MovDisordV3, PascalFrancis, Curation, bibRecord, 001905

Long-Term Follow-Up of Impulse Control Disorders in Parkinson's Disease

Identifieur interne : 001905 ( PascalFrancis/Curation ); précédent : 001904; suivant : 001906

Long-Term Follow-Up of Impulse Control Disorders in Parkinson's Disease

Auteurs : Eugenia Mamikonyan [États-Unis] ; Andrew D. Siderowf [États-Unis] ; John E. Duda [États-Unis] ; Marc N. Potenza [États-Unis] ; Stacy Horn [États-Unis] ; Matthew B. Stem [États-Unis] ; Daniel Weintraub [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0115899

Descripteurs français

Pascal (Inist)
- Trouble du contrôle des impulsions, Maladie de Parkinson, Pathologie du système nerveux, Long terme, Stimulant dopaminergique.

English descriptors

KwdEn :
- Dopamine agonist, Impulse control disorder, Long term, Nervous system diseases, Parkinson disease.

Abstract

Recent studies have linked dopamine agonist (DA) usage with the development of impulse control disorders (ICDs) in Parkinson's disease (PD). Little is known about optimal management strategies or the long-term outcomes of affected patients. To report on the clinical interventions and long-term outcomes of PD patients who developed an ICD after DA initiation. Subjects contacted by telephone for a follow-up interview after a mean time period of 29.2 months. They were administered a modified Minnesota Impulse Disorder Interview for compulsive buying, gambling, and sexuality, and also self-rated changes in their ICD symptomatology. Baseline and follow-up dopamine replacement therapy use was recorded and verified by chart review. Of 18 subjects, 15 (83.3%) participated in the follow-up interview. At follow-up, patients were receiving a significantly lower DA levodopa equivalent daily dosage (LEDD) (Z = -3.1, P = 0.002) and a higher daily levodopa dosage (Z = -1.9, P = 0.05), but a similar total LEDD dosage (Z = -0.47, P = 0.64) with no changes in Unified Parkinson's Disease Rating Scale motor score (Z = -1.3, P = 0.19). As part of ICD management, 12 (80.0%) patients discontinued or significantly decreased DA treatment, all of whom experienced full or partial remission of ICD symptoms by self-report, and 10 (83.3%) of whom no longer met diagnostic criteria for an ICD. For PD patients who develop an ICD in the context of DA treatment, discontinuing or significantly decreasing DA exposure, even when offset by an increase in levodopa treatment, is associated with remission of or significant reduction in ICD behaviors without worsening in motor symptoms.

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A11	`02`	`1`		`@1 SIDEROWF (Andrew D.)`
A11	`03`	`1`		`@1 DUDA (John E.)`
A11	`04`	`1`		`@1 POTENZA (Marc N.)`
A11	`05`	`1`		`@1 HORN (Stacy)`
A11	`06`	`1`		`@1 STEM (Matthew B.)`
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A14	`03`			`@1 Parkinson's Disease Research, Education and Clinical Center (PADRECC), Philadelphia Veterans Affairs Medical Center @2 Philadelphia, Pennsylvania @3 USA @Z 2 aut. @Z 3 aut. @Z 6 aut. @Z 7 aut.`
A14	`04`			`@1 Department of Psychiatry, Yale University @2 New Haven, Connecticut @3 USA @Z 4 aut.`
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C01	`01`		`ENG`	@0 Recent studies have linked dopamine agonist (DA) usage with the development of impulse control disorders (ICDs) in Parkinson's disease (PD). Little is known about optimal management strategies or the long-term outcomes of affected patients. To report on the clinical interventions and long-term outcomes of PD patients who developed an ICD after DA initiation. Subjects contacted by telephone for a follow-up interview after a mean time period of 29.2 months. They were administered a modified Minnesota Impulse Disorder Interview for compulsive buying, gambling, and sexuality, and also self-rated changes in their ICD symptomatology. Baseline and follow-up dopamine replacement therapy use was recorded and verified by chart review. Of 18 subjects, 15 (83.3%) participated in the follow-up interview. At follow-up, patients were receiving a significantly lower DA levodopa equivalent daily dosage (LEDD) (Z = -3.1, P = 0.002) and a higher daily levodopa dosage (Z = -1.9, P = 0.05), but a similar total LEDD dosage (Z = -0.47, P = 0.64) with no changes in Unified Parkinson's Disease Rating Scale motor score (Z = -1.3, P = 0.19). As part of ICD management, 12 (80.0%) patients discontinued or significantly decreased DA treatment, all of whom experienced full or partial remission of ICD symptoms by self-report, and 10 (83.3%) of whom no longer met diagnostic criteria for an ICD. For PD patients who develop an ICD in the context of DA treatment, discontinuing or significantly decreasing DA exposure, even when offset by an increase in levodopa treatment, is associated with remission of or significant reduction in ICD behaviors without worsening in motor symptoms.
C02	`01`	`X`		`@0 002B17`
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C03	`01`	`X`	`FRE`	`@0 Trouble du contrôle des impulsions @2 NM @5 01`
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C03	`01`	`X`	`SPA`	`@0 Trastorno control impulso @2 NM @5 01`
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C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Long terme @5 09`
C03	`04`	`X`	`ENG`	`@0 Long term @5 09`
C03	`04`	`X`	`SPA`	`@0 Largo plazo @5 09`
C03	`05`	`X`	`FRE`	`@0 Stimulant dopaminergique @5 10`
C03	`05`	`X`	`ENG`	`@0 Dopamine agonist @5 10`
C03	`05`	`X`	`SPA`	`@0 Estimulante dopaminérgico @5 10`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
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Pascal:08-0115899

Le document en format XML

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<keywords scheme="Pascal" xml:lang="fr"><term>Trouble du contrôle des impulsions</term>
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<front><div type="abstract" xml:lang="en">Recent studies have linked dopamine agonist (DA) usage with the development of impulse control disorders (ICDs) in Parkinson's disease (PD). Little is known about optimal management strategies or the long-term outcomes of affected patients. To report on the clinical interventions and long-term outcomes of PD patients who developed an ICD after DA initiation. Subjects contacted by telephone for a follow-up interview after a mean time period of 29.2 months. They were administered a modified Minnesota Impulse Disorder Interview for compulsive buying, gambling, and sexuality, and also self-rated changes in their ICD symptomatology. Baseline and follow-up dopamine replacement therapy use was recorded and verified by chart review. Of 18 subjects, 15 (83.3%) participated in the follow-up interview. At follow-up, patients were receiving a significantly lower DA levodopa equivalent daily dosage (LEDD) (Z = -3.1, P = 0.002) and a higher daily levodopa dosage (Z = -1.9, P = 0.05), but a similar total LEDD dosage (Z = -0.47, P = 0.64) with no changes in Unified Parkinson's Disease Rating Scale motor score (Z = -1.3, P = 0.19). As part of ICD management, 12 (80.0%) patients discontinued or significantly decreased DA treatment, all of whom experienced full or partial remission of ICD symptoms by self-report, and 10 (83.3%) of whom no longer met diagnostic criteria for an ICD. For PD patients who develop an ICD in the context of DA treatment, discontinuing or significantly decreasing DA exposure, even when offset by an increase in levodopa treatment, is associated with remission of or significant reduction in ICD behaviors without worsening in motor symptoms.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Long-Term Follow-Up of Impulse Control Disorders in Parkinson's Disease

Long-Term Follow-Up of Impulse Control Disorders in Parkinson's Disease

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