MovDisordV3, PascalFrancis, Curation, bibRecord, 000642

Presynaptic parkinsonism in multiple system atrophy mimicking Parkinson's disease: A clinicopathological case study

Identifieur interne : 000642 ( PascalFrancis/Curation ); précédent : 000641; suivant : 000643

Presynaptic parkinsonism in multiple system atrophy mimicking Parkinson's disease: A clinicopathological case study

Auteurs : José Berciano [Espagne] ; Francesc Valldeoriola [Espagne] ; Isidre Ferrer [Espagne] ; Jordi Rumia [Espagne] ; Julio Pascual [Espagne] ; Concepcion Marin [Espagne] ; Maria J. Rey [Espagne] ; Eduardo Tolosa [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0456878

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Parkinson maladie, Parkinsonisme, Présynaptique, Etude cas, Diagnostic différentiel, Anatomopathologie, Personne âgée, Mâle.
Wicri :
- topic : Personne âgée.

English descriptors

KwdEn :
- Case study, Differential diagnostic, Elderly, Male, Multiple system atrophy, Parkinson disease, Parkinsonism, Pathology, Presynaptic.

Abstract

We describe the clinicopathological findings in a patient aged 63 years at death who, at age 55 years, developed levodopa-responsive parkinsonism with no atypical features. A diagnosis of idiopathic Parkinson's disease (PD) was made. During the clinical course, fluctuations and dyskinesias appeared. Eight years after onset, he was successfully treated with subthalamic nucleus stimulation but died 3 weeks postoperatively from pulmonary embolus. Brain autopsy showed marked neuronal loss and gliosis in the substantia nigra and locus coeruleus, and, to a much lesser extent, in the basis pontis, inferior olivary nuclei, and cerebellar cortex. Striatum was normal. There were numerous oligodendroglial and neuronal cytoplasmic inclusions and neuropil threads, the highest density being localized in the pons and cerebellar white matter. No Lewy bodies were observed. We conclude that nigral, presynaptic parkinsonism may occur in multiple system atrophy, which even in the long run can be indistinguishable from PD. Putaminal preservation accounts for good response to both levodopa therapy and subthalamic nucleus stimulation.

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A08	`01`	`1`	`ENG`	`@1 Presynaptic parkinsonism in multiple system atrophy mimicking Parkinson's disease: A clinicopathological case study`
A11	`01`	`1`		`@1 BERCIANO (José)`
A11	`02`	`1`		`@1 VALLDEORIOLA (Francesc)`
A11	`03`	`1`		`@1 FERRER (Isidre)`
A11	`04`	`1`		`@1 RUMIA (Jordi)`
A11	`05`	`1`		`@1 PASCUAL (Julio)`
A11	`06`	`1`		`@1 MARIN (Concepcion)`
A11	`07`	`1`		`@1 REY (Maria J.)`
A11	`08`	`1`		`@1 TOLOSA (Eduardo)`
A14	`01`			`@1 Service of Neurology, University Hospital Marqués de Valdecilla, University of Cantabria @2 Santander @3 ESP @Z 1 aut. @Z 5 aut.`
A14	`02`			`@1 Service of Neurology, Hospital Clinic (IDIBAPS) @2 Barcelona @3 ESP @Z 2 aut. @Z 4 aut. @Z 6 aut. @Z 8 aut.`
A14	`03`			`@1 Banc de Teixits Neurològies, Hospital Clinic (IDIBAPS) @2 Barcelona @3 ESP @Z 3 aut. @Z 7 aut. @Z 8 aut.`
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A44				`@0 0000 @1 © 2002 INIST-CNRS. All rights reserved.`
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A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 We describe the clinicopathological findings in a patient aged 63 years at death who, at age 55 years, developed levodopa-responsive parkinsonism with no atypical features. A diagnosis of idiopathic Parkinson's disease (PD) was made. During the clinical course, fluctuations and dyskinesias appeared. Eight years after onset, he was successfully treated with subthalamic nucleus stimulation but died 3 weeks postoperatively from pulmonary embolus. Brain autopsy showed marked neuronal loss and gliosis in the substantia nigra and locus coeruleus, and, to a much lesser extent, in the basis pontis, inferior olivary nuclei, and cerebellar cortex. Striatum was normal. There were numerous oligodendroglial and neuronal cytoplasmic inclusions and neuropil threads, the highest density being localized in the pons and cerebellar white matter. No Lewy bodies were observed. We conclude that nigral, presynaptic parkinsonism may occur in multiple system atrophy, which even in the long run can be indistinguishable from PD. Putaminal preservation accounts for good response to both levodopa therapy and subthalamic nucleus stimulation.
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C03	`01`	`X`	`FRE`	`@0 Atrophie multisystématisée @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Multiple system atrophy @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Atrofia multisistematizada @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Parkinson maladie @5 04`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @5 04`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @5 04`
C03	`03`	`X`	`FRE`	`@0 Parkinsonisme @2 NM @5 07`
C03	`03`	`X`	`ENG`	`@0 Parkinsonism @2 NM @5 07`
C03	`03`	`X`	`SPA`	`@0 Parkinson síndrome @2 NM @5 07`
C03	`04`	`X`	`FRE`	`@0 Présynaptique @5 08`
C03	`04`	`X`	`ENG`	`@0 Presynaptic @5 08`
C03	`04`	`X`	`SPA`	`@0 Presináptico @5 08`
C03	`05`	`X`	`FRE`	`@0 Etude cas @5 17`
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C03	`07`	`X`	`SPA`	`@0 Anatomía patológica @5 19`
C03	`08`	`X`	`FRE`	`@0 Personne âgée @5 20`
C03	`08`	`X`	`ENG`	`@0 Elderly @5 20`
C03	`08`	`X`	`SPA`	`@0 Anciano @5 20`
C03	`09`	`X`	`FRE`	`@0 Mâle @5 21`
C03	`09`	`X`	`ENG`	`@0 Male @5 21`
C03	`09`	`X`	`SPA`	`@0 Macho @5 21`
C07	`01`	`X`	`FRE`	`@0 Homme`
C07	`01`	`X`	`ENG`	`@0 Human`
C07	`01`	`X`	`SPA`	`@0 Hombre`
C07	`02`	`X`	`FRE`	`@0 Système nerveux pathologie @5 45`
C07	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 45`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 45`
C07	`03`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 46`
C07	`03`	`X`	`ENG`	`@0 Central nervous system disease @5 46`
C07	`03`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 46`
C07	`04`	`X`	`FRE`	`@0 Encéphale pathologie @5 47`
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C07	`04`	`X`	`SPA`	`@0 Encéfalo patología @5 47`
C07	`05`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 48`
C07	`05`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 48`
C07	`05`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 48`
C07	`06`	`X`	`FRE`	`@0 Maladie dégénérative @5 49`
C07	`06`	`X`	`ENG`	`@0 Degenerative disease @5 49`
C07	`06`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 49`
C07	`07`	`X`	`FRE`	`@0 Trouble neurologique @5 53`
C07	`07`	`X`	`ENG`	`@0 Neurological disorder @5 53`
C07	`07`	`X`	`SPA`	`@0 Trastorno neurológico @5 53`
N21				`@1 266`
N82				`@1 PSI`

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Le document en format XML

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<front><div type="abstract" xml:lang="en">We describe the clinicopathological findings in a patient aged 63 years at death who, at age 55 years, developed levodopa-responsive parkinsonism with no atypical features. A diagnosis of idiopathic Parkinson's disease (PD) was made. During the clinical course, fluctuations and dyskinesias appeared. Eight years after onset, he was successfully treated with subthalamic nucleus stimulation but died 3 weeks postoperatively from pulmonary embolus. Brain autopsy showed marked neuronal loss and gliosis in the substantia nigra and locus coeruleus, and, to a much lesser extent, in the basis pontis, inferior olivary nuclei, and cerebellar cortex. Striatum was normal. There were numerous oligodendroglial and neuronal cytoplasmic inclusions and neuropil threads, the highest density being localized in the pons and cerebellar white matter. No Lewy bodies were observed. We conclude that nigral, presynaptic parkinsonism may occur in multiple system atrophy, which even in the long run can be indistinguishable from PD. Putaminal preservation accounts for good response to both levodopa therapy and subthalamic nucleus stimulation.</div>
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<fA20><s1>812-816</s1>
</fA20>
<fA21><s1>2002</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000108922560330</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2002 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>22 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>02-0456878</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>We describe the clinicopathological findings in a patient aged 63 years at death who, at age 55 years, developed levodopa-responsive parkinsonism with no atypical features. A diagnosis of idiopathic Parkinson's disease (PD) was made. During the clinical course, fluctuations and dyskinesias appeared. Eight years after onset, he was successfully treated with subthalamic nucleus stimulation but died 3 weeks postoperatively from pulmonary embolus. Brain autopsy showed marked neuronal loss and gliosis in the substantia nigra and locus coeruleus, and, to a much lesser extent, in the basis pontis, inferior olivary nuclei, and cerebellar cortex. Striatum was normal. There were numerous oligodendroglial and neuronal cytoplasmic inclusions and neuropil threads, the highest density being localized in the pons and cerebellar white matter. No Lewy bodies were observed. We conclude that nigral, presynaptic parkinsonism may occur in multiple system atrophy, which even in the long run can be indistinguishable from PD. Putaminal preservation accounts for good response to both levodopa therapy and subthalamic nucleus stimulation.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Atrophie multisystématisée</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Multiple system atrophy</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Atrofia multisistematizada</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Parkinsonisme</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Parkinsonism</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Parkinson síndrome</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Présynaptique</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Presynaptic</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Presináptico</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Etude cas</s0>
<s5>17</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Case study</s0>
<s5>17</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Estudio caso</s0>
<s5>17</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Diagnostic différentiel</s0>
<s5>18</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Differential diagnostic</s0>
<s5>18</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Diagnóstico diferencial</s0>
<s5>18</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Anatomopathologie</s0>
<s5>19</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Pathology</s0>
<s5>19</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Anatomía patológica</s0>
<s5>19</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Personne âgée</s0>
<s5>20</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Elderly</s0>
<s5>20</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Anciano</s0>
<s5>20</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Mâle</s0>
<s5>21</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Male</s0>
<s5>21</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Macho</s0>
<s5>21</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>45</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>45</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>45</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>46</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>46</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>46</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>47</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>47</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>47</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>48</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>48</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>48</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>49</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>49</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>49</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>53</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>53</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>53</s5>
</fC07>
<fN21><s1>266</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Presynaptic parkinsonism in multiple system atrophy mimicking Parkinson's disease: A clinicopathological case study

Presynaptic parkinsonism in multiple system atrophy mimicking Parkinson's disease: A clinicopathological case study

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