MovDisordV3, PascalFrancis, Corpus, bibRecord, 002983

Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease

Identifieur interne : 002983 ( PascalFrancis/Corpus ); précédent : 002982; suivant : 002984

Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease

Auteurs : Marie-Paule Muriel ; Yves Agid ; Etienne Hirsch

Source :

Movement disorders [ 0885-3185 ] ; 2001.

RBID : Pascal:01-0378507

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Corps strié, Récepteur dopaminergique D1, Immunohistochimie, Plasticité synaptique, Physiopathologie, Homme, Postmortem.

English descriptors

KwdEn :
- Corpus striatum, D1 Dopamine receptor, Human, Immunohistochemistry, Parkinson disease, Pathophysiology, Postmortem, Synaptic plasticity.

Abstract

The loss of dopaminergic neurons in the substantia nigra provokes a plasticity of corticostriatal synapses in Parkinson's disease (PD). The corticostriatal pathway nevertheless makes synapses with neurons bearing Dl dopamine receptors (D1R) and/or D2 dopamine receptors. At the ultrastructural level, we analyzed the morphological characteristics of synapses formed by afferent fibers making asymmetric contacts with the dendritic spines of neurons identified by D1R immunoreactivity, in the striatum of control subjects and PD patients. A quantitative analysis of the morphological characteristics of the synapses and of the number of perforated synapses (considered to be very active) was performed. In PD, a 50% increase in the number of perforated synapses making contact with D1R dendritic spines was observed, whereas no change in the number of perforated synapses on non-DIR spines was observed. The change in the number of perforated synapses on D1R dendrites was associated with a slight but nonsignificant increase in the surface area of the corticostriatal afferent fibers and the surface of the mitochondria in these fibers (+29.0% and +34.6%, respectively). This suggests a hyperactivity of corticostriatal fibers in contact with DIR-bearing neurons of the direct pathway in the basal ganglia circuitry. Since stimulation of the direct pathway is thought to alleviate the clinical symptoms of PD, this suggests that the differences observed may be involved in compensatory mechanisms.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 The loss of dopaminergic neurons in the substantia nigra provokes a plasticity of corticostriatal synapses in Parkinson's disease (PD). The corticostriatal pathway nevertheless makes synapses with neurons bearing Dl dopamine receptors (D1R) and/or D2 dopamine receptors. At the ultrastructural level, we analyzed the morphological characteristics of synapses formed by afferent fibers making asymmetric contacts with the dendritic spines of neurons identified by D1R immunoreactivity, in the striatum of control subjects and PD patients. A quantitative analysis of the morphological characteristics of the synapses and of the number of perforated synapses (considered to be very active) was performed. In PD, a 50% increase in the number of perforated synapses making contact with D1R dendritic spines was observed, whereas no change in the number of perforated synapses on non-DIR spines was observed. The change in the number of perforated synapses on D1R dendrites was associated with a slight but nonsignificant increase in the surface area of the corticostriatal afferent fibers and the surface of the mitochondria in these fibers (+29.0% and +34.6%, respectively). This suggests a hyperactivity of corticostriatal fibers in contact with DIR-bearing neurons of the direct pathway in the basal ganglia circuitry. Since stimulation of the direct pathway is thought to alleviate the clinical symptoms of PD, this suggests that the differences observed may be involved in compensatory mechanisms.
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N21				`@1 267`

Format Inist (serveur)

NO :	PASCAL 01-0378507 INIST
ET :	Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease
AU :	MURIEL (Marie-Paule); AGID (Yves); HIRSCH (Etienne)
AF :	INSERM U 289, Experimental Neurology and Therapeutics, Hôpital de la Salpêtrière/Paris/France (1 aut., 2 aut., 3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 3; Pp. 435-441; Bibl. 45 ref.
LA :	Anglais
EA :	The loss of dopaminergic neurons in the substantia nigra provokes a plasticity of corticostriatal synapses in Parkinson's disease (PD). The corticostriatal pathway nevertheless makes synapses with neurons bearing Dl dopamine receptors (D1R) and/or D2 dopamine receptors. At the ultrastructural level, we analyzed the morphological characteristics of synapses formed by afferent fibers making asymmetric contacts with the dendritic spines of neurons identified by D1R immunoreactivity, in the striatum of control subjects and PD patients. A quantitative analysis of the morphological characteristics of the synapses and of the number of perforated synapses (considered to be very active) was performed. In PD, a 50% increase in the number of perforated synapses making contact with D1R dendritic spines was observed, whereas no change in the number of perforated synapses on non-DIR spines was observed. The change in the number of perforated synapses on D1R dendrites was associated with a slight but nonsignificant increase in the surface area of the corticostriatal afferent fibers and the surface of the mitochondria in these fibers (+29.0% and +34.6%, respectively). This suggests a hyperactivity of corticostriatal fibers in contact with DIR-bearing neurons of the direct pathway in the basal ganglia circuitry. Since stimulation of the direct pathway is thought to alleviate the clinical symptoms of PD, this suggests that the differences observed may be involved in compensatory mechanisms.
CC :	002B17G
FD :	Parkinson maladie; Corps strié; Récepteur dopaminergique D1; Immunohistochimie; Plasticité synaptique; Physiopathologie; Homme; Postmortem
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Encéphale; Anatomopathologie
ED :	Parkinson disease; Corpus striatum; D1 Dopamine receptor; Immunohistochemistry; Synaptic plasticity; Pathophysiology; Human; Postmortem
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Brain (vertebrata); Pathology
SD :	Parkinson enfermedad; Cuerpo estriado; Receptor dopaminérgico D1; Inmunohistoquímica; Plasticidad sináptica; Fisiopatología; Hombre; Postmortem
LO :	INIST-20953.354000099011180050
ID :	01-0378507

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The loss of dopaminergic neurons in the substantia nigra provokes a plasticity of corticostriatal synapses in Parkinson's disease (PD). The corticostriatal pathway nevertheless makes synapses with neurons bearing Dl dopamine receptors (D1R) and/or D2 dopamine receptors. At the ultrastructural level, we analyzed the morphological characteristics of synapses formed by afferent fibers making asymmetric contacts with the dendritic spines of neurons identified by D1R immunoreactivity, in the striatum of control subjects and PD patients. A quantitative analysis of the morphological characteristics of the synapses and of the number of perforated synapses (considered to be very active) was performed. In PD, a 50% increase in the number of perforated synapses making contact with D1R dendritic spines was observed, whereas no change in the number of perforated synapses on non-DIR spines was observed. The change in the number of perforated synapses on D1R dendrites was associated with a slight but nonsignificant increase in the surface area of the corticostriatal afferent fibers and the surface of the mitochondria in these fibers (+29.0% and +34.6%, respectively). This suggests a hyperactivity of corticostriatal fibers in contact with DIR-bearing neurons of the direct pathway in the basal ganglia circuitry. Since stimulation of the direct pathway is thought to alleviate the clinical symptoms of PD, this suggests that the differences observed may be involved in compensatory mechanisms.</div>
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<server><NO>PASCAL 01-0378507 INIST</NO>
<ET>Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease</ET>
<AU>MURIEL (Marie-Paule); AGID (Yves); HIRSCH (Etienne)</AU>
<AF>INSERM U 289, Experimental Neurology and Therapeutics, Hôpital de la Salpêtrière/Paris/France (1 aut., 2 aut., 3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 3; Pp. 435-441; Bibl. 45 ref.</SO>
<LA>Anglais</LA>
<EA>The loss of dopaminergic neurons in the substantia nigra provokes a plasticity of corticostriatal synapses in Parkinson's disease (PD). The corticostriatal pathway nevertheless makes synapses with neurons bearing Dl dopamine receptors (D1R) and/or D2 dopamine receptors. At the ultrastructural level, we analyzed the morphological characteristics of synapses formed by afferent fibers making asymmetric contacts with the dendritic spines of neurons identified by D1R immunoreactivity, in the striatum of control subjects and PD patients. A quantitative analysis of the morphological characteristics of the synapses and of the number of perforated synapses (considered to be very active) was performed. In PD, a 50% increase in the number of perforated synapses making contact with D1R dendritic spines was observed, whereas no change in the number of perforated synapses on non-DIR spines was observed. The change in the number of perforated synapses on D1R dendrites was associated with a slight but nonsignificant increase in the surface area of the corticostriatal afferent fibers and the surface of the mitochondria in these fibers (+29.0% and +34.6%, respectively). This suggests a hyperactivity of corticostriatal fibers in contact with DIR-bearing neurons of the direct pathway in the basal ganglia circuitry. Since stimulation of the direct pathway is thought to alleviate the clinical symptoms of PD, this suggests that the differences observed may be involved in compensatory mechanisms.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Corps strié; Récepteur dopaminergique D1; Immunohistochimie; Plasticité synaptique; Physiopathologie; Homme; Postmortem</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Encéphale; Anatomopathologie</FG>
<ED>Parkinson disease; Corpus striatum; D1 Dopamine receptor; Immunohistochemistry; Synaptic plasticity; Pathophysiology; Human; Postmortem</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Brain (vertebrata); Pathology</EG>
<SD>Parkinson enfermedad; Cuerpo estriado; Receptor dopaminérgico D1; Inmunohistoquímica; Plasticidad sináptica; Fisiopatología; Hombre; Postmortem</SD>
<LO>INIST-20953.354000099011180050</LO>
<ID>01-0378507</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease

Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease

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