The Neurobiology and Neural Circuitry of Cognitive Changes in Parkinson’s Disease Revealed by Functional Neuroimaging
Identifieur interne : 000152 ( Pmc/Checkpoint ); précédent : 000151; suivant : 000153The Neurobiology and Neural Circuitry of Cognitive Changes in Parkinson’s Disease Revealed by Functional Neuroimaging
Auteurs : Nicola J. Ray [Canada] ; Antonio P. Strafella [Canada]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.
Abstract
Patients with Parkinson’s disease (PD) often develop a spectrum of cognitive symptoms that can evolve into dementia. Dopamine (DA) replacement medications, though improving motor symptoms, can exert both positive and negative effects on cognitive ability, depending on the severity of the disease and the specific skill being tested. By considering the behavioral and clinical aspects of disease- and treatment-mediated changes in cognition alongside the pathophysiology of PD, an understanding of the factors that govern the heterogeneous expression of cognitive impairment in PD is beginning to emerge. Here, we review the neuroimaging studies revealing the neural correlates of cognitive changes after DA loss and DA replacement as well as those that may accompany the conversion from milder stages of cognitive impairment to frank dementia.
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DOI: 10.1002/mds.25173
PubMed: 23038645
PubMed Central: 4452226
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Strafella</name><affiliation wicri:level="1"><nlm:aff id="A1">Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorder Unit & E.J. 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Dopamine (DA) replacement medications, though improving motor symptoms, can exert both positive and negative effects on cognitive ability, depending on the severity of the disease and the specific skill being tested. By considering the behavioral and clinical aspects of disease- and treatment-mediated changes in cognition alongside the pathophysiology of PD, an understanding of the factors that govern the heterogeneous expression of cognitive impairment in PD is beginning to emerge. Here, we review the neuroimaging studies revealing the neural correlates of cognitive changes after DA loss and DA replacement as well as those that may accompany the conversion from milder stages of cognitive impairment to frank dementia.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23038645</article-id><article-id pub-id-type="pmc">4452226</article-id><article-id pub-id-type="doi">10.1002/mds.25173</article-id><article-id pub-id-type="manuscript">CAMS4604</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The Neurobiology and Neural Circuitry of Cognitive Changes in Parkinson’s Disease Revealed by Functional Neuroimaging</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ray</surname><given-names>Nicola J.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Strafella</surname><given-names>Antonio P.</given-names></name><degrees>MD, PhD, FRCPC</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A2"><label>2</label>Research Imaging Center, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A3"><label>3</label>Division of Brain, Imaging, and Behavior–Systems Neuroscience, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence to: Antonio P. Strafella, Correspondence to: Dr. Antonio P. Strafella, Toronto Western Hospital and Institute, CAMH Research Imaging Center, University of Toronto, 399 Bathurst Street, Toronto, Ontario, M5T 2S8 Canada; <email>antonio.strafella@uhnres.utoronto.ca</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>25</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>04</day><month>10</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>02</day><month>6</month><year>2015</year></pub-date><volume>27</volume><issue>12</issue><fpage>1484</fpage><lpage>1492</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.25173</pmc-comment>
<permissions><copyright-statement>© 2012 <italic>Movement</italic> Disorder Society</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p id="P1">Patients with Parkinson’s disease (PD) often develop a spectrum of cognitive symptoms that can evolve into dementia. Dopamine (DA) replacement medications, though improving motor symptoms, can exert both positive and negative effects on cognitive ability, depending on the severity of the disease and the specific skill being tested. By considering the behavioral and clinical aspects of disease- and treatment-mediated changes in cognition alongside the pathophysiology of PD, an understanding of the factors that govern the heterogeneous expression of cognitive impairment in PD is beginning to emerge. Here, we review the neuroimaging studies revealing the neural correlates of cognitive changes after DA loss and DA replacement as well as those that may accompany the conversion from milder stages of cognitive impairment to frank dementia.</p></abstract><kwd-group><kwd>PET</kwd><kwd>fMRI</kwd><kwd>cognition</kwd><kwd>executive functions</kwd><kwd>PD</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Ray, Nicola J" sort="Ray, Nicola J" uniqKey="Ray N" first="Nicola J." last="Ray">Nicola J. Ray</name></noRegion><name sortKey="Ray, Nicola J" sort="Ray, Nicola J" uniqKey="Ray N" first="Nicola J." last="Ray">Nicola J. Ray</name><name sortKey="Ray, Nicola J" sort="Ray, Nicola J" uniqKey="Ray N" first="Nicola J." last="Ray">Nicola J. Ray</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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