Effects of apomorphine on flexor reflex and periodic limb movement
Identifieur interne : 002729 ( PascalFrancis/Corpus ); précédent : 002728; suivant : 002730Effects of apomorphine on flexor reflex and periodic limb movement
Auteurs : Guillermo Paradiso ; Farooq Khan ; Robert ChenSource :
- Movement disorders [ 0885-3185 ] ; 2002.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
It has been suggested that periodic leg movements (PLM) and spinal flexor reflex (FR) share common mechanisms Although dopaminergic agents improve PLM in humans and strongly influence spinal FR circuitry in animal studies, its effects on FR have not been documented in humans. We describe a 65-year-old man with PLM after overnight withdrawal of dopaminergic agents. The electromyographic pattern of spontaneous PLM closely resembled that of the FR elicited by medial plantar nerve stimulation. Thirty minutes after subcutaneous injection of apomorphine, both PLM and FR were completely abolished. These findings demonstrate that dopaminergic agents can suppress exaggerated FR in humans, and support the hypothesis of common mechanisms for PLM and FR.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 02-0369774 INIST |
---|---|
ET : | Effects of apomorphine on flexor reflex and periodic limb movement |
AU : | PARADISO (Guillermo); KHAN (Farooq); CHEN (Robert) |
AF : | Division of Neurology, Toronto Western Hospital and The Toronto Western Research Institute, University Health Network, University of Toronto/Toronto, Ontario/Canada (1 aut., 2 aut., 3 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 3; Pp. 594-597; Bibl. 12 ref. |
LA : | Anglais |
EA : | It has been suggested that periodic leg movements (PLM) and spinal flexor reflex (FR) share common mechanisms Although dopaminergic agents improve PLM in humans and strongly influence spinal FR circuitry in animal studies, its effects on FR have not been documented in humans. We describe a 65-year-old man with PLM after overnight withdrawal of dopaminergic agents. The electromyographic pattern of spontaneous PLM closely resembled that of the FR elicited by medial plantar nerve stimulation. Thirty minutes after subcutaneous injection of apomorphine, both PLM and FR were completely abolished. These findings demonstrate that dopaminergic agents can suppress exaggerated FR in humans, and support the hypothesis of common mechanisms for PLM and FR. |
CC : | 002B17A01 |
FD : | Mouvement périodique; Membre inférieur; Impatience membre inférieur syndrome; Réflexe; Muscle fléchisseur; Apomorphine; Agoniste; Récepteur dopaminergique; Electromyographie; Stimulant dopaminergique; Pathogénie; Effet biologique; Etude cas; Personne âgée; Mâle |
FG : | Homme; Système nerveux pathologie; Trouble neurologique; Trouble sensibilité; Electrodiagnostic |
ED : | Periodic motion; Lower limb; Restless legs syndrome; Reflex; Flexor muscle; Agonist; Dopamine receptor; Electromyography; Dopamine agonist; Pathogenesis; Biological effect; Case study; Elderly; Male |
EG : | Human; Nervous system diseases; Neurological disorder; Sensitivity disorder; Electrodiagnosis |
SD : | Movimiento periódico; Miembro inferior; Acroparestesia nocturna; Reflejo; Músculo flexor; Agonista; Receptor dopaminérgico; Electromiografía; Estimulante dopaminérgico; Patogenia; Efecto biológico; Estudio caso; Anciano; Macho |
LO : | INIST-20953.354000108224770260 |
ID : | 02-0369774 |
Links to Exploration step
Pascal:02-0369774Le document en format XML
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<front><div type="abstract" xml:lang="en">It has been suggested that periodic leg movements (PLM) and spinal flexor reflex (FR) share common mechanisms Although dopaminergic agents improve PLM in humans and strongly influence spinal FR circuitry in animal studies, its effects on FR have not been documented in humans. We describe a 65-year-old man with PLM after overnight withdrawal of dopaminergic agents. The electromyographic pattern of spontaneous PLM closely resembled that of the FR elicited by medial plantar nerve stimulation. Thirty minutes after subcutaneous injection of apomorphine, both PLM and FR were completely abolished. These findings demonstrate that dopaminergic agents can suppress exaggerated FR in humans, and support the hypothesis of common mechanisms for PLM and FR.</div>
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<server><NO>PASCAL 02-0369774 INIST</NO>
<ET>Effects of apomorphine on flexor reflex and periodic limb movement</ET>
<AU>PARADISO (Guillermo); KHAN (Farooq); CHEN (Robert)</AU>
<AF>Division of Neurology, Toronto Western Hospital and The Toronto Western Research Institute, University Health Network, University of Toronto/Toronto, Ontario/Canada (1 aut., 2 aut., 3 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 3; Pp. 594-597; Bibl. 12 ref.</SO>
<LA>Anglais</LA>
<EA>It has been suggested that periodic leg movements (PLM) and spinal flexor reflex (FR) share common mechanisms Although dopaminergic agents improve PLM in humans and strongly influence spinal FR circuitry in animal studies, its effects on FR have not been documented in humans. We describe a 65-year-old man with PLM after overnight withdrawal of dopaminergic agents. The electromyographic pattern of spontaneous PLM closely resembled that of the FR elicited by medial plantar nerve stimulation. Thirty minutes after subcutaneous injection of apomorphine, both PLM and FR were completely abolished. These findings demonstrate that dopaminergic agents can suppress exaggerated FR in humans, and support the hypothesis of common mechanisms for PLM and FR.</EA>
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<FG>Homme; Système nerveux pathologie; Trouble neurologique; Trouble sensibilité; Electrodiagnostic</FG>
<ED>Periodic motion; Lower limb; Restless legs syndrome; Reflex; Flexor muscle; Agonist; Dopamine receptor; Electromyography; Dopamine agonist; Pathogenesis; Biological effect; Case study; Elderly; Male</ED>
<EG>Human; Nervous system diseases; Neurological disorder; Sensitivity disorder; Electrodiagnosis</EG>
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