MovDisordV3, PascalFrancis, Curation, bibRecord, 002062

No Brain Structure Abnormalities in Boys with Tourette's Syndrome: A Voxel-Based Morphometry Study

Identifieur interne : 002062 ( PascalFrancis/Curation ); précédent : 002061; suivant : 002063

No Brain Structure Abnormalities in Boys with Tourette's Syndrome: A Voxel-Based Morphometry Study

Auteurs : Veit Roessner [Allemagne] ; Sebastian Overlack [Allemagne] ; Juergen Baudewig [Allemagne] ; Peter Dechent [Allemagne] ; Aribert Rothenberger [Allemagne] ; Gunther Helms [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:10-0071270

Descripteurs français

Pascal (Inist)
- Syndrome de Gilles de la Tourette, Tic, Pathologie du système nerveux, Encéphale, Enfant, Voxel, Morphométrie, Psychiatrie, Neurologie, Imagerie RMN.
Wicri :
- topic : Enfant, Psychiatrie, Neurologie.

English descriptors

KwdEn :
- Child, Encephalon, Gilles de la Tourette syndrome, Morphometry, Nervous system diseases, Neurology, Nuclear magnetic resonance imaging, Psychiatry, Tic, Voxel.

Abstract

Morphometric findings in Tourette's syndrome (TS) are still inconsistent probably due to differences in analysis approaches as well as several confounders (coexisting psychiatric conditions, medication status, etc.). Our aim was to identify possible morphometric changes in a well-defined sample of drug-naïve boys with "pure" TS. High-resolution structural magnetic resonance images of 38 boys with TS were compared with those of 38 healthy boys matched for age and IQ using voxel-based morphometry (VBM). Coexisting psychiatric conditions and previous medication were excluded. The inclusion of 10- to 15-year-old boys minimized the well known compensatory changes due to tic suppression over many years. VBM analyses revealed no differences between the treatment naïve boys with "pure" TS and healthy controls. Brain morphology is not altered in boys with "pure" TS. Further studies should reveal whether previous findings might be ascribed to confounding factors like coexisting psychiatric conditions or long-term compensatory mechanisms due to voluntary tic suppression.

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A11	`04`	`1`		`@1 DECHENT (Peter)`
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A11	`06`	`1`		`@1 HELMS (Gunther)`
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C03	`05`	`X`	`SPA`	`@0 Niño @5 10`
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C07	`06`	`X`	`FRE`	`@0 Mouvement involontaire @5 42`
C07	`06`	`X`	`ENG`	`@0 Involuntary movement @5 42`
C07	`06`	`X`	`SPA`	`@0 Movimiento involuntario @5 42`
C07	`07`	`X`	`FRE`	`@0 Trouble neurologique @5 43`
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C07	`07`	`X`	`SPA`	`@0 Trastorno neurológico @5 43`
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Le document en format XML

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<front><div type="abstract" xml:lang="en">Morphometric findings in Tourette's syndrome (TS) are still inconsistent probably due to differences in analysis approaches as well as several confounders (coexisting psychiatric conditions, medication status, etc.). Our aim was to identify possible morphometric changes in a well-defined sample of drug-naïve boys with "pure" TS. High-resolution structural magnetic resonance images of 38 boys with TS were compared with those of 38 healthy boys matched for age and IQ using voxel-based morphometry (VBM). Coexisting psychiatric conditions and previous medication were excluded. The inclusion of 10- to 15-year-old boys minimized the well known compensatory changes due to tic suppression over many years. VBM analyses revealed no differences between the treatment naïve boys with "pure" TS and healthy controls. Brain morphology is not altered in boys with "pure" TS. Further studies should reveal whether previous findings might be ascribed to confounding factors like coexisting psychiatric conditions or long-term compensatory mechanisms due to voluntary tic suppression.</div>
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<fC01 i1="01" l="ENG"><s0>Morphometric findings in Tourette's syndrome (TS) are still inconsistent probably due to differences in analysis approaches as well as several confounders (coexisting psychiatric conditions, medication status, etc.). Our aim was to identify possible morphometric changes in a well-defined sample of drug-naïve boys with "pure" TS. High-resolution structural magnetic resonance images of 38 boys with TS were compared with those of 38 healthy boys matched for age and IQ using voxel-based morphometry (VBM). Coexisting psychiatric conditions and previous medication were excluded. The inclusion of 10- to 15-year-old boys minimized the well known compensatory changes due to tic suppression over many years. VBM analyses revealed no differences between the treatment naïve boys with "pure" TS and healthy controls. Brain morphology is not altered in boys with "pure" TS. Further studies should reveal whether previous findings might be ascribed to confounding factors like coexisting psychiatric conditions or long-term compensatory mechanisms due to voluntary tic suppression.</s0>
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<fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Enfant</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Child</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Niño</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Voxel</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Voxel</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Voxel</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Morphométrie</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Morphometry</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Morfometría</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Psychiatrie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Psychiatry</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Psiquiatría</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Neurologie</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Neurology</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Neurología</s0>
<s5>14</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Imagerie RMN</s0>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Imaginería RMN</s0>
<s5>15</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>43</s5>
</fC07>
<fN21><s1>046</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

No Brain Structure Abnormalities in Boys with Tourette's Syndrome: A Voxel-Based Morphometry Study

No Brain Structure Abnormalities in Boys with Tourette's Syndrome: A Voxel-Based Morphometry Study

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