MovDisordV3, PascalFrancis, Curation, bibRecord, 001953

Compartmental Loss of Striatal Medium Spiny Neurons in Multiple System Atrophy of Parkinsonian Type

Identifieur interne : 001953 ( PascalFrancis/Curation ); précédent : 001952; suivant : 001954

Compartmental Loss of Striatal Medium Spiny Neurons in Multiple System Atrophy of Parkinsonian Type

Auteurs : Kenta Sato [Japon] ; Ryuji Kaji [Japon] ; Sadayuki Matsumoto [Japon] ; Shinji Nagahiro [Japon] ; Satoshi Goto [Japon]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:08-0146936

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Maladie de Parkinson, Pathologie du système nerveux, Neurone.

English descriptors

KwdEn :
- Multiple system atrophy, Nervous system diseases, Neuron, Parkinson disease.

Abstract

Topographical or compartmental involvement of the putamen and caudate nucleus has not been fully elucidated in multiple system atrophy predominantly presenting with Parkinsonism (MSA-P). We carried out immunohistochemical studies using antibodies to calbindin (CALB) and calcineurin (CaN) as neurochemical markers for striatal medium spiny neurons. We found that in the caudal and dorsolateral putamen, the area most affected in MSA-P, the medium spiny neurons positive for CALB were severely depleted, while CaN-positive neurons were relatively spared in a mosaic pattern. In the dorsal caudate nucleus, an area less affected in MSA, residual CALB-positive neurons exhibited a compartmentalized distribution that corresponded with the striosomal arrangement visualized by Met-enkephalin immunostaining. Our findings suggest that there is a compartmental difference in the susceptibility of striatal medium spiny neurons to neurodegeneration in MSA-P.

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A03		`1`		`@0 Mov. disord.`
A05				`@2 22`
A06				`@2 16`
A08	`01`	`1`	`ENG`	`@1 Compartmental Loss of Striatal Medium Spiny Neurons in Multiple System Atrophy of Parkinsonian Type`
A11	`01`	`1`		`@1 SATO (Kenta)`
A11	`02`	`1`		`@1 KAJI (Ryuji)`
A11	`03`	`1`		`@1 MATSUMOTO (Sadayuki)`
A11	`04`	`1`		`@1 NAGAHIRO (Shinji)`
A11	`05`	`1`		`@1 GOTO (Satoshi)`
A14	`01`			`@1 Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima @2 Tokushima @3 JPN @Z 1 aut. @Z 2 aut. @Z 5 aut.`
A14	`02`			`@1 Department of Neurology, Kitano Hospital and Neurological Center @2 Osaka @3 JPN @Z 3 aut.`
A14	`03`			`@1 Department of Neurosurgery, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima @2 Tokushima @3 JPN @Z 4 aut.`
A20				`@1 2365-2370`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000162715700100`
A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 34 ref.`
A47	`01`	`1`		`@0 08-0146936`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Topographical or compartmental involvement of the putamen and caudate nucleus has not been fully elucidated in multiple system atrophy predominantly presenting with Parkinsonism (MSA-P). We carried out immunohistochemical studies using antibodies to calbindin (CALB) and calcineurin (CaN) as neurochemical markers for striatal medium spiny neurons. We found that in the caudal and dorsolateral putamen, the area most affected in MSA-P, the medium spiny neurons positive for CALB were severely depleted, while CaN-positive neurons were relatively spared in a mosaic pattern. In the dorsal caudate nucleus, an area less affected in MSA, residual CALB-positive neurons exhibited a compartmentalized distribution that corresponded with the striosomal arrangement visualized by Met-enkephalin immunostaining. Our findings suggest that there is a compartmental difference in the susceptibility of striatal medium spiny neurons to neurodegeneration in MSA-P.
C02	`01`	`X`		`@0 002B17`
C03	`01`	`X`	`FRE`	`@0 Atrophie multisystématisée @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Multiple system atrophy @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Atrofia multisistematizada @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 02`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Neurone @5 09`
C03	`04`	`X`	`ENG`	`@0 Neuron @5 09`
C03	`04`	`X`	`SPA`	`@0 Neurona @5 09`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
N21				`@1 091`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:08-0146936

Le document en format XML

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<author><name sortKey="Sato, Kenta" sort="Sato, Kenta" uniqKey="Sato K" first="Kenta" last="Sato">Kenta Sato</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima</s1>
<s2>Tokushima</s2>
<s3>JPN</s3>
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<country>Japon</country>
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<author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name>
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<author><name sortKey="Matsumoto, Sadayuki" sort="Matsumoto, Sadayuki" uniqKey="Matsumoto S" first="Sadayuki" last="Matsumoto">Sadayuki Matsumoto</name>
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<author><name sortKey="Nagahiro, Shinji" sort="Nagahiro, Shinji" uniqKey="Nagahiro S" first="Shinji" last="Nagahiro">Shinji Nagahiro</name>
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<author><name sortKey="Goto, Satoshi" sort="Goto, Satoshi" uniqKey="Goto S" first="Satoshi" last="Goto">Satoshi Goto</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Compartmental Loss of Striatal Medium Spiny Neurons in Multiple System Atrophy of Parkinsonian Type</title>
<author><name sortKey="Sato, Kenta" sort="Sato, Kenta" uniqKey="Sato K" first="Kenta" last="Sato">Kenta Sato</name>
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<author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name>
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<author><name sortKey="Matsumoto, Sadayuki" sort="Matsumoto, Sadayuki" uniqKey="Matsumoto S" first="Sadayuki" last="Matsumoto">Sadayuki Matsumoto</name>
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<author><name sortKey="Nagahiro, Shinji" sort="Nagahiro, Shinji" uniqKey="Nagahiro S" first="Shinji" last="Nagahiro">Shinji Nagahiro</name>
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<series><title level="j" type="main">Movement disorders</title>
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<front><div type="abstract" xml:lang="en">Topographical or compartmental involvement of the putamen and caudate nucleus has not been fully elucidated in multiple system atrophy predominantly presenting with Parkinsonism (MSA-P). We carried out immunohistochemical studies using antibodies to calbindin (CALB) and calcineurin (CaN) as neurochemical markers for striatal medium spiny neurons. We found that in the caudal and dorsolateral putamen, the area most affected in MSA-P, the medium spiny neurons positive for CALB were severely depleted, while CaN-positive neurons were relatively spared in a mosaic pattern. In the dorsal caudate nucleus, an area less affected in MSA, residual CALB-positive neurons exhibited a compartmentalized distribution that corresponded with the striosomal arrangement visualized by Met-enkephalin immunostaining. Our findings suggest that there is a compartmental difference in the susceptibility of striatal medium spiny neurons to neurodegeneration in MSA-P.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Compartmental Loss of Striatal Medium Spiny Neurons in Multiple System Atrophy of Parkinsonian Type

Compartmental Loss of Striatal Medium Spiny Neurons in Multiple System Atrophy of Parkinsonian Type

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri