MovDisordV3, PascalFrancis, Curation, bibRecord, 001A85

The Frequency of Cardiac Valvular Regurgitation in Parkinson's Disease

Identifieur interne : 001A85 ( PascalFrancis/Curation ); précédent : 001A84; suivant : 001A86

The Frequency of Cardiac Valvular Regurgitation in Parkinson's Disease

Auteurs : Kazuo Yamashiro [Japon] ; Miki Komine-Kobayashi [Japon] ; Taku Hatano [Japon] ; Takao Urabe [Japon] ; Hideki Mochizuki [Japon] ; Nobutaka Hattori [Japon] ; Yoshitaka Iwama [Japon] ; Hiroyuki Daida [Japon] ; Michi Sakai [Japon] ; Takeo Nakayama [Japon] ; Yoshikuni Mizuno [Japon]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0305148

Descripteurs français

Pascal (Inist)
- Insuffisance valvulaire, Cardiopathie valvulaire, Maladie de Parkinson, Pathologie du système nerveux, Stimulant dopaminergique.

English descriptors

KwdEn :
- Cardiac valvular disease, Dopamine agonist, Nervous system diseases, Parkinson disease, Valvular regurgitation.

Abstract

To investigate the frequency of cardiac valve regurgitation related with low dose dopamine agonists in patients with Parkinson's disease (PD), echocardiograms were analyzed in 527 consecutive PD patients (448 patients treated with dopamine agonists, 79 patients never treated with dopamine agonists as age-matched controls). The frequency of mild or above mild regurgitation of the aortic valve (AR) was significantly higher in the cabergoline group (13.7%, P < 0.05) compared with the controls (2.5%). Odds ratio adjusted by age and sex for AR was significantly higher in the cabergoline group (OR, 6.45; 95% CI, 1.46-28.60; P = 0.01): odds ratio was significantly higher in patients treated with higher daily doses (OR, 14.41; 95% CI, 3.08-67.38; P = 0.0007) and higher cumulative doses (OR, 15.29; 95% CI, 3.19-73.18; P = 0.0006). No statistical difference was identified in the frequency of the tricuspid and mitral regurgitation. None of the other dopamine agonist groups including pergolide gave higher frequency or higher odds ratio compared with the controls. None of our patients showed severe regurgitation or was operated for valvular heart disease. The question as to whether or not longer duration of low dose dopamine agonist treatment would yield the same results needs further studies.

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A03		`1`		`@0 Mov. disord.`
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A08	`01`	`1`	`ENG`	`@1 The Frequency of Cardiac Valvular Regurgitation in Parkinson's Disease`
A11	`01`	`1`		`@1 YAMASHIRO (Kazuo)`
A11	`02`	`1`		`@1 KOMINE-KOBAYASHI (Miki)`
A11	`03`	`1`		`@1 HATANO (Taku)`
A11	`04`	`1`		`@1 URABE (Takao)`
A11	`05`	`1`		`@1 MOCHIZUKI (Hideki)`
A11	`06`	`1`		`@1 HATTORI (Nobutaka)`
A11	`07`	`1`		`@1 IWAMA (Yoshitaka)`
A11	`08`	`1`		`@1 DAIDA (Hiroyuki)`
A11	`09`	`1`		`@1 SAKAI (Michi)`
A11	`10`	`1`		`@1 NAKAYAMA (Takeo)`
A11	`11`	`1`		`@1 MIZUNO (Yoshikuni)`
A14	`01`			`@1 Department of Neurology, Juntendo University School of Medicine @2 Tokyo @3 JPN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Cardiology, Juntendo University School of Medicine @2 Tokyo @3 JPN @Z 7 aut. @Z 8 aut.`
A14	`03`			`@1 Department of Health Informatics, Kyoto University School of Public Health @2 Kyoto @3 JPN @Z 9 aut. @Z 10 aut.`
A14	`04`			`@1 Research Institute for diseases of Old Age, Juntendo University School of Medicine @2 Tokyo @3 JPN @Z 11 aut.`
A20				`@1 935-941`
A21				`@1 2008`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000200276040020`
A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 25 ref.`
A47	`01`	`1`		`@0 08-0305148`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 To investigate the frequency of cardiac valve regurgitation related with low dose dopamine agonists in patients with Parkinson's disease (PD), echocardiograms were analyzed in 527 consecutive PD patients (448 patients treated with dopamine agonists, 79 patients never treated with dopamine agonists as age-matched controls). The frequency of mild or above mild regurgitation of the aortic valve (AR) was significantly higher in the cabergoline group (13.7%, P < 0.05) compared with the controls (2.5%). Odds ratio adjusted by age and sex for AR was significantly higher in the cabergoline group (OR, 6.45; 95% CI, 1.46-28.60; P = 0.01): odds ratio was significantly higher in patients treated with higher daily doses (OR, 14.41; 95% CI, 3.08-67.38; P = 0.0007) and higher cumulative doses (OR, 15.29; 95% CI, 3.19-73.18; P = 0.0006). No statistical difference was identified in the frequency of the tricuspid and mitral regurgitation. None of the other dopamine agonist groups including pergolide gave higher frequency or higher odds ratio compared with the controls. None of our patients showed severe regurgitation or was operated for valvular heart disease. The question as to whether or not longer duration of low dose dopamine agonist treatment would yield the same results needs further studies.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Insuffisance valvulaire @5 01`
C03	`01`	`X`	`ENG`	`@0 Valvular regurgitation @5 01`
C03	`01`	`X`	`SPA`	`@0 Insuficiencia valvular @5 01`
C03	`02`	`X`	`FRE`	`@0 Cardiopathie valvulaire @5 02`
C03	`02`	`X`	`ENG`	`@0 Cardiac valvular disease @5 02`
C03	`02`	`X`	`SPA`	`@0 Cardiopatía valvular @5 02`
C03	`03`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 03`
C03	`03`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 03`
C03	`03`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 03`
C03	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 04`
C03	`04`	`X`	`ENG`	`@0 Nervous system diseases @5 04`
C03	`04`	`X`	`SPA`	`@0 Sistema nervioso patología @5 04`
C03	`05`	`X`	`FRE`	`@0 Stimulant dopaminergique @5 09`
C03	`05`	`X`	`ENG`	`@0 Dopamine agonist @5 09`
C03	`05`	`X`	`SPA`	`@0 Estimulante dopaminérgico @5 09`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'appareil circulatoire @5 37`
C07	`01`	`X`	`ENG`	`@0 Cardiovascular disease @5 37`
C07	`01`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 38`
C07	`02`	`X`	`ENG`	`@0 Cerebral disorder @5 38`
C07	`02`	`X`	`SPA`	`@0 Encéfalo patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 39`
C07	`03`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 39`
C07	`03`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 39`
C07	`04`	`X`	`FRE`	`@0 Maladie dégénérative @5 40`
C07	`04`	`X`	`ENG`	`@0 Degenerative disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 41`
N21				`@1 189`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:08-0305148

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Frequency of Cardiac Valvular Regurgitation in Parkinson's Disease</title>
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<author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name>
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<author><name sortKey="Iwama, Yoshitaka" sort="Iwama, Yoshitaka" uniqKey="Iwama Y" first="Yoshitaka" last="Iwama">Yoshitaka Iwama</name>
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<author><name sortKey="Daida, Hiroyuki" sort="Daida, Hiroyuki" uniqKey="Daida H" first="Hiroyuki" last="Daida">Hiroyuki Daida</name>
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<author><name sortKey="Nakayama, Takeo" sort="Nakayama, Takeo" uniqKey="Nakayama T" first="Takeo" last="Nakayama">Takeo Nakayama</name>
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<author><name sortKey="Mizuno, Yoshikuni" sort="Mizuno, Yoshikuni" uniqKey="Mizuno Y" first="Yoshikuni" last="Mizuno">Yoshikuni Mizuno</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Research Institute for diseases of Old Age, Juntendo University School of Medicine</s1>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiac valvular disease</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Insuffisance valvulaire</term>
<term>Cardiopathie valvulaire</term>
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<front><div type="abstract" xml:lang="en">To investigate the frequency of cardiac valve regurgitation related with low dose dopamine agonists in patients with Parkinson's disease (PD), echocardiograms were analyzed in 527 consecutive PD patients (448 patients treated with dopamine agonists, 79 patients never treated with dopamine agonists as age-matched controls). The frequency of mild or above mild regurgitation of the aortic valve (AR) was significantly higher in the cabergoline group (13.7%, P < 0.05) compared with the controls (2.5%). Odds ratio adjusted by age and sex for AR was significantly higher in the cabergoline group (OR, 6.45; 95% CI, 1.46-28.60; P = 0.01): odds ratio was significantly higher in patients treated with higher daily doses (OR, 14.41; 95% CI, 3.08-67.38; P = 0.0007) and higher cumulative doses (OR, 15.29; 95% CI, 3.19-73.18; P = 0.0006). No statistical difference was identified in the frequency of the tricuspid and mitral regurgitation. None of the other dopamine agonist groups including pergolide gave higher frequency or higher odds ratio compared with the controls. None of our patients showed severe regurgitation or was operated for valvular heart disease. The question as to whether or not longer duration of low dose dopamine agonist treatment would yield the same results needs further studies.</div>
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Movement Disorders (revue)

The Frequency of Cardiac Valvular Regurgitation in Parkinson's Disease

The Frequency of Cardiac Valvular Regurgitation in Parkinson's Disease

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