Movement Disorders (revue)

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Family history information on essential tremor : Potential biases related to the source of the cases

Identifieur interne : 000310 ( PascalFrancis/Curation ); précédent : 000309; suivant : 000311

Family history information on essential tremor : Potential biases related to the source of the cases

Auteurs : Elan D. Louis [États-Unis] ; Livia F. Barnes [États-Unis] ; Blair Ford [États-Unis] ; Ruth Ottman [États-Unis]

Source :

RBID : Pascal:01-0335233

Descripteurs français

English descriptors

Abstract

The proportion of essential tremor (ET) cases that can be attributed to genetic factors is unknown; estimates range from 17-100%. One possible reason for this variability is that clinic and community cases may differ with regard to family history of ET. This is because clinic patients are self-selected and represent as few as 0.5% of all ET cases. Our goal was to determine whether ET cases ascertained from a clinic differed from those ascertained from a community in terms of the family history information that they provided. Subjects (57 clinic, 64 community) underwent a family history interview. Clinic cases were 4.73 times more likely to report an affected relative than were community cases. We conclude that there was a substantial difference between our clinic and community ET cases in terms of the information they provided regarding their family history. Selection and reporting biases could have accounted for this difference. Because of these biases, the source of the cases must be taken into consideration when investigators are trying to synthesize the widely variable results of studies that have estimated the genetic contribution to ET.
pA  
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A08 01  1  ENG  @1 Family history information on essential tremor : Potential biases related to the source of the cases
A11 01  1    @1 LOUIS (Elan D.)
A11 02  1    @1 BARNES (Livia F.)
A11 03  1    @1 FORD (Blair)
A11 04  1    @1 OTTMAN (Ruth)
A14 01      @1 Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University @2 New York, New York @3 USA @Z 1 aut. @Z 2 aut. @Z 4 aut.
A14 02      @1 Department of Neurology, College of Physicians and Surgeons, Columbia University @2 New York, New York @3 USA @Z 1 aut. @Z 3 aut.
A14 03      @1 School of Public Health (Epidemiology Division), Columbia University @2 New York, New York @3 USA @Z 4 aut.
A14 04      @1 Epidemiology of Brain Disorders Research Department, New York State Psychiatric Institute @2 New York, New York @3 USA @Z 4 aut.
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A21       @1 2001
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C01 01    ENG  @0 The proportion of essential tremor (ET) cases that can be attributed to genetic factors is unknown; estimates range from 17-100%. One possible reason for this variability is that clinic and community cases may differ with regard to family history of ET. This is because clinic patients are self-selected and represent as few as 0.5% of all ET cases. Our goal was to determine whether ET cases ascertained from a clinic differed from those ascertained from a community in terms of the family history information that they provided. Subjects (57 clinic, 64 community) underwent a family history interview. Clinic cases were 4.73 times more likely to report an affected relative than were community cases. We conclude that there was a substantial difference between our clinic and community ET cases in terms of the information they provided regarding their family history. Selection and reporting biases could have accounted for this difference. Because of these biases, the source of the cases must be taken into consideration when investigators are trying to synthesize the widely variable results of studies that have estimated the genetic contribution to ET.
C02 01  X    @0 002B17A01
C03 01  X  FRE  @0 Tremblement @5 01
C03 01  X  ENG  @0 Tremor @5 01
C03 01  X  SPA  @0 Temblor @5 01
C03 02  X  FRE  @0 Essentiel @5 02
C03 02  X  ENG  @0 Essential @5 02
C03 02  X  SPA  @0 Esencial @5 02
C03 03  X  FRE  @0 Histoire familiale @5 04
C03 03  X  ENG  @0 Family story @5 04
C03 03  X  SPA  @0 Historia familiar @5 04
C03 04  X  FRE  @0 Biais méthodologique @5 07
C03 04  X  ENG  @0 Methodological bias @5 07
C03 04  X  SPA  @0 Ruta metodológica @5 07
C03 05  X  FRE  @0 Sélection groupe @5 10
C03 05  X  ENG  @0 Group selection @5 10
C03 05  X  SPA  @0 Selección grupal @5 10
C03 06  X  FRE  @0 Epidémiologie @5 17
C03 06  X  ENG  @0 Epidemiology @5 17
C03 06  X  SPA  @0 Epidemiología @5 17
C03 07  X  FRE  @0 Méthodologie @5 18
C03 07  X  ENG  @0 Methodology @5 18
C03 07  X  SPA  @0 Metodología @5 18
C07 01  X  FRE  @0 Système nerveux pathologie @5 37
C07 01  X  ENG  @0 Nervous system diseases @5 37
C07 01  X  SPA  @0 Sistema nervioso patología @5 37
C07 02  X  FRE  @0 Trouble neurologique @5 38
C07 02  X  ENG  @0 Neurological disorder @5 38
C07 02  X  SPA  @0 Trastorno neurológico @5 38
C07 03  X  FRE  @0 Mouvement involontaire @5 39
C07 03  X  ENG  @0 Involuntary movement @5 39
C07 03  X  SPA  @0 Movimiento involuntario @5 39
N21       @1 232

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Pascal:01-0335233

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<div type="abstract" xml:lang="en">The proportion of essential tremor (ET) cases that can be attributed to genetic factors is unknown; estimates range from 17-100%. One possible reason for this variability is that clinic and community cases may differ with regard to family history of ET. This is because clinic patients are self-selected and represent as few as 0.5% of all ET cases. Our goal was to determine whether ET cases ascertained from a clinic differed from those ascertained from a community in terms of the family history information that they provided. Subjects (57 clinic, 64 community) underwent a family history interview. Clinic cases were 4.73 times more likely to report an affected relative than were community cases. We conclude that there was a substantial difference between our clinic and community ET cases in terms of the information they provided regarding their family history. Selection and reporting biases could have accounted for this difference. Because of these biases, the source of the cases must be taken into consideration when investigators are trying to synthesize the widely variable results of studies that have estimated the genetic contribution to ET.</div>
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