MovDisordV3, PascalFrancis, Curation, bibRecord, 001E20

Factors Predicting Improvement in Primary Generalized Dystonia Treated by Pallidal Deep Brain Stimulation

Identifieur interne : 001E20 ( PascalFrancis/Curation ); précédent : 001E19; suivant : 001E21

Factors Predicting Improvement in Primary Generalized Dystonia Treated by Pallidal Deep Brain Stimulation

Auteurs : Xavier Vasques [France] ; Laura Cif [France] ; Victoria Gonzalez [France] ; Claire Nicholson [France] ; Philippe Coubes [France]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0223193

Descripteurs français

Pascal (Inist)
- Dystonie, Pathologie du système nerveux, Amélioration, Traitement, Pronostic, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Dystonia, Improvement, Nervous system diseases, Prognosis, Treatment.

Abstract

Despite the beneficial effects of Globus Pallidus intemus (GPi) deep brain stimulation (DBS) in patients with primary generalized dystonia (PGD), the degree of improvement varies from one patient to another. The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke-Fahn-Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady-state patients with PGD who had been treated by bilateral GPi lead implantation. The follow-up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state.

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C01	`01`		`ENG`	@0 Despite the beneficial effects of Globus Pallidus intemus (GPi) deep brain stimulation (DBS) in patients with primary generalized dystonia (PGD), the degree of improvement varies from one patient to another. The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke-Fahn-Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady-state patients with PGD who had been treated by bilateral GPi lead implantation. The follow-up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state.
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Pascal:09-0223193

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Factors Predicting Improvement in Primary Generalized Dystonia Treated by Pallidal Deep Brain Stimulation</title>
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<author><name sortKey="Gonzalez, Victoria" sort="Gonzalez, Victoria" uniqKey="Gonzalez V" first="Victoria" last="Gonzalez">Victoria Gonzalez</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CHRU Montpellier, Service de Neurochirurgie</s1>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>CNRS, UMRS203</s1>
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<sZ>1 aut.</sZ>
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<author><name sortKey="Nicholson, Claire" sort="Nicholson, Claire" uniqKey="Nicholson C" first="Claire" last="Nicholson">Claire Nicholson</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CHRU Montpellier, Service de Neurochirurgie</s1>
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<sZ>1 aut.</sZ>
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<country>France</country>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>IGF</s1>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>CNRS, UMRS203</s1>
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<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Univ Montpellier I</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<country>France</country>
</affiliation>
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<author><name sortKey="Coubes, Philippe" sort="Coubes, Philippe" uniqKey="Coubes P" first="Philippe" last="Coubes">Philippe Coubes</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CHRU Montpellier, Service de Neurochirurgie</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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<country>France</country>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>IGF</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>CNRS, UMRS203</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<country>France</country>
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<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>INSERM, U06-1</s1>
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<country>France</country>
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<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Univ Montpellier I</s1>
<s2>Montpellier</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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<country>France</country>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2009">2009</date>
</imprint>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<idno type="ISSN">0885-3185</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>Dystonia</term>
<term>Improvement</term>
<term>Nervous system diseases</term>
<term>Prognosis</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term>
<term>Pathologie du   système nerveux</term>
<term>Amélioration</term>
<term>Traitement</term>
<term>Pronostic</term>
<term>Stimulation cérébrale profonde</term>
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<front><div type="abstract" xml:lang="en">Despite the beneficial effects of Globus Pallidus intemus (GPi) deep brain stimulation (DBS) in patients with primary generalized dystonia (PGD), the degree of improvement varies from one patient to another. The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke-Fahn-Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady-state patients with PGD who had been treated by bilateral GPi lead implantation. The follow-up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Factors Predicting Improvement in Primary Generalized Dystonia Treated by Pallidal Deep Brain Stimulation</s1>
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<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>Despite the beneficial effects of Globus Pallidus intemus (GPi) deep brain stimulation (DBS) in patients with primary generalized dystonia (PGD), the degree of improvement varies from one patient to another. The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke-Fahn-Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady-state patients with PGD who had been treated by bilateral GPi lead implantation. The follow-up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state.</s0>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Factors Predicting Improvement in Primary Generalized Dystonia Treated by Pallidal Deep Brain Stimulation

Factors Predicting Improvement in Primary Generalized Dystonia Treated by Pallidal Deep Brain Stimulation

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