MovDisordV3, PascalFrancis, Corpus, bibRecord, 002774

Mechanisms of deep brain stimulation

Identifieur interne : 002774 ( PascalFrancis/Corpus ); précédent : 002773; suivant : 002775

Mechanisms of deep brain stimulation

Auteurs : Jonathan O. Dostrovsky ; Andres M. Lozano

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0313239

Descripteurs français

Pascal (Inist)
- Mouvement involontaire, Stimulation instrumentale, Electrique, Haute fréquence, Encéphale, GABA, Noyau gris central, Mécanisme action, Traitement, Homme.

English descriptors

KwdEn :
- Basal ganglion, Brain (vertebrata), Electric, GABA, High frequency, Human, Instrumental stimulation, Involuntary movement, Mechanism of action, Treatment.

Abstract

High frequency electrical stimulation by means of electrodes implanted into the brain (deep brain stimulation; DBS) recently has become an accepted technique for the treatment of several movement disorders and in particular for Parkinson's disease. Because the effects produced by DBS are similar to those produced by making a lesion in the same region, it has been proposed that the overall effect of DBS is to inhibit the neural activity in the region stimulated. However, whether this is actually the case is presently not known, but various mechanisms have been proposed in an attempt to explain how DBS could mimic the effects of a lesion. We describe the various mechanisms that have been proposed to account for the inhibition or disruption of the pathologic outflow by high-frequency DBS, ranging from depolarisation block to stimulation-evoked release of γ-aminobutyric acid and describes preliminary findings that show that stimulation within these structures can result in inhibition.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 17`
A06				`@3 SUP3`
A08	`01`	`1`	`ENG`	`@1 Mechanisms of deep brain stimulation`
A09	`01`	`1`	`ENG`	`@1 Deep Brain Stimulation for Movement Disorders`
A11	`01`	`1`		`@1 DOSTROVSKY (Jonathan O.)`
A11	`02`	`1`		`@1 LOZANO (Andres M.)`
A12	`01`	`1`		`@1 DEUSCHL (Günther) @9 ed.`
A12	`02`	`1`		`@1 KRACK (Paul) @9 ed.`
A12	`03`	`1`		`@1 VOLKMANN (Jens) @9 ed.`
A14	`01`			`@1 Department of Physiology and Division of Neurosurgery, University of Toronto @2 Toronto, Ontario @3 CAN @Z 1 aut.`
A14	`02`			`@1 Toronto Western Research Institute, University of Toronto @2 Toronto, Ontario @3 CAN @Z 1 aut. @Z 2 aut.`
A14	`03`			`@1 Department of Surgery, University of Toronto @2 Toronto, Ontario @3 CAN @Z 2 aut.`
A15	`01`			`@1 Christian-Albrechts-Universität @2 Kiel @3 DEU @Z 1 aut. @Z 3 aut.`
A15	`02`			`@1 Centre hospitalier universitaire de Grenoble @2 Grenoble @3 FRA @Z 2 aut.`
A18	`01`	`1`		`@1 Movement Disorder Society. European Section @3 INC @9 patr.`
A20				`@2 S63-S68`
A21				`@1 2002`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000100905390080`
A44				`@0 0000 @1 © 2002 INIST-CNRS. All rights reserved.`
A45				`@0 31 ref.`
A47	`01`	`1`		`@0 02-0313239`
A60				`@1 P @2 C`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 High frequency electrical stimulation by means of electrodes implanted into the brain (deep brain stimulation; DBS) recently has become an accepted technique for the treatment of several movement disorders and in particular for Parkinson's disease. Because the effects produced by DBS are similar to those produced by making a lesion in the same region, it has been proposed that the overall effect of DBS is to inhibit the neural activity in the region stimulated. However, whether this is actually the case is presently not known, but various mechanisms have been proposed in an attempt to explain how DBS could mimic the effects of a lesion. We describe the various mechanisms that have been proposed to account for the inhibition or disruption of the pathologic outflow by high-frequency DBS, ranging from depolarisation block to stimulation-evoked release of γ-aminobutyric acid and describes preliminary findings that show that stimulation within these structures can result in inhibition.
C02	`01`	`X`		`@0 002B17A01`
C03	`01`	`X`	`FRE`	`@0 Mouvement involontaire @5 01`
C03	`01`	`X`	`ENG`	`@0 Involuntary movement @5 01`
C03	`01`	`X`	`SPA`	`@0 Movimiento involuntario @5 01`
C03	`02`	`X`	`FRE`	`@0 Stimulation instrumentale @5 04`
C03	`02`	`X`	`ENG`	`@0 Instrumental stimulation @5 04`
C03	`02`	`X`	`SPA`	`@0 Estimulación instrumental @5 04`
C03	`03`	`X`	`FRE`	`@0 Electrique @5 05`
C03	`03`	`X`	`ENG`	`@0 Electric @5 05`
C03	`03`	`X`	`SPA`	`@0 Eléctrico @5 05`
C03	`04`	`X`	`FRE`	`@0 Haute fréquence @5 06`
C03	`04`	`X`	`ENG`	`@0 High frequency @5 06`
C03	`04`	`X`	`SPA`	`@0 Alta frecuencia @5 06`
C03	`05`	`X`	`FRE`	`@0 Encéphale @5 07`
C03	`05`	`X`	`ENG`	`@0 Brain (vertebrata) @5 07`
C03	`05`	`X`	`SPA`	`@0 Encéfalo @5 07`
C03	`06`	`X`	`FRE`	`@0 GABA @2 NK @5 10`
C03	`06`	`X`	`ENG`	`@0 GABA @2 NK @5 10`
C03	`06`	`X`	`SPA`	`@0 GABA @2 NK @5 10`
C03	`07`	`X`	`FRE`	`@0 Noyau gris central @5 13`
C03	`07`	`X`	`ENG`	`@0 Basal ganglion @5 13`
C03	`07`	`X`	`SPA`	`@0 Núcleo basal @5 13`
C03	`08`	`X`	`FRE`	`@0 Mécanisme action @5 17`
C03	`08`	`X`	`ENG`	`@0 Mechanism of action @5 17`
C03	`08`	`X`	`SPA`	`@0 Mecanismo acción @5 17`
C03	`09`	`X`	`FRE`	`@0 Traitement @5 18`
C03	`09`	`X`	`ENG`	`@0 Treatment @5 18`
C03	`09`	`X`	`SPA`	`@0 Tratamiento @5 18`
C03	`10`	`X`	`FRE`	`@0 Homme @5 20`
C03	`10`	`X`	`ENG`	`@0 Human @5 20`
C03	`10`	`X`	`SPA`	`@0 Hombre @5 20`
C07	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 37`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Trouble neurologique @5 38`
C07	`02`	`X`	`ENG`	`@0 Neurological disorder @5 38`
C07	`02`	`X`	`SPA`	`@0 Trastorno neurológico @5 38`
C07	`03`	`X`	`FRE`	`@0 Traitement instrumental @5 45`
C07	`03`	`X`	`ENG`	`@0 Instrumentation therapy @5 45`
C07	`03`	`X`	`SPA`	`@0 Tratamiento instrumental @5 45`
C07	`04`	`X`	`FRE`	`@0 Système nerveux central @5 53`
C07	`04`	`X`	`ENG`	`@0 Central nervous system @5 53`
C07	`04`	`X`	`SPA`	`@0 Sistema nervioso central @5 53`
N21				`@1 175`
N82				`@1 PSI`

A30	`01`	`1`	`ENG`	`@1 Management of Patients with Deep Brain Stimulators. Meeting @3 Kiel DEU @4 2001-06-03`

Format Inist (serveur)

NO :	PASCAL 02-0313239 INIST
ET :	Mechanisms of deep brain stimulation
AU :	DOSTROVSKY (Jonathan O.); LOZANO (Andres M.); DEUSCHL (Günther); KRACK (Paul); VOLKMANN (Jens)
AF :	Department of Physiology and Division of Neurosurgery, University of Toronto/Toronto, Ontario/Canada (1 aut.); Toronto Western Research Institute, University of Toronto/Toronto, Ontario/Canada (1 aut., 2 aut.); Department of Surgery, University of Toronto/Toronto, Ontario/Canada (2 aut.); Christian-Albrechts-Universität/Kiel/Alle magne (1 aut., 3 aut.); Centre hospitalier universitaire de Grenoble/Grenoble/France (2 aut.)
DT :	Publication en série; Congrès; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. SUP3; S63-S68; Bibl. 31 ref.
LA :	Anglais
EA :	High frequency electrical stimulation by means of electrodes implanted into the brain (deep brain stimulation; DBS) recently has become an accepted technique for the treatment of several movement disorders and in particular for Parkinson's disease. Because the effects produced by DBS are similar to those produced by making a lesion in the same region, it has been proposed that the overall effect of DBS is to inhibit the neural activity in the region stimulated. However, whether this is actually the case is presently not known, but various mechanisms have been proposed in an attempt to explain how DBS could mimic the effects of a lesion. We describe the various mechanisms that have been proposed to account for the inhibition or disruption of the pathologic outflow by high-frequency DBS, ranging from depolarisation block to stimulation-evoked release of γ-aminobutyric acid and describes preliminary findings that show that stimulation within these structures can result in inhibition.
CC :	002B17A01
FD :	Mouvement involontaire; Stimulation instrumentale; Electrique; Haute fréquence; Encéphale; GABA; Noyau gris central; Mécanisme action; Traitement; Homme
FG :	Système nerveux pathologie; Trouble neurologique; Traitement instrumental; Système nerveux central
ED :	Involuntary movement; Instrumental stimulation; Electric; High frequency; Brain (vertebrata); GABA; Basal ganglion; Mechanism of action; Treatment; Human
EG :	Nervous system diseases; Neurological disorder; Instrumentation therapy; Central nervous system
SD :	Movimiento involuntario; Estimulación instrumental; Eléctrico; Alta frecuencia; Encéfalo; GABA; Núcleo basal; Mecanismo acción; Tratamiento; Hombre
LO :	INIST-20953.354000100905390080
ID :	02-0313239

Links to Exploration step

Pascal:02-0313239

Le document en format XML

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<front><div type="abstract" xml:lang="en">High frequency electrical stimulation by means of electrodes implanted into the brain (deep brain stimulation; DBS) recently has become an accepted technique for the treatment of several movement disorders and in particular for Parkinson's disease. Because the effects produced by DBS are similar to those produced by making a lesion in the same region, it has been proposed that the overall effect of DBS is to inhibit the neural activity in the region stimulated. However, whether this is actually the case is presently not known, but various mechanisms have been proposed in an attempt to explain how DBS could mimic the effects of a lesion. We describe the various mechanisms that have been proposed to account for the inhibition or disruption of the pathologic outflow by high-frequency DBS, ranging from depolarisation block to stimulation-evoked release of γ-aminobutyric acid and describes preliminary findings that show that stimulation within these structures can result in inhibition.</div>
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<fC01 i1="01" l="ENG"><s0>High frequency electrical stimulation by means of electrodes implanted into the brain (deep brain stimulation; DBS) recently has become an accepted technique for the treatment of several movement disorders and in particular for Parkinson's disease. Because the effects produced by DBS are similar to those produced by making a lesion in the same region, it has been proposed that the overall effect of DBS is to inhibit the neural activity in the region stimulated. However, whether this is actually the case is presently not known, but various mechanisms have been proposed in an attempt to explain how DBS could mimic the effects of a lesion. We describe the various mechanisms that have been proposed to account for the inhibition or disruption of the pathologic outflow by high-frequency DBS, ranging from depolarisation block to stimulation-evoked release of γ-aminobutyric acid and describes preliminary findings that show that stimulation within these structures can result in inhibition.</s0>
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<s5>20</s5>
</fC03>
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<s5>37</s5>
</fC07>
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<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
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<s5>38</s5>
</fC07>
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<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Traitement instrumental</s0>
<s5>45</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Instrumentation therapy</s0>
<s5>45</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Tratamiento instrumental</s0>
<s5>45</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>53</s5>
</fC07>
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<s5>53</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>53</s5>
</fC07>
<fN21><s1>175</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
<pR><fA30 i1="01" i2="1" l="ENG"><s1>Management of Patients with Deep Brain Stimulators. Meeting</s1>
<s3>Kiel DEU</s3>
<s4>2001-06-03</s4>
</fA30>
</pR>
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<server><NO>PASCAL 02-0313239 INIST</NO>
<ET>Mechanisms of deep brain stimulation</ET>
<AU>DOSTROVSKY (Jonathan O.); LOZANO (Andres M.); DEUSCHL (Günther); KRACK (Paul); VOLKMANN (Jens)</AU>
<AF>Department of Physiology and Division of Neurosurgery, University of Toronto/Toronto, Ontario/Canada (1 aut.); Toronto Western Research Institute, University of Toronto/Toronto, Ontario/Canada (1 aut., 2 aut.); Department of Surgery, University of Toronto/Toronto, Ontario/Canada (2 aut.); Christian-Albrechts-Universität/Kiel/Alle magne (1 aut., 3 aut.); Centre hospitalier universitaire de Grenoble/Grenoble/France (2 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. SUP3; S63-S68; Bibl. 31 ref.</SO>
<LA>Anglais</LA>
<EA>High frequency electrical stimulation by means of electrodes implanted into the brain (deep brain stimulation; DBS) recently has become an accepted technique for the treatment of several movement disorders and in particular for Parkinson's disease. Because the effects produced by DBS are similar to those produced by making a lesion in the same region, it has been proposed that the overall effect of DBS is to inhibit the neural activity in the region stimulated. However, whether this is actually the case is presently not known, but various mechanisms have been proposed in an attempt to explain how DBS could mimic the effects of a lesion. We describe the various mechanisms that have been proposed to account for the inhibition or disruption of the pathologic outflow by high-frequency DBS, ranging from depolarisation block to stimulation-evoked release of γ-aminobutyric acid and describes preliminary findings that show that stimulation within these structures can result in inhibition.</EA>
<CC>002B17A01</CC>
<FD>Mouvement involontaire; Stimulation instrumentale; Electrique; Haute fréquence; Encéphale; GABA; Noyau gris central; Mécanisme action; Traitement; Homme</FD>
<FG>Système nerveux pathologie; Trouble neurologique; Traitement instrumental; Système nerveux central</FG>
<ED>Involuntary movement; Instrumental stimulation; Electric; High frequency; Brain (vertebrata); GABA; Basal ganglion; Mechanism of action; Treatment; Human</ED>
<EG>Nervous system diseases; Neurological disorder; Instrumentation therapy; Central nervous system</EG>
<SD>Movimiento involuntario; Estimulación instrumental; Eléctrico; Alta frecuencia; Encéfalo; GABA; Núcleo basal; Mecanismo acción; Tratamiento; Hombre</SD>
<LO>INIST-20953.354000100905390080</LO>
<ID>02-0313239</ID>
</server>
</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Mechanisms of deep brain stimulation

Mechanisms of deep brain stimulation

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