MovDisordV3, PascalFrancis, Curation, bibRecord, 002944

Pain Sensitivity and Clinical Progression in Parkinson's Disease

Identifieur interne : 002944 ( PascalFrancis/Curation ); précédent : 002943; suivant : 002945

Pain Sensitivity and Clinical Progression in Parkinson's Disease

Auteurs : Veit Mylius [Allemagne] ; Juliane Brebbermann [Allemagne] ; Helena Dohmann [Allemagne] ; Isabel Engau [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Jens C. Möller [Allemagne, Suisse]

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0481759

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Sensibilité douleur, Diagnostic, Réflexe flexion, Douleur, Perception.

English descriptors

KwdEn :
- Diagnosis, Flexion reflex, Nervous system diseases, Pain, Pain sensitivity, Parkinson disease, Perception.

Abstract

Pain sensitivity in Parkinson's disease is known to be altered in an _L-dopa-dependent manner with increased spinal nociception and experimental pain perception in the medication-defined "off" state. As Parkinson's disease-related pain can be an early symptom in Parkinson's disease, the present study aimed to investigate experimental pain sensitivity and spinal nociception during clinical progression. The nociceptive flexion reflex as a marker of spinal nociception as well as electrical and heat pain thresholds were assessed during the medication-defined "off" state in 29 patients with Parkinson's disease divided into 3 severity groups (according to their Unified Parkinson's Disease Rating Scale motor score) and compared with 27 healthy elderly subjects. Parkinson's disease-related pain was also quantified. Data provided evidence that spinal nociception and pain sensitivity are preserved during the early phase of Parkinson's disease. Following increased spinal nociception (F_1,36 = 6.838, P = .013), experimental thermal and electrical pain sensitivity were augmented during the course of Parkinson's disease (F_1,34 = 5.397, P = .014; F_1,34 = 6.038, P = 0.053), whereas spinal nociception further increased (F_1,34 = 5.397, P <.001). Increased experimental pain sensitivity was observed in patients exhibiting Parkinson's disease-related pain. Spinal alterations either on the local level or induced by diminished dopaminergic descending inhibition probably led to increased pain sensitivity in later stages. Because Parkinson's disease-related pain is correlated with experimental pain sensitivity these 2 observations likely reflect a causal relation.

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A08	`01`	`1`	`ENG`	`@1 Pain Sensitivity and Clinical Progression in Parkinson's Disease`
A11	`01`	`1`		`@1 MYLIUS (Veit)`
A11	`02`	`1`		`@1 BREBBERMANN (Juliane)`
A11	`03`	`1`		`@1 DOHMANN (Helena)`
A11	`04`	`1`		`@1 ENGAU (Isabel)`
A11	`05`	`1`		`@1 OERTEL (Wolfgang H.)`
A11	`06`	`1`		`@1 MÖLLER (Jens C.)`
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C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Sensibilité douleur @5 09`
C03	`03`	`X`	`ENG`	`@0 Pain sensitivity @5 09`
C03	`03`	`X`	`SPA`	`@0 Sensibilidad dolor @5 09`
C03	`04`	`X`	`FRE`	`@0 Diagnostic @5 10`
C03	`04`	`X`	`ENG`	`@0 Diagnosis @5 10`
C03	`04`	`X`	`SPA`	`@0 Diagnóstico @5 10`
C03	`05`	`X`	`FRE`	`@0 Réflexe flexion @5 11`
C03	`05`	`X`	`ENG`	`@0 Flexion reflex @5 11`
C03	`05`	`X`	`SPA`	`@0 Reflejo flexión @5 11`
C03	`06`	`X`	`FRE`	`@0 Douleur @5 12`
C03	`06`	`X`	`ENG`	`@0 Pain @5 12`
C03	`06`	`X`	`SPA`	`@0 Dolor @5 12`
C03	`07`	`X`	`FRE`	`@0 Perception @5 13`
C03	`07`	`X`	`ENG`	`@0 Perception @5 13`
C03	`07`	`X`	`SPA`	`@0 Percepción @5 13`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
N21				`@1 332`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Pain Sensitivity and Clinical Progression in Parkinson's Disease</title>
<author><name sortKey="Mylius, Veit" sort="Mylius, Veit" uniqKey="Mylius V" first="Veit" last="Mylius">Veit Mylius</name>
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<author><name sortKey="Brebbermann, Juliane" sort="Brebbermann, Juliane" uniqKey="Brebbermann J" first="Juliane" last="Brebbermann">Juliane Brebbermann</name>
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<author><name sortKey="Dohmann, Helena" sort="Dohmann, Helena" uniqKey="Dohmann H" first="Helena" last="Dohmann">Helena Dohmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
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<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>6 aut.</sZ>
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<country>Allemagne</country>
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<author><name sortKey="Engau, Isabel" sort="Engau, Isabel" uniqKey="Engau I" first="Isabel" last="Engau">Isabel Engau</name>
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<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
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<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Moller, Jens C" sort="Moller, Jens C" uniqKey="Moller J" first="Jens C." last="Möller">Jens C. Möller</name>
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<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<country>Allemagne</country>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diagnosis</term>
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<term>Pain sensitivity</term>
<term>Parkinson disease</term>
<term>Perception</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Sensibilité douleur</term>
<term>Diagnostic</term>
<term>Réflexe flexion</term>
<term>Douleur</term>
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<front><div type="abstract" xml:lang="en">Pain sensitivity in Parkinson's disease is known to be altered in an <sub>L</sub>
-dopa-dependent manner with increased spinal nociception and experimental pain perception in the medication-defined "off" state. As Parkinson's disease-related pain can be an early symptom in Parkinson's disease, the present study aimed to investigate experimental pain sensitivity and spinal nociception during clinical progression. The nociceptive flexion reflex as a marker of spinal nociception as well as electrical and heat pain thresholds were assessed during the medication-defined "off" state in 29 patients with Parkinson's disease divided into 3 severity groups (according to their Unified Parkinson's Disease Rating Scale motor score) and compared with 27 healthy elderly subjects. Parkinson's disease-related pain was also quantified. Data provided evidence that spinal nociception and pain sensitivity are preserved during the early phase of Parkinson's disease. Following increased spinal nociception (F<sub>1,36</sub>
 = 6.838, P = .013), experimental thermal and electrical pain sensitivity were augmented during the course of Parkinson's disease (F<sub>1,34</sub>
 = 5.397, P = .014; F<sub>1,34</sub>
 = 6.038, P = 0.053), whereas spinal nociception further increased (F<sub>1,34</sub>
 = 5.397, P <.001). Increased experimental pain sensitivity was observed in patients exhibiting Parkinson's disease-related pain. Spinal alterations either on the local level or induced by diminished dopaminergic descending inhibition probably led to increased pain sensitivity in later stages. Because Parkinson's disease-related pain is correlated with experimental pain sensitivity these 2 observations likely reflect a causal relation.</div>
</front>
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<fA11 i1="01" i2="1"><s1>MYLIUS (Veit)</s1>
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<fA11 i1="02" i2="1"><s1>BREBBERMANN (Juliane)</s1>
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<fA11 i1="03" i2="1"><s1>DOHMANN (Helena)</s1>
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<fA11 i1="05" i2="1"><s1>OERTEL (Wolfgang H.)</s1>
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<fA11 i1="06" i2="1"><s1>MÖLLER (Jens C.)</s1>
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<fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<fA14 i1="02"><s1>Paediatric Clinic Siegen</s1>
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<fA14 i1="03"><s1>Neurocentro della Svizzera Italiana, Ente Ospedaliero Cantonale</s1>
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<fC01 i1="01" l="ENG"><s0>Pain sensitivity in Parkinson's disease is known to be altered in an <sub>L</sub>
-dopa-dependent manner with increased spinal nociception and experimental pain perception in the medication-defined "off" state. As Parkinson's disease-related pain can be an early symptom in Parkinson's disease, the present study aimed to investigate experimental pain sensitivity and spinal nociception during clinical progression. The nociceptive flexion reflex as a marker of spinal nociception as well as electrical and heat pain thresholds were assessed during the medication-defined "off" state in 29 patients with Parkinson's disease divided into 3 severity groups (according to their Unified Parkinson's Disease Rating Scale motor score) and compared with 27 healthy elderly subjects. Parkinson's disease-related pain was also quantified. Data provided evidence that spinal nociception and pain sensitivity are preserved during the early phase of Parkinson's disease. Following increased spinal nociception (F<sub>1,36</sub>
 = 6.838, P = .013), experimental thermal and electrical pain sensitivity were augmented during the course of Parkinson's disease (F<sub>1,34</sub>
 = 5.397, P = .014; F<sub>1,34</sub>
 = 6.038, P = 0.053), whereas spinal nociception further increased (F<sub>1,34</sub>
 = 5.397, P <.001). Increased experimental pain sensitivity was observed in patients exhibiting Parkinson's disease-related pain. Spinal alterations either on the local level or induced by diminished dopaminergic descending inhibition probably led to increased pain sensitivity in later stages. Because Parkinson's disease-related pain is correlated with experimental pain sensitivity these 2 observations likely reflect a causal relation.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
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<s5>02</s5>
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<s5>02</s5>
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<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Sensibilité douleur</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Pain sensitivity</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sensibilidad dolor</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Diagnostic</s0>
<s5>10</s5>
</fC03>
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<s5>10</s5>
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<s5>10</s5>
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<s5>11</s5>
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<s5>12</s5>
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<s5>37</s5>
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<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
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<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
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<s5>39</s5>
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<s5>40</s5>
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<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>332</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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Movement Disorders (revue)

Pain Sensitivity and Clinical Progression in Parkinson's Disease

Pain Sensitivity and Clinical Progression in Parkinson's Disease

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