Movement Disorders (revue)

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Bilateral Pedunculopontine Nuclei Strokes Presenting as Freezing of Gait

Identifieur interne : 001A16 ( PascalFrancis/Curation ); précédent : 001A15; suivant : 001A17

Bilateral Pedunculopontine Nuclei Strokes Presenting as Freezing of Gait

Auteurs : Sheng-Han Kuo [États-Unis] ; Christopher Kenney [États-Unis] ; Joseph Jankovic [États-Unis]

Source :

RBID : Pascal:08-0199367

Descripteurs français

English descriptors

Abstract

The penduculopontine nucleus (PPN) has been suggested to play an important role in locomotion, based on animal studies, but its function in humans has not been well defined. Autopsy studies have suggested that PPN pathology correlates with gait dysfunction in Parkinson's disease and in progressive supranuclear palsy but direct clinical evidence is lacking. We report a patient with bilateral PPN infarcts whose dominant clinical feature was freezing of gait, thus providing evidence that PPN is involved in human locomotion and that damage to the PPN may lead to abnormal gait.
pA  
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A03   1    @0 Mov. disord.
A05       @2 23
A06       @2 4
A08 01  1  ENG  @1 Bilateral Pedunculopontine Nuclei Strokes Presenting as Freezing of Gait
A11 01  1    @1 KUO (Sheng-Han)
A11 02  1    @1 KENNEY (Christopher)
A11 03  1    @1 JANKOVIC (Joseph)
A14 01      @1 Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine @2 Houston, Texas @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut.
A20       @1 616-619
A21       @1 2008
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C01 01    ENG  @0 The penduculopontine nucleus (PPN) has been suggested to play an important role in locomotion, based on animal studies, but its function in humans has not been well defined. Autopsy studies have suggested that PPN pathology correlates with gait dysfunction in Parkinson's disease and in progressive supranuclear palsy but direct clinical evidence is lacking. We report a patient with bilateral PPN infarcts whose dominant clinical feature was freezing of gait, thus providing evidence that PPN is involved in human locomotion and that damage to the PPN may lead to abnormal gait.
C02 01  X    @0 002B17
C02 02  X    @0 002B17C
C03 01  X  FRE  @0 Accident cérébrovasculaire @5 01
C03 01  X  ENG  @0 Stroke @5 01
C03 01  X  SPA  @0 Accidente cerebrovascular @5 01
C03 02  X  FRE  @0 Pathologie du système nerveux @5 02
C03 02  X  ENG  @0 Nervous system diseases @5 02
C03 02  X  SPA  @0 Sistema nervioso patología @5 02
C03 03  X  FRE  @0 Congélation @5 09
C03 03  X  ENG  @0 Freezing @5 09
C03 03  X  SPA  @0 Congelación @5 09
C07 01  X  FRE  @0 Pathologie de l'appareil circulatoire @5 37
C07 01  X  ENG  @0 Cardiovascular disease @5 37
C07 01  X  SPA  @0 Aparato circulatorio patología @5 37
C07 02  X  FRE  @0 Pathologie cérébrovasculaire @5 38
C07 02  X  ENG  @0 Cerebrovascular disease @5 38
C07 02  X  SPA  @0 Vaso sanguíneo encéfalo patología @5 38
C07 03  X  FRE  @0 Pathologie de l'encéphale @5 39
C07 03  X  ENG  @0 Cerebral disorder @5 39
C07 03  X  SPA  @0 Encéfalo patología @5 39
C07 04  X  FRE  @0 Pathologie du système nerveux central @5 40
C07 04  X  ENG  @0 Central nervous system disease @5 40
C07 04  X  SPA  @0 Sistema nervosio central patología @5 40
C07 05  X  FRE  @0 Pathologie des vaisseaux sanguins @5 42
C07 05  X  ENG  @0 Vascular disease @5 42
C07 05  X  SPA  @0 Vaso sanguíneo patología @5 42
N21       @1 126
N44 01      @1 OTO
N82       @1 OTO

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