Movement Disorders (revue)

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The pathogenesis of multiple system atrophy : Past, present, and future

Identifieur interne : 002B33 ( PascalFrancis/Corpus ); précédent : 002B32; suivant : 002B34

The pathogenesis of multiple system atrophy : Past, present, and future

Auteurs : Evelyn Jaros ; David J. Burn

Source :

RBID : Pascal:00-0481440

Descripteurs français

English descriptors

Abstract

Multiple system atrophy is a sporadic, adult-onset neurodegenerative disease of unknown etiology. The condition may be unique among neurodegenerative diseases by the prominent, if not primary, role played by the oligodendroglial cell in the pathogenetic process. Recent developments in our understanding of multiple system atrophy have included the detection of glial cytoplasmic inclusions and α-synuclein accumulation in these inclusions. The latter finding links multiple system atrophy as an "a-synucleinopathy" to Parkinson's disease and dementia with Lewy bodies. This article reviews recent important findings of potential relevance to the pathogenesis of multiple system atrophy. We also speculate on areas in which further advances may be made to progress our understanding of this devastating condition.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
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A03   1    @0 Mov. disord.
A05       @2 15
A06       @2 5
A08 01  1  ENG  @1 The pathogenesis of multiple system atrophy : Past, present, and future
A11 01  1    @1 JAROS (Evelyn)
A11 02  1    @1 BURN (David J.)
A14 01      @1 Department of Neuropathology, Newcastle General Hospital @2 Newcastle upon Tyne @3 GBR @Z 1 aut.
A14 02      @1 Department of Neurology, Royal Victoria Infirmary @2 Newcastle upon Tyne @3 GBR @Z 2 aut.
A20       @1 784-788
A21       @1 2000
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000091356830030
A44       @0 0000 @1 © 2000 INIST-CNRS. All rights reserved.
A45       @0 61 ref.
A47 01  1    @0 00-0481440
A60       @1 P
A61       @0 A
A64 01  1    @0 Movement disorders
A66 01      @0 USA
C01 01    ENG  @0 Multiple system atrophy is a sporadic, adult-onset neurodegenerative disease of unknown etiology. The condition may be unique among neurodegenerative diseases by the prominent, if not primary, role played by the oligodendroglial cell in the pathogenetic process. Recent developments in our understanding of multiple system atrophy have included the detection of glial cytoplasmic inclusions and α-synuclein accumulation in these inclusions. The latter finding links multiple system atrophy as an "a-synucleinopathy" to Parkinson's disease and dementia with Lewy bodies. This article reviews recent important findings of potential relevance to the pathogenesis of multiple system atrophy. We also speculate on areas in which further advances may be made to progress our understanding of this devastating condition.
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C03 01  X  ENG  @0 Multiple system atrophy @2 NM @5 01
C03 01  X  SPA  @0 Atrofia multisistematizada @2 NM @5 01
C03 02  X  FRE  @0 Inclusion cellulaire @5 04
C03 02  X  ENG  @0 Cell inclusion @5 04
C03 02  X  SPA  @0 Inclusión celular @5 04
C03 03  X  FRE  @0 Facteur trophique @5 07
C03 03  X  ENG  @0 Trophic factor @5 07
C03 03  X  SPA  @0 Factor trófico @5 07
C03 04  X  FRE  @0 Pathogénie @5 17
C03 04  X  ENG  @0 Pathogenesis @5 17
C03 04  X  SPA  @0 Patogenia @5 17
C03 05  X  FRE  @0 Evolution @5 18
C03 05  X  ENG  @0 Evolution @5 18
C03 05  X  SPA  @0 Evolución @5 18
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C03 06  X  ENG  @0 Human @5 20
C03 06  X  SPA  @0 Hombre @5 20
C03 07  X  FRE  @0 α-Synucléine @4 INC @5 86 @6 «α»-Synucléine
C07 01  X  FRE  @0 Système nerveux pathologie @5 37
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C07 01  X  SPA  @0 Sistema nervioso patología @5 37
C07 02  X  FRE  @0 Système nerveux central pathologie @5 38
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C07 02  X  SPA  @0 Sistema nervosio central patología @5 38
C07 03  X  FRE  @0 Encéphale pathologie @5 39
C07 03  X  ENG  @0 Cerebral disorder @5 39
C07 03  X  SPA  @0 Encéfalo patología @5 39
C07 04  X  FRE  @0 Maladie dégénérative @5 40
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N21       @1 318

Format Inist (serveur)

NO : PASCAL 00-0481440 INIST
ET : The pathogenesis of multiple system atrophy : Past, present, and future
AU : JAROS (Evelyn); BURN (David J.)
AF : Department of Neuropathology, Newcastle General Hospital/Newcastle upon Tyne/Royaume-Uni (1 aut.); Department of Neurology, Royal Victoria Infirmary/Newcastle upon Tyne/Royaume-Uni (2 aut.)
DT : Publication en série; Niveau analytique
SO : Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2000; Vol. 15; No. 5; Pp. 784-788; Bibl. 61 ref.
LA : Anglais
EA : Multiple system atrophy is a sporadic, adult-onset neurodegenerative disease of unknown etiology. The condition may be unique among neurodegenerative diseases by the prominent, if not primary, role played by the oligodendroglial cell in the pathogenetic process. Recent developments in our understanding of multiple system atrophy have included the detection of glial cytoplasmic inclusions and α-synuclein accumulation in these inclusions. The latter finding links multiple system atrophy as an "a-synucleinopathy" to Parkinson's disease and dementia with Lewy bodies. This article reviews recent important findings of potential relevance to the pathogenesis of multiple system atrophy. We also speculate on areas in which further advances may be made to progress our understanding of this devastating condition.
CC : 002B17G
FD : Atrophie multisystématisée; Inclusion cellulaire; Facteur trophique; Pathogénie; Evolution; Homme; α-Synucléine
FG : Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Maladie dégénérative
ED : Multiple system atrophy; Cell inclusion; Trophic factor; Pathogenesis; Evolution; Human
EG : Nervous system diseases; Central nervous system disease; Cerebral disorder; Degenerative disease
SD : Atrofia multisistematizada; Inclusión celular; Factor trófico; Patogenia; Evolución; Hombre
LO : INIST-20953.354000091356830030
ID : 00-0481440

Links to Exploration step

Pascal:00-0481440

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