Picconi B" first="Barbara" last="Picconi">Barbara Picconi</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Wang, Yingfei" sort="Wang, Yingfei" uniqKey="Wang Y" first="Yingfei" last="Wang">Yingfei Wang</name></region><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M." last="Dawson">Ted M. Dawson</name><name sortKey="Dawson, Valina L" sort="Dawson, Valina L" uniqKey="Dawson V" first="Valina L." last="Dawson">Valina L. Dawson</name><name sortKey="Stankowski, Jeannette N" sort="Stankowski, Jeannette N" uniqKey="Stankowski J" first="Jeannette N." last="Stankowski">Jeannette N. Stankowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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