Movement Disorders (revue)

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Treatment of Dysarthria Following Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease

Identifieur interne : 002976 ( PascalFrancis/Curation ); précédent : 002975; suivant : 002977

Treatment of Dysarthria Following Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease

Auteurs : Elina Tripoliti [Royaume-Uni] ; Laura Strong [Royaume-Uni] ; Freya Hickey [Royaume-Uni] ; Tom Foltynie [Royaume-Uni] ; Ludvic Zrinzo [Royaume-Uni] ; Joseph Candelario [Royaume-Uni] ; Marwan Hariz [Royaume-Uni] ; Patricia Limousin [Royaume-Uni]

Source :

RBID : Pascal:12-0026981

Descripteurs français

English descriptors

Abstract

Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established treatment for patients with Parkinson's disease (PD). Speech impairment is a frequent side effect of the surgery. This study examined the efficacy of an intensive speech treatment, the Lee Silverman Voice Treatment (LSVT) on dysarthria after STN-DBS. Methods: The LSVT was administered to 10 patients with STN-DBS (surgical group) and 10 patients without (medical group). Patients were assessed before, immediately after, and 6 months following the speech treatment using sustained phonation, a speech intelligibility scale, and monologue. Vocal loudness, speech intelligibility, and perceptual ratings were the primary outcome measures. Results: Vocal loudness and perceptual scores improved significantly across tasks for the medical group only. Speech intelligibility did not significantly change for either group. Results in the surgical group were variable, with some patients deteriorating. Conclusions: Treatment of dysarthria following STN-DBS needs further investigation because of the variable response to LSVT.
pA  
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A08 01  1  ENG  @1 Treatment of Dysarthria Following Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease
A11 01  1    @1 TRIPOLITI (Elina)
A11 02  1    @1 STRONG (Laura)
A11 03  1    @1 HICKEY (Freya)
A11 04  1    @1 FOLTYNIE (Tom)
A11 05  1    @1 ZRINZO (Ludvic)
A11 06  1    @1 CANDELARIO (Joseph)
A11 07  1    @1 HARIZ (Marwan)
A11 08  1    @1 LIMOUSIN (Patricia)
A14 01      @1 UCL, Institute of Neurology, Sobell Department, Unit of Functional Neurosurgery, Queen Square @2 London @3 GBR @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut.
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A44       @0 0000 @1 © 2012 INIST-CNRS. All rights reserved.
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C01 01    ENG  @0 Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established treatment for patients with Parkinson's disease (PD). Speech impairment is a frequent side effect of the surgery. This study examined the efficacy of an intensive speech treatment, the Lee Silverman Voice Treatment (LSVT) on dysarthria after STN-DBS. Methods: The LSVT was administered to 10 patients with STN-DBS (surgical group) and 10 patients without (medical group). Patients were assessed before, immediately after, and 6 months following the speech treatment using sustained phonation, a speech intelligibility scale, and monologue. Vocal loudness, speech intelligibility, and perceptual ratings were the primary outcome measures. Results: Vocal loudness and perceptual scores improved significantly across tasks for the medical group only. Speech intelligibility did not significantly change for either group. Results in the surgical group were variable, with some patients deteriorating. Conclusions: Treatment of dysarthria following STN-DBS needs further investigation because of the variable response to LSVT.
C02 01  X    @0 002B17
C02 02  X    @0 002B17G
C03 01  X  FRE  @0 Dysarthrie @5 01
C03 01  X  ENG  @0 Dysarthria @5 01
C03 01  X  SPA  @0 Disartria @5 01
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C03 04  X  FRE  @0 Traitement @5 09
C03 04  X  ENG  @0 Treatment @5 09
C03 04  X  SPA  @0 Tratamiento @5 09
C03 05  X  FRE  @0 Noyau sousthalamique @5 10
C03 05  X  ENG  @0 Subthalamic nucleus @5 10
C03 05  X  SPA  @0 Núcleo subtalámico @5 10
C03 06  X  FRE  @0 Parole @5 11
C03 06  X  ENG  @0 Speech @5 11
C03 06  X  SPA  @0 Habla @5 11
C03 07  X  FRE  @0 Stimulation cérébrale profonde @4 CD @5 96
C03 07  X  ENG  @0 Deep brain stimulation @4 CD @5 96
C07 01  X  FRE  @0 Trouble de la communication @5 38
C07 01  X  ENG  @0 Communication disorder @5 38
C07 01  X  SPA  @0 Trastorno comunicación @5 38
C07 02  X  FRE  @0 Trouble du langage @5 39
C07 02  X  ENG  @0 Language disorder @5 39
C07 02  X  SPA  @0 Trastorno lenguaje @5 39
C07 03  X  FRE  @0 Trouble neurologique @5 40
C07 03  X  ENG  @0 Neurological disorder @5 40
C07 03  X  SPA  @0 Trastorno neurológico @5 40
C07 04  X  FRE  @0 Encéphale @5 41
C07 04  X  ENG  @0 Encephalon @5 41
C07 04  X  SPA  @0 Encéfalo @5 41
C07 05  X  FRE  @0 Système nerveux central @5 42
C07 05  X  ENG  @0 Central nervous system @5 42
C07 05  X  SPA  @0 Sistema nervioso central @5 42
C07 06  X  FRE  @0 Pathologie de l'encéphale @5 43
C07 06  X  ENG  @0 Cerebral disorder @5 43
C07 06  X  SPA  @0 Encéfalo patología @5 43
C07 07  X  FRE  @0 Syndrome extrapyramidal @5 44
C07 07  X  ENG  @0 Extrapyramidal syndrome @5 44
C07 07  X  SPA  @0 Extrapiramidal síndrome @5 44
C07 08  X  FRE  @0 Maladie dégénérative @5 45
C07 08  X  ENG  @0 Degenerative disease @5 45
C07 08  X  SPA  @0 Enfermedad degenerativa @5 45
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N21       @1 009
N44 01      @1 OTO
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Pascal:12-0026981

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<term>Deep brain stimulation</term>
<term>Dysarthria</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Speech</term>
<term>Subthalamic nucleus</term>
<term>Treatment</term>
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<term>Dysarthrie</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Traitement</term>
<term>Noyau sousthalamique</term>
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<div type="abstract" xml:lang="en">Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established treatment for patients with Parkinson's disease (PD). Speech impairment is a frequent side effect of the surgery. This study examined the efficacy of an intensive speech treatment, the Lee Silverman Voice Treatment (LSVT) on dysarthria after STN-DBS. Methods: The LSVT was administered to 10 patients with STN-DBS (surgical group) and 10 patients without (medical group). Patients were assessed before, immediately after, and 6 months following the speech treatment using sustained phonation, a speech intelligibility scale, and monologue. Vocal loudness, speech intelligibility, and perceptual ratings were the primary outcome measures. Results: Vocal loudness and perceptual scores improved significantly across tasks for the medical group only. Speech intelligibility did not significantly change for either group. Results in the surgical group were variable, with some patients deteriorating. Conclusions: Treatment of dysarthria following STN-DBS needs further investigation because of the variable response to LSVT.</div>
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<fA11 i1="08" i2="1">
<s1>LIMOUSIN (Patricia)</s1>
</fA11>
<fA14 i1="01">
<s1>UCL, Institute of Neurology, Sobell Department, Unit of Functional Neurosurgery, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA20>
<s1>2434-2437</s1>
</fA20>
<fA21>
<s1>2011</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
<fA43 i1="01">
<s1>INIST</s1>
<s2>20953</s2>
<s5>354000505925010220</s5>
</fA43>
<fA44>
<s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>24 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>12-0026981</s0>
</fA47>
<fA60>
<s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Movement disorders</s0>
</fA64>
<fA66 i1="01">
<s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established treatment for patients with Parkinson's disease (PD). Speech impairment is a frequent side effect of the surgery. This study examined the efficacy of an intensive speech treatment, the Lee Silverman Voice Treatment (LSVT) on dysarthria after STN-DBS. Methods: The LSVT was administered to 10 patients with STN-DBS (surgical group) and 10 patients without (medical group). Patients were assessed before, immediately after, and 6 months following the speech treatment using sustained phonation, a speech intelligibility scale, and monologue. Vocal loudness, speech intelligibility, and perceptual ratings were the primary outcome measures. Results: Vocal loudness and perceptual scores improved significantly across tasks for the medical group only. Speech intelligibility did not significantly change for either group. Results in the surgical group were variable, with some patients deteriorating. Conclusions: Treatment of dysarthria following STN-DBS needs further investigation because of the variable response to LSVT.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X">
<s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Dysarthrie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Dysarthria</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Disartria</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Pathologie du système nerveux</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Traitement</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Treatment</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Tratamiento</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Noyau sousthalamique</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Subthalamic nucleus</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Núcleo subtalámico</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Parole</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Speech</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Habla</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Stimulation cérébrale profonde</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Trouble de la communication</s0>
<s5>38</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Communication disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Trastorno comunicación</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Trouble du langage</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Language disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Trastorno lenguaje</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Trouble neurologique</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Neurological disorder</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Trastorno neurológico</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Encéphale</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Encephalon</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Encéfalo</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Système nerveux central</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Central nervous system</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Sistema nervioso central</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Pathologie de l'encéphale</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Syndrome extrapyramidal</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>44</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>45</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE">
<s0>Pathologie du système nerveux central</s0>
<s5>46</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>46</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>46</s5>
</fC07>
<fN21>
<s1>009</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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