Movement Disorders (revue)

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Parkinson's disease patients with bilateral subthalamic deep brain stimulation gain weight

Identifieur interne : 000B55 ( PascalFrancis/Curation ); précédent : 000B54; suivant : 000B56

Parkinson's disease patients with bilateral subthalamic deep brain stimulation gain weight

Auteurs : Frédéric Macia [France] ; Caroline Perlemoine [France] ; Irène Coman [France] ; Dominique Guehl [France] ; Pierre Burbaud [France] ; Emmanuel Cuny [France] ; Henri Gin [France] ; Vincent Rigalleau [France] ; Francois Tison [France]

Source :

RBID : Pascal:04-0365460

Descripteurs français

English descriptors

Abstract

Weight, body mass index (BMI) and energy expenditure/energy intake (EE/EI) was studied in 19 Parkinson disease (PD) patients after subthalamic deep brain stimulation (STN-DBS) versus 14 nonoperated ones. Operated patients had a significant weight gain (WG, + 9.7 ± 7 kg) and BMI increase (+ 4.7 kg/m2). The fat mass was higher after STN-DBS. Resting EE (REE; offdrug/ON stimulation) was significantly decreased in STN-DBS patients, while their daily energy expenditure (DEI) was not significantly different. A significant correlation was found among WG, BMI increase, and pre-operative levodopa-equivalent daily dose, their reduction after STN-DBS, and the differential REE related to stimulation and the REE in the offdrug/OFF stimulation condition. In conclusion, STN-DBS in PD induces a significant WG associated with a reduction in REE without DEI adjustment.
pA  
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A03   1    @0 Mov. disord.
A05       @2 19
A06       @2 2
A08 01  1  ENG  @1 Parkinson's disease patients with bilateral subthalamic deep brain stimulation gain weight
A11 01  1    @1 MACIA (Frédéric)
A11 02  1    @1 PERLEMOINE (Caroline)
A11 03  1    @1 COMAN (Irène)
A11 04  1    @1 GUEHL (Dominique)
A11 05  1    @1 BURBAUD (Pierre)
A11 06  1    @1 CUNY (Emmanuel)
A11 07  1    @1 GIN (Henri)
A11 08  1    @1 RIGALLEAU (Vincent)
A11 09  1    @1 TISON (Francois)
A14 01      @1 Service de Neurologie, Hôpital Haut Lévèque @2 Pessac @3 FRA @Z 1 aut. @Z 3 aut. @Z 9 aut.
A14 02      @1 Diabétologie et Nutrition, Hôpital Haut Lévèque @2 Pessac @3 FRA @Z 2 aut. @Z 7 aut. @Z 8 aut.
A14 03      @1 Explorations Fonctionnelles du Système Nerveux, Hôpital Haut Lévèque @2 Pessac @3 FRA @Z 4 aut. @Z 5 aut.
A14 04      @1 Service de Neurochirurgie B, Hôpital Pellegrin, CHU de Bordeaux @2 Bordeaux @3 FRA @Z 6 aut.
A20       @1 206-212
A21       @1 2004
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000119281330120
A44       @0 0000 @1 © 2004 INIST-CNRS. All rights reserved.
A45       @0 34 ref.
A47 01  1    @0 04-0365460
A60       @1 P @3 CC
A61       @0 A
A64 01  1    @0 Movement disorders
A66 01      @0 USA
C01 01    ENG  @0 Weight, body mass index (BMI) and energy expenditure/energy intake (EE/EI) was studied in 19 Parkinson disease (PD) patients after subthalamic deep brain stimulation (STN-DBS) versus 14 nonoperated ones. Operated patients had a significant weight gain (WG, + 9.7 ± 7 kg) and BMI increase (+ 4.7 kg/m2). The fat mass was higher after STN-DBS. Resting EE (REE; offdrug/ON stimulation) was significantly decreased in STN-DBS patients, while their daily energy expenditure (DEI) was not significantly different. A significant correlation was found among WG, BMI increase, and pre-operative levodopa-equivalent daily dose, their reduction after STN-DBS, and the differential REE related to stimulation and the REE in the offdrug/OFF stimulation condition. In conclusion, STN-DBS in PD induces a significant WG associated with a reduction in REE without DEI adjustment.
C02 01  X    @0 002B17
C03 01  X  FRE  @0 Parkinson maladie @5 01
C03 01  X  ENG  @0 Parkinson disease @5 01
C03 01  X  SPA  @0 Parkinson enfermedad @5 01
C03 02  X  FRE  @0 Homme @5 02
C03 02  X  ENG  @0 Human @5 02
C03 02  X  SPA  @0 Hombre @5 02
C03 03  X  FRE  @0 Prise poids @5 03
C03 03  X  ENG  @0 Weight gain @5 03
C03 03  X  SPA  @0 Ganancia peso @5 03
C03 04  X  FRE  @0 Système nerveux pathologie @5 04
C03 04  X  ENG  @0 Nervous system diseases @5 04
C03 04  X  SPA  @0 Sistema nervioso patología @5 04
C07 01  X  FRE  @0 Encéphale pathologie @5 37
C07 01  X  ENG  @0 Cerebral disorder @5 37
C07 01  X  SPA  @0 Encéfalo patología @5 37
C07 02  X  FRE  @0 Extrapyramidal syndrome @5 38
C07 02  X  ENG  @0 Extrapyramidal syndrome @5 38
C07 02  X  SPA  @0 Extrapiramidal síndrome @5 38
C07 03  X  FRE  @0 Maladie dégénérative @5 39
C07 03  X  ENG  @0 Degenerative disease @5 39
C07 03  X  SPA  @0 Enfermedad degenerativa @5 39
C07 04  X  FRE  @0 Système nerveux central pathologie @5 40
C07 04  X  ENG  @0 Central nervous system disease @5 40
C07 04  X  SPA  @0 Sistema nervosio central patología @5 40
N21       @1 208
N44 01      @1 OTO
N82       @1 OTO

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Pascal:04-0365460

Le document en format XML

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<div type="abstract" xml:lang="en">Weight, body mass index (BMI) and energy expenditure/energy intake (EE/EI) was studied in 19 Parkinson disease (PD) patients after subthalamic deep brain stimulation (STN-DBS) versus 14 nonoperated ones. Operated patients had a significant weight gain (WG, + 9.7 ± 7 kg) and BMI increase (+ 4.7 kg/m
<sup>2</sup>
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<sup>2</sup>
). The fat mass was higher after STN-DBS. Resting EE (REE; offdrug/ON stimulation) was significantly decreased in STN-DBS patients, while their daily energy expenditure (DEI) was not significantly different. A significant correlation was found among WG, BMI increase, and pre-operative levodopa-equivalent daily dose, their reduction after STN-DBS, and the differential REE related to stimulation and the REE in the offdrug/OFF stimulation condition. In conclusion, STN-DBS in PD induces a significant WG associated with a reduction in REE without DEI adjustment.</s0>
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<s5>01</s5>
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<fC03 i1="02" i2="X" l="FRE">
<s0>Homme</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Human</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Hombre</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Prise poids</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Weight gain</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Ganancia peso</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Système nerveux pathologie</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>04</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21>
<s1>208</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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