MovDisordV3, PascalFrancis, Curation, bibRecord, 002903

Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio

Identifieur interne : 002903 ( PascalFrancis/Curation ); précédent : 002902; suivant : 002904

Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio

Auteurs : Marios Politis [Royaume-Uni] ; Wolfgang H. Oertel [Allemagne] ; KIT WU [Royaume-Uni] ; Niall P. Quinn [Royaume-Uni] ; Oliver Pogarell [Allemagne] ; David J. Brooks [Royaume-Uni] ; Anders Bjorklund [Suède] ; Olle Lindvall [Suède] ; Paola Piccini [Royaume-Uni]

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0444613

Descripteurs français

Pascal (Inist)
- Dyskinésie, Maladie de Parkinson, Pathologie du système nerveux, Greffe, Dopamine, Transplantation, Transporteur sérotonine.

English descriptors

KwdEn :
- Dopamine, Dyskinesia, Graft, Nervous system diseases, Parkinson disease, Serotonin transporter, Transplantation.

Abstract

Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT_1A agonist suppressed graft-induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft-induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias.

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C01	`01`		`ENG`	@0 Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT_1A agonist suppressed graft-induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft-induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias.
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C07	`07`	`X`	`FRE`	`@0 Catécholamine @5 44`
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C07	`07`	`X`	`SPA`	`@0 Catecolamina @5 44`
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Pascal:11-0444613

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio</title>
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<author><name sortKey="Kit Wu" sort="Kit Wu" uniqKey="Kit Wu" last="Kit Wu">KIT WU</name>
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<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
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<author><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name>
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<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
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<author><name sortKey="Bjorklund, Anders" sort="Bjorklund, Anders" uniqKey="Bjorklund A" first="Anders" last="Bjorklund">Anders Bjorklund</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Neurobiology Unit, Wallenberg Neuroscience Center</s1>
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<author><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center</s1>
<s2>Lund</s2>
<s3>SWE</s3>
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<country>Suède</country>
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<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Lund Stem Cell Center</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinical Sciences Center, Medical Research Council, Hammersmith Hospital, Imperial College London</s1>
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<series><title level="j" type="main">Movement disorders</title>
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<term>Serotonin transporter</term>
<term>Transplantation</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
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<term>Dopamine</term>
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<front><div type="abstract" xml:lang="en">Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT<sub>1A</sub>
 agonist suppressed graft-induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft-induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio

Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio

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