MovDisordV3, PascalFrancis, Corpus, bibRecord, 002639

Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease

Identifieur interne : 002639 ( PascalFrancis/Corpus ); précédent : 002638; suivant : 002640

Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease

Auteurs : Joseph O'Neill ; Norbert Schuff ; William J. Jr Marks ; Robert Feiwell ; Michael J. Aminoff ; Michael W. Weiner

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0583402

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Imagerie RMN, Spectrométrie RMN, Analyse quantitative, Encéphale, Exploration, Homme.

English descriptors

KwdEn :
- Brain (vertebrata), Exploration, Human, NMR spectrometry, Nuclear magnetic resonance imaging, Parkinson disease, Quantitative analysis.

Abstract

Magnetic resonance imaging (MRI) and ¹H magnetic resonance spectroscopy (MRS) of the substantia nigra, basal ganglia, and cerebral cortex were performed on 10 patients with Parkinson's disease (PD) and 13 age-matched, healthy control subjects. Compared to controls, PD patients had approximately 24% lower creatine in the region of the substantia nigra and smaller volumes of the putamen (11%), globus pallidus (16%), and prefrontal cortex (6%; all P < 0.05). No other significant between-group differences were found in nine regions examined. Thus, quantitative MRI may show regional neurodegenerative changes outside the substantia nigra in PD but PD-linked extranigral metabolic abnormalities, if they exist, may be difficult to detect with current ¹H MRS methods. In additional, exploratory tests, volumes of the caudate (r = -0.56), putamen (r = -0.66), and globus pallidus (r = -0.60; all P < 0.05) were negatively correlated with the volume of the substantia nigra pars compacta in controls. In PD these correlations did not hold. Instead, pallidal volume in PD was positively correlated with compacta volume (r = 0.64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 Magnetic resonance imaging (MRI) and ¹H magnetic resonance spectroscopy (MRS) of the substantia nigra, basal ganglia, and cerebral cortex were performed on 10 patients with Parkinson's disease (PD) and 13 age-matched, healthy control subjects. Compared to controls, PD patients had approximately 24% lower creatine in the region of the substantia nigra and smaller volumes of the putamen (11%), globus pallidus (16%), and prefrontal cortex (6%; all P < 0.05). No other significant between-group differences were found in nine regions examined. Thus, quantitative MRI may show regional neurodegenerative changes outside the substantia nigra in PD but PD-linked extranigral metabolic abnormalities, if they exist, may be difficult to detect with current ¹H MRS methods. In additional, exploratory tests, volumes of the caudate (r = -0.56), putamen (r = -0.66), and globus pallidus (r = -0.60; all P < 0.05) were negatively correlated with the volume of the substantia nigra pars compacta in controls. In PD these correlations did not hold. Instead, pallidal volume in PD was positively correlated with compacta volume (r = 0.64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects.
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Format Inist (serveur)

NO :	PASCAL 02-0583402 INIST
ET :	Quantitative ¹H magnetic resonance spectroscopy and MRI of Parkinson's disease
AU :	O'NEILL (Joseph); SCHUFF (Norbert); MARKS (William J. JR); FEIWELL (Robert); AMINOFF (Michael J.); WEINER (Michael W.)
AF :	Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California/San Francisco, California/Etats-Unis (1 aut., 2 aut., 6 aut.); Department of Radiology and Neurology, University of California/San Francisco, California/Etats-Unis (1 aut., 2 aut., 4 aut., 6 aut.); Center for Parkinson's Disease and Movement Disorders, Department of Veterans Affairs Medical Center, University of California/San Francisco, California/Etats-Unis (3 aut., 5 aut.); Department of Neurology, University of California/San Francisco, California/Etats-Unis (3 aut., 5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 5; Pp. 917-927; Bibl. 47 ref.
LA :	Anglais
EA :	Magnetic resonance imaging (MRI) and ¹H magnetic resonance spectroscopy (MRS) of the substantia nigra, basal ganglia, and cerebral cortex were performed on 10 patients with Parkinson's disease (PD) and 13 age-matched, healthy control subjects. Compared to controls, PD patients had approximately 24% lower creatine in the region of the substantia nigra and smaller volumes of the putamen (11%), globus pallidus (16%), and prefrontal cortex (6%; all P < 0.05). No other significant between-group differences were found in nine regions examined. Thus, quantitative MRI may show regional neurodegenerative changes outside the substantia nigra in PD but PD-linked extranigral metabolic abnormalities, if they exist, may be difficult to detect with current ¹H MRS methods. In additional, exploratory tests, volumes of the caudate (r = -0.56), putamen (r = -0.66), and globus pallidus (r = -0.60; all P < 0.05) were negatively correlated with the volume of the substantia nigra pars compacta in controls. In PD these correlations did not hold. Instead, pallidal volume in PD was positively correlated with compacta volume (r = 0.64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects.
CC :	002B17G
FD :	Parkinson maladie; Imagerie RMN; Spectrométrie RMN; Analyse quantitative; Encéphale; Exploration; Homme
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Imagerie médicale; Système nerveux central
ED :	Parkinson disease; Nuclear magnetic resonance imaging; NMR spectrometry; Quantitative analysis; Brain (vertebrata); Exploration; Human
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Medical imagery; Central nervous system
SD :	Parkinson enfermedad; Imaginería RMN; Espectrometría RMN; Análisis cuantitativo; Encéfalo; Exploración; Hombre
LO :	INIST-20953.354000105152380070
ID :	02-0583402

Links to Exploration step

Pascal:02-0583402

Le document en format XML

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<front><div type="abstract" xml:lang="en">Magnetic resonance imaging (MRI) and <sup>1</sup>
H magnetic resonance spectroscopy (MRS) of the substantia nigra, basal ganglia, and cerebral cortex were performed on 10 patients with Parkinson's disease (PD) and 13 age-matched, healthy control subjects. Compared to controls, PD patients had approximately 24% lower creatine in the region of the substantia nigra and smaller volumes of the putamen (11%), globus pallidus (16%), and prefrontal cortex (6%; all P < 0.05). No other significant between-group differences were found in nine regions examined. Thus, quantitative MRI may show regional neurodegenerative changes outside the substantia nigra in PD but PD-linked extranigral metabolic abnormalities, if they exist, may be difficult to detect with current <sup>1</sup>
H MRS methods. In additional, exploratory tests, volumes of the caudate (r = -0.56), putamen (r = -0.66), and globus pallidus (r = -0.60; all P < 0.05) were negatively correlated with the volume of the substantia nigra pars compacta in controls. In PD these correlations did not hold. Instead, pallidal volume in PD was positively correlated with compacta volume (r = 0.64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects.</div>
</front>
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<fA11 i1="05" i2="1"><s1>AMINOFF (Michael J.)</s1>
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<fA14 i1="02"><s1>Department of Radiology and Neurology, University of California</s1>
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<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
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<fA14 i1="04"><s1>Department of Neurology, University of California</s1>
<s2>San Francisco, California</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
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H magnetic resonance spectroscopy (MRS) of the substantia nigra, basal ganglia, and cerebral cortex were performed on 10 patients with Parkinson's disease (PD) and 13 age-matched, healthy control subjects. Compared to controls, PD patients had approximately 24% lower creatine in the region of the substantia nigra and smaller volumes of the putamen (11%), globus pallidus (16%), and prefrontal cortex (6%; all P < 0.05). No other significant between-group differences were found in nine regions examined. Thus, quantitative MRI may show regional neurodegenerative changes outside the substantia nigra in PD but PD-linked extranigral metabolic abnormalities, if they exist, may be difficult to detect with current <sup>1</sup>
H MRS methods. In additional, exploratory tests, volumes of the caudate (r = -0.56), putamen (r = -0.66), and globus pallidus (r = -0.60; all P < 0.05) were negatively correlated with the volume of the substantia nigra pars compacta in controls. In PD these correlations did not hold. Instead, pallidal volume in PD was positively correlated with compacta volume (r = 0.64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects.</s0>
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<s5>10</s5>
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<s5>40</s5>
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<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
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<s5>40</s5>
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<s5>41</s5>
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<s5>41</s5>
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<s5>41</s5>
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<server><NO>PASCAL 02-0583402 INIST</NO>
<ET>Quantitative <sup>1</sup>
H magnetic resonance spectroscopy and MRI of Parkinson's disease</ET>
<AU>O'NEILL (Joseph); SCHUFF (Norbert); MARKS (William J. JR); FEIWELL (Robert); AMINOFF (Michael J.); WEINER (Michael W.)</AU>
<AF>Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California/San Francisco, California/Etats-Unis (1 aut., 2 aut., 6 aut.); Department of Radiology and Neurology, University of California/San Francisco, California/Etats-Unis (1 aut., 2 aut., 4 aut., 6 aut.); Center for Parkinson's Disease and Movement Disorders, Department of Veterans Affairs Medical Center, University of California/San Francisco, California/Etats-Unis (3 aut., 5 aut.); Department of Neurology, University of California/San Francisco, California/Etats-Unis (3 aut., 5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 5; Pp. 917-927; Bibl. 47 ref.</SO>
<LA>Anglais</LA>
<EA>Magnetic resonance imaging (MRI) and <sup>1</sup>
H magnetic resonance spectroscopy (MRS) of the substantia nigra, basal ganglia, and cerebral cortex were performed on 10 patients with Parkinson's disease (PD) and 13 age-matched, healthy control subjects. Compared to controls, PD patients had approximately 24% lower creatine in the region of the substantia nigra and smaller volumes of the putamen (11%), globus pallidus (16%), and prefrontal cortex (6%; all P < 0.05). No other significant between-group differences were found in nine regions examined. Thus, quantitative MRI may show regional neurodegenerative changes outside the substantia nigra in PD but PD-linked extranigral metabolic abnormalities, if they exist, may be difficult to detect with current <sup>1</sup>
H MRS methods. In additional, exploratory tests, volumes of the caudate (r = -0.56), putamen (r = -0.66), and globus pallidus (r = -0.60; all P < 0.05) were negatively correlated with the volume of the substantia nigra pars compacta in controls. In PD these correlations did not hold. Instead, pallidal volume in PD was positively correlated with compacta volume (r = 0.64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Imagerie RMN; Spectrométrie RMN; Analyse quantitative; Encéphale; Exploration; Homme</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Imagerie médicale; Système nerveux central</FG>
<ED>Parkinson disease; Nuclear magnetic resonance imaging; NMR spectrometry; Quantitative analysis; Brain (vertebrata); Exploration; Human</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Medical imagery; Central nervous system</EG>
<SD>Parkinson enfermedad; Imaginería RMN; Espectrometría RMN; Análisis cuantitativo; Encéfalo; Exploración; Hombre</SD>
<LO>INIST-20953.354000105152380070</LO>
<ID>02-0583402</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease

Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease

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