MovDisordV3, PascalFrancis, Corpus, bibRecord, 002836

Riluzole therapy in cervical dystonia

Identifieur interne : 002836 ( PascalFrancis/Corpus ); précédent : 002835; suivant : 002837

Riluzole therapy in cervical dystonia

Auteurs : Jörg Müller ; Gregor K. Wenning ; Jörg Wissel ; Angelika Baldauf ; Klaus Seppi ; Christian Brenneis ; Werner Poewe

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0204637

Descripteurs français

Pascal (Inist)
- Dystonie, Cou, Réfractaire, Riluzole, Chimiothérapie, Psychotrope, Myorelaxant, Traitement, Pronostic, Etude cas, Adulte, Mâle, Femelle, Benzothiazole.

English descriptors

KwdEn :
- Adult, Benzothiazole, Case study, Chemotherapy, Dystonia, Female, Male, Muscle relaxant, Neck, Prognosis, Psychotropic, Refractory, Riluzole, Treatment.

Abstract

We conducted a 6-week open-label pilot study with blinded video rating of riluzole (50 mg twice a day) in six patients with cervical dystonia (CD) refractory to botulinum toxin A and oral pharmacological treatment. The Tsui rating scale served as primary efficacy measure and improved significantly under riluzole (P = 0.002). In three of six patients, the Tsui score improved by more than 30% with a greater 50% reduction in the head tremor/jerk subscore of the Tsui scale. These data suggest that riluzole may be helpful in a subgroup of patients with disabling CD refractory to other therapies.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 17`
A06				`@2 1`
A08	`01`	`1`	`ENG`	`@1 Riluzole therapy in cervical dystonia`
A11	`01`	`1`		`@1 MÜLLER (Jörg)`
A11	`02`	`1`		`@1 WENNING (Gregor K.)`
A11	`03`	`1`		`@1 WISSEL (Jörg)`
A11	`04`	`1`		`@1 BALDAUF (Angelika)`
A11	`05`	`1`		`@1 SEPPI (Klaus)`
A11	`06`	`1`		`@1 BRENNEIS (Christian)`
A11	`07`	`1`		`@1 POEWE (Werner)`
A14	`01`			`@1 Department of Neurology, Innsbruck University Hospital @2 Innsbruck @3 AUT @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut.`
A20				`@1 198-200`
A21				`@1 2002`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000100147290350`
A44				`@0 0000 @1 © 2002 INIST-CNRS. All rights reserved.`
A45				`@0 11 ref.`
A47	`01`	`1`		`@0 02-0204637`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 We conducted a 6-week open-label pilot study with blinded video rating of riluzole (50 mg twice a day) in six patients with cervical dystonia (CD) refractory to botulinum toxin A and oral pharmacological treatment. The Tsui rating scale served as primary efficacy measure and improved significantly under riluzole (P = 0.002). In three of six patients, the Tsui score improved by more than 30% with a greater 50% reduction in the head tremor/jerk subscore of the Tsui scale. These data suggest that riluzole may be helpful in a subgroup of patients with disabling CD refractory to other therapies.
C02	`01`	`X`		`@0 002B02C`
C02	`02`	`X`		`@0 002B02B10`
C03	`01`	`X`	`FRE`	`@0 Dystonie @5 01`
C03	`01`	`X`	`ENG`	`@0 Dystonia @5 01`
C03	`01`	`X`	`SPA`	`@0 Distonía @5 01`
C03	`02`	`X`	`FRE`	`@0 Cou @5 02`
C03	`02`	`X`	`ENG`	`@0 Neck @5 02`
C03	`02`	`X`	`SPA`	`@0 Cuello @5 02`
C03	`03`	`X`	`FRE`	`@0 Réfractaire @5 03`
C03	`03`	`X`	`ENG`	`@0 Refractory @5 03`
C03	`03`	`X`	`SPA`	`@0 Refractario @5 03`
C03	`04`	`X`	`FRE`	`@0 Riluzole @2 NK @2 FR @5 04`
C03	`04`	`X`	`ENG`	`@0 Riluzole @2 NK @2 FR @5 04`
C03	`04`	`X`	`SPA`	`@0 Riluzol @2 NK @2 FR @5 04`
C03	`05`	`X`	`FRE`	`@0 Chimiothérapie @5 05`
C03	`05`	`X`	`ENG`	`@0 Chemotherapy @5 05`
C03	`05`	`X`	`SPA`	`@0 Quimioterapia @5 05`
C03	`06`	`X`	`FRE`	`@0 Psychotrope @2 FX @5 06`
C03	`06`	`X`	`ENG`	`@0 Psychotropic @2 FX @5 06`
C03	`06`	`X`	`SPA`	`@0 Psicotropo @2 FX @5 06`
C03	`07`	`X`	`FRE`	`@0 Myorelaxant @5 07`
C03	`07`	`X`	`ENG`	`@0 Muscle relaxant @5 07`
C03	`07`	`X`	`SPA`	`@0 Relajante muscular @5 07`
C03	`08`	`X`	`FRE`	`@0 Traitement @5 17`
C03	`08`	`X`	`ENG`	`@0 Treatment @5 17`
C03	`08`	`X`	`SPA`	`@0 Tratamiento @5 17`
C03	`09`	`X`	`FRE`	`@0 Pronostic @5 18`
C03	`09`	`X`	`ENG`	`@0 Prognosis @5 18`
C03	`09`	`X`	`SPA`	`@0 Pronóstico @5 18`
C03	`10`	`X`	`FRE`	`@0 Etude cas @5 19`
C03	`10`	`X`	`ENG`	`@0 Case study @5 19`
C03	`10`	`X`	`SPA`	`@0 Estudio caso @5 19`
C03	`11`	`X`	`FRE`	`@0 Adulte @5 20`
C03	`11`	`X`	`ENG`	`@0 Adult @5 20`
C03	`11`	`X`	`SPA`	`@0 Adulto @5 20`
C03	`12`	`X`	`FRE`	`@0 Mâle @5 21`
C03	`12`	`X`	`ENG`	`@0 Male @5 21`
C03	`12`	`X`	`SPA`	`@0 Macho @5 21`
C03	`13`	`X`	`FRE`	`@0 Femelle @5 22`
C03	`13`	`X`	`ENG`	`@0 Female @5 22`
C03	`13`	`X`	`SPA`	`@0 Hembra @5 22`
C03	`14`	`X`	`FRE`	`@0 Benzothiazole @5 27`
C03	`14`	`X`	`ENG`	`@0 Benzothiazole @5 27`
C03	`14`	`X`	`SPA`	`@0 Benzotiazol @5 27`
C07	`01`	`X`	`FRE`	`@0 Homme`
C07	`01`	`X`	`ENG`	`@0 Human`
C07	`01`	`X`	`SPA`	`@0 Hombre`
C07	`02`	`X`	`FRE`	`@0 Muscle strié pathologie @5 37`
C07	`02`	`X`	`ENG`	`@0 Striated muscle disease @5 37`
C07	`02`	`X`	`SPA`	`@0 Músculo estriado patología @5 37`
C07	`03`	`X`	`FRE`	`@0 Système nerveux pathologie @5 38`
C07	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 38`
C07	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 38`
C07	`04`	`X`	`FRE`	`@0 Trouble neurologique @5 39`
C07	`04`	`X`	`ENG`	`@0 Neurological disorder @5 39`
C07	`04`	`X`	`SPA`	`@0 Trastorno neurológico @5 39`
C07	`05`	`X`	`FRE`	`@0 Mouvement involontaire @5 40`
C07	`05`	`X`	`ENG`	`@0 Involuntary movement @5 40`
C07	`05`	`X`	`SPA`	`@0 Movimiento involuntario @5 40`
C07	`06`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 41`
C07	`06`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 41`
C07	`06`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 41`
N21				`@1 119`
N82				`@1 PSI`

Format Inist (serveur)

NO :	PASCAL 02-0204637 INIST
ET :	Riluzole therapy in cervical dystonia
AU :	MÜLLER (Jörg); WENNING (Gregor K.); WISSEL (Jörg); BALDAUF (Angelika); SEPPI (Klaus); BRENNEIS (Christian); POEWE (Werner)
AF :	Department of Neurology, Innsbruck University Hospital/Innsbruck/Autriche (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 1; Pp. 198-200; Bibl. 11 ref.
LA :	Anglais
EA :	We conducted a 6-week open-label pilot study with blinded video rating of riluzole (50 mg twice a day) in six patients with cervical dystonia (CD) refractory to botulinum toxin A and oral pharmacological treatment. The Tsui rating scale served as primary efficacy measure and improved significantly under riluzole (P = 0.002). In three of six patients, the Tsui score improved by more than 30% with a greater 50% reduction in the head tremor/jerk subscore of the Tsui scale. These data suggest that riluzole may be helpful in a subgroup of patients with disabling CD refractory to other therapies.
CC :	002B02C; 002B02B10
FD :	Dystonie; Cou; Réfractaire; Riluzole; Chimiothérapie; Psychotrope; Myorelaxant; Traitement; Pronostic; Etude cas; Adulte; Mâle; Femelle; Benzothiazole
FG :	Homme; Muscle strié pathologie; Système nerveux pathologie; Trouble neurologique; Mouvement involontaire; Extrapyramidal syndrome
ED :	Dystonia; Neck; Refractory; Riluzole; Chemotherapy; Psychotropic; Muscle relaxant; Treatment; Prognosis; Case study; Adult; Male; Female; Benzothiazole
EG :	Human; Striated muscle disease; Nervous system diseases; Neurological disorder; Involuntary movement; Extrapyramidal syndrome
SD :	Distonía; Cuello; Refractario; Riluzol; Quimioterapia; Psicotropo; Relajante muscular; Tratamiento; Pronóstico; Estudio caso; Adulto; Macho; Hembra; Benzotiazol
LO :	INIST-20953.354000100147290350
ID :	02-0204637

Links to Exploration step

Pascal:02-0204637

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Benzothiazole</term>
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<term>Female</term>
<term>Male</term>
<term>Muscle relaxant</term>
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<front><div type="abstract" xml:lang="en">We conducted a 6-week open-label pilot study with blinded video rating of riluzole (50 mg twice a day) in six patients with cervical dystonia (CD) refractory to botulinum toxin A and oral pharmacological treatment. The Tsui rating scale served as primary efficacy measure and improved significantly under riluzole (P = 0.002). In three of six patients, the Tsui score improved by more than 30% with a greater 50% reduction in the head tremor/jerk subscore of the Tsui scale. These data suggest that riluzole may be helpful in a subgroup of patients with disabling CD refractory to other therapies.</div>
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<fA11 i1="01" i2="1"><s1>MÜLLER (Jörg)</s1>
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<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA20><s1>198-200</s1>
</fA20>
<fA21><s1>2002</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000100147290350</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2002 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>11 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>02-0204637</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>We conducted a 6-week open-label pilot study with blinded video rating of riluzole (50 mg twice a day) in six patients with cervical dystonia (CD) refractory to botulinum toxin A and oral pharmacological treatment. The Tsui rating scale served as primary efficacy measure and improved significantly under riluzole (P = 0.002). In three of six patients, the Tsui score improved by more than 30% with a greater 50% reduction in the head tremor/jerk subscore of the Tsui scale. These data suggest that riluzole may be helpful in a subgroup of patients with disabling CD refractory to other therapies.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02C</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B02B10</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Dystonie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Dystonia</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Distonía</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Cou</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Neck</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Cuello</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Réfractaire</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Refractory</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Refractario</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Riluzole</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Riluzole</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Riluzol</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Chimiothérapie</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Chemotherapy</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Quimioterapia</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Psychotrope</s0>
<s2>FX</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Psychotropic</s0>
<s2>FX</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Psicotropo</s0>
<s2>FX</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Myorelaxant</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Muscle relaxant</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Relajante muscular</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Traitement</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Treatment</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Pronostic</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Prognosis</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Pronóstico</s0>
<s5>18</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Etude cas</s0>
<s5>19</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Case study</s0>
<s5>19</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Estudio caso</s0>
<s5>19</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Adulte</s0>
<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Adult</s0>
<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Adulto</s0>
<s5>20</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Mâle</s0>
<s5>21</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Male</s0>
<s5>21</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Macho</s0>
<s5>21</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Femelle</s0>
<s5>22</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Female</s0>
<s5>22</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Hembra</s0>
<s5>22</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Benzothiazole</s0>
<s5>27</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Benzothiazole</s0>
<s5>27</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Benzotiazol</s0>
<s5>27</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Muscle strié pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Striated muscle disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Músculo estriado patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>41</s5>
</fC07>
<fN21><s1>119</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 02-0204637 INIST</NO>
<ET>Riluzole therapy in cervical dystonia</ET>
<AU>MÜLLER (Jörg); WENNING (Gregor K.); WISSEL (Jörg); BALDAUF (Angelika); SEPPI (Klaus); BRENNEIS (Christian); POEWE (Werner)</AU>
<AF>Department of Neurology, Innsbruck University Hospital/Innsbruck/Autriche (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 1; Pp. 198-200; Bibl. 11 ref.</SO>
<LA>Anglais</LA>
<EA>We conducted a 6-week open-label pilot study with blinded video rating of riluzole (50 mg twice a day) in six patients with cervical dystonia (CD) refractory to botulinum toxin A and oral pharmacological treatment. The Tsui rating scale served as primary efficacy measure and improved significantly under riluzole (P = 0.002). In three of six patients, the Tsui score improved by more than 30% with a greater 50% reduction in the head tremor/jerk subscore of the Tsui scale. These data suggest that riluzole may be helpful in a subgroup of patients with disabling CD refractory to other therapies.</EA>
<CC>002B02C; 002B02B10</CC>
<FD>Dystonie; Cou; Réfractaire; Riluzole; Chimiothérapie; Psychotrope; Myorelaxant; Traitement; Pronostic; Etude cas; Adulte; Mâle; Femelle; Benzothiazole</FD>
<FG>Homme; Muscle strié pathologie; Système nerveux pathologie; Trouble neurologique; Mouvement involontaire; Extrapyramidal syndrome</FG>
<ED>Dystonia; Neck; Refractory; Riluzole; Chemotherapy; Psychotropic; Muscle relaxant; Treatment; Prognosis; Case study; Adult; Male; Female; Benzothiazole</ED>
<EG>Human; Striated muscle disease; Nervous system diseases; Neurological disorder; Involuntary movement; Extrapyramidal syndrome</EG>
<SD>Distonía; Cuello; Refractario; Riluzol; Quimioterapia; Psicotropo; Relajante muscular; Tratamiento; Pronóstico; Estudio caso; Adulto; Macho; Hembra; Benzotiazol</SD>
<LO>INIST-20953.354000100147290350</LO>
<ID>02-0204637</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Riluzole therapy in cervical dystonia

Riluzole therapy in cervical dystonia

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