Tremor Severity and Age: A Cross-Sectional, Population-Based Study of 2,524 Young and Midlife Normal Adults
Identifieur interne : 002804 ( PascalFrancis/Curation ); précédent : 002803; suivant : 002805Tremor Severity and Age: A Cross-Sectional, Population-Based Study of 2,524 Young and Midlife Normal Adults
Auteurs : Elan D. Louis [États-Unis] ; Danella Hafeman [États-Unis] ; Faruque Parvez [États-Unis] ; XINHUA LIU [États-Unis] ; Roy N. Alcalay [États-Unis] ; Tariqul Islam [Bangladesh] ; Alauddin Ahmed [Bangladesh] ; ABU BAKAR SIDDIQUE [Bangladesh] ; TAZUL ISLAM PATWARY [Bangladesh] ; Stephanie Melkonian [États-Unis] ; Maria Argos [États-Unis] ; Diane Levy [États-Unis] ; Habibul Ahsan [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Mild action tremor occurs in most normal people. Yet this tremor mainly has been studied within the context of advanced age rather than among the vast bulk of adults who are not elderly. Whether this tremor worsens during young and middle age is unknown. Using cross-sectional data from a large population-based study of young and midlife normal adults (age range, 18-60 years), we assessed whether increasing age is associated with more severe action tremor. Two thousand five hundred and twenty-four adults in Araihazar, Bangladesh, drew an Archimedes spiral with each hand. Tremor in spirals was rated (0-3) by a blinded neurologist, and a spiral score (range, 0-6) was assigned. Spiral score was correlated with age (r = 0.06, P =.004). With each advancing decade, the spiral score increased (P = .002) so that the spiral score in participants in the highest age group (age 60) was approximately twice that of participants in the youngest age group (age 18-19); P = .003. In the regression model that adjusted for potential confounders (sex, cigarettes, medications, asthma inhalers, and tea and betel nut use), spiral score was associated with age (P = .0045). In this cross-sectional, population-based study of more than 2500 young and midlife normal adults, there was a clear association between age and tremor severity. Although the magnitude of the correlation coefficient was modest, tremor severity was higher with each passing decade. These data suggest that age-dependent increase in tremor amplitude is not restricted to older people but occurs in all adult age groups.
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Louis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Hafeman, Danella" sort="Hafeman, Danella" uniqKey="Hafeman D" first="Danella" last="Hafeman">Danella Hafeman</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Psychiatry, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Parvez, Faruque" sort="Parvez, Faruque" uniqKey="Parvez F" first="Faruque" last="Parvez">Faruque Parvez</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Xinhua Liu" sort="Xinhua Liu" uniqKey="Xinhua Liu" last="Xinhua Liu">XINHUA LIU</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Biostatistics, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N." last="Alcalay">Roy N. Alcalay</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Islam, Tariqul" sort="Islam, Tariqul" uniqKey="Islam T" first="Tariqul" last="Islam">Tariqul Islam</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Columbia University/University of Chicago Arsenic Research Office in Bangladesh</s1><s2>Dhaka</s2><s3>BGD</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Bangladesh</country></affiliation></author><author><name sortKey="Ahmed, Alauddin" sort="Ahmed, Alauddin" uniqKey="Ahmed A" first="Alauddin" last="Ahmed">Alauddin Ahmed</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Columbia University/University of Chicago Arsenic Research Office in Bangladesh</s1><s2>Dhaka</s2><s3>BGD</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Bangladesh</country></affiliation></author><author><name sortKey="Abu Bakar Siddique" sort="Abu Bakar Siddique" uniqKey="Abu Bakar Siddique" last="Abu Bakar Siddique">ABU BAKAR SIDDIQUE</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Columbia University/University of Chicago Arsenic Research Office in Bangladesh</s1><s2>Dhaka</s2><s3>BGD</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Bangladesh</country></affiliation></author><author><name sortKey="Tazul Islam Patwary" sort="Tazul Islam Patwary" uniqKey="Tazul Islam Patwary" last="Tazul Islam Patwary">TAZUL ISLAM PATWARY</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Columbia University/University of Chicago Arsenic Research Office in Bangladesh</s1><s2>Dhaka</s2><s3>BGD</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Bangladesh</country></affiliation></author><author><name sortKey="Melkonian, Stephanie" sort="Melkonian, Stephanie" uniqKey="Melkonian S" first="Stephanie" last="Melkonian">Stephanie Melkonian</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Argos, Maria" sort="Argos, Maria" uniqKey="Argos M" first="Maria" last="Argos">Maria Argos</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Levy, Diane" sort="Levy, Diane" uniqKey="Levy D" first="Diane" last="Levy">Diane Levy</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Biostatistics, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0353392</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0353392 INIST</idno><idno type="RBID">Pascal:11-0353392</idno><idno type="wicri:Area/PascalFrancis/Corpus">000514</idno><idno type="wicri:Area/PascalFrancis/Curation">002804</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Tremor Severity and Age: A Cross-Sectional, Population-Based Study of 2,524 Young and Midlife Normal Adults</title><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Hafeman, Danella" sort="Hafeman, Danella" uniqKey="Hafeman D" first="Danella" last="Hafeman">Danella Hafeman</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Psychiatry, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Parvez, Faruque" sort="Parvez, Faruque" uniqKey="Parvez F" first="Faruque" last="Parvez">Faruque Parvez</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Xinhua Liu" sort="Xinhua Liu" uniqKey="Xinhua Liu" last="Xinhua Liu">XINHUA LIU</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Biostatistics, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N." last="Alcalay">Roy N. Alcalay</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Islam, Tariqul" sort="Islam, Tariqul" uniqKey="Islam T" first="Tariqul" last="Islam">Tariqul Islam</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Columbia University/University of Chicago Arsenic Research Office in Bangladesh</s1><s2>Dhaka</s2><s3>BGD</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Bangladesh</country></affiliation></author><author><name sortKey="Ahmed, Alauddin" sort="Ahmed, Alauddin" uniqKey="Ahmed A" first="Alauddin" last="Ahmed">Alauddin Ahmed</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Columbia University/University of Chicago Arsenic Research Office in Bangladesh</s1><s2>Dhaka</s2><s3>BGD</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Bangladesh</country></affiliation></author><author><name sortKey="Abu Bakar Siddique" sort="Abu Bakar Siddique" uniqKey="Abu Bakar Siddique" last="Abu Bakar Siddique">ABU BAKAR SIDDIQUE</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Columbia University/University of Chicago Arsenic Research Office in Bangladesh</s1><s2>Dhaka</s2><s3>BGD</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Bangladesh</country></affiliation></author><author><name sortKey="Tazul Islam Patwary" sort="Tazul Islam Patwary" uniqKey="Tazul Islam Patwary" last="Tazul Islam Patwary">TAZUL ISLAM PATWARY</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Columbia University/University of Chicago Arsenic Research Office in Bangladesh</s1><s2>Dhaka</s2><s3>BGD</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Bangladesh</country></affiliation></author><author><name sortKey="Melkonian, Stephanie" sort="Melkonian, Stephanie" uniqKey="Melkonian S" first="Stephanie" last="Melkonian">Stephanie Melkonian</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Argos, Maria" sort="Argos, Maria" uniqKey="Argos M" first="Maria" last="Argos">Maria Argos</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Levy, Diane" sort="Levy, Diane" uniqKey="Levy D" first="Diane" last="Levy">Diane Levy</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Biostatistics, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cross sectional study</term><term>Epidemiology</term><term>Nervous system diseases</term><term>Tremor</term><term>Young adult</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tremblement</term><term>Pathologie du système nerveux</term><term>Etude transversale</term><term>Adulte jeune</term><term>Epidémiologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mild action tremor occurs in most normal people. Yet this tremor mainly has been studied within the context of advanced age rather than among the vast bulk of adults who are not elderly. Whether this tremor worsens during young and middle age is unknown. Using cross-sectional data from a large population-based study of young and midlife normal adults (age range, 18-60 years), we assessed whether increasing age is associated with more severe action tremor. Two thousand five hundred and twenty-four adults in Araihazar, Bangladesh, drew an Archimedes spiral with each hand. Tremor in spirals was rated (0-3) by a blinded neurologist, and a spiral score (range, 0-6) was assigned. Spiral score was correlated with age (r = 0.06, P =.004). With each advancing decade, the spiral score increased (P = .002) so that the spiral score in participants in the highest age group (age 60) was approximately twice that of participants in the youngest age group (age 18-19); P = .003. In the regression model that adjusted for potential confounders (sex, cigarettes, medications, asthma inhalers, and tea and betel nut use), spiral score was associated with age (P = .0045). In this cross-sectional, population-based study of more than 2500 young and midlife normal adults, there was a clear association between age and tremor severity. Although the magnitude of the correlation coefficient was modest, tremor severity was higher with each passing decade. These data suggest that age-dependent increase in tremor amplitude is not restricted to older people but occurs in all adult age groups.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>26</s2></fA05><fA06><s2>8</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Tremor Severity and Age: A Cross-Sectional, Population-Based Study of 2,524 Young and Midlife Normal Adults</s1></fA08><fA11 i1="01" i2="1"><s1>LOUIS (Elan D.)</s1></fA11><fA11 i1="02" i2="1"><s1>HAFEMAN (Danella)</s1></fA11><fA11 i1="03" i2="1"><s1>PARVEZ (Faruque)</s1></fA11><fA11 i1="04" i2="1"><s1>XINHUA LIU</s1></fA11><fA11 i1="05" i2="1"><s1>ALCALAY (Roy N.)</s1></fA11><fA11 i1="06" i2="1"><s1>ISLAM (Tariqul)</s1></fA11><fA11 i1="07" i2="1"><s1>AHMED (Alauddin)</s1></fA11><fA11 i1="08" i2="1"><s1>ABU BAKAR SIDDIQUE</s1></fA11><fA11 i1="09" i2="1"><s1>TAZUL ISLAM PATWARY</s1></fA11><fA11 i1="10" i2="1"><s1>MELKONIAN (Stephanie)</s1></fA11><fA11 i1="11" i2="1"><s1>ARGOS (Maria)</s1></fA11><fA11 i1="12" i2="1"><s1>LEVY (Diane)</s1></fA11><fA11 i1="13" i2="1"><s1>AHSAN (Habibul)</s1></fA11><fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Epidemiology, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="04"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Psychiatry, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>3 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Biostatistics, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="08"><s1>Columbia University/University of Chicago Arsenic Research Office in Bangladesh</s1><s2>Dhaka</s2><s3>BGD</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="09"><s1>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></fA14><fA20><s1>1515-1520</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000508552620210</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>39 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0353392</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Mild action tremor occurs in most normal people. Yet this tremor mainly has been studied within the context of advanced age rather than among the vast bulk of adults who are not elderly. Whether this tremor worsens during young and middle age is unknown. Using cross-sectional data from a large population-based study of young and midlife normal adults (age range, 18-60 years), we assessed whether increasing age is associated with more severe action tremor. Two thousand five hundred and twenty-four adults in Araihazar, Bangladesh, drew an Archimedes spiral with each hand. Tremor in spirals was rated (0-3) by a blinded neurologist, and a spiral score (range, 0-6) was assigned. Spiral score was correlated with age (r = 0.06, P =.004). With each advancing decade, the spiral score increased (P = .002) so that the spiral score in participants in the highest age group (age 60) was approximately twice that of participants in the youngest age group (age 18-19); P = .003. In the regression model that adjusted for potential confounders (sex, cigarettes, medications, asthma inhalers, and tea and betel nut use), spiral score was associated with age (P = .0045). In this cross-sectional, population-based study of more than 2500 young and midlife normal adults, there was a clear association between age and tremor severity. Although the magnitude of the correlation coefficient was modest, tremor severity was higher with each passing decade. These data suggest that age-dependent increase in tremor amplitude is not restricted to older people but occurs in all adult age groups.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17A01</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Tremblement</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Tremor</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Temblor</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Etude transversale</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Cross sectional study</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Estudio transversal</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Adulte jeune</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Young adult</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Adulto joven</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Epidémiologie</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Epidemiology</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Epidemiología</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Human</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Mouvement involontaire</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Involuntary movement</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Movimiento involuntario</s0><s5>37</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Trouble neurologique</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Neurological disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Trastorno neurológico</s0><s5>39</s5></fC07><fN21><s1>241</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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