The pathogenesis of multiple system atrophy : Past, present, and future
Identifieur interne : 002B33 ( PascalFrancis/Corpus ); précédent : 002B32; suivant : 002B34The pathogenesis of multiple system atrophy : Past, present, and future
Auteurs : Evelyn Jaros ; David J. BurnSource :
- Movement disorders [ 0885-3185 ] ; 2000.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Multiple system atrophy is a sporadic, adult-onset neurodegenerative disease of unknown etiology. The condition may be unique among neurodegenerative diseases by the prominent, if not primary, role played by the oligodendroglial cell in the pathogenetic process. Recent developments in our understanding of multiple system atrophy have included the detection of glial cytoplasmic inclusions and α-synuclein accumulation in these inclusions. The latter finding links multiple system atrophy as an "a-synucleinopathy" to Parkinson's disease and dementia with Lewy bodies. This article reviews recent important findings of potential relevance to the pathogenesis of multiple system atrophy. We also speculate on areas in which further advances may be made to progress our understanding of this devastating condition.
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Format Inist (serveur)
NO : | PASCAL 00-0481440 INIST |
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ET : | The pathogenesis of multiple system atrophy : Past, present, and future |
AU : | JAROS (Evelyn); BURN (David J.) |
AF : | Department of Neuropathology, Newcastle General Hospital/Newcastle upon Tyne/Royaume-Uni (1 aut.); Department of Neurology, Royal Victoria Infirmary/Newcastle upon Tyne/Royaume-Uni (2 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2000; Vol. 15; No. 5; Pp. 784-788; Bibl. 61 ref. |
LA : | Anglais |
EA : | Multiple system atrophy is a sporadic, adult-onset neurodegenerative disease of unknown etiology. The condition may be unique among neurodegenerative diseases by the prominent, if not primary, role played by the oligodendroglial cell in the pathogenetic process. Recent developments in our understanding of multiple system atrophy have included the detection of glial cytoplasmic inclusions and α-synuclein accumulation in these inclusions. The latter finding links multiple system atrophy as an "a-synucleinopathy" to Parkinson's disease and dementia with Lewy bodies. This article reviews recent important findings of potential relevance to the pathogenesis of multiple system atrophy. We also speculate on areas in which further advances may be made to progress our understanding of this devastating condition. |
CC : | 002B17G |
FD : | Atrophie multisystématisée; Inclusion cellulaire; Facteur trophique; Pathogénie; Evolution; Homme; α-Synucléine |
FG : | Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Maladie dégénérative |
ED : | Multiple system atrophy; Cell inclusion; Trophic factor; Pathogenesis; Evolution; Human |
EG : | Nervous system diseases; Central nervous system disease; Cerebral disorder; Degenerative disease |
SD : | Atrofia multisistematizada; Inclusión celular; Factor trófico; Patogenia; Evolución; Hombre |
LO : | INIST-20953.354000091356830030 |
ID : | 00-0481440 |
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Pascal:00-0481440Le document en format XML
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<front><div type="abstract" xml:lang="en">Multiple system atrophy is a sporadic, adult-onset neurodegenerative disease of unknown etiology. The condition may be unique among neurodegenerative diseases by the prominent, if not primary, role played by the oligodendroglial cell in the pathogenetic process. Recent developments in our understanding of multiple system atrophy have included the detection of glial cytoplasmic inclusions and α-synuclein accumulation in these inclusions. The latter finding links multiple system atrophy as an "a-synucleinopathy" to Parkinson's disease and dementia with Lewy bodies. This article reviews recent important findings of potential relevance to the pathogenesis of multiple system atrophy. We also speculate on areas in which further advances may be made to progress our understanding of this devastating condition.</div>
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<ET>The pathogenesis of multiple system atrophy : Past, present, and future</ET>
<AU>JAROS (Evelyn); BURN (David J.)</AU>
<AF>Department of Neuropathology, Newcastle General Hospital/Newcastle upon Tyne/Royaume-Uni (1 aut.); Department of Neurology, Royal Victoria Infirmary/Newcastle upon Tyne/Royaume-Uni (2 aut.)</AF>
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<EA>Multiple system atrophy is a sporadic, adult-onset neurodegenerative disease of unknown etiology. The condition may be unique among neurodegenerative diseases by the prominent, if not primary, role played by the oligodendroglial cell in the pathogenetic process. Recent developments in our understanding of multiple system atrophy have included the detection of glial cytoplasmic inclusions and α-synuclein accumulation in these inclusions. The latter finding links multiple system atrophy as an "a-synucleinopathy" to Parkinson's disease and dementia with Lewy bodies. This article reviews recent important findings of potential relevance to the pathogenesis of multiple system atrophy. We also speculate on areas in which further advances may be made to progress our understanding of this devastating condition.</EA>
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