MovDisordV3, PascalFrancis, Curation, bibRecord, 001C47

Predictive Value of Nigrostriatal Dysfunction in Isolated Tremor : A Clinical and SPECT Study

Identifieur interne : 001C47 ( PascalFrancis/Curation ); précédent : 001C46; suivant : 001C48

Predictive Value of Nigrostriatal Dysfunction in Isolated Tremor : A Clinical and SPECT Study

Auteurs : Roberto Ceravolo [Italie] ; Angelo Antonini [Italie] ; Duccio Volterrani [Italie] ; Carlo Rossi [Italie] ; Lorenzo Kiferle [Italie] ; Daniela Frosini [Italie] ; Claudio Lucetti [Italie] ; Ioannis U. Isaias [Italie] ; Riccardo Benti [Italie] ; Luigi Murri [Italie] ; Ubaldo Bonuccelli [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0536663

Descripteurs français

Pascal (Inist)
- Tremblement, Maladie de Parkinson, Pathologie du système nerveux, Valeur prédictive, Trouble fonctionnel, Tomoscintigraphie émission monophotonique, Photon, Dopamine.

English descriptors

KwdEn :
- Dopamine, Dysfunction, Nervous system diseases, Parkinson disease, Photon, Predictive value, Single photon emission tomography, Tremor.

Abstract

The overlap among tremor disorders is wide and complex because essential tremor patients may present resting tremor coexisting with postural tremor, while postural may coexist with resting tremor in Parkinson's disease. We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I-FPCIT SPECT imaging at baseline. Patients were followed-up clinically for 28.4 ± 7.2 months. Twenty-five patients with baseline normal SPECT continued to present only tremor at follow-up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow-up. The value of 123I-FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, P = 0.015; Mixed tremor, P = 0.015; Postural tremor, P = 0.039; chi-square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early-stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as "isolated tremor with dopaminergic presynaptic dysfunction.

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A14	`02`			`@1 Parkinson Institute, Istituti Clinici di Perfezionamento @2 Milan @3 ITA @Z 2 aut. @Z 8 aut.`
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C01	`01`		`ENG`	@0 The overlap among tremor disorders is wide and complex because essential tremor patients may present resting tremor coexisting with postural tremor, while postural may coexist with resting tremor in Parkinson's disease. We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I-FPCIT SPECT imaging at baseline. Patients were followed-up clinically for 28.4 ± 7.2 months. Twenty-five patients with baseline normal SPECT continued to present only tremor at follow-up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow-up. The value of 123I-FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, P = 0.015; Mixed tremor, P = 0.015; Postural tremor, P = 0.039; chi-square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early-stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as "isolated tremor with dopaminergic presynaptic dysfunction.
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C03	`07`	`X`	`FRE`	`@0 Photon @5 12`
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C03	`07`	`X`	`SPA`	`@0 Fotón @5 12`
C03	`08`	`X`	`FRE`	`@0 Dopamine @2 NK @2 FR @5 13`
C03	`08`	`X`	`ENG`	`@0 Dopamine @2 NK @2 FR @5 13`
C03	`08`	`X`	`SPA`	`@0 Dopamina @2 NK @2 FR @5 13`
C07	`01`	`X`	`FRE`	`@0 Mouvement involontaire @5 37`
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C07	`02`	`X`	`FRE`	`@0 Trouble neurologique @5 39`
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C07	`02`	`X`	`SPA`	`@0 Trastorno neurológico @5 39`
C07	`03`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 40`
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C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 40`
C07	`04`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 41`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 41`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 41`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 42`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 42`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 42`
C07	`06`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 43`
C07	`06`	`X`	`ENG`	`@0 Central nervous system disease @5 43`
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C07	`07`	`X`	`FRE`	`@0 Catécholamine @5 44`
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C07	`07`	`X`	`SPA`	`@0 Catecolamina @5 44`
C07	`08`	`X`	`FRE`	`@0 Neurotransmetteur @5 45`
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C07	`08`	`X`	`SPA`	`@0 Neurotransmisor @5 45`
N21				`@1 350`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:08-0536663

Le document en format XML

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<author><name sortKey="Benti, Riccardo" sort="Benti, Riccardo" uniqKey="Benti R" first="Riccardo" last="Benti">Riccardo Benti</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Predictive Value of Nigrostriatal Dysfunction in Isolated Tremor : A Clinical and SPECT Study</title>
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<author><name sortKey="Volterrani, Duccio" sort="Volterrani, Duccio" uniqKey="Volterrani D" first="Duccio" last="Volterrani">Duccio Volterrani</name>
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<author><name sortKey="Rossi, Carlo" sort="Rossi, Carlo" uniqKey="Rossi C" first="Carlo" last="Rossi">Carlo Rossi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Neurologic Clinic, University of Pisa</s1>
<s2>Pisa</s2>
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<author><name sortKey="Frosini, Daniela" sort="Frosini, Daniela" uniqKey="Frosini D" first="Daniela" last="Frosini">Daniela Frosini</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Neurologic Clinic, University of Pisa</s1>
<s2>Pisa</s2>
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<author><name sortKey="Lucetti, Claudio" sort="Lucetti, Claudio" uniqKey="Lucetti C" first="Claudio" last="Lucetti">Claudio Lucetti</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Neurologic Clinic, University of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
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<author><name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1>
<s2>Milan</s2>
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<author><name sortKey="Benti, Riccardo" sort="Benti, Riccardo" uniqKey="Benti R" first="Riccardo" last="Benti">Riccardo Benti</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Nuclear Medicine, IRCCS-Ospedale Maggiore</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Murri, Luigi" sort="Murri, Luigi" uniqKey="Murri L" first="Luigi" last="Murri">Luigi Murri</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Neurologic Clinic, University of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
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<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Bonuccelli, Ubaldo" sort="Bonuccelli, Ubaldo" uniqKey="Bonuccelli U" first="Ubaldo" last="Bonuccelli">Ubaldo Bonuccelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences, Neurologic Clinic, University of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dopamine</term>
<term>Dysfunction</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Photon</term>
<term>Predictive value</term>
<term>Single photon emission tomography</term>
<term>Tremor</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tremblement</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Valeur prédictive</term>
<term>Trouble fonctionnel</term>
<term>Tomoscintigraphie émission monophotonique</term>
<term>Photon</term>
<term>Dopamine</term>
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<front><div type="abstract" xml:lang="en">The overlap among tremor disorders is wide and complex because essential tremor patients may present resting tremor coexisting with postural tremor, while postural may coexist with resting tremor in Parkinson's disease. We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I-FPCIT SPECT imaging at baseline. Patients were followed-up clinically for 28.4 ± 7.2 months. Twenty-five patients with baseline normal SPECT continued to present only tremor at follow-up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow-up. The value of 123I-FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, P = 0.015; Mixed tremor, P = 0.015; Postural tremor, P = 0.039; chi-square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early-stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as "isolated tremor with dopaminergic presynaptic dysfunction.</div>
</front>
</TEI>
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<fA06><s2>14</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Predictive Value of Nigrostriatal Dysfunction in Isolated Tremor : A Clinical and SPECT Study</s1>
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<fA11 i1="01" i2="1"><s1>CERAVOLO (Roberto)</s1>
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<fA11 i1="02" i2="1"><s1>ANTONINI (Angelo)</s1>
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<fA11 i1="03" i2="1"><s1>VOLTERRANI (Duccio)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>ROSSI (Carlo)</s1>
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<fA11 i1="05" i2="1"><s1>KIFERLE (Lorenzo)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>FROSINI (Daniela)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>LUCETTI (Claudio)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>ISAIAS (Ioannis U.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>BENTI (Riccardo)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>MURRI (Luigi)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>BONUCCELLI (Ubaldo)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neurosciences, Neurologic Clinic, University of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Nuclear Medicine, University of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Nuclear Medicine, IRCCS-Ospedale Maggiore</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA20><s1>2049-2054</s1>
</fA20>
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</fA21>
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<fC01 i1="01" l="ENG"><s0>The overlap among tremor disorders is wide and complex because essential tremor patients may present resting tremor coexisting with postural tremor, while postural may coexist with resting tremor in Parkinson's disease. We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I-FPCIT SPECT imaging at baseline. Patients were followed-up clinically for 28.4 ± 7.2 months. Twenty-five patients with baseline normal SPECT continued to present only tremor at follow-up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow-up. The value of 123I-FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, P = 0.015; Mixed tremor, P = 0.015; Postural tremor, P = 0.039; chi-square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early-stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as "isolated tremor with dopaminergic presynaptic dysfunction.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B24B07</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Tremblement</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Tremor</s0>
<s5>01</s5>
</fC03>
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<s5>01</s5>
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<s2>NM</s2>
<s5>02</s5>
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<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
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<s2>NM</s2>
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<s5>03</s5>
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<s5>03</s5>
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<s5>03</s5>
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<fC03 i1="04" i2="X" l="FRE"><s0>Valeur prédictive</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Predictive value</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Valor predictivo</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Trouble fonctionnel</s0>
<s5>10</s5>
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<fC03 i1="05" i2="X" l="ENG"><s0>Dysfunction</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Trastorno funcional</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Tomoscintigraphie émission monophotonique</s0>
<s5>11</s5>
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<fC03 i1="06" i2="X" l="ENG"><s0>Single photon emission tomography</s0>
<s5>11</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Tomografía emisión fotón único</s0>
<s5>11</s5>
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<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Photon</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Fotón</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>13</s5>
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<fC03 i1="08" i2="X" l="ENG"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>13</s5>
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<fC03 i1="08" i2="X" l="SPA"><s0>Dopamina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>13</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>37</s5>
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<fC07 i1="02" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>42</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Catécholamine</s0>
<s5>44</s5>
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<fC07 i1="07" i2="X" l="ENG"><s0>Catecholamine</s0>
<s5>44</s5>
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<s5>44</s5>
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<s5>45</s5>
</fC07>
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<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Neurotransmisor</s0>
<s5>45</s5>
</fC07>
<fN21><s1>350</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Predictive Value of Nigrostriatal Dysfunction in Isolated Tremor : A Clinical and SPECT Study

Predictive Value of Nigrostriatal Dysfunction in Isolated Tremor : A Clinical and SPECT Study

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