MovDisordV3, PascalFrancis, Curation, bibRecord, 001417

Tetrabenazine therapy of pediatric hyperkinetic movement disorders

Identifieur interne : 001417 ( PascalFrancis/Curation ); précédent : 001416; suivant : 001418

Tetrabenazine therapy of pediatric hyperkinetic movement disorders

Auteurs : Samay Jain [États-Unis] ; Paul E. Greene [États-Unis] ; Steven J. Frucht [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:07-0021727

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Hyperkinésie, Tétrabénazine, Traitement, Enfant, Pédiatrie.
Wicri :
- topic : Enfant, Pédiatrie.

English descriptors

KwdEn :
- Child, Hyperkinesia, Nervous system diseases, Pediatrics, Tetrabenazine, Treatment.

Abstract

Tetrabenazine (TBZ), a presynaptic dopamine depletor and postsynaptic dopamine receptor blocker, is widely used for the treatment of hyperkinetic movement disorders in adults. However, reports of its use in children are limited. We review the efficacy and tolerability of TBZ therapy in 31 children with hyperkinetic movement disorders refractory to other medications. TBZ was effective in reducing the severity of movement disorders resistant to treatment with other medicines. When compared to adult patients, pediatric patients required higher doses. Side effects were similar to the adult population; however, children had a lower incidence of drug-induced Parkinsonism.

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A11	`02`	`1`		`@1 GREENE (Paul E.)`
A11	`03`	`1`		`@1 FRUCHT (Steven J.)`
A14	`01`			`@1 Department of Neurology, Movement Disorders Division, University of Pittsburgh Medical Center @2 Pittsburgh, PA @3 USA @Z 1 aut.`
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C01	`01`		`ENG`	@0 Tetrabenazine (TBZ), a presynaptic dopamine depletor and postsynaptic dopamine receptor blocker, is widely used for the treatment of hyperkinetic movement disorders in adults. However, reports of its use in children are limited. We review the efficacy and tolerability of TBZ therapy in 31 children with hyperkinetic movement disorders refractory to other medications. TBZ was effective in reducing the severity of movement disorders resistant to treatment with other medicines. When compared to adult patients, pediatric patients required higher doses. Side effects were similar to the adult population; however, children had a lower incidence of drug-induced Parkinsonism.
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C03	`03`	`X`	`FRE`	`@0 Tétrabénazine @2 NK @2 FR @5 09`
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Pascal:07-0021727

Le document en format XML

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	Movement Disorders (revue)
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Movement Disorders (revue)

Tetrabenazine therapy of pediatric hyperkinetic movement disorders

Tetrabenazine therapy of pediatric hyperkinetic movement disorders

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri