MovDisordV3, PascalFrancis, Corpus, bibRecord, 002A86

Linkage exclusion in French families with probable Parkinson's disease

Identifieur interne : 002A86 ( PascalFrancis/Corpus ); précédent : 002A85; suivant : 002A87

Linkage exclusion in French families with probable Parkinson's disease

Auteurs : Matt Farrer ; Alain Destee ; Estelle Becquet ; Fabienne Wavrant-De Vrieze ; Vincent Mouroux ; Florence Richard ; Luc Defebvre ; Sarah Lincoln ; John Hardy ; Philippe Amouyel ; Marie-Christine Chartier-Harlin

Source :

Movement disorders [ 0885-3185 ] ; 2000.

RBID : Pascal:01-0017636

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Caractère autosomique, Caractère dominant, Liaison génétique, Français, Mutation, Protéine tau, Haplotype, Etude familiale, Déterminisme génétique, Homme, α-Synucléine, Ubiquitin carboxy-terminal hydrolase.

English descriptors

KwdEn :
- Autosomal character, Dominant character, Family study, French, Genetic determinism, Haplotype, Human, Linkage, Mutation, Parkinson disease, Tau protein.

Abstract

We analyzed the segregation of genetic markers spanning chromosomal regions 2p13, 4p14-15, 4q21-23, 6q25-27, and 17q21 in nine French families affected by autosomal-dominant probable Parkinson's disease. These regions have been linked or associated with familial Parkinson's disease. Multipoint linkage and haplotype analyses excluded 2p13 and 4p14-15 loci in five of nine families. For three families, which were equivocal for two-point linkage at D4S405, the ubiquitin carboxy-terminal hydrolase gene (UCH-LI) was sequenced. In one family, a novel UCH-LI M124L mutation that did not segregate with early-onset disease was identified. This suggests that rare variants in this gene may not be pathogenic. In seven of nine families, it could be inferred that affected individuals did not share 4q21-23 (a-synuclein) haplotypes. All families were unequivocally excluded by haplotype analysis from the parkin locus on 6q25-27. Finally, the 17q21 region was excluded in four of nine families, and no mutation in the tau gene was identified in the five remaining families. Findings from this study confirm genetic heterogeneity within familial parkinsonism.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`03`	`1`		`@1 BECQUET (Estelle)`
A11	`04`	`1`		`@1 VRIEZE (Fabienne Wavrant-De)`
A11	`05`	`1`		`@1 MOUROUX (Vincent)`
A11	`06`	`1`		`@1 RICHARD (Florence)`
A11	`07`	`1`		`@1 DEFEBVRE (Luc)`
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C01	`01`		`ENG`	@0 We analyzed the segregation of genetic markers spanning chromosomal regions 2p13, 4p14-15, 4q21-23, 6q25-27, and 17q21 in nine French families affected by autosomal-dominant probable Parkinson's disease. These regions have been linked or associated with familial Parkinson's disease. Multipoint linkage and haplotype analyses excluded 2p13 and 4p14-15 loci in five of nine families. For three families, which were equivocal for two-point linkage at D4S405, the ubiquitin carboxy-terminal hydrolase gene (UCH-LI) was sequenced. In one family, a novel UCH-LI M124L mutation that did not segregate with early-onset disease was identified. This suggests that rare variants in this gene may not be pathogenic. In seven of nine families, it could be inferred that affected individuals did not share 4q21-23 (a-synuclein) haplotypes. All families were unequivocally excluded by haplotype analysis from the parkin locus on 6q25-27. Finally, the 17q21 region was excluded in four of nine families, and no mutation in the tau gene was identified in the five remaining families. Findings from this study confirm genetic heterogeneity within familial parkinsonism.
C02	`01`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Parkinson maladie @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @5 01`
C03	`02`	`X`	`FRE`	`@0 Caractère autosomique @5 02`
C03	`02`	`X`	`ENG`	`@0 Autosomal character @5 02`
C03	`02`	`X`	`SPA`	`@0 Carácter autosómico @5 02`
C03	`03`	`X`	`FRE`	`@0 Caractère dominant @5 03`
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C03	`04`	`X`	`ENG`	`@0 Linkage @5 04`
C03	`04`	`X`	`SPA`	`@0 Ligamiento genético @5 04`
C03	`05`	`X`	`FRE`	`@0 Français @5 07`
C03	`05`	`X`	`ENG`	`@0 French @5 07`
C03	`05`	`X`	`SPA`	`@0 Francés @5 07`
C03	`06`	`X`	`FRE`	`@0 Mutation @5 08`
C03	`06`	`X`	`ENG`	`@0 Mutation @5 08`
C03	`06`	`X`	`SPA`	`@0 Mutación @5 08`
C03	`07`	`X`	`FRE`	`@0 Protéine tau @5 10`
C03	`07`	`X`	`ENG`	`@0 Tau protein @5 10`
C03	`07`	`X`	`SPA`	`@0 Proteína tau @5 10`
C03	`08`	`X`	`FRE`	`@0 Haplotype @5 13`
C03	`08`	`X`	`ENG`	`@0 Haplotype @5 13`
C03	`08`	`X`	`SPA`	`@0 Haplotipo @5 13`
C03	`09`	`X`	`FRE`	`@0 Etude familiale @5 17`
C03	`09`	`X`	`ENG`	`@0 Family study @5 17`
C03	`09`	`X`	`SPA`	`@0 Estudio familiar @5 17`
C03	`10`	`X`	`FRE`	`@0 Déterminisme génétique @5 18`
C03	`10`	`X`	`ENG`	`@0 Genetic determinism @5 18`
C03	`10`	`X`	`SPA`	`@0 Determinismo genético @5 18`
C03	`11`	`X`	`FRE`	`@0 Homme @5 20`
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C07	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Encéphale pathologie @5 39`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
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Format Inist (serveur)

NO :	PASCAL 01-0017636 INIST
ET :	Linkage exclusion in French families with probable Parkinson's disease
AU :	FARRER (Matt); DESTEE (Alain); BECQUET (Estelle); VRIEZE (Fabienne Wavrant-De); MOUROUX (Vincent); RICHARD (Florence); DEFEBVRE (Luc); LINCOLN (Sarah); HARDY (John); AMOUYEL (Philippe); CHARTIER-HARLIN (Marie-Christine)
AF :	Neurogenetics Laboratory, Mayo Clinic Jacksonville/Jacksonville, Florida/Etats-Unis (1 aut., 4 aut., 8 aut., 9 aut.); Clinique Neurologique, Central and Regional Hospital/Lille/France; INSERM 508, Institut Pasteur de Lille/Lille/France
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2000; Vol. 15; No. 6; Pp. 1075-1083; Bibl. 26 ref.
LA :	Anglais
EA :	We analyzed the segregation of genetic markers spanning chromosomal regions 2p13, 4p14-15, 4q21-23, 6q25-27, and 17q21 in nine French families affected by autosomal-dominant probable Parkinson's disease. These regions have been linked or associated with familial Parkinson's disease. Multipoint linkage and haplotype analyses excluded 2p13 and 4p14-15 loci in five of nine families. For three families, which were equivocal for two-point linkage at D4S405, the ubiquitin carboxy-terminal hydrolase gene (UCH-LI) was sequenced. In one family, a novel UCH-LI M124L mutation that did not segregate with early-onset disease was identified. This suggests that rare variants in this gene may not be pathogenic. In seven of nine families, it could be inferred that affected individuals did not share 4q21-23 (a-synuclein) haplotypes. All families were unequivocally excluded by haplotype analysis from the parkin locus on 6q25-27. Finally, the 17q21 region was excluded in four of nine families, and no mutation in the tau gene was identified in the five remaining families. Findings from this study confirm genetic heterogeneity within familial parkinsonism.
CC :	002B17G
FD :	Parkinson maladie; Caractère autosomique; Caractère dominant; Liaison génétique; Français; Mutation; Protéine tau; Haplotype; Etude familiale; Déterminisme génétique; Homme; α-Synucléine; Ubiquitin carboxy-terminal hydrolase
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire; Génétique
ED :	Parkinson disease; Autosomal character; Dominant character; Linkage; French; Mutation; Tau protein; Haplotype; Family study; Genetic determinism; Human
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Genetics
SD :	Parkinson enfermedad; Carácter autosómico; Carácter dominante; Ligamiento genético; Francés; Mutación; Proteína tau; Haplotipo; Estudio familiar; Determinismo genético; Hombre
LO :	INIST-20953.354000092814950040
ID :	01-0017636

Links to Exploration step

Pascal:01-0017636

Le document en format XML

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<term>Human</term>
<term>Linkage</term>
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<term>Mutation</term>
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<term>Etude familiale</term>
<term>Déterminisme génétique</term>
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<front><div type="abstract" xml:lang="en">We analyzed the segregation of genetic markers spanning chromosomal regions 2p13, 4p14-15, 4q21-23, 6q25-27, and 17q21 in nine French families affected by autosomal-dominant probable Parkinson's disease. These regions have been linked or associated with familial Parkinson's disease. Multipoint linkage and haplotype analyses excluded 2p13 and 4p14-15 loci in five of nine families. For three families, which were equivocal for two-point linkage at D4S405, the ubiquitin carboxy-terminal hydrolase gene (UCH-LI) was sequenced. In one family, a novel UCH-LI M124L mutation that did not segregate with early-onset disease was identified. This suggests that rare variants in this gene may not be pathogenic. In seven of nine families, it could be inferred that affected individuals did not share 4q21-23 (a-synuclein) haplotypes. All families were unequivocally excluded by haplotype analysis from the parkin locus on 6q25-27. Finally, the 17q21 region was excluded in four of nine families, and no mutation in the tau gene was identified in the five remaining families. Findings from this study confirm genetic heterogeneity within familial parkinsonism.</div>
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<fA11 i1="08" i2="1"><s1>LINCOLN (Sarah)</s1>
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<fA11 i1="09" i2="1"><s1>HARDY (John)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>AMOUYEL (Philippe)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>CHARTIER-HARLIN (Marie-Christine)</s1>
</fA11>
<fA14 i1="01"><s1>Neurogenetics Laboratory, Mayo Clinic Jacksonville</s1>
<s2>Jacksonville, Florida</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Clinique Neurologique, Central and Regional Hospital</s1>
<s2>Lille</s2>
<s3>FRA</s3>
</fA14>
<fA14 i1="03"><s1>INSERM 508, Institut Pasteur de Lille</s1>
<s2>Lille</s2>
<s3>FRA</s3>
</fA14>
<fA20><s1>1075-1083</s1>
</fA20>
<fA21><s1>2000</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000092814950040</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2001 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>26 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>01-0017636</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>We analyzed the segregation of genetic markers spanning chromosomal regions 2p13, 4p14-15, 4q21-23, 6q25-27, and 17q21 in nine French families affected by autosomal-dominant probable Parkinson's disease. These regions have been linked or associated with familial Parkinson's disease. Multipoint linkage and haplotype analyses excluded 2p13 and 4p14-15 loci in five of nine families. For three families, which were equivocal for two-point linkage at D4S405, the ubiquitin carboxy-terminal hydrolase gene (UCH-LI) was sequenced. In one family, a novel UCH-LI M124L mutation that did not segregate with early-onset disease was identified. This suggests that rare variants in this gene may not be pathogenic. In seven of nine families, it could be inferred that affected individuals did not share 4q21-23 (a-synuclein) haplotypes. All families were unequivocally excluded by haplotype analysis from the parkin locus on 6q25-27. Finally, the 17q21 region was excluded in four of nine families, and no mutation in the tau gene was identified in the five remaining families. Findings from this study confirm genetic heterogeneity within familial parkinsonism.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Caractère autosomique</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Autosomal character</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Carácter autosómico</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Caractère dominant</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Dominant character</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Carácter dominante</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Liaison génétique</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Linkage</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Ligamiento genético</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Français</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>French</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Francés</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Mutation</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Mutation</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Mutación</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Protéine tau</s0>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Tau protein</s0>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Proteína tau</s0>
<s5>10</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Haplotype</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Haplotype</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Haplotipo</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Etude familiale</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Family study</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Estudio familiar</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Déterminisme génétique</s0>
<s5>18</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Genetic determinism</s0>
<s5>18</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Determinismo genético</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Homme</s0>
<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Human</s0>
<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Hombre</s0>
<s5>20</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>α-Synucléine</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Ubiquitin carboxy-terminal hydrolase</s0>
<s2>FE</s2>
<s4>INC</s4>
<s5>87</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Maladie héréditaire</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Genetic disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Génétique</s0>
<s5>45</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Genetics</s0>
<s5>45</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Genética</s0>
<s5>45</s5>
</fC07>
<fN21><s1>008</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 01-0017636 INIST</NO>
<ET>Linkage exclusion in French families with probable Parkinson's disease</ET>
<AU>FARRER (Matt); DESTEE (Alain); BECQUET (Estelle); VRIEZE (Fabienne Wavrant-De); MOUROUX (Vincent); RICHARD (Florence); DEFEBVRE (Luc); LINCOLN (Sarah); HARDY (John); AMOUYEL (Philippe); CHARTIER-HARLIN (Marie-Christine)</AU>
<AF>Neurogenetics Laboratory, Mayo Clinic Jacksonville/Jacksonville, Florida/Etats-Unis (1 aut., 4 aut., 8 aut., 9 aut.); Clinique Neurologique, Central and Regional Hospital/Lille/France; INSERM 508, Institut Pasteur de Lille/Lille/France</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2000; Vol. 15; No. 6; Pp. 1075-1083; Bibl. 26 ref.</SO>
<LA>Anglais</LA>
<EA>We analyzed the segregation of genetic markers spanning chromosomal regions 2p13, 4p14-15, 4q21-23, 6q25-27, and 17q21 in nine French families affected by autosomal-dominant probable Parkinson's disease. These regions have been linked or associated with familial Parkinson's disease. Multipoint linkage and haplotype analyses excluded 2p13 and 4p14-15 loci in five of nine families. For three families, which were equivocal for two-point linkage at D4S405, the ubiquitin carboxy-terminal hydrolase gene (UCH-LI) was sequenced. In one family, a novel UCH-LI M124L mutation that did not segregate with early-onset disease was identified. This suggests that rare variants in this gene may not be pathogenic. In seven of nine families, it could be inferred that affected individuals did not share 4q21-23 (a-synuclein) haplotypes. All families were unequivocally excluded by haplotype analysis from the parkin locus on 6q25-27. Finally, the 17q21 region was excluded in four of nine families, and no mutation in the tau gene was identified in the five remaining families. Findings from this study confirm genetic heterogeneity within familial parkinsonism.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Caractère autosomique; Caractère dominant; Liaison génétique; Français; Mutation; Protéine tau; Haplotype; Etude familiale; Déterminisme génétique; Homme; α-Synucléine; Ubiquitin carboxy-terminal hydrolase</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire; Génétique</FG>
<ED>Parkinson disease; Autosomal character; Dominant character; Linkage; French; Mutation; Tau protein; Haplotype; Family study; Genetic determinism; Human</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Genetics</EG>
<SD>Parkinson enfermedad; Carácter autosómico; Carácter dominante; Ligamiento genético; Francés; Mutación; Proteína tau; Haplotipo; Estudio familiar; Determinismo genético; Hombre</SD>
<LO>INIST-20953.354000092814950040</LO>
<ID>01-0017636</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Linkage exclusion in French families with probable Parkinson's disease

Linkage exclusion in French families with probable Parkinson's disease

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