MovDisordV3, PascalFrancis, Corpus, bibRecord, 002805

Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease

Identifieur interne : 002805 ( PascalFrancis/Corpus ); précédent : 002804; suivant : 002806

Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease

Auteurs : Abdelhamid Benazzouz ; Sorin Breit ; Adnan Koudsie ; Pierre Pollak ; Paul Krack ; Alim-Louis Benabid

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0309290

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Stimulation instrumentale, Noyau sousthalamique, Microélectrode, Electrodiagnostic, Chirurgie stéréotaxique, Exploration, Peropératoire, Homme, Chirurgie.

English descriptors

KwdEn :
- Electrodiagnosis, Exploration, Human, Instrumental stimulation, Intraoperative, Microelectrode, Parkinson disease, Stereotaxic surgery, Subthalamic nucleus, Surgery.

Abstract

Microelectrode recordings of single unit neuronal activity were used during stereotactic surgery to define the subthalamic nucleus for chronic deep brain stimulation in the treatment of Parkinson's disease. By using five parallel trajectories, often two to three microelectrodes allow us to recognize subthalamic nucleus (STN) neuronal activity. STN neurons were easily distinguished from cells of the overlying zona incerta and the underlying substantia nigra. During a typical exploratory track, we can observe a very low background noise in the zona incerta and almost complete absence of single cell recording. Penetration of the electrode tip into the STN is characterized by a sudden increase in background activity and single cell activity of spontaneously active neurons. The exit of electrode tip out of the STN corresponds to a decrease in background noise and a loss of single cell activity. Spontaneous neuronal activity increases again when the electrode tips enters the substantia nigra pars reticulata (SNr); however, the activity is less rich than in the STN, indicating a more cell-sparse nucleus. STN neurons are characterized by a mean firing rate of 42.30 ± 22.00 spikes/sec (mean ± SD). The STN cells exhibited irregular or bursty discharge pattern. The pattern of single cell activity in the SNr is a more regular tonic activity that can easily be distinguished from the bursting pattern in the STN. The most useful criteria to select a trajectory are (1) the length of an individual trajectory displaying typical STN activity, (2) the bursting pattern of activity, and (3) motor responses typical of the sensorimotor part of the nucleus. In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A15	`01`			`@1 Christian-Albrechts-Universität @2 Kiel @3 DEU @Z 1 aut. @Z 3 aut.`
A15	`02`			`@1 Centre hospitalier universitaire de Grenoble @2 Grenoble @3 FRA @Z 2 aut.`
A18	`01`	`1`		`@1 Movement Disorder Society. European Section @3 INC @9 patr.`
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C01	`01`		`ENG`	@0 Microelectrode recordings of single unit neuronal activity were used during stereotactic surgery to define the subthalamic nucleus for chronic deep brain stimulation in the treatment of Parkinson's disease. By using five parallel trajectories, often two to three microelectrodes allow us to recognize subthalamic nucleus (STN) neuronal activity. STN neurons were easily distinguished from cells of the overlying zona incerta and the underlying substantia nigra. During a typical exploratory track, we can observe a very low background noise in the zona incerta and almost complete absence of single cell recording. Penetration of the electrode tip into the STN is characterized by a sudden increase in background activity and single cell activity of spontaneously active neurons. The exit of electrode tip out of the STN corresponds to a decrease in background noise and a loss of single cell activity. Spontaneous neuronal activity increases again when the electrode tips enters the substantia nigra pars reticulata (SNr); however, the activity is less rich than in the STN, indicating a more cell-sparse nucleus. STN neurons are characterized by a mean firing rate of 42.30 ± 22.00 spikes/sec (mean ± SD). The STN cells exhibited irregular or bursty discharge pattern. The pattern of single cell activity in the SNr is a more regular tonic activity that can easily be distinguished from the bursting pattern in the STN. The most useful criteria to select a trajectory are (1) the length of an individual trajectory displaying typical STN activity, (2) the bursting pattern of activity, and (3) motor responses typical of the sensorimotor part of the nucleus. In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN.
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C03	`02`	`X`	`ENG`	`@0 Instrumental stimulation @5 04`
C03	`02`	`X`	`SPA`	`@0 Estimulación instrumental @5 04`
C03	`03`	`X`	`FRE`	`@0 Noyau sousthalamique @5 07`
C03	`03`	`X`	`ENG`	`@0 Subthalamic nucleus @5 07`
C03	`03`	`X`	`SPA`	`@0 Núcleo subtalámico @5 07`
C03	`04`	`X`	`FRE`	`@0 Microélectrode @5 10`
C03	`04`	`X`	`ENG`	`@0 Microelectrode @5 10`
C03	`04`	`X`	`SPA`	`@0 Microeléctrodo @5 10`
C03	`05`	`X`	`FRE`	`@0 Electrodiagnostic @5 13`
C03	`05`	`X`	`ENG`	`@0 Electrodiagnosis @5 13`
C03	`05`	`X`	`SPA`	`@0 Electrodiagnóstico @5 13`
C03	`06`	`X`	`FRE`	`@0 Chirurgie stéréotaxique @5 16`
C03	`06`	`X`	`ENG`	`@0 Stereotaxic surgery @5 16`
C03	`06`	`X`	`SPA`	`@0 Cirugía estereotáxica @5 16`
C03	`07`	`X`	`FRE`	`@0 Exploration @5 17`
C03	`07`	`X`	`ENG`	`@0 Exploration @5 17`
C03	`07`	`X`	`SPA`	`@0 Exploración @5 17`
C03	`08`	`X`	`FRE`	`@0 Peropératoire @5 18`
C03	`08`	`X`	`ENG`	`@0 Intraoperative @5 18`
C03	`08`	`X`	`SPA`	`@0 Peroperatorio @5 18`
C03	`09`	`X`	`FRE`	`@0 Homme @5 20`
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C07	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
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C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
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N21				`@1 175`
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A30	`01`	`1`	`ENG`	`@1 Management of Patients with Deep Brain Stimulators. Meeting @3 Kiel DEU @4 2001-06-03`

Format Inist (serveur)

NO :	PASCAL 02-0309290 INIST
ET :	Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease
AU :	BENAZZOUZ (Abdelhamid); BREIT (Sorin); KOUDSIE (Adnan); POLLAK (Pierre); KRACK (Paul); BENABID (Alim-Louis); DEUSCHL (Günther); KRACK (Paul); VOLKMANN (Jens)
AF :	Department of Clinical and Biological Neurosciences, Institut National de la Santé et de la Recherche Médicale U.318, University Hospital A. Michallon, Pavillon B/Grenoble/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Christian-Albrechts-Universität/Kie l/Allemagne (1 aut., 3 aut.); Centre hospitalier universitaire de Grenoble/Grenoble/France (2 aut.)
DT :	Publication en série; Congrès; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. SUP3; S145-S149; Bibl. 23 ref.
LA :	Anglais
EA :	Microelectrode recordings of single unit neuronal activity were used during stereotactic surgery to define the subthalamic nucleus for chronic deep brain stimulation in the treatment of Parkinson's disease. By using five parallel trajectories, often two to three microelectrodes allow us to recognize subthalamic nucleus (STN) neuronal activity. STN neurons were easily distinguished from cells of the overlying zona incerta and the underlying substantia nigra. During a typical exploratory track, we can observe a very low background noise in the zona incerta and almost complete absence of single cell recording. Penetration of the electrode tip into the STN is characterized by a sudden increase in background activity and single cell activity of spontaneously active neurons. The exit of electrode tip out of the STN corresponds to a decrease in background noise and a loss of single cell activity. Spontaneous neuronal activity increases again when the electrode tips enters the substantia nigra pars reticulata (SNr); however, the activity is less rich than in the STN, indicating a more cell-sparse nucleus. STN neurons are characterized by a mean firing rate of 42.30 ± 22.00 spikes/sec (mean ± SD). The STN cells exhibited irregular or bursty discharge pattern. The pattern of single cell activity in the SNr is a more regular tonic activity that can easily be distinguished from the bursting pattern in the STN. The most useful criteria to select a trajectory are (1) the length of an individual trajectory displaying typical STN activity, (2) the bursting pattern of activity, and (3) motor responses typical of the sensorimotor part of the nucleus. In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN.
CC :	002B17G
FD :	Parkinson maladie; Stimulation instrumentale; Noyau sousthalamique; Microélectrode; Electrodiagnostic; Chirurgie stéréotaxique; Exploration; Peropératoire; Homme; Chirurgie
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Traitement instrumental; Encéphale
ED :	Parkinson disease; Instrumental stimulation; Subthalamic nucleus; Microelectrode; Electrodiagnosis; Stereotaxic surgery; Exploration; Intraoperative; Human; Surgery
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Instrumentation therapy; Brain (vertebrata)
SD :	Parkinson enfermedad; Estimulación instrumental; Núcleo subtalámico; Microeléctrodo; Electrodiagnóstico; Cirugía estereotáxica; Exploración; Peroperatorio; Hombre; Cirugía
LO :	INIST-20953.354000100905390210
ID :	02-0309290

Links to Exploration step

Pascal:02-0309290

Le document en format XML

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<front><div type="abstract" xml:lang="en">Microelectrode recordings of single unit neuronal activity were used during stereotactic surgery to define the subthalamic nucleus for chronic deep brain stimulation in the treatment of Parkinson's disease. By using five parallel trajectories, often two to three microelectrodes allow us to recognize subthalamic nucleus (STN) neuronal activity. STN neurons were easily distinguished from cells of the overlying zona incerta and the underlying substantia nigra. During a typical exploratory track, we can observe a very low background noise in the zona incerta and almost complete absence of single cell recording. Penetration of the electrode tip into the STN is characterized by a sudden increase in background activity and single cell activity of spontaneously active neurons. The exit of electrode tip out of the STN corresponds to a decrease in background noise and a loss of single cell activity. Spontaneous neuronal activity increases again when the electrode tips enters the substantia nigra pars reticulata (SNr); however, the activity is less rich than in the STN, indicating a more cell-sparse nucleus. STN neurons are characterized by a mean firing rate of 42.30 ± 22.00 spikes/sec (mean ± SD). The STN cells exhibited irregular or bursty discharge pattern. The pattern of single cell activity in the SNr is a more regular tonic activity that can easily be distinguished from the bursting pattern in the STN. The most useful criteria to select a trajectory are (1) the length of an individual trajectory displaying typical STN activity, (2) the bursting pattern of activity, and (3) motor responses typical of the sensorimotor part of the nucleus. In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN.</div>
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<fA03 i2="1"><s0>Mov. disord.</s0>
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<fA05><s2>17</s2>
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<fA06><s3>SUP3</s3>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease</s1>
</fA08>
<fA09 i1="01" i2="1" l="ENG"><s1>Deep Brain Stimulation for Movement Disorders</s1>
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<fA11 i1="01" i2="1"><s1>BENAZZOUZ (Abdelhamid)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>BREIT (Sorin)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>KOUDSIE (Adnan)</s1>
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<fA11 i1="05" i2="1"><s1>KRACK (Paul)</s1>
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<fA12 i1="01" i2="1"><s1>DEUSCHL (Günther)</s1>
<s9>ed.</s9>
</fA12>
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<s9>ed.</s9>
</fA12>
<fA12 i1="03" i2="1"><s1>VOLKMANN (Jens)</s1>
<s9>ed.</s9>
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<fA14 i1="01"><s1>Department of Clinical and Biological Neurosciences, Institut National de la Santé et de la Recherche Médicale U.318, University Hospital A. Michallon, Pavillon B</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA15 i1="01"><s1>Christian-Albrechts-Universität</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</fA15>
<fA15 i1="02"><s1>Centre hospitalier universitaire de Grenoble</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
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<fA18 i1="01" i2="1"><s1>Movement Disorder Society. European Section</s1>
<s3>INC</s3>
<s9>patr.</s9>
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<fC01 i1="01" l="ENG"><s0>Microelectrode recordings of single unit neuronal activity were used during stereotactic surgery to define the subthalamic nucleus for chronic deep brain stimulation in the treatment of Parkinson's disease. By using five parallel trajectories, often two to three microelectrodes allow us to recognize subthalamic nucleus (STN) neuronal activity. STN neurons were easily distinguished from cells of the overlying zona incerta and the underlying substantia nigra. During a typical exploratory track, we can observe a very low background noise in the zona incerta and almost complete absence of single cell recording. Penetration of the electrode tip into the STN is characterized by a sudden increase in background activity and single cell activity of spontaneously active neurons. The exit of electrode tip out of the STN corresponds to a decrease in background noise and a loss of single cell activity. Spontaneous neuronal activity increases again when the electrode tips enters the substantia nigra pars reticulata (SNr); however, the activity is less rich than in the STN, indicating a more cell-sparse nucleus. STN neurons are characterized by a mean firing rate of 42.30 ± 22.00 spikes/sec (mean ± SD). The STN cells exhibited irregular or bursty discharge pattern. The pattern of single cell activity in the SNr is a more regular tonic activity that can easily be distinguished from the bursting pattern in the STN. The most useful criteria to select a trajectory are (1) the length of an individual trajectory displaying typical STN activity, (2) the bursting pattern of activity, and (3) motor responses typical of the sensorimotor part of the nucleus. In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN.</s0>
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</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>01</s5>
</fC03>
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<s5>01</s5>
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<s5>07</s5>
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<s5>07</s5>
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<s5>07</s5>
</fC03>
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<s5>10</s5>
</fC03>
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<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Microeléctrodo</s0>
<s5>10</s5>
</fC03>
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<s5>13</s5>
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<s5>13</s5>
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<s5>18</s5>
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<fC03 i1="08" i2="X" l="SPA"><s0>Peroperatorio</s0>
<s5>18</s5>
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<s5>20</s5>
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<fC03 i1="09" i2="X" l="SPA"><s0>Hombre</s0>
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<s5>23</s5>
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<s5>23</s5>
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<s5>37</s5>
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<s5>37</s5>
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<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
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<s5>39</s5>
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<s5>39</s5>
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<s5>40</s5>
</fC07>
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<s5>40</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
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<s5>41</s5>
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<s5>41</s5>
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<s5>45</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Tratamiento instrumental</s0>
<s5>45</s5>
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<fC07 i1="07" i2="X" l="FRE"><s0>Encéphale</s0>
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<s5>53</s5>
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<s5>53</s5>
</fC07>
<fN21><s1>175</s1>
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<pR><fA30 i1="01" i2="1" l="ENG"><s1>Management of Patients with Deep Brain Stimulators. Meeting</s1>
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<server><NO>PASCAL 02-0309290 INIST</NO>
<ET>Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease</ET>
<AU>BENAZZOUZ (Abdelhamid); BREIT (Sorin); KOUDSIE (Adnan); POLLAK (Pierre); KRACK (Paul); BENABID (Alim-Louis); DEUSCHL (Günther); KRACK (Paul); VOLKMANN (Jens)</AU>
<AF>Department of Clinical and Biological Neurosciences, Institut National de la Santé et de la Recherche Médicale U.318, University Hospital A. Michallon, Pavillon B/Grenoble/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Christian-Albrechts-Universität/Kie l/Allemagne (1 aut., 3 aut.); Centre hospitalier universitaire de Grenoble/Grenoble/France (2 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. SUP3; S145-S149; Bibl. 23 ref.</SO>
<LA>Anglais</LA>
<EA>Microelectrode recordings of single unit neuronal activity were used during stereotactic surgery to define the subthalamic nucleus for chronic deep brain stimulation in the treatment of Parkinson's disease. By using five parallel trajectories, often two to three microelectrodes allow us to recognize subthalamic nucleus (STN) neuronal activity. STN neurons were easily distinguished from cells of the overlying zona incerta and the underlying substantia nigra. During a typical exploratory track, we can observe a very low background noise in the zona incerta and almost complete absence of single cell recording. Penetration of the electrode tip into the STN is characterized by a sudden increase in background activity and single cell activity of spontaneously active neurons. The exit of electrode tip out of the STN corresponds to a decrease in background noise and a loss of single cell activity. Spontaneous neuronal activity increases again when the electrode tips enters the substantia nigra pars reticulata (SNr); however, the activity is less rich than in the STN, indicating a more cell-sparse nucleus. STN neurons are characterized by a mean firing rate of 42.30 ± 22.00 spikes/sec (mean ± SD). The STN cells exhibited irregular or bursty discharge pattern. The pattern of single cell activity in the SNr is a more regular tonic activity that can easily be distinguished from the bursting pattern in the STN. The most useful criteria to select a trajectory are (1) the length of an individual trajectory displaying typical STN activity, (2) the bursting pattern of activity, and (3) motor responses typical of the sensorimotor part of the nucleus. In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Stimulation instrumentale; Noyau sousthalamique; Microélectrode; Electrodiagnostic; Chirurgie stéréotaxique; Exploration; Peropératoire; Homme; Chirurgie</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Traitement instrumental; Encéphale</FG>
<ED>Parkinson disease; Instrumental stimulation; Subthalamic nucleus; Microelectrode; Electrodiagnosis; Stereotaxic surgery; Exploration; Intraoperative; Human; Surgery</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Instrumentation therapy; Brain (vertebrata)</EG>
<SD>Parkinson enfermedad; Estimulación instrumental; Núcleo subtalámico; Microeléctrodo; Electrodiagnóstico; Cirugía estereotáxica; Exploración; Peroperatorio; Hombre; Cirugía</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease

Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease

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