MovDisordV3, PascalFrancis, Corpus, bibRecord, 002A05

Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor

Identifieur interne : 002A05 ( PascalFrancis/Corpus ); précédent : 002A04; suivant : 002A06

Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor

Auteurs : William C. Koller ; Kelly E. Lyons ; Steven B. Wilkinson ; Alexander I. Troster ; Rajesh Pahwa

Source :

Movement disorders [ 0885-3185 ] ; 2001.

RBID : Pascal:01-0377460

Descripteurs français

Pascal (Inist)
- Tremblement, Essentiel, Stimulation instrumentale, Unilatéral, Noyau ventromédial, Thalamus, Long terme, Efficacité traitement, Tolérance, Homme.

English descriptors

KwdEn :
- Essential, Human, Instrumental stimulation, Long term, Thalamus, Tolerance, Treatment efficiency, Tremor, Unilateral, Ventromedial nucleus.

Abstract

Our objective was to investigate the long-term safety and efficacy of unilateral deep brain stimulation (DBS) of the VIM nucleus of the thalamus in essential tremor. Forty-nine patients were evaluated for DBS between December 1993 and March 1998. Tremor was assessed by a clinical rating scale at 3 and 12 months and then yearly. Three patients were not implanted, seven were explanted prior to 24 months, 11 were lost to long-term follow-up, and three died from unrelated causes. Twenty-five patients were evaluated with follow-up greater than or equal to 2 years. The last postsurgical follow-up occurred on average 40.2 ± 14.7 months after surgery. Tremor scores were significantly improved with stimulation on at the long-term follow-up as compared to baseline. There was no change in tremor scores from baseline to long-term follow-up with stimulation off, There was no significant change in any stimulus parameters from 3 months to the long-term follow-up. Three patients had asymptomatic intracerebral hemorrhages and one patient had postoperative seizures. Stimulus-related adverse reactions were mild and easily controlled with changes in stimulus parameters. Device-related complications were common and required repeated surgical procedures. Unilateral DBS of the thalamus has long-term efficacy in some patients for treatment of essential tremor. However, this therapy is compromised by loss of efficacy in some patients and device complications which increase the risk of additional surgical procedures.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor`
A11	`01`	`1`		`@1 KOLLER (William C.)`
A11	`02`	`1`		`@1 LYONS (Kelly E.)`
A11	`03`	`1`		`@1 WILKINSON (Steven B.)`
A11	`04`	`1`		`@1 TROSTER (Alexander I.)`
A11	`05`	`1`		`@1 PAHWA (Rajesh)`
A14	`01`			`@1 Department of Neurology, University of Miami Medical Center @2 Miami, Florida @3 USA @Z 1 aut. @Z 2 aut.`
A14	`02`			`@1 Department of Neurosurgery, University of Kansas Medical Center @2 Kansas @3 USA @Z 3 aut.`
A14	`03`			`@1 Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine @2 Seattle, Washington @3 USA @Z 4 aut.`
A14	`04`			`@1 Department of Neurological Surgery, University of Washington School of Medicine @2 Seattle, Washington @3 USA @Z 4 aut.`
A14	`05`			`@1 Department of Neurology, University of Kansas Medical Center @2 Kansas @3 USA @Z 5 aut.`
A20				`@1 464-468`
A21				`@1 2001`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000099011180090`
A44				`@0 0000 @1 © 2001 INIST-CNRS. All rights reserved.`
A45				`@0 23 ref.`
A47	`01`	`1`		`@0 01-0377460`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
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C01	`01`		`ENG`	@0 Our objective was to investigate the long-term safety and efficacy of unilateral deep brain stimulation (DBS) of the VIM nucleus of the thalamus in essential tremor. Forty-nine patients were evaluated for DBS between December 1993 and March 1998. Tremor was assessed by a clinical rating scale at 3 and 12 months and then yearly. Three patients were not implanted, seven were explanted prior to 24 months, 11 were lost to long-term follow-up, and three died from unrelated causes. Twenty-five patients were evaluated with follow-up greater than or equal to 2 years. The last postsurgical follow-up occurred on average 40.2 ± 14.7 months after surgery. Tremor scores were significantly improved with stimulation on at the long-term follow-up as compared to baseline. There was no change in tremor scores from baseline to long-term follow-up with stimulation off, There was no significant change in any stimulus parameters from 3 months to the long-term follow-up. Three patients had asymptomatic intracerebral hemorrhages and one patient had postoperative seizures. Stimulus-related adverse reactions were mild and easily controlled with changes in stimulus parameters. Device-related complications were common and required repeated surgical procedures. Unilateral DBS of the thalamus has long-term efficacy in some patients for treatment of essential tremor. However, this therapy is compromised by loss of efficacy in some patients and device complications which increase the risk of additional surgical procedures.
C02	`01`	`X`		`@0 002B17A01`
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C03	`02`	`X`	`FRE`	`@0 Essentiel @5 02`
C03	`02`	`X`	`ENG`	`@0 Essential @5 02`
C03	`02`	`X`	`SPA`	`@0 Esencial @5 02`
C03	`03`	`X`	`FRE`	`@0 Stimulation instrumentale @5 04`
C03	`03`	`X`	`ENG`	`@0 Instrumental stimulation @5 04`
C03	`03`	`X`	`SPA`	`@0 Estimulación instrumental @5 04`
C03	`04`	`X`	`FRE`	`@0 Unilatéral @5 05`
C03	`04`	`X`	`ENG`	`@0 Unilateral @5 05`
C03	`04`	`X`	`SPA`	`@0 Unilateral @5 05`
C03	`05`	`X`	`FRE`	`@0 Noyau ventromédial @5 07`
C03	`05`	`X`	`ENG`	`@0 Ventromedial nucleus @5 07`
C03	`05`	`X`	`SPA`	`@0 Núcleo ventromedial @5 07`
C03	`06`	`X`	`FRE`	`@0 Thalamus @5 08`
C03	`06`	`X`	`ENG`	`@0 Thalamus @5 08`
C03	`06`	`X`	`SPA`	`@0 Tálamo @5 08`
C03	`07`	`X`	`FRE`	`@0 Long terme @5 16`
C03	`07`	`X`	`ENG`	`@0 Long term @5 16`
C03	`07`	`X`	`SPA`	`@0 Largo plazo @5 16`
C03	`08`	`X`	`FRE`	`@0 Efficacité traitement @5 17`
C03	`08`	`X`	`ENG`	`@0 Treatment efficiency @5 17`
C03	`08`	`X`	`SPA`	`@0 Eficacia tratamiento @5 17`
C03	`09`	`X`	`FRE`	`@0 Tolérance @5 18`
C03	`09`	`X`	`ENG`	`@0 Tolerance @5 18`
C03	`09`	`X`	`SPA`	`@0 Tolerancia @5 18`
C03	`10`	`X`	`FRE`	`@0 Homme @5 20`
C03	`10`	`X`	`ENG`	`@0 Human @5 20`
C03	`10`	`X`	`SPA`	`@0 Hombre @5 20`
C07	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 37`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Trouble neurologique @5 38`
C07	`02`	`X`	`ENG`	`@0 Neurological disorder @5 38`
C07	`02`	`X`	`SPA`	`@0 Trastorno neurológico @5 38`
C07	`03`	`X`	`FRE`	`@0 Mouvement involontaire @5 39`
C07	`03`	`X`	`ENG`	`@0 Involuntary movement @5 39`
C07	`03`	`X`	`SPA`	`@0 Movimiento involuntario @5 39`
C07	`04`	`X`	`FRE`	`@0 Traitement instrumental @5 45`
C07	`04`	`X`	`ENG`	`@0 Instrumentation therapy @5 45`
C07	`04`	`X`	`SPA`	`@0 Tratamiento instrumental @5 45`
C07	`05`	`X`	`FRE`	`@0 Encéphale @5 53`
C07	`05`	`X`	`ENG`	`@0 Brain (vertebrata) @5 53`
C07	`05`	`X`	`SPA`	`@0 Encéfalo @5 53`
N21				`@1 267`

Format Inist (serveur)

NO :	PASCAL 01-0377460 INIST
ET :	Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor
AU :	KOLLER (William C.); LYONS (Kelly E.); WILKINSON (Steven B.); TROSTER (Alexander I.); PAHWA (Rajesh)
AF :	Department of Neurology, University of Miami Medical Center/Miami, Florida/Etats-Unis (1 aut., 2 aut.); Department of Neurosurgery, University of Kansas Medical Center/Kansas/Etats-Unis (3 aut.); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine/Seattle, Washington/Etats-Unis (4 aut.); Department of Neurological Surgery, University of Washington School of Medicine/Seattle, Washington/Etats-Unis (4 aut.); Department of Neurology, University of Kansas Medical Center/Kansas/Etats-Unis (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 3; Pp. 464-468; Bibl. 23 ref.
LA :	Anglais
EA :	Our objective was to investigate the long-term safety and efficacy of unilateral deep brain stimulation (DBS) of the VIM nucleus of the thalamus in essential tremor. Forty-nine patients were evaluated for DBS between December 1993 and March 1998. Tremor was assessed by a clinical rating scale at 3 and 12 months and then yearly. Three patients were not implanted, seven were explanted prior to 24 months, 11 were lost to long-term follow-up, and three died from unrelated causes. Twenty-five patients were evaluated with follow-up greater than or equal to 2 years. The last postsurgical follow-up occurred on average 40.2 ± 14.7 months after surgery. Tremor scores were significantly improved with stimulation on at the long-term follow-up as compared to baseline. There was no change in tremor scores from baseline to long-term follow-up with stimulation off, There was no significant change in any stimulus parameters from 3 months to the long-term follow-up. Three patients had asymptomatic intracerebral hemorrhages and one patient had postoperative seizures. Stimulus-related adverse reactions were mild and easily controlled with changes in stimulus parameters. Device-related complications were common and required repeated surgical procedures. Unilateral DBS of the thalamus has long-term efficacy in some patients for treatment of essential tremor. However, this therapy is compromised by loss of efficacy in some patients and device complications which increase the risk of additional surgical procedures.
CC :	002B17A01
FD :	Tremblement; Essentiel; Stimulation instrumentale; Unilatéral; Noyau ventromédial; Thalamus; Long terme; Efficacité traitement; Tolérance; Homme
FG :	Système nerveux pathologie; Trouble neurologique; Mouvement involontaire; Traitement instrumental; Encéphale
ED :	Tremor; Essential; Instrumental stimulation; Unilateral; Ventromedial nucleus; Thalamus; Long term; Treatment efficiency; Tolerance; Human
EG :	Nervous system diseases; Neurological disorder; Involuntary movement; Instrumentation therapy; Brain (vertebrata)
SD :	Temblor; Esencial; Estimulación instrumental; Unilateral; Núcleo ventromedial; Tálamo; Largo plazo; Eficacia tratamiento; Tolerancia; Hombre
LO :	INIST-20953.354000099011180090
ID :	01-0377460

Links to Exploration step

Pascal:01-0377460

Le document en format XML

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<front><div type="abstract" xml:lang="en">Our objective was to investigate the long-term safety and efficacy of unilateral deep brain stimulation (DBS) of the VIM nucleus of the thalamus in essential tremor. Forty-nine patients were evaluated for DBS between December 1993 and March 1998. Tremor was assessed by a clinical rating scale at 3 and 12 months and then yearly. Three patients were not implanted, seven were explanted prior to 24 months, 11 were lost to long-term follow-up, and three died from unrelated causes. Twenty-five patients were evaluated with follow-up greater than or equal to 2 years. The last postsurgical follow-up occurred on average 40.2 ± 14.7 months after surgery. Tremor scores were significantly improved with stimulation on at the long-term follow-up as compared to baseline. There was no change in tremor scores from baseline to long-term follow-up with stimulation off, There was no significant change in any stimulus parameters from 3 months to the long-term follow-up. Three patients had asymptomatic intracerebral hemorrhages and one patient had postoperative seizures. Stimulus-related adverse reactions were mild and easily controlled with changes in stimulus parameters. Device-related complications were common and required repeated surgical procedures. Unilateral DBS of the thalamus has long-term efficacy in some patients for treatment of essential tremor. However, this therapy is compromised by loss of efficacy in some patients and device complications which increase the risk of additional surgical procedures.</div>
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<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Stimulation instrumentale</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Instrumental stimulation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Estimulación instrumental</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Unilatéral</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Unilateral</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Unilateral</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Noyau ventromédial</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Ventromedial nucleus</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Núcleo ventromedial</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Thalamus</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Thalamus</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Tálamo</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Long terme</s0>
<s5>16</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Long term</s0>
<s5>16</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Largo plazo</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Efficacité traitement</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Treatment efficiency</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Eficacia tratamiento</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Tolérance</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Tolerance</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Tolerancia</s0>
<s5>18</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Homme</s0>
<s5>20</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Human</s0>
<s5>20</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Hombre</s0>
<s5>20</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Traitement instrumental</s0>
<s5>45</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Instrumentation therapy</s0>
<s5>45</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Tratamiento instrumental</s0>
<s5>45</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>53</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Brain (vertebrata)</s0>
<s5>53</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>53</s5>
</fC07>
<fN21><s1>267</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 01-0377460 INIST</NO>
<ET>Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor</ET>
<AU>KOLLER (William C.); LYONS (Kelly E.); WILKINSON (Steven B.); TROSTER (Alexander I.); PAHWA (Rajesh)</AU>
<AF>Department of Neurology, University of Miami Medical Center/Miami, Florida/Etats-Unis (1 aut., 2 aut.); Department of Neurosurgery, University of Kansas Medical Center/Kansas/Etats-Unis (3 aut.); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine/Seattle, Washington/Etats-Unis (4 aut.); Department of Neurological Surgery, University of Washington School of Medicine/Seattle, Washington/Etats-Unis (4 aut.); Department of Neurology, University of Kansas Medical Center/Kansas/Etats-Unis (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 3; Pp. 464-468; Bibl. 23 ref.</SO>
<LA>Anglais</LA>
<EA>Our objective was to investigate the long-term safety and efficacy of unilateral deep brain stimulation (DBS) of the VIM nucleus of the thalamus in essential tremor. Forty-nine patients were evaluated for DBS between December 1993 and March 1998. Tremor was assessed by a clinical rating scale at 3 and 12 months and then yearly. Three patients were not implanted, seven were explanted prior to 24 months, 11 were lost to long-term follow-up, and three died from unrelated causes. Twenty-five patients were evaluated with follow-up greater than or equal to 2 years. The last postsurgical follow-up occurred on average 40.2 ± 14.7 months after surgery. Tremor scores were significantly improved with stimulation on at the long-term follow-up as compared to baseline. There was no change in tremor scores from baseline to long-term follow-up with stimulation off, There was no significant change in any stimulus parameters from 3 months to the long-term follow-up. Three patients had asymptomatic intracerebral hemorrhages and one patient had postoperative seizures. Stimulus-related adverse reactions were mild and easily controlled with changes in stimulus parameters. Device-related complications were common and required repeated surgical procedures. Unilateral DBS of the thalamus has long-term efficacy in some patients for treatment of essential tremor. However, this therapy is compromised by loss of efficacy in some patients and device complications which increase the risk of additional surgical procedures.</EA>
<CC>002B17A01</CC>
<FD>Tremblement; Essentiel; Stimulation instrumentale; Unilatéral; Noyau ventromédial; Thalamus; Long terme; Efficacité traitement; Tolérance; Homme</FD>
<FG>Système nerveux pathologie; Trouble neurologique; Mouvement involontaire; Traitement instrumental; Encéphale</FG>
<ED>Tremor; Essential; Instrumental stimulation; Unilateral; Ventromedial nucleus; Thalamus; Long term; Treatment efficiency; Tolerance; Human</ED>
<EG>Nervous system diseases; Neurological disorder; Involuntary movement; Instrumentation therapy; Brain (vertebrata)</EG>
<SD>Temblor; Esencial; Estimulación instrumental; Unilateral; Núcleo ventromedial; Tálamo; Largo plazo; Eficacia tratamiento; Tolerancia; Hombre</SD>
<LO>INIST-20953.354000099011180090</LO>
<ID>01-0377460</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor

Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor

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