MovDisordV3, PascalFrancis, Corpus, bibRecord, 002761

Do risk factors for Alzheimer's Disease predict dementia in Parkinson's disease? An exploratory study

Identifieur interne : 002761 ( PascalFrancis/Corpus ); précédent : 002760; suivant : 002762

Do risk factors for Alzheimer's Disease predict dementia in Parkinson's disease? An exploratory study

Auteurs : Gilberto Levy ; Ming-Xin Tang ; Lucien J. Cote ; Elan D. Louis ; Brenda Alfaro ; Helen Mejia ; Yaakov Stern ; Karen Marder

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0315697

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Démence, Tabagisme, Traumatisme, Crânioencéphalique, Hypertension artérielle, Diabète, Epidémiologie, Facteur risque, Evolution, Homme, Métabolisme pathologie, Endocrinopathie, Etude cohorte.

English descriptors

KwdEn :
- Cohort study, Craniocerebral, Dementia, Diabetes mellitus, Endocrinopathy, Epidemiology, Evolution, Human, Hypertension, Metabolic diseases, Parkinson disease, Risk factor, Tobacco smoking, Trauma.

Abstract

The extent to which concomitant Alzheimer's disease (AD) is etiologically related to the development of dementia in Parkinson's disease (PD) remains controversial. We explored the association of four risk factors associated with AD, including head injury, smoking, hypertension, and diabetes mellitus, with incident dementia in PD. A cohort of 180 nondemented PD patients from the Washington Heights community in northern Manhattan, New York, completed a risk factor questionnaire at baseline and was followed annually with neurological and neuropsychological evaluations. The association of baseline variables with incident dementia was analyzed by using Cox proportional hazards models. All analyses controlled for age at baseline, gender, years of education, duration of PD, and total Unified Parkinson's Disease Rating Scale (UPDRS) motor score at baseline. Of 180 patients (mean age, 71.0 ± 10.3 years), 52 (29%) became demented during a mean follow-up period of 3.6 ± 2.2 years. Head injury risk ratio ([RR] 0.9; 95% confidence interval [CI], 0.4-2.2; P = 0.9), hypertension (RR, 0.7; 95% CI, 0.4-1.4, P = 0.3), and diabetes mellitus (RR, 0.8; 95% CI, 0.3-2.3; P = 0.7) were not significantly associated with incident dementia in the Cox models. Patients who reported having ever smoked were at increased risk for the development of dementia compared with non;makers (RR, 2.0; 95% CI, 1.0-3.9; P = 0.05). Current smoking was significantly associated with incident dementia (RR, 4.5; 95% CI, 1.2-16.4; P = 0.02), whereas past smoking approached significance (RR, 1.9; 95% CI, 0.9-3.7; P = 0.07). Although an inverse association between smoking and PD has been reported in several studies, our study showed a positive association between smoking and dementia in the setting of PD. The association of smoking with incident dementia in PD deserves further study.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 02-0315697 INIST
ET :	Do risk factors for Alzheimer's Disease predict dementia in Parkinson's disease? An exploratory study
AU :	LEVY (Gilberto); TANG (Ming-Xin); COTE (Lucien J.); LOUIS (Elan D.); ALFARO (Brenda); MEJIA (Helen); STERN (Yaakov); MARDER (Karen)
AF :	Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Division of Biostatistics, School of Public Health, Columbia University/New York, New York/Etats-Unis (2 aut.); The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University/New York, New York/Etats-Unis (2 aut., 7 aut., 8 aut.); Department of Neurology, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Department of Psychiatry, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 2; Pp. 250-257; Bibl. 59 ref.
LA :	Anglais
EA :	The extent to which concomitant Alzheimer's disease (AD) is etiologically related to the development of dementia in Parkinson's disease (PD) remains controversial. We explored the association of four risk factors associated with AD, including head injury, smoking, hypertension, and diabetes mellitus, with incident dementia in PD. A cohort of 180 nondemented PD patients from the Washington Heights community in northern Manhattan, New York, completed a risk factor questionnaire at baseline and was followed annually with neurological and neuropsychological evaluations. The association of baseline variables with incident dementia was analyzed by using Cox proportional hazards models. All analyses controlled for age at baseline, gender, years of education, duration of PD, and total Unified Parkinson's Disease Rating Scale (UPDRS) motor score at baseline. Of 180 patients (mean age, 71.0 ± 10.3 years), 52 (29%) became demented during a mean follow-up period of 3.6 ± 2.2 years. Head injury risk ratio ([RR] 0.9; 95% confidence interval [CI], 0.4-2.2; P = 0.9), hypertension (RR, 0.7; 95% CI, 0.4-1.4, P = 0.3), and diabetes mellitus (RR, 0.8; 95% CI, 0.3-2.3; P = 0.7) were not significantly associated with incident dementia in the Cox models. Patients who reported having ever smoked were at increased risk for the development of dementia compared with non;makers (RR, 2.0; 95% CI, 1.0-3.9; P = 0.05). Current smoking was significantly associated with incident dementia (RR, 4.5; 95% CI, 1.2-16.4; P = 0.02), whereas past smoking approached significance (RR, 1.9; 95% CI, 0.9-3.7; P = 0.07). Although an inverse association between smoking and PD has been reported in several studies, our study showed a positive association between smoking and dementia in the setting of PD. The association of smoking with incident dementia in PD deserves further study.
CC :	002B17G
FD :	Parkinson maladie; Démence; Tabagisme; Traumatisme; Crânioencéphalique; Hypertension artérielle; Diabète; Epidémiologie; Facteur risque; Evolution; Homme; Métabolisme pathologie; Endocrinopathie; Etude cohorte
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système ostéoarticulaire pathologie; Crâne pathologie; Appareil circulatoire pathologie
ED :	Parkinson disease; Dementia; Tobacco smoking; Trauma; Craniocerebral; Hypertension; Diabetes mellitus; Epidemiology; Risk factor; Evolution; Human; Metabolic diseases; Endocrinopathy; Cohort study
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Diseases of the osteoarticular system; Skull disease; Cardiovascular disease
SD :	Parkinson enfermedad; Demencia; Tabaquismo; Traumatismo; Craneoencefálico; Hipertensión arterial; Diabetes; Epidemiología; Factor riesgo; Evolución; Hombre; Metabolismo patología; Endocrinopatía; Estudio cohorte
LO :	INIST-20953.354000100907450040
ID :	02-0315697

Links to Exploration step

Pascal:02-0315697

Le document en format XML

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<affiliation><inist:fA14 i1="04"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Do risk factors for Alzheimer's Disease predict dementia in Parkinson's disease? An exploratory study</title>
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<author><name sortKey="Tang, Ming Xin" sort="Tang, Ming Xin" uniqKey="Tang M" first="Ming-Xin" last="Tang">Ming-Xin Tang</name>
<affiliation><inist:fA14 i1="01"><s1>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1>
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<affiliation><inist:fA14 i1="02"><s1>Division of Biostatistics, School of Public Health, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University</s1>
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<author><name sortKey="Cote, Lucien J" sort="Cote, Lucien J" uniqKey="Cote L" first="Lucien J." last="Cote">Lucien J. Cote</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
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<author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name>
<affiliation><inist:fA14 i1="01"><s1>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1>
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<affiliation><inist:fA14 i1="04"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1>
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<author><name sortKey="Alfaro, Brenda" sort="Alfaro, Brenda" uniqKey="Alfaro B" first="Brenda" last="Alfaro">Brenda Alfaro</name>
<affiliation><inist:fA14 i1="01"><s1>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
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<affiliation><inist:fA14 i1="04"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1>
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<author><name sortKey="Mejia, Helen" sort="Mejia, Helen" uniqKey="Mejia H" first="Helen" last="Mejia">Helen Mejia</name>
<affiliation><inist:fA14 i1="01"><s1>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
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<affiliation><inist:fA14 i1="04"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1>
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<author><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name>
<affiliation><inist:fA14 i1="01"><s1>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
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<sZ>1 aut.</sZ>
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<affiliation><inist:fA14 i1="03"><s1>The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<affiliation><inist:fA14 i1="04"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<sZ>7 aut.</sZ>
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<affiliation><inist:fA14 i1="05"><s1>Department of Psychiatry, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name>
<affiliation><inist:fA14 i1="01"><s1>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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<affiliation><inist:fA14 i1="03"><s1>The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cohort study</term>
<term>Craniocerebral</term>
<term>Dementia</term>
<term>Diabetes mellitus</term>
<term>Endocrinopathy</term>
<term>Epidemiology</term>
<term>Evolution</term>
<term>Human</term>
<term>Hypertension</term>
<term>Metabolic diseases</term>
<term>Parkinson disease</term>
<term>Risk factor</term>
<term>Tobacco smoking</term>
<term>Trauma</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Démence</term>
<term>Tabagisme</term>
<term>Traumatisme</term>
<term>Crânioencéphalique</term>
<term>Hypertension artérielle</term>
<term>Diabète</term>
<term>Epidémiologie</term>
<term>Facteur risque</term>
<term>Evolution</term>
<term>Homme</term>
<term>Métabolisme pathologie</term>
<term>Endocrinopathie</term>
<term>Etude cohorte</term>
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<front><div type="abstract" xml:lang="en">The extent to which concomitant Alzheimer's disease (AD) is etiologically related to the development of dementia in Parkinson's disease (PD) remains controversial. We explored the association of four risk factors associated with AD, including head injury, smoking, hypertension, and diabetes mellitus, with incident dementia in PD. A cohort of 180 nondemented PD patients from the Washington Heights community in northern Manhattan, New York, completed a risk factor questionnaire at baseline and was followed annually with neurological and neuropsychological evaluations. The association of baseline variables with incident dementia was analyzed by using Cox proportional hazards models. All analyses controlled for age at baseline, gender, years of education, duration of PD, and total Unified Parkinson's Disease Rating Scale (UPDRS) motor score at baseline. Of 180 patients (mean age, 71.0 ± 10.3 years), 52 (29%) became demented during a mean follow-up period of 3.6 ± 2.2 years. Head injury risk ratio ([RR] 0.9; 95% confidence interval [CI], 0.4-2.2; P = 0.9), hypertension (RR, 0.7; 95% CI, 0.4-1.4, P = 0.3), and diabetes mellitus (RR, 0.8; 95% CI, 0.3-2.3; P = 0.7) were not significantly associated with incident dementia in the Cox models. Patients who reported having ever smoked were at increased risk for the development of dementia compared with non;makers (RR, 2.0; 95% CI, 1.0-3.9; P = 0.05). Current smoking was significantly associated with incident dementia (RR, 4.5; 95% CI, 1.2-16.4; P = 0.02), whereas past smoking approached significance (RR, 1.9; 95% CI, 0.9-3.7; P = 0.07). Although an inverse association between smoking and PD has been reported in several studies, our study showed a positive association between smoking and dementia in the setting of PD. The association of smoking with incident dementia in PD deserves further study.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Do risk factors for Alzheimer's Disease predict dementia in Parkinson's disease? An exploratory study</s1>
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<sZ>7 aut.</sZ>
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<fA14 i1="02"><s1>Division of Biostatistics, School of Public Health, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University</s1>
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<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<fA14 i1="04"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
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<sZ>4 aut.</sZ>
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<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Psychiatry, College of Physicians and Surgeons, Columbia University</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
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<fC01 i1="01" l="ENG"><s0>The extent to which concomitant Alzheimer's disease (AD) is etiologically related to the development of dementia in Parkinson's disease (PD) remains controversial. We explored the association of four risk factors associated with AD, including head injury, smoking, hypertension, and diabetes mellitus, with incident dementia in PD. A cohort of 180 nondemented PD patients from the Washington Heights community in northern Manhattan, New York, completed a risk factor questionnaire at baseline and was followed annually with neurological and neuropsychological evaluations. The association of baseline variables with incident dementia was analyzed by using Cox proportional hazards models. All analyses controlled for age at baseline, gender, years of education, duration of PD, and total Unified Parkinson's Disease Rating Scale (UPDRS) motor score at baseline. Of 180 patients (mean age, 71.0 ± 10.3 years), 52 (29%) became demented during a mean follow-up period of 3.6 ± 2.2 years. Head injury risk ratio ([RR] 0.9; 95% confidence interval [CI], 0.4-2.2; P = 0.9), hypertension (RR, 0.7; 95% CI, 0.4-1.4, P = 0.3), and diabetes mellitus (RR, 0.8; 95% CI, 0.3-2.3; P = 0.7) were not significantly associated with incident dementia in the Cox models. Patients who reported having ever smoked were at increased risk for the development of dementia compared with non;makers (RR, 2.0; 95% CI, 1.0-3.9; P = 0.05). Current smoking was significantly associated with incident dementia (RR, 4.5; 95% CI, 1.2-16.4; P = 0.02), whereas past smoking approached significance (RR, 1.9; 95% CI, 0.9-3.7; P = 0.07). Although an inverse association between smoking and PD has been reported in several studies, our study showed a positive association between smoking and dementia in the setting of PD. The association of smoking with incident dementia in PD deserves further study.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17G</s0>
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<s5>01</s5>
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<s5>04</s5>
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<s5>04</s5>
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<fC03 i1="03" i2="X" l="FRE"><s0>Tabagisme</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Tobacco smoking</s0>
<s5>07</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Tabaquismo</s0>
<s5>07</s5>
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<s5>10</s5>
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<s5>10</s5>
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<s5>10</s5>
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<s5>11</s5>
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<s5>13</s5>
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<s5>13</s5>
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<s5>13</s5>
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<s5>16</s5>
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<s5>16</s5>
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<s5>16</s5>
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<s5>17</s5>
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<s5>17</s5>
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<s5>18</s5>
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<s5>18</s5>
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<fC03 i1="09" i2="X" l="SPA"><s0>Factor riesgo</s0>
<s5>18</s5>
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<fC03 i1="10" i2="X" l="FRE"><s0>Evolution</s0>
<s5>19</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Evolution</s0>
<s5>19</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Evolución</s0>
<s5>19</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Homme</s0>
<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Human</s0>
<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Hombre</s0>
<s5>20</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Métabolisme pathologie</s0>
<s5>23</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Metabolic diseases</s0>
<s5>23</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Metabolismo patología</s0>
<s5>23</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Endocrinopathie</s0>
<s5>24</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Endocrinopathy</s0>
<s5>24</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Endocrinopatía</s0>
<s5>24</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Etude cohorte</s0>
<s5>35</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Cohort study</s0>
<s5>35</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Estudio cohorte</s0>
<s5>35</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système ostéoarticulaire pathologie</s0>
<s5>64</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Diseases of the osteoarticular system</s0>
<s5>64</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema osteoarticular patología</s0>
<s5>64</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Crâne pathologie</s0>
<s5>65</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Skull disease</s0>
<s5>65</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Cráneo patología</s0>
<s5>65</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Appareil circulatoire pathologie</s0>
<s5>69</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>69</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>69</s5>
</fC07>
<fN21><s1>175</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
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<server><NO>PASCAL 02-0315697 INIST</NO>
<ET>Do risk factors for Alzheimer's Disease predict dementia in Parkinson's disease? An exploratory study</ET>
<AU>LEVY (Gilberto); TANG (Ming-Xin); COTE (Lucien J.); LOUIS (Elan D.); ALFARO (Brenda); MEJIA (Helen); STERN (Yaakov); MARDER (Karen)</AU>
<AF>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (1 aut., 2 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Division of Biostatistics, School of Public Health, Columbia University/New York, New York/Etats-Unis (2 aut.); The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University/New York, New York/Etats-Unis (2 aut., 7 aut., 8 aut.); Department of Neurology, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.); Department of Psychiatry, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 2; Pp. 250-257; Bibl. 59 ref.</SO>
<LA>Anglais</LA>
<EA>The extent to which concomitant Alzheimer's disease (AD) is etiologically related to the development of dementia in Parkinson's disease (PD) remains controversial. We explored the association of four risk factors associated with AD, including head injury, smoking, hypertension, and diabetes mellitus, with incident dementia in PD. A cohort of 180 nondemented PD patients from the Washington Heights community in northern Manhattan, New York, completed a risk factor questionnaire at baseline and was followed annually with neurological and neuropsychological evaluations. The association of baseline variables with incident dementia was analyzed by using Cox proportional hazards models. All analyses controlled for age at baseline, gender, years of education, duration of PD, and total Unified Parkinson's Disease Rating Scale (UPDRS) motor score at baseline. Of 180 patients (mean age, 71.0 ± 10.3 years), 52 (29%) became demented during a mean follow-up period of 3.6 ± 2.2 years. Head injury risk ratio ([RR] 0.9; 95% confidence interval [CI], 0.4-2.2; P = 0.9), hypertension (RR, 0.7; 95% CI, 0.4-1.4, P = 0.3), and diabetes mellitus (RR, 0.8; 95% CI, 0.3-2.3; P = 0.7) were not significantly associated with incident dementia in the Cox models. Patients who reported having ever smoked were at increased risk for the development of dementia compared with non;makers (RR, 2.0; 95% CI, 1.0-3.9; P = 0.05). Current smoking was significantly associated with incident dementia (RR, 4.5; 95% CI, 1.2-16.4; P = 0.02), whereas past smoking approached significance (RR, 1.9; 95% CI, 0.9-3.7; P = 0.07). Although an inverse association between smoking and PD has been reported in several studies, our study showed a positive association between smoking and dementia in the setting of PD. The association of smoking with incident dementia in PD deserves further study.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Démence; Tabagisme; Traumatisme; Crânioencéphalique; Hypertension artérielle; Diabète; Epidémiologie; Facteur risque; Evolution; Homme; Métabolisme pathologie; Endocrinopathie; Etude cohorte</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système ostéoarticulaire pathologie; Crâne pathologie; Appareil circulatoire pathologie</FG>
<ED>Parkinson disease; Dementia; Tobacco smoking; Trauma; Craniocerebral; Hypertension; Diabetes mellitus; Epidemiology; Risk factor; Evolution; Human; Metabolic diseases; Endocrinopathy; Cohort study</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Diseases of the osteoarticular system; Skull disease; Cardiovascular disease</EG>
<SD>Parkinson enfermedad; Demencia; Tabaquismo; Traumatismo; Craneoencefálico; Hipertensión arterial; Diabetes; Epidemiología; Factor riesgo; Evolución; Hombre; Metabolismo patología; Endocrinopatía; Estudio cohorte</SD>
<LO>INIST-20953.354000100907450040</LO>
<ID>02-0315697</ID>
</server>
</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Do risk factors for Alzheimer's Disease predict dementia in Parkinson's disease? An exploratory study

Do risk factors for Alzheimer's Disease predict dementia in Parkinson's disease? An exploratory study

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