MovDisordV3, PascalFrancis, Curation, bibRecord, 002400

Midbrain SERT in Degenerative Parkinsonisms: A 123I-FP-CIT SPECT Study

Identifieur interne : 002400 ( PascalFrancis/Curation ); précédent : 002399; suivant : 002401

Midbrain SERT in Degenerative Parkinsonisms: A 123I-FP-CIT SPECT Study

Auteurs : Francesco Roselli [Italie, Allemagne] ; Nicola M. Pisciotta [Italie] ; Michele Pennelli [Italie] ; Maria S. Aniello [Italie] ; Angelo Gigante [Italie] ; Maria F. De Caro [Italie] ; Ermanno Ferrannini [Italie] ; Bruno Tartaglione [Italie] ; Artor Niccoli-Asabella [Italie] ; Giovanni Defazio [Italie] ; Paolo Livrea [Italie] ; Giuseppe Rubini [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0446312

Descripteurs français

Pascal (Inist)
- Parkinsonisme, Démence à corps de Lewy, Pathologie du système nerveux, Mésencéphale, Tomoscintigraphie émission monophotonique, Photon, Transporteur sérotonine.

English descriptors

KwdEn :
- Lewy body dementia, Midbrain, Nervous system diseases, Parkinsonism, Photon, Serotonin transporter, Single photon emission tomography.

Abstract

SPECT imaging is widely used for the differential diagnosis of degenerative parkinsonisms by exploiting the high affinitiy of the radiotracer ¹²³I-FP-CIT for the dopamine transporter. Reduced levels of DAT are found in Parkinson Disease (PD), Dementia with Lewy Bodies (DLB), and Progressive Supranuclear Palsy (PSP) compared to in Essential Tremor (ET) and Healthy Controls (HC). However, the extent of the neurodegenerative process may extend beyond nigrostriatal system. We have exploited the affinity of the same radiotracer ¹²³I-FP-CIT for the serotonin transporter to investigate SERT levels in the midbrain of patients with PD, DLB, PSP, and ET compared to HC. Using MRI images as anatomical templates for midbrain uptake quantification, we found a mild decrease in SERT levels in PD compared to ET and HC, with marked inter-individual variability; on the other side, PSP and DLB patients displayed markedly reduced to undetectable levels of SERT, respectively. These findings show that the neurodegenerative process affects serotoninergic neurons in parkinsonisms, with much more severe involvement in DLB than in PD patients, despite the comparable loss of striatal DAT. SERT-dependent ¹²³I-FP-CIT uptake may allow a more comprehensive assessment of neurochemical disturbances in degenerative parkinsonisms and may have a value for differential diagnosis.

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A11	`03`	`1`		`@1 PENNELLI (Michele)`
A11	`04`	`1`		`@1 ANIELLO (Maria S.)`
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C01	`01`		`ENG`	@0 SPECT imaging is widely used for the differential diagnosis of degenerative parkinsonisms by exploiting the high affinitiy of the radiotracer ¹²³I-FP-CIT for the dopamine transporter. Reduced levels of DAT are found in Parkinson Disease (PD), Dementia with Lewy Bodies (DLB), and Progressive Supranuclear Palsy (PSP) compared to in Essential Tremor (ET) and Healthy Controls (HC). However, the extent of the neurodegenerative process may extend beyond nigrostriatal system. We have exploited the affinity of the same radiotracer ¹²³I-FP-CIT for the serotonin transporter to investigate SERT levels in the midbrain of patients with PD, DLB, PSP, and ET compared to HC. Using MRI images as anatomical templates for midbrain uptake quantification, we found a mild decrease in SERT levels in PD compared to ET and HC, with marked inter-individual variability; on the other side, PSP and DLB patients displayed markedly reduced to undetectable levels of SERT, respectively. These findings show that the neurodegenerative process affects serotoninergic neurons in parkinsonisms, with much more severe involvement in DLB than in PD patients, despite the comparable loss of striatal DAT. SERT-dependent ¹²³I-FP-CIT uptake may allow a more comprehensive assessment of neurochemical disturbances in degenerative parkinsonisms and may have a value for differential diagnosis.
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C03	`04`	`X`	`ENG`	`@0 Midbrain @5 09`
C03	`04`	`X`	`SPA`	`@0 Mesencéfalo @5 09`
C03	`05`	`X`	`FRE`	`@0 Tomoscintigraphie émission monophotonique @5 10`
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C03	`06`	`X`	`SPA`	`@0 Fotón @5 11`
C03	`07`	`X`	`FRE`	`@0 Transporteur sérotonine @4 CD @5 96`
C03	`07`	`X`	`ENG`	`@0 Serotonin transporter @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Système nerveux central @5 37`
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C07	`01`	`X`	`SPA`	`@0 Sistema nervioso central @5 37`
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Pascal:10-0446312

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Midbrain SERT in Degenerative Parkinsonisms: A 123I-FP-CIT SPECT Study</title>
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<author><name sortKey="Pisciotta, Nicola M" sort="Pisciotta, Nicola M" uniqKey="Pisciotta N" first="Nicola M." last="Pisciotta">Nicola M. Pisciotta</name>
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<author><name sortKey="Pennelli, Michele" sort="Pennelli, Michele" uniqKey="Pennelli M" first="Michele" last="Pennelli">Michele Pennelli</name>
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<author><name sortKey="Aniello, Maria S" sort="Aniello, Maria S" uniqKey="Aniello M" first="Maria S." last="Aniello">Maria S. Aniello</name>
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<author><name sortKey="Gigante, Angelo" sort="Gigante, Angelo" uniqKey="Gigante A" first="Angelo" last="Gigante">Angelo Gigante</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological and Psychiatric Sciences, University of Bari</s1>
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<author><name sortKey="De Caro, Maria F" sort="De Caro, Maria F" uniqKey="De Caro M" first="Maria F." last="De Caro">Maria F. De Caro</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological and Psychiatric Sciences, University of Bari</s1>
<s2>Bari</s2>
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<author><name sortKey="Ferrannini, Ermanno" sort="Ferrannini, Ermanno" uniqKey="Ferrannini E" first="Ermanno" last="Ferrannini">Ermanno Ferrannini</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, "Madonnina" Hospital</s1>
<s2>Bari</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Tartaglione, Bruno" sort="Tartaglione, Bruno" uniqKey="Tartaglione B" first="Bruno" last="Tartaglione">Bruno Tartaglione</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological and Psychiatric Sciences, University of Bari</s1>
<s2>Bari</s2>
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<author><name sortKey="Niccoli Asabella, Artor" sort="Niccoli Asabella, Artor" uniqKey="Niccoli Asabella A" first="Artor" last="Niccoli-Asabella">Artor Niccoli-Asabella</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Nuclear Medicine, University of Bari</s1>
<s2>Bari</s2>
<s3>ITA</s3>
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<front><div type="abstract" xml:lang="en">SPECT imaging is widely used for the differential diagnosis of degenerative parkinsonisms by exploiting the high affinitiy of the radiotracer <sup>123</sup>
I-FP-CIT for the dopamine transporter. Reduced levels of DAT are found in Parkinson Disease (PD), Dementia with Lewy Bodies (DLB), and Progressive Supranuclear Palsy (PSP) compared to in Essential Tremor (ET) and Healthy Controls (HC). However, the extent of the neurodegenerative process may extend beyond nigrostriatal system. We have exploited the affinity of the same radiotracer <sup>123</sup>
I-FP-CIT for the serotonin transporter to investigate SERT levels in the midbrain of patients with PD, DLB, PSP, and ET compared to HC. Using MRI images as anatomical templates for midbrain uptake quantification, we found a mild decrease in SERT levels in PD compared to ET and HC, with marked inter-individual variability; on the other side, PSP and DLB patients displayed markedly reduced to undetectable levels of SERT, respectively. These findings show that the neurodegenerative process affects serotoninergic neurons in parkinsonisms, with much more severe involvement in DLB than in PD patients, despite the comparable loss of striatal DAT. SERT-dependent <sup>123</sup>
I-FP-CIT uptake may allow a more comprehensive assessment of neurochemical disturbances in degenerative parkinsonisms and may have a value for differential diagnosis.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Midbrain SERT in Degenerative Parkinsonisms: A 123I-FP-CIT SPECT Study

Midbrain SERT in Degenerative Parkinsonisms: A 123I-FP-CIT SPECT Study

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