MovDisordV3, PascalFrancis, Corpus, bibRecord, 002577

Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in Parkinsonian rats

Identifieur interne : 002577 ( PascalFrancis/Corpus ); précédent : 002576; suivant : 002578

Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in Parkinsonian rats

Auteurs : Marie-Paule Muriel ; Gaël Orieux ; Etienne C. Hirsch

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:03-0039776

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Récepteur dopaminergique D1, Lévodopa, Antiparkinsonien, Ropinirole, Agoniste, Immunohistochimie, Chimiothérapie, Traitement, Animal, Rat, Modèle animal, Internalisation.

English descriptors

KwdEn :
- Agonist, Animal, Animal model, Antiparkinson agent, Chemotherapy, D1 Dopamine receptor, Immunohistochemistry, Internalization, Levodopa, Parkinson disease, Rat, Ropinirole, Treatment.

Abstract

Levodopa therapy in Parkinson's disease is mediated by dopamine receptors and, in a recent study, we showed that a Dl full agonist can induce an internalization of D1 dopamine receptors. The aim of the present study was to determine whether levodopa or a dopamine agonist such as ropinirole can also induce the internalization of D1 dopamine receptors in the striatum of control and hemiparkinsonian rats. The distribution of Dl dopamine receptors was analyzed by immunohistochemistry using a specific antibody. In control animals and 6-hydroxydopamine (6-OHDA)-lesioned animals treated with saline, Dl dopamine receptors were localized at the level of the plasma membrane. In contrast, in both lesioned and nonlesioned animals receiving a single dose of levodopa, but not in animals receiving ropinirole, D1 dopamine receptors were internalized in the cytoplasm. This result is likely explained by the fact that ropinirole binds to non-D1 dopamine receptors, whereas levodopa, which increases dopamine levels, indirectly acts on both D1 and D2 receptors. Ropinirole is consequently less likely to desensitize Dl dopamine receptors than levodopa and, thus, to reduce the efficacy of the treatment.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 03-0039776 INIST
ET :	Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in Parkinsonian rats
AU :	MURIEL (Marie-Paule); ORIEUX (Gaël); HIRSCH (Etienne C.)
AF :	Institut National de la Santé et de la Recherche Médicale U 289, Hôpital de la salpêtrière/Paris/France (1 aut., 2 aut., 3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 6; Pp. 1174-1179; Bibl. 20 ref.
LA :	Anglais
EA :	Levodopa therapy in Parkinson's disease is mediated by dopamine receptors and, in a recent study, we showed that a Dl full agonist can induce an internalization of D1 dopamine receptors. The aim of the present study was to determine whether levodopa or a dopamine agonist such as ropinirole can also induce the internalization of D1 dopamine receptors in the striatum of control and hemiparkinsonian rats. The distribution of Dl dopamine receptors was analyzed by immunohistochemistry using a specific antibody. In control animals and 6-hydroxydopamine (6-OHDA)-lesioned animals treated with saline, Dl dopamine receptors were localized at the level of the plasma membrane. In contrast, in both lesioned and nonlesioned animals receiving a single dose of levodopa, but not in animals receiving ropinirole, D1 dopamine receptors were internalized in the cytoplasm. This result is likely explained by the fact that ropinirole binds to non-D1 dopamine receptors, whereas levodopa, which increases dopamine levels, indirectly acts on both D1 and D2 receptors. Ropinirole is consequently less likely to desensitize Dl dopamine receptors than levodopa and, thus, to reduce the efficacy of the treatment.
CC :	002B02B06; 002B17G
FD :	Parkinson maladie; Récepteur dopaminergique D1; Lévodopa; Antiparkinsonien; Ropinirole; Agoniste; Immunohistochimie; Chimiothérapie; Traitement; Animal; Rat; Modèle animal; Internalisation
FG :	Rodentia; Mammalia; Vertebrata; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Anatomopathologie
ED :	Parkinson disease; D1 Dopamine receptor; Levodopa; Antiparkinson agent; Ropinirole; Agonist; Immunohistochemistry; Chemotherapy; Treatment; Animal; Rat; Animal model; Internalization
EG :	Rodentia; Mammalia; Vertebrata; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Pathology
SD :	Parkinson enfermedad; Receptor dopaminérgico D1; Levodopa; Antiparkinsoniano; Ropinirol; Agonista; Inmunohistoquímica; Quimioterapia; Tratamiento; Animal; Rata; Modelo animal; Internalización
LO :	INIST-20953.354000105559450050
ID :	03-0039776

Links to Exploration step

Pascal:03-0039776

Le document en format XML

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<s2>FR</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Ropinirole</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Ropinirol</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Agoniste</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Agonist</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Agonista</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Immunohistochimie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Immunohistochemistry</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Inmunohistoquímica</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Chimiothérapie</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Chemotherapy</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Quimioterapia</s0>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Traitement</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Treatment</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Animal</s0>
<s5>20</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Animal</s0>
<s5>20</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Animal</s0>
<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Rat</s0>
<s5>21</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Rat</s0>
<s5>21</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Rata</s0>
<s5>21</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Modèle animal</s0>
<s5>22</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Animal model</s0>
<s5>22</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Modelo animal</s0>
<s5>22</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Internalisation</s0>
<s5>23</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Internalization</s0>
<s5>23</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Internalización</s0>
<s5>23</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Anatomopathologie</s0>
<s5>69</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Pathology</s0>
<s5>69</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Anatomía patológica</s0>
<s5>69</s5>
</fC07>
<fN21><s1>020</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 03-0039776 INIST</NO>
<ET>Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in Parkinsonian rats</ET>
<AU>MURIEL (Marie-Paule); ORIEUX (Gaël); HIRSCH (Etienne C.)</AU>
<AF>Institut National de la Santé et de la Recherche Médicale U 289, Hôpital de la salpêtrière/Paris/France (1 aut., 2 aut., 3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 6; Pp. 1174-1179; Bibl. 20 ref.</SO>
<LA>Anglais</LA>
<EA>Levodopa therapy in Parkinson's disease is mediated by dopamine receptors and, in a recent study, we showed that a Dl full agonist can induce an internalization of D1 dopamine receptors. The aim of the present study was to determine whether levodopa or a dopamine agonist such as ropinirole can also induce the internalization of D1 dopamine receptors in the striatum of control and hemiparkinsonian rats. The distribution of Dl dopamine receptors was analyzed by immunohistochemistry using a specific antibody. In control animals and 6-hydroxydopamine (6-OHDA)-lesioned animals treated with saline, Dl dopamine receptors were localized at the level of the plasma membrane. In contrast, in both lesioned and nonlesioned animals receiving a single dose of levodopa, but not in animals receiving ropinirole, D1 dopamine receptors were internalized in the cytoplasm. This result is likely explained by the fact that ropinirole binds to non-D1 dopamine receptors, whereas levodopa, which increases dopamine levels, indirectly acts on both D1 and D2 receptors. Ropinirole is consequently less likely to desensitize Dl dopamine receptors than levodopa and, thus, to reduce the efficacy of the treatment.</EA>
<CC>002B02B06; 002B17G</CC>
<FD>Parkinson maladie; Récepteur dopaminergique D1; Lévodopa; Antiparkinsonien; Ropinirole; Agoniste; Immunohistochimie; Chimiothérapie; Traitement; Animal; Rat; Modèle animal; Internalisation</FD>
<FG>Rodentia; Mammalia; Vertebrata; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Anatomopathologie</FG>
<ED>Parkinson disease; D1 Dopamine receptor; Levodopa; Antiparkinson agent; Ropinirole; Agonist; Immunohistochemistry; Chemotherapy; Treatment; Animal; Rat; Animal model; Internalization</ED>
<EG>Rodentia; Mammalia; Vertebrata; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Pathology</EG>
<SD>Parkinson enfermedad; Receptor dopaminérgico D1; Levodopa; Antiparkinsoniano; Ropinirol; Agonista; Inmunohistoquímica; Quimioterapia; Tratamiento; Animal; Rata; Modelo animal; Internalización</SD>
<LO>INIST-20953.354000105559450050</LO>
<ID>03-0039776</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in Parkinsonian rats

Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in Parkinsonian rats

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