Movement Disorders (revue)

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Dopamine Transporter SPECT: How to Remove Subjectivity?

Identifieur interne : 002030 ( PascalFrancis/Curation ); précédent : 002029; suivant : 002031

Dopamine Transporter SPECT: How to Remove Subjectivity?

Auteurs : Christoph Scherfler [Autriche] ; Michael Nocker [Autriche]

Source :

RBID : Pascal:10-0038103

Descripteurs français

English descriptors

Abstract

Clinical criteria enable accurate and reliable diagnosis of parkinsonian syndromes when cardinal clinical features are fully developed. Single photon emission computed tomography (SPECT) investigating the striatal dopamine transporter (DAT) status have been suggested to increase the diagnostic accuracy in uncertain parkinsonian syndromes such as isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug-induced, vascular and psycho-genetic parkinsonism. Several approaches for the analysis of the striatal DAT distribution have been tested for their ability to analyze and quantify SPECT images. Visual assessment of DAT binding and semiquantitative analysis using region of interests have been recommended by Nuclear Medicine Associations to be incorporated in the routine work-up of DAT-SPECT. Besides these observer dependent approaches, fully automated image-analysis techniques have been validated in the clinical setting. Their potential as tools to improve the diagnostic accuracy in patients presenting with parkinsonian features is reviewed here.
pA  
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A08 01  1  ENG  @1 Dopamine Transporter SPECT: How to Remove Subjectivity?
A09 01  1  ENG  @1 Imaging in Parkinson's Disease
A11 01  1    @1 SCHERFLER (Christoph)
A11 02  1    @1 NOCKER (Michael)
A12 01  1    @1 POEWE (Werner) @9 ed.
A12 02  1    @1 SCHERFLER (Christopher) @9 ed.
A14 01      @1 Department of Neurology, Innsbruck Medical University, Anichstrasse 35 @2 Innsbruck @3 AUT @Z 1 aut. @Z 2 aut.
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C01 01    ENG  @0 Clinical criteria enable accurate and reliable diagnosis of parkinsonian syndromes when cardinal clinical features are fully developed. Single photon emission computed tomography (SPECT) investigating the striatal dopamine transporter (DAT) status have been suggested to increase the diagnostic accuracy in uncertain parkinsonian syndromes such as isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug-induced, vascular and psycho-genetic parkinsonism. Several approaches for the analysis of the striatal DAT distribution have been tested for their ability to analyze and quantify SPECT images. Visual assessment of DAT binding and semiquantitative analysis using region of interests have been recommended by Nuclear Medicine Associations to be incorporated in the routine work-up of DAT-SPECT. Besides these observer dependent approaches, fully automated image-analysis techniques have been validated in the clinical setting. Their potential as tools to improve the diagnostic accuracy in patients presenting with parkinsonian features is reviewed here.
C02 01  X    @0 002B17
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C03 01  X  FRE  @0 Pathologie du système nerveux @5 01
C03 01  X  ENG  @0 Nervous system diseases @5 01
C03 01  X  SPA  @0 Sistema nervioso patología @5 01
C03 02  X  FRE  @0 Dopamine @2 NK @2 FR @5 09
C03 02  X  ENG  @0 Dopamine @2 NK @2 FR @5 09
C03 02  X  SPA  @0 Dopamina @2 NK @2 FR @5 09
C03 03  X  FRE  @0 Tomoscintigraphie émission monophotonique @5 10
C03 03  X  ENG  @0 Single photon emission tomography @5 10
C03 03  X  SPA  @0 Tomografía emisión fotón único @5 10
C03 04  X  FRE  @0 Photon @5 11
C03 04  X  ENG  @0 Photon @5 11
C03 04  X  SPA  @0 Fotón @5 11
C07 01  X  FRE  @0 Catécholamine @5 37
C07 01  X  ENG  @0 Catecholamine @5 37
C07 01  X  SPA  @0 Catecolamina @5 37
C07 02  X  FRE  @0 Neurotransmetteur @5 38
C07 02  X  ENG  @0 Neurotransmitter @5 38
C07 02  X  SPA  @0 Neurotransmisor @5 38
N21       @1 025
N44 01      @1 OTO
N82       @1 OTO

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Pascal:10-0038103

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