Movement Disorders (revue)

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Treatment of dementia with lewy bodies and Parkinson's disease dementia

Identifieur interne : 000F48 ( PascalFrancis/Curation ); précédent : 000F47; suivant : 000F49

Treatment of dementia with lewy bodies and Parkinson's disease dementia

Auteurs : Werner Poewe [Autriche]

Source :

RBID : Pascal:05-0457542

Descripteurs français

English descriptors

Abstract

Cognitive decline and dementia affect approximately 30% to 40% of patients with idiopathic Parkinson's disease during the course of their illness. PD-dementia (PDD) and dementia with Lewy bodies (DLB) are second to Alzheimer's disease in causing degenerative dementia in the elderly. The nosological distinction of the conditions has remained controversial because of broad clinical and pathological overlap. Treatment issues in both clinical settings are virtually identical. Treatment of Parkinsonism is often complicated by drug-induced psychosis and reduced levodopa responsiveness. Cognition, alertness, attention, as well as apathy or aggressive behavior have been shown to respond to treatment with cholinesterase inhibitors in randomized controlled trials both in DLB and PDD. Such treatment may also improve hallucinosis, but many patients will require add-on treatment with atypical neuroleptics to control drug-induced psychotic reactions. Clozapine and quetiapine are the drugs most commonly used and, contrary to classic neuroleptics, risperidone or olanzapine do not seem to cause severe side effects according to published data.
pA  
A01 01  1    @0 0885-3185
A03   1    @0 Mov. disord.
A05       @2 20
A06       @3 SUP12
A08 01  1  ENG  @1 Treatment of dementia with lewy bodies and Parkinson's disease dementia
A09 01  1  ENG  @1 Atypical Parkinsonian Disorders
A11 01  1    @1 POEWE (Werner)
A12 01  1    @1 POEWE (Werner) @9 ed.
A12 02  1    @1 WENNING (Gregor K.) @9 ed.
A14 01      @1 Department of Neurology, Medical University of Innsbruck @3 AUT @Z 1 aut.
A15 01      @1 Department of Neurology, Medical University Innsbruck @2 Innsbruck @3 AUT @Z 1 aut. @Z 2 aut.
A20       @2 S77-S82
A21       @1 2005
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000132714250120
A44       @0 0000 @1 © 2005 INIST-CNRS. All rights reserved.
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A47 01  1    @0 05-0457542
A60       @1 P @2 C
A61       @0 A
A64 01  1    @0 Movement disorders
A66 01      @0 USA
C01 01    ENG  @0 Cognitive decline and dementia affect approximately 30% to 40% of patients with idiopathic Parkinson's disease during the course of their illness. PD-dementia (PDD) and dementia with Lewy bodies (DLB) are second to Alzheimer's disease in causing degenerative dementia in the elderly. The nosological distinction of the conditions has remained controversial because of broad clinical and pathological overlap. Treatment issues in both clinical settings are virtually identical. Treatment of Parkinsonism is often complicated by drug-induced psychosis and reduced levodopa responsiveness. Cognition, alertness, attention, as well as apathy or aggressive behavior have been shown to respond to treatment with cholinesterase inhibitors in randomized controlled trials both in DLB and PDD. Such treatment may also improve hallucinosis, but many patients will require add-on treatment with atypical neuroleptics to control drug-induced psychotic reactions. Clozapine and quetiapine are the drugs most commonly used and, contrary to classic neuroleptics, risperidone or olanzapine do not seem to cause severe side effects according to published data.
C02 01  X    @0 002B17
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C03 01  X  FRE  @0 Système nerveux pathologie @5 01
C03 01  X  ENG  @0 Nervous system diseases @5 01
C03 01  X  SPA  @0 Sistema nervioso patología @5 01
C03 02  X  FRE  @0 Parkinson maladie @5 02
C03 02  X  ENG  @0 Parkinson disease @5 02
C03 02  X  SPA  @0 Parkinson enfermedad @5 02
C03 03  X  FRE  @0 Traitement @5 09
C03 03  X  ENG  @0 Treatment @5 09
C03 03  X  SPA  @0 Tratamiento @5 09
C03 04  X  FRE  @0 Démence corps Lewy @2 NM @5 10
C03 04  X  ENG  @0 Lewy body dementia @2 NM @5 10
C03 04  X  SPA  @0 Demencia cuerpos Lewy @2 NM @5 10
C03 05  X  FRE  @0 Cholinesterase @2 FE @5 11
C03 05  X  ENG  @0 Cholinesterase @2 FE @5 11
C03 05  X  SPA  @0 Cholinesterase @2 FE @5 11
C03 06  X  FRE  @0 Antipsychotique @5 12
C03 06  X  ENG  @0 Antipsychotic @5 12
C03 06  X  SPA  @0 Antipsicótico @5 12
C07 01  X  FRE  @0 Carboxylic ester hydrolases @2 FE
C07 01  X  ENG  @0 Carboxylic ester hydrolases @2 FE
C07 01  X  SPA  @0 Carboxylic ester hydrolases @2 FE
C07 02  X  FRE  @0 Esterases @2 FE
C07 02  X  ENG  @0 Esterases @2 FE
C07 02  X  SPA  @0 Esterases @2 FE
C07 03  X  FRE  @0 Hydrolases @2 FE
C07 03  X  ENG  @0 Hydrolases @2 FE
C07 03  X  SPA  @0 Hydrolases @2 FE
C07 04  X  FRE  @0 Enzyme @2 FE
C07 04  X  ENG  @0 Enzyme @2 FE
C07 04  X  SPA  @0 Enzima @2 FE
C07 05  X  FRE  @0 Encéphale pathologie @5 37
C07 05  X  ENG  @0 Cerebral disorder @5 37
C07 05  X  SPA  @0 Encéfalo patología @5 37
C07 06  X  FRE  @0 Extrapyramidal syndrome @5 38
C07 06  X  ENG  @0 Extrapyramidal syndrome @5 38
C07 06  X  SPA  @0 Extrapiramidal síndrome @5 38
C07 07  X  FRE  @0 Maladie dégénérative @5 39
C07 07  X  ENG  @0 Degenerative disease @5 39
C07 07  X  SPA  @0 Enfermedad degenerativa @5 39
C07 08  X  FRE  @0 Système nerveux central pathologie @5 40
C07 08  X  ENG  @0 Central nervous system disease @5 40
C07 08  X  SPA  @0 Sistema nervosio central patología @5 40
N21       @1 318
N44 01      @1 OTO
N82       @1 OTO
pR  
A30 01  1  ENG  @1 Atypical Parkinsonian Disorders - From Protein Dysfunction to Therapeutic Intervention. International Meeting @3 Innsbruck AUT @4 2003-02-19

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Pascal:05-0457542

Le document en format XML

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<div type="abstract" xml:lang="en">Cognitive decline and dementia affect approximately 30% to 40% of patients with idiopathic Parkinson's disease during the course of their illness. PD-dementia (PDD) and dementia with Lewy bodies (DLB) are second to Alzheimer's disease in causing degenerative dementia in the elderly. The nosological distinction of the conditions has remained controversial because of broad clinical and pathological overlap. Treatment issues in both clinical settings are virtually identical. Treatment of Parkinsonism is often complicated by drug-induced psychosis and reduced levodopa responsiveness. Cognition, alertness, attention, as well as apathy or aggressive behavior have been shown to respond to treatment with cholinesterase inhibitors in randomized controlled trials both in DLB and PDD. Such treatment may also improve hallucinosis, but many patients will require add-on treatment with atypical neuroleptics to control drug-induced psychotic reactions. Clozapine and quetiapine are the drugs most commonly used and, contrary to classic neuroleptics, risperidone or olanzapine do not seem to cause severe side effects according to published data.</div>
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