Entacapone-induced hepatotoxicity and hepatic dysfunction
Identifieur interne : 002587 ( PascalFrancis/Corpus ); précédent : 002586; suivant : 002588Entacapone-induced hepatotoxicity and hepatic dysfunction
Auteurs : Alexander Fisher ; James Croft-Baker ; Michael Davis ; Patrick Purcell ; Allan J. McleanSource :
- Movement disorders [ 0885-3185 ] ; 2002.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
We describe 2 patients with Parkinson's disease who developed hepatotoxicity associated with the use of entacapone, a novel, mainly peripheral acting inhibitor of catechol-D-methyltransferase. Hepatotoxicity resolved rapidly with discontinuation of the drug. Analysis of causality in a further case initially linked to entacapone exposure was confounded by conflicting serial adverse reaction reports.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 03-0038722 INIST |
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ET : | Entacapone-induced hepatotoxicity and hepatic dysfunction |
AU : | FISHER (Alexander); CROFT-BAKER (James); DAVIS (Michael); PURCELL (Patrick); MCLEAN (Allan J.) |
AF : | Department of Geriatric Medicine, The Canberra Hospital/Canberra/Australie (1 aut., 2 aut., 3 aut., 5 aut.); Canberra Clinical School of the University of Sydney/Canberra/Australie (3 aut.); Therapeutic Goods Administration/Canberra/Australie (4 aut., 5 aut.); National Ageing Research Institute, University of Melbourne, Royal Melbourne Hospital, and Melbourne Health/Melbourne/Australie (5 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 6; Pp. 1362-1365; Bibl. 20 ref. |
LA : | Anglais |
EA : | We describe 2 patients with Parkinson's disease who developed hepatotoxicity associated with the use of entacapone, a novel, mainly peripheral acting inhibitor of catechol-D-methyltransferase. Hepatotoxicity resolved rapidly with discontinuation of the drug. Analysis of causality in a further case initially linked to entacapone exposure was confounded by conflicting serial adverse reaction reports. |
CC : | 002B02U01; 002B17G; 235 |
FD : | Parkinson maladie; Entacapone; Antiparkinsonien; Inhibiteur enzyme; Catechol O-methyltransferase; Foie pathologie; Etude cas; Toxicité; Homme |
FG : | Methyltransferases; Transferases; Enzyme; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Appareil digestif pathologie |
ED : | Parkinson disease; Entacapone; Antiparkinson agent; Enzyme inhibitor; Catechol O-methyltransferase; Hepatic disease; Case study; Toxicity; Human |
EG : | Methyltransferases; Transferases; Enzyme; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Digestive diseases |
SD : | Parkinson enfermedad; Entacapona; Antiparkinsoniano; Inhibidor enzima; Catechol O-methyltransferase; Hígado patología; Estudio caso; Toxicidad; Hombre |
LO : | INIST-20953.354000105559450350 |
ID : | 03-0038722 |
Links to Exploration step
Pascal:03-0038722Le document en format XML
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<front><div type="abstract" xml:lang="en">We describe 2 patients with Parkinson's disease who developed hepatotoxicity associated with the use of entacapone, a novel, mainly peripheral acting inhibitor of catechol-D-methyltransferase. Hepatotoxicity resolved rapidly with discontinuation of the drug. Analysis of causality in a further case initially linked to entacapone exposure was confounded by conflicting serial adverse reaction reports.</div>
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<ET>Entacapone-induced hepatotoxicity and hepatic dysfunction</ET>
<AU>FISHER (Alexander); CROFT-BAKER (James); DAVIS (Michael); PURCELL (Patrick); MCLEAN (Allan J.)</AU>
<AF>Department of Geriatric Medicine, The Canberra Hospital/Canberra/Australie (1 aut., 2 aut., 3 aut., 5 aut.); Canberra Clinical School of the University of Sydney/Canberra/Australie (3 aut.); Therapeutic Goods Administration/Canberra/Australie (4 aut., 5 aut.); National Ageing Research Institute, University of Melbourne, Royal Melbourne Hospital, and Melbourne Health/Melbourne/Australie (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 6; Pp. 1362-1365; Bibl. 20 ref.</SO>
<LA>Anglais</LA>
<EA>We describe 2 patients with Parkinson's disease who developed hepatotoxicity associated with the use of entacapone, a novel, mainly peripheral acting inhibitor of catechol-D-methyltransferase. Hepatotoxicity resolved rapidly with discontinuation of the drug. Analysis of causality in a further case initially linked to entacapone exposure was confounded by conflicting serial adverse reaction reports.</EA>
<CC>002B02U01; 002B17G; 235</CC>
<FD>Parkinson maladie; Entacapone; Antiparkinsonien; Inhibiteur enzyme; Catechol O-methyltransferase; Foie pathologie; Etude cas; Toxicité; Homme</FD>
<FG>Methyltransferases; Transferases; Enzyme; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Appareil digestif pathologie</FG>
<ED>Parkinson disease; Entacapone; Antiparkinson agent; Enzyme inhibitor; Catechol O-methyltransferase; Hepatic disease; Case study; Toxicity; Human</ED>
<EG>Methyltransferases; Transferases; Enzyme; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Digestive diseases</EG>
<SD>Parkinson enfermedad; Entacapona; Antiparkinsoniano; Inhibidor enzima; Catechol O-methyltransferase; Hígado patología; Estudio caso; Toxicidad; Hombre</SD>
<LO>INIST-20953.354000105559450350</LO>
<ID>03-0038722</ID>
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