MovDisordV3, PascalFrancis, Curation, bibRecord, 002D00

Progression of Cortical Thinning in Early Parkinson's Disease

Identifieur interne : 002D00 ( PascalFrancis/Curation ); précédent : 002C99; suivant : 002D01

Progression of Cortical Thinning in Early Parkinson's Disease

Auteurs : Naroa Ibarretxe-Bilbao [Espagne] ; Carme Junque [Espagne] ; Barbara Segura [Espagne] ; Hugo C. Baggio [Espagne] ; Maria J. Marti [Espagne] ; Francesc Valldeoriola [Espagne] ; Nuria Bargallo [Espagne] ; Eduardo Tolosa [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:13-0063588

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Cognition.

English descriptors

KwdEn :
- Cognition, Nervous system diseases, Parkinson disease.

Abstract

The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early-PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process.

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A11	`02`	`1`		`@1 JUNQUE (Carme)`
A11	`03`	`1`		`@1 SEGURA (Barbara)`
A11	`04`	`1`		`@1 BAGGIO (Hugo C.)`
A11	`05`	`1`		`@1 MARTI (Maria J.)`
A11	`06`	`1`		`@1 VALLDEORIOLA (Francesc)`
A11	`07`	`1`		`@1 BARGALLO (Nuria)`
A11	`08`	`1`		`@1 TOLOSA (Eduardo)`
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A14	`03`			`@1 Department of Psychiatry and Clinical Psychobiology, University of Barcelona @2 Catalonia @3 ESP @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
A14	`04`			`@1 Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clinic de Neurociències, Hospital Clinic de Barcelona @2 Catalonia @3 ESP @Z 5 aut. @Z 6 aut. @Z 8 aut.`
A14	`05`			`@1 Centre de Diagnostic per la Imatge Hospital Clinic de Barcelona, Hospital Clinic de Barcelona @2 Catalonia @3 ESP @Z 7 aut.`
A14	`06`			`@1 Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Basque Country @2 Bilbao @3 ESP @Z 1 aut.`
A20				`@1 1746-1754`
A21				`@1 2012`
A23	`01`			`@0 ENG`
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C01	`01`		`ENG`	@0 The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early-PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process.
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C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Cognition @5 09`
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C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
N21				`@1 042`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Progression of Cortical Thinning in Early Parkinson's Disease</title>
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<front><div type="abstract" xml:lang="en">The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early-PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Progression of Cortical Thinning in Early Parkinson's Disease

Progression of Cortical Thinning in Early Parkinson's Disease

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