MovDisordV3, PascalFrancis, Curation, bibRecord, 000E16

Pallidotomy effect on the cortical excitability in patients with severe Parkinson's disease

Identifieur interne : 000E16 ( PascalFrancis/Curation ); précédent : 000E15; suivant : 000E17

Pallidotomy effect on the cortical excitability in patients with severe Parkinson's disease

Auteurs : Chon-Haw Tsai [Taïwan] ; Fang-Chia Chang [Taïwan] ; Chin-Song Lu [Taïwan] ; Shih-Tseng Lee [Taïwan] ; Yu-Ting Huang [Taïwan] ; Ming-Kuei Lu [Taïwan] ; Rou-Shayn Chen [Taïwan] ; TONY WU [Taïwan] ; Jiann-Der Lee [Taïwan] ; Yi-Hsin Weng [Taïwan] ; Hsiu-Chen Chang [Taïwan]

Source :

Movement disorders [ 0885-3185 ] ; 2005.

RBID : Pascal:05-0262069

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Excitabilité, Homme, Parkinson maladie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Excitability, Human, Nervous system diseases, Parkinson disease.

Abstract

Surgical lesions in the medial pallidum have been shown to ameliorate motor deficits in patients with Parkinson's disease (PD). It is believed that interruption of the pallidothalamocortical projections to the motor cortex is required for the satisfactory results. In this report, we adopt cortico-cortical inhibition as the tool to assess the pallidotomy effect on cortical excitability in PD. Interstimulus interval between 1 and 15 msec were investigated. The average peak-to-peak amplitude was measured and calculated at each delay. A total of 8 patients (M:F = 4:4) 54.9 years of age (SD = 9.6) and 10 controls were recruited for the study. In the controls, the inhibitory phenomenon was observed from the 1-msec to the 4-msec delay points and the maximal inhibition was at the 3-msec delay point (33.69% ± 6.50% of the control response). Mild facilitation was noticed since the 5-msec delay point and thereafter. In patients before operation, a similar trend of inhibition was also observed in the initial 4 msec with the maximal inhibition also at the 3-msec delay point (64.66 ± 6.77% of the control response). In the postoperative group, the short interstimulus interval inhibition can no longer be observed and the conditioned response was 95.06 ± 23.68% of the control at the 3-msec delay point. The suppression was gone at and after the 7-msec delay point. Results of repeated-measures analysis of variance show a significant difference among the controls and PD patients before and 3 months after pallidotomy (F = 3.40, P = 0.05). Post hoc examination revealed a significant difference between the controls and PD patients 3 months after pallidotomy at the 3-msec delay point (P = 0.004). However, no correlation was observed between the 3-msec inhibition and the Unified Parkinson's Disease Rating Scale Motor score or the dyskinesia score. The results suggest that pallidotomy can modulate the cortical inhibitory circuitry in patients with PD.

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A08	`01`	`1`	`ENG`	`@1 Pallidotomy effect on the cortical excitability in patients with severe Parkinson's disease`
A11	`01`	`1`		`@1 TSAI (Chon-Haw)`
A11	`02`	`1`		`@1 CHANG (Fang-Chia)`
A11	`03`	`1`		`@1 LU (Chin-Song)`
A11	`04`	`1`		`@1 LEE (Shih-Tseng)`
A11	`05`	`1`		`@1 HUANG (Yu-Ting)`
A11	`06`	`1`		`@1 LU (Ming-Kuei)`
A11	`07`	`1`		`@1 CHEN (Rou-Shayn)`
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C01	`01`		`ENG`	@0 Surgical lesions in the medial pallidum have been shown to ameliorate motor deficits in patients with Parkinson's disease (PD). It is believed that interruption of the pallidothalamocortical projections to the motor cortex is required for the satisfactory results. In this report, we adopt cortico-cortical inhibition as the tool to assess the pallidotomy effect on cortical excitability in PD. Interstimulus interval between 1 and 15 msec were investigated. The average peak-to-peak amplitude was measured and calculated at each delay. A total of 8 patients (M:F = 4:4) 54.9 years of age (SD = 9.6) and 10 controls were recruited for the study. In the controls, the inhibitory phenomenon was observed from the 1-msec to the 4-msec delay points and the maximal inhibition was at the 3-msec delay point (33.69% ± 6.50% of the control response). Mild facilitation was noticed since the 5-msec delay point and thereafter. In patients before operation, a similar trend of inhibition was also observed in the initial 4 msec with the maximal inhibition also at the 3-msec delay point (64.66 ± 6.77% of the control response). In the postoperative group, the short interstimulus interval inhibition can no longer be observed and the conditioned response was 95.06 ± 23.68% of the control at the 3-msec delay point. The suppression was gone at and after the 7-msec delay point. Results of repeated-measures analysis of variance show a significant difference among the controls and PD patients before and 3 months after pallidotomy (F = 3.40, P = 0.05). Post hoc examination revealed a significant difference between the controls and PD patients 3 months after pallidotomy at the 3-msec delay point (P = 0.004). However, no correlation was observed between the 3-msec inhibition and the Unified Parkinson's Disease Rating Scale Motor score or the dyskinesia score. The results suggest that pallidotomy can modulate the cortical inhibitory circuitry in patients with PD.
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Le document en format XML

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<author><name sortKey="Chang, Fang Chia" sort="Chang, Fang Chia" uniqKey="Chang F" first="Fang-Chia" last="Chang">Fang-Chia Chang</name>
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<author><name sortKey="Tony Wu" sort="Tony Wu" uniqKey="Tony Wu" last="Tony Wu">TONY WU</name>
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<author><name sortKey="Weng, Yi Hsin" sort="Weng, Yi Hsin" uniqKey="Weng Y" first="Yi-Hsin" last="Weng">Yi-Hsin Weng</name>
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<author><name sortKey="Chang, Hsiu Chen" sort="Chang, Hsiu Chen" uniqKey="Chang H" first="Hsiu-Chen" last="Chang">Hsiu-Chen Chang</name>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Excitability</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Excitabilité</term>
<term>Homme</term>
<term>Parkinson maladie</term>
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<front><div type="abstract" xml:lang="en">Surgical lesions in the medial pallidum have been shown to ameliorate motor deficits in patients with Parkinson's disease (PD). It is believed that interruption of the pallidothalamocortical projections to the motor cortex is required for the satisfactory results. In this report, we adopt cortico-cortical inhibition as the tool to assess the pallidotomy effect on cortical excitability in PD. Interstimulus interval between 1 and 15 msec were investigated. The average peak-to-peak amplitude was measured and calculated at each delay. A total of 8 patients (M:F = 4:4) 54.9 years of age (SD = 9.6) and 10 controls were recruited for the study. In the controls, the inhibitory phenomenon was observed from the 1-msec to the 4-msec delay points and the maximal inhibition was at the 3-msec delay point (33.69% ± 6.50% of the control response). Mild facilitation was noticed since the 5-msec delay point and thereafter. In patients before operation, a similar trend of inhibition was also observed in the initial 4 msec with the maximal inhibition also at the 3-msec delay point (64.66 ± 6.77% of the control response). In the postoperative group, the short interstimulus interval inhibition can no longer be observed and the conditioned response was 95.06 ± 23.68% of the control at the 3-msec delay point. The suppression was gone at and after the 7-msec delay point. Results of repeated-measures analysis of variance show a significant difference among the controls and PD patients before and 3 months after pallidotomy (F = 3.40, P = 0.05). Post hoc examination revealed a significant difference between the controls and PD patients 3 months after pallidotomy at the 3-msec delay point (P = 0.004). However, no correlation was observed between the 3-msec inhibition and the Unified Parkinson's Disease Rating Scale Motor score or the dyskinesia score. The results suggest that pallidotomy can modulate the cortical inhibitory circuitry in patients with PD.</div>
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<fA11 i1="11" i2="1"><s1>CHANG (Hsiu-Chen)</s1>
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<fA14 i1="05"><s1>Department of Electrical Engineering, Chang Gung Memorial Hospital</s1>
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<fC01 i1="01" l="ENG"><s0>Surgical lesions in the medial pallidum have been shown to ameliorate motor deficits in patients with Parkinson's disease (PD). It is believed that interruption of the pallidothalamocortical projections to the motor cortex is required for the satisfactory results. In this report, we adopt cortico-cortical inhibition as the tool to assess the pallidotomy effect on cortical excitability in PD. Interstimulus interval between 1 and 15 msec were investigated. The average peak-to-peak amplitude was measured and calculated at each delay. A total of 8 patients (M:F = 4:4) 54.9 years of age (SD = 9.6) and 10 controls were recruited for the study. In the controls, the inhibitory phenomenon was observed from the 1-msec to the 4-msec delay points and the maximal inhibition was at the 3-msec delay point (33.69% ± 6.50% of the control response). Mild facilitation was noticed since the 5-msec delay point and thereafter. In patients before operation, a similar trend of inhibition was also observed in the initial 4 msec with the maximal inhibition also at the 3-msec delay point (64.66 ± 6.77% of the control response). In the postoperative group, the short interstimulus interval inhibition can no longer be observed and the conditioned response was 95.06 ± 23.68% of the control at the 3-msec delay point. The suppression was gone at and after the 7-msec delay point. Results of repeated-measures analysis of variance show a significant difference among the controls and PD patients before and 3 months after pallidotomy (F = 3.40, P = 0.05). Post hoc examination revealed a significant difference between the controls and PD patients 3 months after pallidotomy at the 3-msec delay point (P = 0.004). However, no correlation was observed between the 3-msec inhibition and the Unified Parkinson's Disease Rating Scale Motor score or the dyskinesia score. The results suggest that pallidotomy can modulate the cortical inhibitory circuitry in patients with PD.</s0>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Pallidotomy effect on the cortical excitability in patients with severe Parkinson's disease

Pallidotomy effect on the cortical excitability in patients with severe Parkinson's disease

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