Torpedoes in Parkinson's Disease, Alzheimer's Disease, Essential Tremor, and Control Brains
Identifieur interne : 001F31 ( PascalFrancis/Curation ); précédent : 001F30; suivant : 001F32Torpedoes in Parkinson's Disease, Alzheimer's Disease, Essential Tremor, and Control Brains
Auteurs : Elan D. Louis [États-Unis] ; Phyllis L. Faust [États-Unis] ; Jean-Paul G. Vonsattel [États-Unis] ; Lawrence S. Honig [États-Unis] ; Alex Rajput [Canada] ; Ali Rajput [Canada] ; Rajesh Pahwa [États-Unis] ; Kelly E. Lyons [États-Unis] ; Webster G. Ross [États-Unis] ; Rodger J. Elble [États-Unis] ; Cordelia Erickson-Davis [États-Unis] ; Carol B. Moskowitz [États-Unis] ; Arlene Lawton [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
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Abstract
Purkinje cell axonal swellings ("torpedoes"), described in several cerebellar disorders as well as essential tremor (ET), have not been quantified in common neurodegenerative conditions. The aim of this study was to quantify torpedoes Parkinson's disease (PD) and Alzheimer's disease (AD) compared with ET and control brains. Brains included 40 ET cases (34 cerebellar ET, 6 Lewy body variant of ET) and age-matched comparison brains (21 AD, 14 PD/diffuse Lewy body disease, 25 controls). Torpedoes were counted in 20 X 25 mm cerebellar cortical sections stained with Luxol Fast Blue/Hematoxylin and Eosin. The median number of torpedoes in cerebellar ET (12) was 12× higher than that of controls (1) and nearly 2.5× higher than in AD (5) or PD/ DLBD (5) (all P < 0.005). Furthermore, in a logistic regression model that adjusted for age and Alzheimer's-type changes, each torpedo more than doubled the odds of having cerebellar ET (Odds ratiocerebellar ET vs. control = 2.57, P = 0.006), indicating that the association between increased torpedoes and cerebellar ET was independent of these Alzheimer's-type changes. Although torpedoes are increased in AD and PD, as well as cerebellar ET, the magnitude of increase in cerebellar ET is greater, and cannot be accounted for by concomitant AD or PD pathology.
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Lyons</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, University of Kansas Medical Center</s1><s2>Kansas City, Kansas</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Ross, Webster G" sort="Ross, Webster G" uniqKey="Ross W" first="Webster G." last="Ross">Webster G. Ross</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Veterans Affairs Pacific Islands Health Care System, University of Hawaii, John A. Burns School of Medicine</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Medicine, University of Hawaii, John A. Burns School of Medicine</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Geriatrics, University of Hawaii, John A. Burns School of Medicine</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Pacific Health Research Institute</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Kuakini Medical Center/Honolulu-Asia Aging Study</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Elble, Rodger J" sort="Elble, Rodger J" uniqKey="Elble R" first="Rodger J." last="Elble">Rodger J. Elble</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, Southern Illinois University School of Medicine</s1><s2>Springfield, Illinois</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Erickson Davis, Cordelia" sort="Erickson Davis, Cordelia" uniqKey="Erickson Davis C" first="Cordelia" last="Erickson-Davis">Cordelia Erickson-Davis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Moskowitz, Carol B" sort="Moskowitz, Carol B" uniqKey="Moskowitz C" first="Carol B." last="Moskowitz">Carol B. Moskowitz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Lawton, Arlene" sort="Lawton, Arlene" uniqKey="Lawton A" first="Arlene" last="Lawton">Arlene Lawton</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0386511</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0386511 INIST</idno><idno type="RBID">Pascal:09-0386511</idno><idno type="wicri:Area/PascalFrancis/Corpus">000D88</idno><idno type="wicri:Area/PascalFrancis/Curation">001F31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Torpedoes in Parkinson's Disease, Alzheimer's Disease, Essential Tremor, and Control Brains</title><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Epidemiology, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Faust, Phyllis L" sort="Faust, Phyllis L" uniqKey="Faust P" first="Phyllis L." last="Faust">Phyllis L. Faust</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Vonsattel, Jean Paul G" sort="Vonsattel, Jean Paul G" uniqKey="Vonsattel J" first="Jean-Paul G." last="Vonsattel">Jean-Paul G. Vonsattel</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Honig, Lawrence S" sort="Honig, Lawrence S" uniqKey="Honig L" first="Lawrence S." last="Honig">Lawrence S. Honig</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Royal University Hospital</s1><s2>Saskatoon, Saskatchewan</s2><s3>CAN</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Rajput, Ali" sort="Rajput, Ali" uniqKey="Rajput A" first="Ali" last="Rajput">Ali Rajput</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Royal University Hospital</s1><s2>Saskatoon, Saskatchewan</s2><s3>CAN</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, University of Kansas Medical Center</s1><s2>Kansas City, Kansas</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly E." last="Lyons">Kelly E. Lyons</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, University of Kansas Medical Center</s1><s2>Kansas City, Kansas</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Ross, Webster G" sort="Ross, Webster G" uniqKey="Ross W" first="Webster G." last="Ross">Webster G. Ross</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Veterans Affairs Pacific Islands Health Care System, University of Hawaii, John A. Burns School of Medicine</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Medicine, University of Hawaii, John A. Burns School of Medicine</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Geriatrics, University of Hawaii, John A. Burns School of Medicine</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Pacific Health Research Institute</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Kuakini Medical Center/Honolulu-Asia Aging Study</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Elble, Rodger J" sort="Elble, Rodger J" uniqKey="Elble R" first="Rodger J." last="Elble">Rodger J. Elble</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, Southern Illinois University School of Medicine</s1><s2>Springfield, Illinois</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Erickson Davis, Cordelia" sort="Erickson Davis, Cordelia" uniqKey="Erickson Davis C" first="Cordelia" last="Erickson-Davis">Cordelia Erickson-Davis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Moskowitz, Carol B" sort="Moskowitz, Carol B" uniqKey="Moskowitz C" first="Carol B." last="Moskowitz">Carol B. Moskowitz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Lawton, Arlene" sort="Lawton, Arlene" uniqKey="Lawton A" first="Arlene" last="Lawton">Arlene Lawton</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Anatomic pathology</term><term>Cerebellum</term><term>Encephalon</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Tremor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Démence d'Alzheimer</term><term>Tremblement</term><term>Pathologie du système nerveux</term><term>Encéphale</term><term>Cervelet</term><term>Anatomopathologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purkinje cell axonal swellings ("torpedoes"), described in several cerebellar disorders as well as essential tremor (ET), have not been quantified in common neurodegenerative conditions. The aim of this study was to quantify torpedoes Parkinson's disease (PD) and Alzheimer's disease (AD) compared with ET and control brains. Brains included 40 ET cases (34 cerebellar ET, 6 Lewy body variant of ET) and age-matched comparison brains (21 AD, 14 PD/diffuse Lewy body disease, 25 controls). Torpedoes were counted in 20 X 25 mm cerebellar cortical sections stained with Luxol Fast Blue/Hematoxylin and Eosin. The median number of torpedoes in cerebellar ET (12) was 12× higher than that of controls (1) and nearly 2.5× higher than in AD (5) or PD/ DLBD (5) (all P < 0.005). Furthermore, in a logistic regression model that adjusted for age and Alzheimer's-type changes, each torpedo more than doubled the odds of having cerebellar ET (Odds ratio<sub>cerebellar</sub> <sub>ET</sub> <sub>vs</sub>. control = <sup>2</sup>.<sup>57</sup>, <sup>P</sup> <sup>=</sup> 0.006), indicating that the association between increased torpedoes and cerebellar ET was independent of these Alzheimer's-type changes. Although torpedoes are increased in AD and PD, as well as cerebellar ET, the magnitude of increase in cerebellar ET is greater, and cannot be accounted for by concomitant AD or PD pathology.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>24</s2></fA05><fA06><s2>11</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Torpedoes in Parkinson's Disease, Alzheimer's Disease, Essential Tremor, and Control Brains</s1></fA08><fA11 i1="01" i2="1"><s1>LOUIS (Elan D.)</s1></fA11><fA11 i1="02" i2="1"><s1>FAUST (Phyllis L.)</s1></fA11><fA11 i1="03" i2="1"><s1>VONSATTEL (Jean-Paul G.)</s1></fA11><fA11 i1="04" i2="1"><s1>HONIG (Lawrence S.)</s1></fA11><fA11 i1="05" i2="1"><s1>RAJPUT (Alex)</s1></fA11><fA11 i1="06" i2="1"><s1>RAJPUT (Ali)</s1></fA11><fA11 i1="07" i2="1"><s1>PAHWA (Rajesh)</s1></fA11><fA11 i1="08" i2="1"><s1>LYONS (Kelly E.)</s1></fA11><fA11 i1="09" i2="1"><s1>ROSS (Webster G.)</s1></fA11><fA11 i1="10" i2="1"><s1>ELBLE (Rodger J.)</s1></fA11><fA11 i1="11" i2="1"><s1>ERICKSON-DAVIS (Cordelia)</s1></fA11><fA11 i1="12" i2="1"><s1>MOSKOWITZ (Carol B.)</s1></fA11><fA11 i1="13" i2="1"><s1>LAWTON (Arlene)</s1></fA11><fA14 i1="01"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="03"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Epidemiology, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurology, Royal University Hospital</s1><s2>Saskatoon, Saskatchewan</s2><s3>CAN</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurology, University of Kansas Medical Center</s1><s2>Kansas City, Kansas</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="08"><s1>Veterans Affairs Pacific Islands Health Care System, University of Hawaii, John A. Burns School of Medicine</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Medicine, University of Hawaii, John A. Burns School of Medicine</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Geriatrics, University of Hawaii, John A. Burns School of Medicine</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="11"><s1>Pacific Health Research Institute</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="12"><s1>Kuakini Medical Center/Honolulu-Asia Aging Study</s1><s2>Honolulu, Hawaii</s2><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="13"><s1>Department of Neurology, Southern Illinois University School of Medicine</s1><s2>Springfield, Illinois</s2><s3>USA</s3><sZ>10 aut.</sZ></fA14><fA20><s1>1600-1605</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000171892190060</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>34 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>09-0386511</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Purkinje cell axonal swellings ("torpedoes"), described in several cerebellar disorders as well as essential tremor (ET), have not been quantified in common neurodegenerative conditions. The aim of this study was to quantify torpedoes Parkinson's disease (PD) and Alzheimer's disease (AD) compared with ET and control brains. Brains included 40 ET cases (34 cerebellar ET, 6 Lewy body variant of ET) and age-matched comparison brains (21 AD, 14 PD/diffuse Lewy body disease, 25 controls). Torpedoes were counted in 20 X 25 mm cerebellar cortical sections stained with Luxol Fast Blue/Hematoxylin and Eosin. The median number of torpedoes in cerebellar ET (12) was 12× higher than that of controls (1) and nearly 2.5× higher than in AD (5) or PD/ DLBD (5) (all P < 0.005). Furthermore, in a logistic regression model that adjusted for age and Alzheimer's-type changes, each torpedo more than doubled the odds of having cerebellar ET (Odds ratio<sub>cerebellar</sub> <sub>ET</sub> <sub>vs</sub>. control = <sup>2</sup>.<sup>57</sup>, <sup>P</sup> <sup>=</sup> 0.006), indicating that the association between increased torpedoes and cerebellar ET was independent of these Alzheimer's-type changes. Although torpedoes are increased in AD and PD, as well as cerebellar ET, the magnitude of increase in cerebellar ET is greater, and cannot be accounted for by concomitant AD or PD pathology.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Démence d'Alzheimer</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Alzheimer disease</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Demencia Alzheimer</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Tremblement</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Tremor</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Temblor</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Encéphale</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Encephalon</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Cervelet</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Cerebellum</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Cerebelo</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Anatomopathologie</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Anatomic pathology</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Anatomía patológica</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Mouvement involontaire</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Involuntary movement</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Movimiento involuntario</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Trouble neurologique</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Neurological disorder</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Trastorno neurológico</s0><s5>43</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>44</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Central nervous system</s0><s5>44</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>44</s5></fC07><fN21><s1>278</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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