MovDisordV3, PascalFrancis, Curation, bibRecord, 001754

Bowel movement frequency in late-life and incidental lewy bodies

Identifieur interne : 001754 ( PascalFrancis/Curation ); précédent : 001753; suivant : 001755

Bowel movement frequency in late-life and incidental lewy bodies

Auteurs : Robert D. Abbott [États-Unis, Japon] ; G. Webster Ross [États-Unis] ; Helen Petrovitch [États-Unis] ; Caroline M. Tanner [États-Unis] ; Daron G. Davis [États-Unis] ; Kamal H. Masaki [États-Unis] ; Lenore J. Launer [États-Unis] ; J. David Curb [États-Unis] ; Lon R. White [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0448793

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Constipation, Parkinson maladie, Corps Lewy, Asymptomatique.

English descriptors

KwdEn :
- Asymptomatic, Constipation, Lewy body, Nervous system diseases, Parkinson disease.

Abstract

It is not known if constipation is associated with the preclinical phase of Parkinson's disease (PD), often characterized by the presence of incidental Lewy bodies (ILB). Such an association could provide evidence that constipation is an early symptom of PD. The purpose of this report is to examine the association between late-life bowel movement frequency and ILB. Bowel movement frequency was assessed from 1991 to 1993 in 245 men aged 71 to 93 years in the Honolulu-Asia Aging Study who later received postmortem examinations. All were without clinical PD and dementia. Brains were examined for ILB in the substantia nigra and locus ceruleus. Among the decedents, 30 men had ILB (12.2%). After age-adjustment, the percent of brains with ILB declined with increasing bowel movement frequency (P = 0.013). For men with <1, 1, and >1 bowel movement/day, corresponding percents were 24.1, 13.5, and 6.5%. Findings persisted after additional adjustment for time to death, mid-life pack-years of smoking and coffee intake, physical activity, and cognitive function. Infrequent bowel movements are associated with ILB. Findings provide evidence that constipation can predate the extrapyramidal signs of PD. Constipation could be one of the earliest markers of the beginning of PD processes.

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A08	`01`	`1`	`ENG`	`@1 Bowel movement frequency in late-life and incidental lewy bodies`
A11	`01`	`1`		`@1 ABBOTT (Robert D.)`
A11	`02`	`1`		`@1 ROSS (G. Webster)`
A11	`03`	`1`		`@1 PETROVITCH (Helen)`
A11	`04`	`1`		`@1 TANNER (Caroline M.)`
A11	`05`	`1`		`@1 DAVIS (Daron G.)`
A11	`06`	`1`		`@1 MASAKI (Kamal H.)`
A11	`07`	`1`		`@1 LAUNER (Lenore J.)`
A11	`08`	`1`		`@1 CURB (J. David)`
A11	`09`	`1`		`@1 WHITE (Lon R.)`
A14	`01`			`@1 Division of Biostatistics and Epidemiology, University of Virginia School of Medicine @2 Charlottesville, Virginia @3 USA @Z 1 aut.`
A14	`02`			`@1 Department of Health Science, Shiga University of Medical Science @2 Otsu @3 JPN @Z 1 aut.`
A14	`03`			`@1 Pacific Health Research Institute @2 Honolulu, Hawaii @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 6 aut. @Z 8 aut. @Z 9 aut.`
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A14	`07`			`@1 Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii @2 Honolulu, Hawaii @3 USA @Z 2 aut. @Z 3 aut. @Z 6 aut. @Z 8 aut. @Z 9 aut.`
A14	`08`			`@1 Parkinson's Institute @2 Sunnyvale, California @3 USA @Z 4 aut.`
A14	`09`			`@1 Pathology and Cytology Laboratories @2 Lexington, Kentucky @3 USA @Z 5 aut.`
A14	`10`			`@1 Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging @2 Bethesda, Maryland @3 USA @Z 7 aut.`
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C01	`01`		`ENG`	@0 It is not known if constipation is associated with the preclinical phase of Parkinson's disease (PD), often characterized by the presence of incidental Lewy bodies (ILB). Such an association could provide evidence that constipation is an early symptom of PD. The purpose of this report is to examine the association between late-life bowel movement frequency and ILB. Bowel movement frequency was assessed from 1991 to 1993 in 245 men aged 71 to 93 years in the Honolulu-Asia Aging Study who later received postmortem examinations. All were without clinical PD and dementia. Brains were examined for ILB in the substantia nigra and locus ceruleus. Among the decedents, 30 men had ILB (12.2%). After age-adjustment, the percent of brains with ILB declined with increasing bowel movement frequency (P = 0.013). For men with <1, 1, and >1 bowel movement/day, corresponding percents were 24.1, 13.5, and 6.5%. Findings persisted after additional adjustment for time to death, mid-life pack-years of smoking and coffee intake, physical activity, and cognitive function. Infrequent bowel movements are associated with ILB. Findings provide evidence that constipation can predate the extrapyramidal signs of PD. Constipation could be one of the earliest markers of the beginning of PD processes.
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C03	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 01`
C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Constipation @5 02`
C03	`02`	`X`	`ENG`	`@0 Constipation @5 02`
C03	`02`	`X`	`SPA`	`@0 Constipación @5 02`
C03	`03`	`X`	`FRE`	`@0 Parkinson maladie @5 03`
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C03	`05`	`X`	`ENG`	`@0 Asymptomatic @5 10`
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C07	`01`	`X`	`FRE`	`@0 Appareil digestif pathologie @5 37`
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C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`06`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 42`
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C07	`06`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 42`
N21				`@1 295`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:07-0448793

Le document en format XML

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<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
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<s2>Honolulu, Hawaii</s2>
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<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii</s1>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Bowel movement frequency in late-life and incidental lewy bodies</title>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asymptomatic</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">It is not known if constipation is associated with the preclinical phase of Parkinson's disease (PD), often characterized by the presence of incidental Lewy bodies (ILB). Such an association could provide evidence that constipation is an early symptom of PD. The purpose of this report is to examine the association between late-life bowel movement frequency and ILB. Bowel movement frequency was assessed from 1991 to 1993 in 245 men aged 71 to 93 years in the Honolulu-Asia Aging Study who later received postmortem examinations. All were without clinical PD and dementia. Brains were examined for ILB in the substantia nigra and locus ceruleus. Among the decedents, 30 men had ILB (12.2%). After age-adjustment, the percent of brains with ILB declined with increasing bowel movement frequency (P = 0.013). For men with <1, 1, and >1 bowel movement/day, corresponding percents were 24.1, 13.5, and 6.5%. Findings persisted after additional adjustment for time to death, mid-life pack-years of smoking and coffee intake, physical activity, and cognitive function. Infrequent bowel movements are associated with ILB. Findings provide evidence that constipation can predate the extrapyramidal signs of PD. Constipation could be one of the earliest markers of the beginning of PD processes.</div>
</front>
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<s5>10</s5>
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<fC03 i1="05" i2="X" l="SPA"><s0>Asintomático</s0>
<s5>10</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Appareil digestif pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Digestive diseases</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Aparato digestivo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Intestin pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Intestinal disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Intestino patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>42</s5>
</fC07>
<fN21><s1>295</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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   |texte=   Bowel movement frequency in late-life and incidental lewy bodies
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	Movement Disorders (revue)
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Movement Disorders (revue)

Bowel movement frequency in late-life and incidental lewy bodies

Bowel movement frequency in late-life and incidental lewy bodies

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