MovDisordV3, PascalFrancis, Curation, bibRecord, 001F70

Temporal Lobe Changes in Early, Untreated Parkinson's Disease

Identifieur interne : 001F70 ( PascalFrancis/Curation ); précédent : 001F69; suivant : 001F71

Temporal Lobe Changes in Early, Untreated Parkinson's Disease

Auteurs : W. R. Wayne Martin [Canada] ; Marguerite Wieler [Canada] ; Myrlene Gee [Canada] ; Richard Camicioli [Canada]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0472206

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Lobe temporal, Imagerie RMN.

English descriptors

KwdEn :
- Nervous system diseases, Nuclear magnetic resonance imaging, Parkinson disease, Temporal lobe.

Abstract

The purpose of this study was to determine if focal cortical abnormalities may occur in early Parkinson's disease (PD). We studied 26 untreated patients with early PD and 14 healthy control subjects, with cognitive screening and magnetic resonance imaging (MRI). Voxel-based morphometry was used to assess for the presence of localized cortical grey matter (GM) and/or subcortical white matter (WM) changes. Patient and control groups showed no differences in age or gender distribution. Females had a greater GM% than males (P = 0.001). Comparison of patients and controls revealed no difference in local GM volumes. In PD, however, there was decreased WM volume in the anterior right fusiform gyrus and superior temporal gyrus. There were no correlations between the California Verbal Learning Test long delay free recall, Judgment of Line Orientation, Trail Making A or B and either the GM or WM localized volumes. These results suggest that right anterior temporal lobe changes occur in untreated patients with PD. The earliest changes may occur in subcortical white matter rather than temporal cortex.

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C01	`01`		`ENG`	@0 The purpose of this study was to determine if focal cortical abnormalities may occur in early Parkinson's disease (PD). We studied 26 untreated patients with early PD and 14 healthy control subjects, with cognitive screening and magnetic resonance imaging (MRI). Voxel-based morphometry was used to assess for the presence of localized cortical grey matter (GM) and/or subcortical white matter (WM) changes. Patient and control groups showed no differences in age or gender distribution. Females had a greater GM% than males (P = 0.001). Comparison of patients and controls revealed no difference in local GM volumes. In PD, however, there was decreased WM volume in the anterior right fusiform gyrus and superior temporal gyrus. There were no correlations between the California Verbal Learning Test long delay free recall, Judgment of Line Orientation, Trail Making A or B and either the GM or WM localized volumes. These results suggest that right anterior temporal lobe changes occur in untreated patients with PD. The earliest changes may occur in subcortical white matter rather than temporal cortex.
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C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
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N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:09-0472206

Le document en format XML

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	Movement Disorders (revue)
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Movement Disorders (revue)

Temporal Lobe Changes in Early, Untreated Parkinson's Disease

Temporal Lobe Changes in Early, Untreated Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri