Movement Disorders (revue)

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Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2

Identifieur interne : 000F93 ( PascalFrancis/Curation ); précédent : 000F92; suivant : 000F94

Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2

Auteurs : Satoshi Orimo [Japon] ; Takeshi Amino [Japon] ; Masayuki Yokochi [Japon] ; Tohru Kojo [Japon] ; Toshiki Uchihara [Japon] ; Atsushi Takahashi [Japon] ; Koichi Wakabayashi [Japon] ; Hitoshi Takahashi [Japon] ; Nobutaka Hattori [Japon] ; Yoshikuni Mizuno [Japon]

Source :

RBID : Pascal:06-0001653

Descripteurs français

English descriptors

Abstract

We performed [123I] MIBG myocardial scintigraphy in two of three patients with PARK2 from unrelated families and examined the heart tissues from the three patients immunohistochemically using an antibody against tyrosine hydroxylase (TH) to see whether cardiac sympathetic nerve is involved. Cardiac uptake of MIBG was normal except for a slight decrease in the late phase in one of the patients. Postmortem examination revealed that TH-immunoreactive nerve fibers in the epicardium were well preserved in all three patients. The present study confirmed that cardiac sympathetic nerve is well preserved in PARK2 with a homozygous exon deletion, which accounts for normal cardiac uptake of MIBG. Moreover, normal cardiac uptake of MIBG might be of potential diagnostic value to indicate the absence of Lewy body pathology, even in patients with levodopa-responsive Parkinsonism, as in PARK2.
pA  
A01 01  1    @0 0885-3185
A03   1    @0 Mov. disord.
A05       @2 20
A06       @2 10
A08 01  1  ENG  @1 Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2
A11 01  1    @1 ORIMO (Satoshi)
A11 02  1    @1 AMINO (Takeshi)
A11 03  1    @1 YOKOCHI (Masayuki)
A11 04  1    @1 KOJO (Tohru)
A11 05  1    @1 UCHIHARA (Toshiki)
A11 06  1    @1 TAKAHASHI (Atsushi)
A11 07  1    @1 WAKABAYASHI (Koichi)
A11 08  1    @1 TAKAHASHI (Hitoshi)
A11 09  1    @1 HATTORI (Nobutaka)
A11 10  1    @1 MIZUNO (Yoshikuni)
A14 01      @1 Department of Neurology, Kanto Central Hospital @2 Tokyo @3 JPN @Z 1 aut. @Z 2 aut.
A14 02      @1 Department of Neurology, Ehara Metropolitan Hospital @2 Tokyo @3 JPN @Z 3 aut.
A14 03      @1 Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience @2 Tokyo @3 JPN @Z 4 aut. @Z 5 aut.
A14 04      @1 Organ and Function Pathology Division, Yokufukai Geriatric Hospital @2 Tokyo @3 JPN @Z 6 aut.
A14 05      @1 Department of Neuropathology, Hirosaki University School of Medicine @2 Hirosaki @3 JPN @Z 7 aut.
A14 06      @1 Department of Pathology, Brain Research Institute, University of Niigata @2 Niigata @3 JPN @Z 8 aut.
A14 07      @1 Department of Neurology. Juntendo University School of Medicine @2 Tokyo @3 JPN @Z 9 aut. @Z 10 aut.
A20       @1 1350-1353
A21       @1 2005
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000135138750140
A44       @0 0000 @1 © 2006 INIST-CNRS. All rights reserved.
A45       @0 21 ref.
A47 01  1    @0 06-0001653
A60       @1 P @3 CC
A61       @0 A
A64 01  1    @0 Movement disorders
A66 01      @0 USA
C01 01    ENG  @0 We performed [123I] MIBG myocardial scintigraphy in two of three patients with PARK2 from unrelated families and examined the heart tissues from the three patients immunohistochemically using an antibody against tyrosine hydroxylase (TH) to see whether cardiac sympathetic nerve is involved. Cardiac uptake of MIBG was normal except for a slight decrease in the late phase in one of the patients. Postmortem examination revealed that TH-immunoreactive nerve fibers in the epicardium were well preserved in all three patients. The present study confirmed that cardiac sympathetic nerve is well preserved in PARK2 with a homozygous exon deletion, which accounts for normal cardiac uptake of MIBG. Moreover, normal cardiac uptake of MIBG might be of potential diagnostic value to indicate the absence of Lewy body pathology, even in patients with levodopa-responsive Parkinsonism, as in PARK2.
C02 01  X    @0 002B17
C02 02  X    @0 002B16B
C02 03  X    @0 002B25J03
C03 01  X  FRE  @0 Système nerveux pathologie @5 01
C03 01  X  ENG  @0 Nervous system diseases @5 01
C03 01  X  SPA  @0 Sistema nervioso patología @5 01
C03 02  X  FRE  @0 Parkinson maladie @5 02
C03 02  X  ENG  @0 Parkinson disease @5 02
C03 02  X  SPA  @0 Parkinson enfermedad @5 02
C03 03  X  FRE  @0 Nerf sympathique @5 09
C03 03  X  ENG  @0 Sympathetic nerve @5 09
C03 03  X  SPA  @0 Nervio simpático @5 09
C03 04  X  FRE  @0 Captation @5 10
C03 04  X  ENG  @0 Uptake @5 10
C03 04  X  SPA  @0 Captación @5 10
C03 05  X  FRE  @0 Scintigraphie @5 11
C03 05  X  ENG  @0 Scintigraphy @5 11
C03 05  X  SPA  @0 Centelleografía @5 11
C03 06  X  FRE  @0 Enervation @5 12
C03 06  X  ENG  @0 Denervation @5 12
C03 06  X  SPA  @0 Denervación @5 12
C07 01  X  FRE  @0 Encéphale pathologie @5 37
C07 01  X  ENG  @0 Cerebral disorder @5 37
C07 01  X  SPA  @0 Encéfalo patología @5 37
C07 02  X  FRE  @0 Extrapyramidal syndrome @5 38
C07 02  X  ENG  @0 Extrapyramidal syndrome @5 38
C07 02  X  SPA  @0 Extrapiramidal síndrome @5 38
C07 03  X  FRE  @0 Maladie dégénérative @5 39
C07 03  X  ENG  @0 Degenerative disease @5 39
C07 03  X  SPA  @0 Enfermedad degenerativa @5 39
C07 04  X  FRE  @0 Système nerveux central pathologie @5 40
C07 04  X  ENG  @0 Central nervous system disease @5 40
C07 04  X  SPA  @0 Sistema nervosio central patología @5 40
N21       @1 002
N44 01      @1 OTO
N82       @1 OTO

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Pascal:06-0001653

Le document en format XML

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<div type="abstract" xml:lang="en">We performed [
<sup>123</sup>
I] MIBG myocardial scintigraphy in two of three patients with PARK2 from unrelated families and examined the heart tissues from the three patients immunohistochemically using an antibody against tyrosine hydroxylase (TH) to see whether cardiac sympathetic nerve is involved. Cardiac uptake of MIBG was normal except for a slight decrease in the late phase in one of the patients. Postmortem examination revealed that TH-immunoreactive nerve fibers in the epicardium were well preserved in all three patients. The present study confirmed that cardiac sympathetic nerve is well preserved in PARK2 with a homozygous exon deletion, which accounts for normal cardiac uptake of MIBG. Moreover, normal cardiac uptake of MIBG might be of potential diagnostic value to indicate the absence of Lewy body pathology, even in patients with levodopa-responsive Parkinsonism, as in PARK2.</div>
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<s0>21 ref.</s0>
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<fA47 i1="01" i2="1">
<s0>06-0001653</s0>
</fA47>
<fA60>
<s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Movement disorders</s0>
</fA64>
<fA66 i1="01">
<s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>We performed [
<sup>123</sup>
I] MIBG myocardial scintigraphy in two of three patients with PARK2 from unrelated families and examined the heart tissues from the three patients immunohistochemically using an antibody against tyrosine hydroxylase (TH) to see whether cardiac sympathetic nerve is involved. Cardiac uptake of MIBG was normal except for a slight decrease in the late phase in one of the patients. Postmortem examination revealed that TH-immunoreactive nerve fibers in the epicardium were well preserved in all three patients. The present study confirmed that cardiac sympathetic nerve is well preserved in PARK2 with a homozygous exon deletion, which accounts for normal cardiac uptake of MIBG. Moreover, normal cardiac uptake of MIBG might be of potential diagnostic value to indicate the absence of Lewy body pathology, even in patients with levodopa-responsive Parkinsonism, as in PARK2.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X">
<s0>002B16B</s0>
</fC02>
<fC02 i1="03" i2="X">
<s0>002B25J03</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Parkinson maladie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Parkinson disease</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Parkinson enfermedad</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Nerf sympathique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Sympathetic nerve</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Nervio simpático</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Captation</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Uptake</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Captación</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Scintigraphie</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Scintigraphy</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Centelleografía</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Enervation</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Denervation</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Denervación</s0>
<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21>
<s1>002</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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