Parkinson's Disease is Overdiagnosed Clinically at Baseline in Diagnostically Uncertain Cases : A 3-Year European Multicenter Study with Repeat [123I]FP-CIT SPECT
Identifieur interne : 001D78 ( PascalFrancis/Curation ); précédent : 001D77; suivant : 001D79Parkinson's Disease is Overdiagnosed Clinically at Baseline in Diagnostically Uncertain Cases : A 3-Year European Multicenter Study with Repeat [123I]FP-CIT SPECT
Auteurs : Vicky L. Marshall [Royaume-Uni] ; Cornelia B. Reininger [Allemagne] ; Moritz Marquardt [Allemagne] ; Jim Patterson [Royaume-Uni] ; Donald M. Hadley [Royaume-Uni] ; Wolfgang H. Oertel [Allemagne] ; Hani T. S. Benamer [Royaume-Uni] ; Paul Kemp [Royaume-Uni] ; David Bum [Royaume-Uni] ; Eduardo Tolosa [Espagne] ; Jamie Kulisevsky [Espagne] ; Luis Cunha [Portugal] ; Durval Costa [Portugal] ; Jan Booij [Pays-Bas] ; Klaus Tatsch [Allemagne] ; K. Ray Chaudhuri [Royaume-Uni] ; Gudrun Ulm [Allemagne] ; Oliver Pogarell [Allemagne] ; Helmut Höffken [Allemagne] ; Anja Gerstner [Allemagne] ; Donald G. Grosset [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
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- Pascal (Inist)
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Abstract
Overdiagnosis of Parkinson's disease (PD) is suggested by specialist review of community diagnosis, and in postmortem studies. In specialist centers 4 to 15% of patients entered into clinical trials as early PD do not have functional imaging support for a PD diagnosis. In a European multicenter, prospective, longitudinal study, we compared clinical diagnosis with functional SPECT imaging using [123I]FP-CIT (DaTSCAN<TM>, GE Healthcare). Repeat observations were performed over 3 years in patients with tremor and/or parkinsonism in whom there was initial diagnostic uncertainty between degenerative parkinsonism and nondegenerative tremor disorders. Video-recording of clinical features was scored independently of functional imaging results by two blinded clinicians at 36 months (= gold standard clinical diagnosis). Three readers, unaware of the clinical diagnosis, classified the images as normal or abnormal by visual inspection. The main endpoint was the sensitivity and specificity of SPECT imaging at baseline compared with the gold standard. In 99 patients completing the three serial assessments, on-site clinical diagnosis overdiagnosed degenerative parkinsonism at baseline in diagnostically uncertain cases compared with the gold standard clinical diagnosis (at 36 months), the latter giving a sensitivity of 93% and specificity of 46%. The corresponding baseline [123I]FP-CIT SPECT results showed a mean sensitivity of 78% and a specificity of 97%. Inter-reader agreement for rating scans as normal or abnormal was high (Cohen's K = 0.94-0.97).
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Oertel</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips-Universität Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Benamer, Hani T S" sort="Benamer, Hani T S" uniqKey="Benamer H" first="Hani T. S." last="Benamer">Hani T. S. Benamer</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>New Cross Hospital</s1><s2>Wolverhampton</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Kemp, Paul" sort="Kemp, Paul" uniqKey="Kemp P" first="Paul" last="Kemp">Paul Kemp</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Nuclear Medicine, Southampton General Hospital</s1><s2>Southampton</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Bum, David" sort="Bum, David" uniqKey="Bum D" first="David" last="Bum">David Bum</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Newcastle General Hospital</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Hospital Clinic i Provincial, Servicio de Neurologia</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>10 aut.</sZ></inist:fA14><country>Espagne</country></affiliation></author><author><name sortKey="Kulisevsky, Jamie" sort="Kulisevsky, Jamie" uniqKey="Kulisevsky J" first="Jamie" last="Kulisevsky">Jamie Kulisevsky</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Servicio de Neurologia and CIBERNED, Hospital de la Santa Creu i Sant Pan</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>11 aut.</sZ></inist:fA14><country>Espagne</country></affiliation></author><author><name sortKey="Cunha, Luis" sort="Cunha, Luis" uniqKey="Cunha L" first="Luis" last="Cunha">Luis Cunha</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Service de Neurologia, Hospitais da Universidade de Coimbra</s1><s2>Coimbra</s2><s3>PRT</s3><sZ>12 aut.</sZ></inist:fA14><country>Portugal</country></affiliation></author><author><name sortKey="Costa, Durval" sort="Costa, Durval" uniqKey="Costa D" first="Durval" last="Costa">Durval Costa</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>HPP Medicina Molecular, SA</s1><s2>Porto</s2><s3>PRT</s3><sZ>13 aut.</sZ></inist:fA14><country>Portugal</country></affiliation></author><author><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Nuclear Medicine, Academic Medical Centre</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country></affiliation></author><author><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Abteilung für Nuklearmedizin, Klinikum Groβhadern</s1><s2>München</s2><s3>DEU</s3><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>King's College Hospital and University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Ulm, Gudrun" sort="Ulm, Gudrun" uniqKey="Ulm G" first="Gudrun" last="Ulm">Gudrun Ulm</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Paracelsius-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Abteilung für. Klinische Neurophysiologie, Klinik fur Psychiatrie der Ludwig-Maximilians-Universität Munchen</s1><s2>Munchen</s2><s3>DEU</s3><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Hoffken, Helmut" sort="Hoffken, Helmut" uniqKey="Hoffken H" first="Helmut" last="Höffken">Helmut Höffken</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips-Universität Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Gerstner, Anja" sort="Gerstner, Anja" uniqKey="Gerstner A" first="Anja" last="Gerstner">Anja Gerstner</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips-Universität Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Grosset, Donald G" sort="Grosset, Donald G" uniqKey="Grosset D" first="Donald G." last="Grosset">Donald G. Grosset</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroradiology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Clinical Physics, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0171593</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0171593 INIST</idno><idno type="RBID">Pascal:09-0171593</idno><idno type="wicri:Area/PascalFrancis/Corpus">000F41</idno><idno type="wicri:Area/PascalFrancis/Curation">001D78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Parkinson's Disease is Overdiagnosed Clinically at Baseline in Diagnostically Uncertain Cases : A 3-Year European Multicenter Study with Repeat [<sup>123</sup>I]FP-CIT SPECT</title><author><name sortKey="Marshall, Vicky L" sort="Marshall, Vicky L" uniqKey="Marshall V" first="Vicky L." last="Marshall">Vicky L. Marshall</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroradiology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Clinical Physics, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Reininger, Cornelia B" sort="Reininger, Cornelia B" uniqKey="Reininger C" first="Cornelia B." last="Reininger">Cornelia B. Reininger</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>General Electric Healthcare, Clinical Research & Development</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Marquardt, Moritz" sort="Marquardt, Moritz" uniqKey="Marquardt M" first="Moritz" last="Marquardt">Moritz Marquardt</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>General Electric Healthcare, Clinical Research & Development</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Patterson, Jim" sort="Patterson, Jim" uniqKey="Patterson J" first="Jim" last="Patterson">Jim Patterson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroradiology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Clinical Physics, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Hadley, Donald M" sort="Hadley, Donald M" uniqKey="Hadley D" first="Donald M." last="Hadley">Donald M. Hadley</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroradiology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Clinical Physics, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips-Universität Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Benamer, Hani T S" sort="Benamer, Hani T S" uniqKey="Benamer H" first="Hani T. S." last="Benamer">Hani T. S. Benamer</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>New Cross Hospital</s1><s2>Wolverhampton</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Kemp, Paul" sort="Kemp, Paul" uniqKey="Kemp P" first="Paul" last="Kemp">Paul Kemp</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Nuclear Medicine, Southampton General Hospital</s1><s2>Southampton</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Bum, David" sort="Bum, David" uniqKey="Bum D" first="David" last="Bum">David Bum</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Newcastle General Hospital</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Hospital Clinic i Provincial, Servicio de Neurologia</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>10 aut.</sZ></inist:fA14><country>Espagne</country></affiliation></author><author><name sortKey="Kulisevsky, Jamie" sort="Kulisevsky, Jamie" uniqKey="Kulisevsky J" first="Jamie" last="Kulisevsky">Jamie Kulisevsky</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Servicio de Neurologia and CIBERNED, Hospital de la Santa Creu i Sant Pan</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>11 aut.</sZ></inist:fA14><country>Espagne</country></affiliation></author><author><name sortKey="Cunha, Luis" sort="Cunha, Luis" uniqKey="Cunha L" first="Luis" last="Cunha">Luis Cunha</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Service de Neurologia, Hospitais da Universidade de Coimbra</s1><s2>Coimbra</s2><s3>PRT</s3><sZ>12 aut.</sZ></inist:fA14><country>Portugal</country></affiliation></author><author><name sortKey="Costa, Durval" sort="Costa, Durval" uniqKey="Costa D" first="Durval" last="Costa">Durval Costa</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>HPP Medicina Molecular, SA</s1><s2>Porto</s2><s3>PRT</s3><sZ>13 aut.</sZ></inist:fA14><country>Portugal</country></affiliation></author><author><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Nuclear Medicine, Academic Medical Centre</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country></affiliation></author><author><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Abteilung für Nuklearmedizin, Klinikum Groβhadern</s1><s2>München</s2><s3>DEU</s3><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>King's College Hospital and University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Ulm, Gudrun" sort="Ulm, Gudrun" uniqKey="Ulm G" first="Gudrun" last="Ulm">Gudrun Ulm</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Paracelsius-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Abteilung für. Klinische Neurophysiologie, Klinik fur Psychiatrie der Ludwig-Maximilians-Universität Munchen</s1><s2>Munchen</s2><s3>DEU</s3><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Hoffken, Helmut" sort="Hoffken, Helmut" uniqKey="Hoffken H" first="Helmut" last="Höffken">Helmut Höffken</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips-Universität Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Gerstner, Anja" sort="Gerstner, Anja" uniqKey="Gerstner A" first="Anja" last="Gerstner">Anja Gerstner</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips-Universität Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Grosset, Donald G" sort="Grosset, Donald G" uniqKey="Grosset D" first="Donald G." last="Grosset">Donald G. Grosset</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroradiology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Clinical Physics, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Multicenter study</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Photon</term><term>Single photon emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Etude multicentrique</term><term>Tomoscintigraphie émission monophotonique</term><term>Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Overdiagnosis of Parkinson's disease (PD) is suggested by specialist review of community diagnosis, and in postmortem studies. In specialist centers 4 to 15% of patients entered into clinical trials as early PD do not have functional imaging support for a PD diagnosis. In a European multicenter, prospective, longitudinal study, we compared clinical diagnosis with functional SPECT imaging using [<sup>123</sup>I]FP-CIT (DaTSCAN<<sup>TM</sup>>, GE Healthcare). Repeat observations were performed over 3 years in patients with tremor and/or parkinsonism in whom there was initial diagnostic uncertainty between degenerative parkinsonism and nondegenerative tremor disorders. Video-recording of clinical features was scored independently of functional imaging results by two blinded clinicians at 36 months (= gold standard clinical diagnosis). Three readers, unaware of the clinical diagnosis, classified the images as normal or abnormal by visual inspection. The main endpoint was the sensitivity and specificity of SPECT imaging at baseline compared with the gold standard. In 99 patients completing the three serial assessments, on-site clinical diagnosis overdiagnosed degenerative parkinsonism at baseline in diagnostically uncertain cases compared with the gold standard clinical diagnosis (at 36 months), the latter giving a sensitivity of 93% and specificity of 46%. The corresponding baseline [<sup>123</sup>I]FP-CIT SPECT results showed a mean sensitivity of 78% and a specificity of 97%. Inter-reader agreement for rating scans as normal or abnormal was high (Cohen's K = 0.94-0.97).</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>24</s2></fA05><fA06><s2>4</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Parkinson's Disease is Overdiagnosed Clinically at Baseline in Diagnostically Uncertain Cases : A 3-Year European Multicenter Study with Repeat [<sup>123</sup>I]FP-CIT SPECT</s1></fA08><fA11 i1="01" i2="1"><s1>MARSHALL (Vicky L.)</s1></fA11><fA11 i1="02" i2="1"><s1>REININGER (Cornelia B.)</s1></fA11><fA11 i1="03" i2="1"><s1>MARQUARDT (Moritz)</s1></fA11><fA11 i1="04" i2="1"><s1>PATTERSON (Jim)</s1></fA11><fA11 i1="05" i2="1"><s1>HADLEY (Donald M.)</s1></fA11><fA11 i1="06" i2="1"><s1>OERTEL (Wolfgang H.)</s1></fA11><fA11 i1="07" i2="1"><s1>BENAMER (Hani T. S.)</s1></fA11><fA11 i1="08" i2="1"><s1>KEMP (Paul)</s1></fA11><fA11 i1="09" i2="1"><s1>BUM (David)</s1></fA11><fA11 i1="10" i2="1"><s1>TOLOSA (Eduardo)</s1></fA11><fA11 i1="11" i2="1"><s1>KULISEVSKY (Jamie)</s1></fA11><fA11 i1="12" i2="1"><s1>CUNHA (Luis)</s1></fA11><fA11 i1="13" i2="1"><s1>COSTA (Durval)</s1></fA11><fA11 i1="14" i2="1"><s1>BOOIJ (Jan)</s1></fA11><fA11 i1="15" i2="1"><s1>TATSCH (Klaus)</s1></fA11><fA11 i1="16" i2="1"><s1>CHAUDHURI (K. Ray)</s1></fA11><fA11 i1="17" i2="1"><s1>ULM (Gudrun)</s1></fA11><fA11 i1="18" i2="1"><s1>POGARELL (Oliver)</s1></fA11><fA11 i1="19" i2="1"><s1>HÖFFKEN (Helmut)</s1></fA11><fA11 i1="20" i2="1"><s1>GERSTNER (Anja)</s1></fA11><fA11 i1="21" i2="1"><s1>GROSSET (Donald G.)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neuroradiology, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Clinical Physics, Southern General Hospital</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ></fA14><fA14 i1="04"><s1>General Electric Healthcare, Clinical Research & Development</s1><s2>Munich</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="05"><s1>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips-Universität Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></fA14><fA14 i1="06"><s1>New Cross Hospital</s1><s2>Wolverhampton</s2><s3>GBR</s3><sZ>7 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Nuclear Medicine, Southampton General Hospital</s1><s2>Southampton</s2><s3>GBR</s3><sZ>8 aut.</sZ></fA14><fA14 i1="08"><s1>Newcastle General Hospital</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>9 aut.</sZ></fA14><fA14 i1="09"><s1>Hospital Clinic i Provincial, Servicio de Neurologia</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>10 aut.</sZ></fA14><fA14 i1="10"><s1>Servicio de Neurologia and CIBERNED, Hospital de la Santa Creu i Sant Pan</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>11 aut.</sZ></fA14><fA14 i1="11"><s1>Service de Neurologia, Hospitais da Universidade de Coimbra</s1><s2>Coimbra</s2><s3>PRT</s3><sZ>12 aut.</sZ></fA14><fA14 i1="12"><s1>HPP Medicina Molecular, SA</s1><s2>Porto</s2><s3>PRT</s3><sZ>13 aut.</sZ></fA14><fA14 i1="13"><s1>Department of Nuclear Medicine, Academic Medical Centre</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>14 aut.</sZ></fA14><fA14 i1="14"><s1>Abteilung für Nuklearmedizin, Klinikum Groβhadern</s1><s2>München</s2><s3>DEU</s3><sZ>15 aut.</sZ></fA14><fA14 i1="15"><s1>King's College Hospital and University Hospital Lewisham</s1><s2>London</s2><s3>GBR</s3><sZ>16 aut.</sZ></fA14><fA14 i1="16"><s1>Paracelsius-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>17 aut.</sZ></fA14><fA14 i1="17"><s1>Abteilung für. Klinische Neurophysiologie, Klinik fur Psychiatrie der Ludwig-Maximilians-Universität Munchen</s1><s2>Munchen</s2><s3>DEU</s3><sZ>18 aut.</sZ></fA14><fA20><s1>500-508</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000187465460030</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>33 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>09-0171593</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Overdiagnosis of Parkinson's disease (PD) is suggested by specialist review of community diagnosis, and in postmortem studies. In specialist centers 4 to 15% of patients entered into clinical trials as early PD do not have functional imaging support for a PD diagnosis. In a European multicenter, prospective, longitudinal study, we compared clinical diagnosis with functional SPECT imaging using [<sup>123</sup>I]FP-CIT (DaTSCAN<<sup>TM</sup>>, GE Healthcare). Repeat observations were performed over 3 years in patients with tremor and/or parkinsonism in whom there was initial diagnostic uncertainty between degenerative parkinsonism and nondegenerative tremor disorders. Video-recording of clinical features was scored independently of functional imaging results by two blinded clinicians at 36 months (= gold standard clinical diagnosis). Three readers, unaware of the clinical diagnosis, classified the images as normal or abnormal by visual inspection. The main endpoint was the sensitivity and specificity of SPECT imaging at baseline compared with the gold standard. In 99 patients completing the three serial assessments, on-site clinical diagnosis overdiagnosed degenerative parkinsonism at baseline in diagnostically uncertain cases compared with the gold standard clinical diagnosis (at 36 months), the latter giving a sensitivity of 93% and specificity of 46%. The corresponding baseline [<sup>123</sup>I]FP-CIT SPECT results showed a mean sensitivity of 78% and a specificity of 97%. Inter-reader agreement for rating scans as normal or abnormal was high (Cohen's K = 0.94-0.97).</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Etude multicentrique</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Multicenter study</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Estudio multicéntrico</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Tomoscintigraphie émission monophotonique</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Single photon emission tomography</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Tomografía emisión fotón único</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Photon</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Photon</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Fotón</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>124</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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