Olfactory loss may be a first sign of idiopathic Parkinson's disease
Identifieur interne : 001625 ( PascalFrancis/Curation ); précédent : 001624; suivant : 001626Olfactory loss may be a first sign of idiopathic Parkinson's disease
Auteurs : Antje Haehner [Allemagne] ; Thomas Hummel [Allemagne] ; Cornelia Hummel [Allemagne] ; Ulrike Sommer [Allemagne] ; Susann Junghanns [Allemagne] ; Heinz Reichmann [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Recent studies support the idea of olfactory dysfunction as a very early sign of idiopathic Parkinson's disease (IPD). Aim of the present study was to clinically follow-up patients with idiopathic hyposmia to find out the percentage of patients developing IPD after 4 years time. At baseline, olfactory tests had been combined with transcranial sonography of the substantia nigra and 123I-FP-CIT SPECT imaging. At the present neurological examination, 7% of the individuals with idiopathic hyposmia had developed clinical IPD. Altogether, 13% presented with abnormalities of the motor system. Our data suggest that a combination of olfactory testing and other tests may constitute a screening tool for the risk to develop IPD.
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<front><div type="abstract" xml:lang="en">Recent studies support the idea of olfactory dysfunction as a very early sign of idiopathic Parkinson's disease (IPD). Aim of the present study was to clinically follow-up patients with idiopathic hyposmia to find out the percentage of patients developing IPD after 4 years time. At baseline, olfactory tests had been combined with transcranial sonography of the substantia nigra and <sup>123</sup>
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