Ten-Year Rate of Longitudinal Change in Neurocognitive and Motor Function in Prediagnosis Huntington Disease
Identifieur interne : 001C23 ( PascalFrancis/Curation ); précédent : 001C22; suivant : 001C24Ten-Year Rate of Longitudinal Change in Neurocognitive and Motor Function in Prediagnosis Huntington Disease
Auteurs : Andrea C. Solomon [États-Unis] ; Julie C. Stout [États-Unis, Australie] ; Marjorie Weaver [États-Unis] ; Sarah Queller [États-Unis] ; Allison Tomusk [États-Unis] ; Kathryn Burr Whitlock [États-Unis] ; Siu L. Hui [États-Unis] ; Jeanine Marshall [États-Unis] ; Jacqueline Gray Jackson [États-Unis] ; Eric R. Siemers [États-Unis] ; Xabier Beristain [États-Unis] ; Joanne Wojcieszek [États-Unis] ; Tatiana Foroud [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2008.
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- Pascal (Inist)
English descriptors
Abstract
Longitudinal studies of neurocognitive function in prediagnosis Huntington disease (pre-HD) have been few, and duration of follow-up has been brief. In this study, 155 individuals at-risk for HD completed a battery of cognitive and motor tasks at two study visits ∼10 years apart. Participants were classified as: (1) at-risk, without the CAG expansion (healthy controls, NC; n = 112), or (2) CAG expanded (CAG+; n = 43). To examine the rate of decline at different stages of the pre-HD period, participants in the CAG+ group were further characterized as converters (i.e., individuals who developed manifest HD over the course of the study; n = 21) or nonconverters (n = 22), and their performances were compared. The CAG+ group exhibited faster rates of neurocognitive decline over the course of the study, relative to the NC group. In addition, more rapid decline was associated with closer proximity to estimated age of disease onset in the CAG+ group. Faster rates of motor and psychomotor decline were observed in the CAG+ converter group, relative to the nonconverters. These findings suggest that neurocognitive decline in pre-HD, particularly in motor and psychomotor domains, begins insidiously and accelerates as individuals approach disease onset.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Ten-Year Rate of Longitudinal Change in Neurocognitive and Motor Function in Prediagnosis Huntington Disease</title><author><name sortKey="Solomon, Andrea C" sort="Solomon, Andrea C" uniqKey="Solomon A" first="Andrea C." last="Solomon">Andrea C. Solomon</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychological and Brain Sciences, Indiana University</s1><s2>Bloomington, Indiana</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C." last="Stout">Julie C. 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Hui</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medicine, Division of Biostatistics, Indiana University School of Medicine, Regenstrief Institute</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Marshall, Jeanine" sort="Marshall, Jeanine" uniqKey="Marshall J" first="Jeanine" last="Marshall">Jeanine Marshall</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medical and Molecular Genetics, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Jackson, Jacqueline Gray" sort="Jackson, Jacqueline Gray" uniqKey="Jackson J" first="Jacqueline Gray" last="Jackson">Jacqueline Gray Jackson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medical and Molecular Genetics, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Siemers, Eric R" sort="Siemers, Eric R" uniqKey="Siemers E" first="Eric R." last="Siemers">Eric R. Siemers</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Lilly Corporate Center</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Beristain, Xabier" sort="Beristain, Xabier" uniqKey="Beristain X" first="Xabier" last="Beristain">Xabier Beristain</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Wojcieszek, Joanne" sort="Wojcieszek, Joanne" uniqKey="Wojcieszek J" first="Joanne" last="Wojcieszek">Joanne Wojcieszek</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medical and Molecular Genetics, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0522177</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0522177 INIST</idno><idno type="RBID">Pascal:08-0522177</idno><idno type="wicri:Area/PascalFrancis/Corpus">001096</idno><idno type="wicri:Area/PascalFrancis/Curation">001C23</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Ten-Year Rate of Longitudinal Change in Neurocognitive and Motor Function in Prediagnosis Huntington Disease</title><author><name sortKey="Solomon, Andrea C" sort="Solomon, Andrea C" uniqKey="Solomon A" first="Andrea C." last="Solomon">Andrea C. Solomon</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychological and Brain Sciences, Indiana University</s1><s2>Bloomington, Indiana</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C." last="Stout">Julie C. Stout</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychological and Brain Sciences, Indiana University</s1><s2>Bloomington, Indiana</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Psychology, Psychiatry, and Psychological Medicine, Monash University</s1><s2>Clayton, Victoria</s2><s3>AUS</s3><sZ>2 aut.</sZ></inist:fA14><country>Australie</country></affiliation></author><author><name sortKey="Weaver, Marjorie" sort="Weaver, Marjorie" uniqKey="Weaver M" first="Marjorie" last="Weaver">Marjorie Weaver</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medical and Molecular Genetics, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Queller, Sarah" sort="Queller, Sarah" uniqKey="Queller S" first="Sarah" last="Queller">Sarah Queller</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychological and Brain Sciences, Indiana University</s1><s2>Bloomington, Indiana</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Tomusk, Allison" sort="Tomusk, Allison" uniqKey="Tomusk A" first="Allison" last="Tomusk">Allison Tomusk</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychological and Brain Sciences, Indiana University</s1><s2>Bloomington, Indiana</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Burr Whitlock, Kathryn" sort="Burr Whitlock, Kathryn" uniqKey="Burr Whitlock K" first="Kathryn" last="Burr Whitlock">Kathryn Burr Whitlock</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychological and Brain Sciences, Indiana University</s1><s2>Bloomington, Indiana</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Hui, Siu L" sort="Hui, Siu L" uniqKey="Hui S" first="Siu L." last="Hui">Siu L. Hui</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medicine, Division of Biostatistics, Indiana University School of Medicine, Regenstrief Institute</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Marshall, Jeanine" sort="Marshall, Jeanine" uniqKey="Marshall J" first="Jeanine" last="Marshall">Jeanine Marshall</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medical and Molecular Genetics, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Jackson, Jacqueline Gray" sort="Jackson, Jacqueline Gray" uniqKey="Jackson J" first="Jacqueline Gray" last="Jackson">Jacqueline Gray Jackson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medical and Molecular Genetics, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Siemers, Eric R" sort="Siemers, Eric R" uniqKey="Siemers E" first="Eric R." last="Siemers">Eric R. Siemers</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Lilly Corporate Center</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Beristain, Xabier" sort="Beristain, Xabier" uniqKey="Beristain X" first="Xabier" last="Beristain">Xabier Beristain</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Wojcieszek, Joanne" sort="Wojcieszek, Joanne" uniqKey="Wojcieszek J" first="Joanne" last="Wojcieszek">Joanne Wojcieszek</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medical and Molecular Genetics, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington disease</term><term>Nervous system diseases</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chorée de Huntington</term><term>Pathologie du système nerveux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Longitudinal studies of neurocognitive function in prediagnosis Huntington disease (pre-HD) have been few, and duration of follow-up has been brief. In this study, 155 individuals at-risk for HD completed a battery of cognitive and motor tasks at two study visits ∼10 years apart. Participants were classified as: (1) at-risk, without the CAG expansion (healthy controls, NC; n = 112), or (2) CAG expanded (CAG+; n = 43). To examine the rate of decline at different stages of the pre-HD period, participants in the CAG+ group were further characterized as converters (i.e., individuals who developed manifest HD over the course of the study; n = 21) or nonconverters (n = 22), and their performances were compared. The CAG+ group exhibited faster rates of neurocognitive decline over the course of the study, relative to the NC group. In addition, more rapid decline was associated with closer proximity to estimated age of disease onset in the CAG+ group. Faster rates of motor and psychomotor decline were observed in the CAG+ converter group, relative to the nonconverters. These findings suggest that neurocognitive decline in pre-HD, particularly in motor and psychomotor domains, begins insidiously and accelerates as individuals approach disease onset.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>23</s2></fA05><fA06><s2>13</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Ten-Year Rate of Longitudinal Change in Neurocognitive and Motor Function in Prediagnosis Huntington Disease</s1></fA08><fA11 i1="01" i2="1"><s1>SOLOMON (Andrea C.)</s1></fA11><fA11 i1="02" i2="1"><s1>STOUT (Julie C.)</s1></fA11><fA11 i1="03" i2="1"><s1>WEAVER (Marjorie)</s1></fA11><fA11 i1="04" i2="1"><s1>QUELLER (Sarah)</s1></fA11><fA11 i1="05" i2="1"><s1>TOMUSK (Allison)</s1></fA11><fA11 i1="06" i2="1"><s1>BURR WHITLOCK (Kathryn)</s1></fA11><fA11 i1="07" i2="1"><s1>HUI (Siu L.)</s1></fA11><fA11 i1="08" i2="1"><s1>MARSHALL (Jeanine)</s1></fA11><fA11 i1="09" i2="1"><s1>JACKSON (Jacqueline Gray)</s1></fA11><fA11 i1="10" i2="1"><s1>SIEMERS (Eric R.)</s1></fA11><fA11 i1="11" i2="1"><s1>BERISTAIN (Xabier)</s1></fA11><fA11 i1="12" i2="1"><s1>WOJCIESZEK (Joanne)</s1></fA11><fA11 i1="13" i2="1"><s1>FOROUD (Tatiana)</s1></fA11><fA14 i1="01"><s1>Department of Psychological and Brain Sciences, Indiana University</s1><s2>Bloomington, Indiana</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>School of Psychology, Psychiatry, and Psychological Medicine, Monash University</s1><s2>Clayton, Victoria</s2><s3>AUS</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Medical and Molecular Genetics, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Medicine, Division of Biostatistics, Indiana University School of Medicine, Regenstrief Institute</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Neurology, Indiana University School of Medicine</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="06"><s1>Lilly Corporate Center</s1><s2>Indianapolis, Indiana</s2><s3>USA</s3><sZ>10 aut.</sZ></fA14><fA20><s1>1830-1836</s1></fA20><fA21><s1>2008</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000184468160060</s5></fA43><fA44><s0>0000</s0><s1>© 2008 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>25 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>08-0522177</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Longitudinal studies of neurocognitive function in prediagnosis Huntington disease (pre-HD) have been few, and duration of follow-up has been brief. In this study, 155 individuals at-risk for HD completed a battery of cognitive and motor tasks at two study visits ∼10 years apart. Participants were classified as: (1) at-risk, without the CAG expansion (healthy controls, NC; n = 112), or (2) CAG expanded (CAG+; n = 43). To examine the rate of decline at different stages of the pre-HD period, participants in the CAG+ group were further characterized as converters (i.e., individuals who developed manifest HD over the course of the study; n = 21) or nonconverters (n = 22), and their performances were compared. The CAG+ group exhibited faster rates of neurocognitive decline over the course of the study, relative to the NC group. In addition, more rapid decline was associated with closer proximity to estimated age of disease onset in the CAG+ group. Faster rates of motor and psychomotor decline were observed in the CAG+ converter group, relative to the nonconverters. These findings suggest that neurocognitive decline in pre-HD, particularly in motor and psychomotor domains, begins insidiously and accelerates as individuals approach disease onset.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Chorée de Huntington</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Huntington disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Corea Huntington</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Maladie héréditaire</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Genetic disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>41</s5></fC07><fN21><s1>343</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Ten-Year Rate of Longitudinal Change in Neurocognitive and Motor Function in Prediagnosis Huntington Disease
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