MovDisordV3, PascalFrancis, Curation, bibRecord, 002295

Lowered Cardiac Sympathetic Nerve Performance in Response to Exercise in Parkinson's Disease

Identifieur interne : 002295 ( PascalFrancis/Curation ); précédent : 002294; suivant : 002296

Lowered Cardiac Sympathetic Nerve Performance in Response to Exercise in Parkinson's Disease

Auteurs : Tomohiko Nakamura [Japon] ; Masaaki Hirayama [Japon] ; Fumitada Yamashita [Japon] ; Kei Uchida [Japon] ; Tetsuo Hama [Japon] ; Hirohisa Watanabe [Japon] ; Gen Sobue [Japon]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0376230

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Fonction myocardique, Nerf sympathique, Exercice physique, Contractilité, Enervation.

English descriptors

KwdEn :
- Cardiac performance, Contractility, Denervation, Nervous system diseases, Parkinson disease, Physical exercise, Sympathetic nerve.

Abstract

We examined whether cardiac sympathetic denervation influences the cardiovascular response to exercise in Parkinson's disease (PD). Sixteen patients with PD were divided into two groups, according to their cardiac uptake of ¹²³I-metaiodobenzylguanidine (denervated group, 10 patients with heart to mediastinum (H/M) ratio < 1.7; innervated group, six patients with H/M ratio > 1.7) and compared changes in blood pressure (BP), heart rate (HR), and cardiac contractility with 13 control subjects during ergometric exercise stress. Velocity index (VI), an indicator of cardiac contractility, was measured using impedance cardiography and recorded every minute. Exercise began at a power output of 20 W for the first 2 min and increased 10 W every 2 min to a maximal intensity of 60 W. All control subjects accomplished the procedure while six patients with PD could not continue after the first minute of 50 W loading. There were no significant differences in BP or HR change between the three groups. However, a significant reduction in VI was observed from the first minute of the 30 W workload in the denervated group compared to the control group. This lowered response continued till 50 W loading and was significantly different to the innervated group at 50 W loading. No significant VI changes were observed between the control and innervated groups throughout the exercise test. Patients with PD with reduced MIBG uptake had a lowered cardiac contractility than innervated subjects during exercise, suggesting that this response represents the impaired exercise capacity of patients with PD with cardiac sympathetic denervation.

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A11	`01`	`1`		`@1 NAKAMURA (Tomohiko)`
A11	`02`	`1`		`@1 HIRAYAMA (Masaaki)`
A11	`03`	`1`		`@1 YAMASHITA (Fumitada)`
A11	`04`	`1`		`@1 UCHIDA (Kei)`
A11	`05`	`1`		`@1 HAMA (Tetsuo)`
A11	`06`	`1`		`@1 WATANABE (Hirohisa)`
A11	`07`	`1`		`@1 SOBUE (Gen)`
A14	`01`			`@1 Department of Neurology, Nagoya University Graduate School of Medicine @2 Showa-ku, Nagoya @3 JPN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut.`
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C01	`01`		`ENG`	@0 We examined whether cardiac sympathetic denervation influences the cardiovascular response to exercise in Parkinson's disease (PD). Sixteen patients with PD were divided into two groups, according to their cardiac uptake of ¹²³I-metaiodobenzylguanidine (denervated group, 10 patients with heart to mediastinum (H/M) ratio < 1.7; innervated group, six patients with H/M ratio > 1.7) and compared changes in blood pressure (BP), heart rate (HR), and cardiac contractility with 13 control subjects during ergometric exercise stress. Velocity index (VI), an indicator of cardiac contractility, was measured using impedance cardiography and recorded every minute. Exercise began at a power output of 20 W for the first 2 min and increased 10 W every 2 min to a maximal intensity of 60 W. All control subjects accomplished the procedure while six patients with PD could not continue after the first minute of 50 W loading. There were no significant differences in BP or HR change between the three groups. However, a significant reduction in VI was observed from the first minute of the 30 W workload in the denervated group compared to the control group. This lowered response continued till 50 W loading and was significantly different to the innervated group at 50 W loading. No significant VI changes were observed between the control and innervated groups throughout the exercise test. Patients with PD with reduced MIBG uptake had a lowered cardiac contractility than innervated subjects during exercise, suggesting that this response represents the impaired exercise capacity of patients with PD with cardiac sympathetic denervation.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Fonction myocardique @5 09`
C03	`03`	`X`	`ENG`	`@0 Cardiac performance @5 09`
C03	`03`	`X`	`SPA`	`@0 Función miocárdica @5 09`
C03	`04`	`X`	`FRE`	`@0 Nerf sympathique @5 10`
C03	`04`	`X`	`ENG`	`@0 Sympathetic nerve @5 10`
C03	`04`	`X`	`SPA`	`@0 Nervio simpático @5 10`
C03	`05`	`X`	`FRE`	`@0 Exercice physique @5 11`
C03	`05`	`X`	`ENG`	`@0 Physical exercise @5 11`
C03	`05`	`X`	`SPA`	`@0 Ejercicio físico @5 11`
C03	`06`	`X`	`FRE`	`@0 Contractilité @5 12`
C03	`06`	`X`	`ENG`	`@0 Contractility @5 12`
C03	`06`	`X`	`SPA`	`@0 Contractilidad @5 12`
C03	`07`	`X`	`FRE`	`@0 Enervation @5 13`
C03	`07`	`X`	`ENG`	`@0 Denervation @5 13`
C03	`07`	`X`	`SPA`	`@0 Denervación @5 13`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
N21				`@1 242`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:10-0376230

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Lowered Cardiac Sympathetic Nerve Performance in Response to Exercise in Parkinson's Disease</title>
<author><name sortKey="Nakamura, Tomohiko" sort="Nakamura, Tomohiko" uniqKey="Nakamura T" first="Tomohiko" last="Nakamura">Tomohiko Nakamura</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Nagoya University Graduate School of Medicine</s1>
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<author><name sortKey="Hirayama, Masaaki" sort="Hirayama, Masaaki" uniqKey="Hirayama M" first="Masaaki" last="Hirayama">Masaaki Hirayama</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Nagoya University Graduate School of Medicine</s1>
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<author><name sortKey="Hama, Tetsuo" sort="Hama, Tetsuo" uniqKey="Hama T" first="Tetsuo" last="Hama">Tetsuo Hama</name>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiac performance</term>
<term>Contractility</term>
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<term>Parkinson disease</term>
<term>Physical exercise</term>
<term>Sympathetic nerve</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Fonction myocardique</term>
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<term>Exercice physique</term>
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<front><div type="abstract" xml:lang="en">We examined whether cardiac sympathetic denervation influences the cardiovascular response to exercise in Parkinson's disease (PD). Sixteen patients with PD were divided into two groups, according to their cardiac uptake of <sup>123</sup>
I-metaiodobenzylguanidine (denervated group, 10 patients with heart to mediastinum (H/M) ratio < 1.7; innervated group, six patients with H/M ratio > 1.7) and compared changes in blood pressure (BP), heart rate (HR), and cardiac contractility with 13 control subjects during ergometric exercise stress. Velocity index (VI), an indicator of cardiac contractility, was measured using impedance cardiography and recorded every minute. Exercise began at a power output of 20 W for the first 2 min and increased 10 W every 2 min to a maximal intensity of 60 W. All control subjects accomplished the procedure while six patients with PD could not continue after the first minute of 50 W loading. There were no significant differences in BP or HR change between the three groups. However, a significant reduction in VI was observed from the first minute of the 30 W workload in the denervated group compared to the control group. This lowered response continued till 50 W loading and was significantly different to the innervated group at 50 W loading. No significant VI changes were observed between the control and innervated groups throughout the exercise test. Patients with PD with reduced MIBG uptake had a lowered cardiac contractility than innervated subjects during exercise, suggesting that this response represents the impaired exercise capacity of patients with PD with cardiac sympathetic denervation.</div>
</front>
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<fA05><s2>25</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Lowered Cardiac Sympathetic Nerve Performance in Response to Exercise in Parkinson's Disease</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>NAKAMURA (Tomohiko)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>HIRAYAMA (Masaaki)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>YAMASHITA (Fumitada)</s1>
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<fA14 i1="01"><s1>Department of Neurology, Nagoya University Graduate School of Medicine</s1>
<s2>Showa-ku, Nagoya</s2>
<s3>JPN</s3>
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</fA66>
<fC01 i1="01" l="ENG"><s0>We examined whether cardiac sympathetic denervation influences the cardiovascular response to exercise in Parkinson's disease (PD). Sixteen patients with PD were divided into two groups, according to their cardiac uptake of <sup>123</sup>
I-metaiodobenzylguanidine (denervated group, 10 patients with heart to mediastinum (H/M) ratio < 1.7; innervated group, six patients with H/M ratio > 1.7) and compared changes in blood pressure (BP), heart rate (HR), and cardiac contractility with 13 control subjects during ergometric exercise stress. Velocity index (VI), an indicator of cardiac contractility, was measured using impedance cardiography and recorded every minute. Exercise began at a power output of 20 W for the first 2 min and increased 10 W every 2 min to a maximal intensity of 60 W. All control subjects accomplished the procedure while six patients with PD could not continue after the first minute of 50 W loading. There were no significant differences in BP or HR change between the three groups. However, a significant reduction in VI was observed from the first minute of the 30 W workload in the denervated group compared to the control group. This lowered response continued till 50 W loading and was significantly different to the innervated group at 50 W loading. No significant VI changes were observed between the control and innervated groups throughout the exercise test. Patients with PD with reduced MIBG uptake had a lowered cardiac contractility than innervated subjects during exercise, suggesting that this response represents the impaired exercise capacity of patients with PD with cardiac sympathetic denervation.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Fonction myocardique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Cardiac performance</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Función miocárdica</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Nerf sympathique</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Sympathetic nerve</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Nervio simpático</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Exercice physique</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Physical exercise</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Ejercicio físico</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Contractilité</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Contractility</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Contractilidad</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Enervation</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Denervation</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Denervación</s0>
<s5>13</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>242</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Lowered Cardiac Sympathetic Nerve Performance in Response to Exercise in Parkinson's Disease

Lowered Cardiac Sympathetic Nerve Performance in Response to Exercise in Parkinson's Disease

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