MovDisordV3, PascalFrancis, Corpus, bibRecord, 002B09

Abnormalities of motor cortical excitability are not correlated with clinical features in atypical parkinsonism

Identifieur interne : 002B09 ( PascalFrancis/Corpus ); précédent : 002B08; suivant : 002B10

Abnormalities of motor cortical excitability are not correlated with clinical features in atypical parkinsonism

Auteurs : Roberta Marchese ; Carlo Trompetto ; Alessandro Buccolieri ; Giovanni Abbruzzese

Source :

Movement disorders [ 0885-3185 ] ; 2000.

RBID : Pascal:01-0016460

Descripteurs français

Pascal (Inist)
- Parkinsonisme, Atypique, Stimulus magnétique, Voie transcrânienne, Atrophie multisystématisée, Cortex moteur, Excitabilité, Inhibition, Spécificité, Diagnostic, Technique, Exploration, Adulte.

English descriptors

KwdEn :
- Adult, Atypical, Diagnosis, Excitability, Exploration, Inhibition, Magnetic stimulus, Motor cortex, Multiple system atrophy, Parkinsonism, Specificity, Technique, Transcranial route.

Abstract

OBJECTIVE: To evaluate the specificity of motor cortical excitability changes in parkinsonian syndromes and their relevance to the pathophysiology of cardinal parkinsonian features. METHODS: Paired transcranial magnetic stimulation (TMS) was used to assess cortico-cortical inhibition (CCI) and facilitation (CCF) in the opponens pollicis muscle of patients with atypical, non-L-dopa- (LD) responsive parkinsonism. RESULTS: Compared with age-matched normal control subjects, CCI (interstimulus interval [ISI], 3 ms) was significantly reduced in 10 patients with predominantly parkinsonian multiple system atrophy (MSA-P) and in seven with vascular parkinsonism (VP), but not in four with predominantly cerebellar MSA. No significant change of CCF (ISI, 12 ms) was observed. No correlation was found between the amount of CCI and clinical status as evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS). In 10 patients (5 MSA-P, 5 VP), CCI was significantly increased by LD acute administration without concurrent clinical changes. CONCLUSIONS: Abnormalities of CCI are not peculiar to idiopathic Parkinson's disease and seem unlikely to underlie any specific parkinsonian feature, but rather possibly reflect a nonspecific imbalance of inhibitory and facilitatory motor cortical circuits.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Abnormalities of motor cortical excitability are not correlated with clinical features in atypical parkinsonism`
A11	`01`	`1`		`@1 MARCHESE (Roberta)`
A11	`02`	`1`		`@1 TROMPETTO (Carlo)`
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A11	`04`	`1`		`@1 ABBRUZZESE (Giovanni)`
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C01	`01`		`ENG`	@0 OBJECTIVE: To evaluate the specificity of motor cortical excitability changes in parkinsonian syndromes and their relevance to the pathophysiology of cardinal parkinsonian features. METHODS: Paired transcranial magnetic stimulation (TMS) was used to assess cortico-cortical inhibition (CCI) and facilitation (CCF) in the opponens pollicis muscle of patients with atypical, non-L-dopa- (LD) responsive parkinsonism. RESULTS: Compared with age-matched normal control subjects, CCI (interstimulus interval [ISI], 3 ms) was significantly reduced in 10 patients with predominantly parkinsonian multiple system atrophy (MSA-P) and in seven with vascular parkinsonism (VP), but not in four with predominantly cerebellar MSA. No significant change of CCF (ISI, 12 ms) was observed. No correlation was found between the amount of CCI and clinical status as evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS). In 10 patients (5 MSA-P, 5 VP), CCI was significantly increased by LD acute administration without concurrent clinical changes. CONCLUSIONS: Abnormalities of CCI are not peculiar to idiopathic Parkinson's disease and seem unlikely to underlie any specific parkinsonian feature, but rather possibly reflect a nonspecific imbalance of inhibitory and facilitatory motor cortical circuits.
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Format Inist (serveur)

NO :	PASCAL 01-0016460 INIST
ET :	Abnormalities of motor cortical excitability are not correlated with clinical features in atypical parkinsonism
AU :	MARCHESE (Roberta); TROMPETTO (Carlo); BUCCOLIERI (Alessandro); ABBRUZZESE (Giovanni)
AF :	Department of Neurological Sciences and Vision, University of Genoa/Genoa/Italie (1 aut., 2 aut., 3 aut., 4 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2000; Vol. 15; No. 6; Pp. 1210-1214; Bibl. 25 ref.
LA :	Anglais
EA :	OBJECTIVE: To evaluate the specificity of motor cortical excitability changes in parkinsonian syndromes and their relevance to the pathophysiology of cardinal parkinsonian features. METHODS: Paired transcranial magnetic stimulation (TMS) was used to assess cortico-cortical inhibition (CCI) and facilitation (CCF) in the opponens pollicis muscle of patients with atypical, non-L-dopa- (LD) responsive parkinsonism. RESULTS: Compared with age-matched normal control subjects, CCI (interstimulus interval [ISI], 3 ms) was significantly reduced in 10 patients with predominantly parkinsonian multiple system atrophy (MSA-P) and in seven with vascular parkinsonism (VP), but not in four with predominantly cerebellar MSA. No significant change of CCF (ISI, 12 ms) was observed. No correlation was found between the amount of CCI and clinical status as evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS). In 10 patients (5 MSA-P, 5 VP), CCI was significantly increased by LD acute administration without concurrent clinical changes. CONCLUSIONS: Abnormalities of CCI are not peculiar to idiopathic Parkinson's disease and seem unlikely to underlie any specific parkinsonian feature, but rather possibly reflect a nonspecific imbalance of inhibitory and facilitatory motor cortical circuits.
CC :	002B17A01
FD :	Parkinsonisme; Atypique; Stimulus magnétique; Voie transcrânienne; Atrophie multisystématisée; Cortex moteur; Excitabilité; Inhibition; Spécificité; Diagnostic; Technique; Exploration; Adulte
FG :	Homme; Trouble neurologique; Système nerveux pathologie; Electrodiagnostic; Système nerveux central pathologie; Encéphale pathologie; Maladie dégénérative
ED :	Parkinsonism; Atypical; Magnetic stimulus; Transcranial route; Multiple system atrophy; Motor cortex; Excitability; Inhibition; Specificity; Diagnosis; Technique; Exploration; Adult
EG :	Human; Neurological disorder; Nervous system diseases; Electrodiagnosis; Central nervous system disease; Cerebral disorder; Degenerative disease
SD :	Parkinson síndrome; Atípico; Estímulo magnético; Vía transcraneana; Atrofia multisistematizada; Corteza motora; Excitabilidad; Inhibición; Especificidad; Diagnóstico; Técnica; Exploración; Adulto
LO :	INIST-20953.354000092814950220
ID :	01-0016460

Links to Exploration step

Pascal:01-0016460

Le document en format XML

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<front><div type="abstract" xml:lang="en">OBJECTIVE: To evaluate the specificity of motor cortical excitability changes in parkinsonian syndromes and their relevance to the pathophysiology of cardinal parkinsonian features. METHODS: Paired transcranial magnetic stimulation (TMS) was used to assess cortico-cortical inhibition (CCI) and facilitation (CCF) in the opponens pollicis muscle of patients with atypical, non-L-dopa- (LD) responsive parkinsonism. RESULTS: Compared with age-matched normal control subjects, CCI (interstimulus interval [ISI], 3 ms) was significantly reduced in 10 patients with predominantly parkinsonian multiple system atrophy (MSA-P) and in seven with vascular parkinsonism (VP), but not in four with predominantly cerebellar MSA. No significant change of CCF (ISI, 12 ms) was observed. No correlation was found between the amount of CCI and clinical status as evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS). In 10 patients (5 MSA-P, 5 VP), CCI was significantly increased by LD acute administration without concurrent clinical changes. CONCLUSIONS: Abnormalities of CCI are not peculiar to idiopathic Parkinson's disease and seem unlikely to underlie any specific parkinsonian feature, but rather possibly reflect a nonspecific imbalance of inhibitory and facilitatory motor cortical circuits.</div>
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<fC01 i1="01" l="ENG"><s0>OBJECTIVE: To evaluate the specificity of motor cortical excitability changes in parkinsonian syndromes and their relevance to the pathophysiology of cardinal parkinsonian features. METHODS: Paired transcranial magnetic stimulation (TMS) was used to assess cortico-cortical inhibition (CCI) and facilitation (CCF) in the opponens pollicis muscle of patients with atypical, non-L-dopa- (LD) responsive parkinsonism. RESULTS: Compared with age-matched normal control subjects, CCI (interstimulus interval [ISI], 3 ms) was significantly reduced in 10 patients with predominantly parkinsonian multiple system atrophy (MSA-P) and in seven with vascular parkinsonism (VP), but not in four with predominantly cerebellar MSA. No significant change of CCF (ISI, 12 ms) was observed. No correlation was found between the amount of CCI and clinical status as evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS). In 10 patients (5 MSA-P, 5 VP), CCI was significantly increased by LD acute administration without concurrent clinical changes. CONCLUSIONS: Abnormalities of CCI are not peculiar to idiopathic Parkinson's disease and seem unlikely to underlie any specific parkinsonian feature, but rather possibly reflect a nonspecific imbalance of inhibitory and facilitatory motor cortical circuits.</s0>
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<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Transcranial route</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Vía transcraneana</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Atrophie multisystématisée</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Multiple system atrophy</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Atrofia multisistematizada</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Cortex moteur</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Motor cortex</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Corteza motora</s0>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Excitabilité</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Excitability</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Excitabilidad</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Inhibition</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Inhibition</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Inhibición</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Spécificité</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Specificity</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Especificidad</s0>
<s5>13</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Diagnostic</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Diagnosis</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Diagnóstico</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Technique</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Technique</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Técnica</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Exploration</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Exploration</s0>
<s5>19</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Exploración</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Adulte</s0>
<s5>20</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Adult</s0>
<s5>20</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Adulto</s0>
<s5>20</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Electrodiagnostic</s0>
<s5>45</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Electrodiagnosis</s0>
<s5>45</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Electrodiagnóstico</s0>
<s5>45</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>53</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>53</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>53</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>54</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>54</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>54</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>55</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>55</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>55</s5>
</fC07>
<fN21><s1>008</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 01-0016460 INIST</NO>
<ET>Abnormalities of motor cortical excitability are not correlated with clinical features in atypical parkinsonism</ET>
<AU>MARCHESE (Roberta); TROMPETTO (Carlo); BUCCOLIERI (Alessandro); ABBRUZZESE (Giovanni)</AU>
<AF>Department of Neurological Sciences and Vision, University of Genoa/Genoa/Italie (1 aut., 2 aut., 3 aut., 4 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2000; Vol. 15; No. 6; Pp. 1210-1214; Bibl. 25 ref.</SO>
<LA>Anglais</LA>
<EA>OBJECTIVE: To evaluate the specificity of motor cortical excitability changes in parkinsonian syndromes and their relevance to the pathophysiology of cardinal parkinsonian features. METHODS: Paired transcranial magnetic stimulation (TMS) was used to assess cortico-cortical inhibition (CCI) and facilitation (CCF) in the opponens pollicis muscle of patients with atypical, non-L-dopa- (LD) responsive parkinsonism. RESULTS: Compared with age-matched normal control subjects, CCI (interstimulus interval [ISI], 3 ms) was significantly reduced in 10 patients with predominantly parkinsonian multiple system atrophy (MSA-P) and in seven with vascular parkinsonism (VP), but not in four with predominantly cerebellar MSA. No significant change of CCF (ISI, 12 ms) was observed. No correlation was found between the amount of CCI and clinical status as evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS). In 10 patients (5 MSA-P, 5 VP), CCI was significantly increased by LD acute administration without concurrent clinical changes. CONCLUSIONS: Abnormalities of CCI are not peculiar to idiopathic Parkinson's disease and seem unlikely to underlie any specific parkinsonian feature, but rather possibly reflect a nonspecific imbalance of inhibitory and facilitatory motor cortical circuits.</EA>
<CC>002B17A01</CC>
<FD>Parkinsonisme; Atypique; Stimulus magnétique; Voie transcrânienne; Atrophie multisystématisée; Cortex moteur; Excitabilité; Inhibition; Spécificité; Diagnostic; Technique; Exploration; Adulte</FD>
<FG>Homme; Trouble neurologique; Système nerveux pathologie; Electrodiagnostic; Système nerveux central pathologie; Encéphale pathologie; Maladie dégénérative</FG>
<ED>Parkinsonism; Atypical; Magnetic stimulus; Transcranial route; Multiple system atrophy; Motor cortex; Excitability; Inhibition; Specificity; Diagnosis; Technique; Exploration; Adult</ED>
<EG>Human; Neurological disorder; Nervous system diseases; Electrodiagnosis; Central nervous system disease; Cerebral disorder; Degenerative disease</EG>
<SD>Parkinson síndrome; Atípico; Estímulo magnético; Vía transcraneana; Atrofia multisistematizada; Corteza motora; Excitabilidad; Inhibición; Especificidad; Diagnóstico; Técnica; Exploración; Adulto</SD>
<LO>INIST-20953.354000092814950220</LO>
<ID>01-0016460</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Abnormalities of motor cortical excitability are not correlated with clinical features in atypical parkinsonism

Abnormalities of motor cortical excitability are not correlated with clinical features in atypical parkinsonism

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