Swallowing abnormalities and dyskinesia in Parkinson's disease
Identifieur interne : 001F06 ( PascalFrancis/Corpus ); précédent : 001F05; suivant : 001F07Swallowing abnormalities and dyskinesia in Parkinson's disease
Auteurs : Francisca Sueli Monte ; Francisco Pereira Da Silva-Junior ; Pedro Braga-Neto ; Miguel Angelo Nobre E Souza ; Veralice Meireles Sales De BruinSource :
- Movement disorders [ 0885-3185 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa-induced dyskinesia. Fifteen dyskinetic patients, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
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Format Inist (serveur)
NO : | PASCAL 05-0262067 INIST |
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ET : | Swallowing abnormalities and dyskinesia in Parkinson's disease |
AU : | MONTE (Francisca Sueli); DA SILVA-JUNIOR (Francisco Pereira); BRAGA-NETO (Pedro); NOBRE E SOUZA (Miguel Angelo); DE BRUIN (Veralice Meireles Sales) |
AF : | Department of Pharmacy, Federal University of Ceard/Brésil (1 aut.); Department of Clinical Medicine, Federal University of Ceard/Brésil (2 aut., 3 aut., 4 aut., 5 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2005; Vol. 20; No. 4; Pp. 457-462; Bibl. 31 ref. |
LA : | Anglais |
EA : | Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa-induced dyskinesia. Fifteen dyskinetic patients, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD. |
CC : | 002B17; 002B17G; 002B02U01 |
FD : | Système nerveux pathologie; Déglutition; Lévodopa; Dyskinésie; Parkinson maladie; Dysphagie |
FG : | Extrapyramidal syndrome; Mouvement involontaire; Trouble neurologique; Encéphale pathologie; Maladie dégénérative; Système nerveux central pathologie; Appareil digestif pathologie; Oesophage pathologie |
ED : | Nervous system diseases; Swallowing; Levodopa; Dyskinesia; Parkinson disease; Dysphagia |
EG : | Extrapyramidal syndrome; Involuntary movement; Neurological disorder; Cerebral disorder; Degenerative disease; Central nervous system disease; Digestive diseases; Esophageal disease |
SD : | Sistema nervioso patología; Deglutición; Levodopa; Disquinesia; Parkinson enfermedad; Disfagia |
LO : | INIST-20953.354000124582390090 |
ID : | 05-0262067 |
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Pascal:05-0262067Le document en format XML
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<front><div type="abstract" xml:lang="en">Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa-induced dyskinesia. Fifteen dyskinetic patients, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD.</div>
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<server><NO>PASCAL 05-0262067 INIST</NO>
<ET>Swallowing abnormalities and dyskinesia in Parkinson's disease</ET>
<AU>MONTE (Francisca Sueli); DA SILVA-JUNIOR (Francisco Pereira); BRAGA-NETO (Pedro); NOBRE E SOUZA (Miguel Angelo); DE BRUIN (Veralice Meireles Sales)</AU>
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<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2005; Vol. 20; No. 4; Pp. 457-462; Bibl. 31 ref.</SO>
<LA>Anglais</LA>
<EA>Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa-induced dyskinesia. Fifteen dyskinetic patients, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD.</EA>
<CC>002B17; 002B17G; 002B02U01</CC>
<FD>Système nerveux pathologie; Déglutition; Lévodopa; Dyskinésie; Parkinson maladie; Dysphagie</FD>
<FG>Extrapyramidal syndrome; Mouvement involontaire; Trouble neurologique; Encéphale pathologie; Maladie dégénérative; Système nerveux central pathologie; Appareil digestif pathologie; Oesophage pathologie</FG>
<ED>Nervous system diseases; Swallowing; Levodopa; Dyskinesia; Parkinson disease; Dysphagia</ED>
<EG>Extrapyramidal syndrome; Involuntary movement; Neurological disorder; Cerebral disorder; Degenerative disease; Central nervous system disease; Digestive diseases; Esophageal disease</EG>
<SD>Sistema nervioso patología; Deglutición; Levodopa; Disquinesia; Parkinson enfermedad; Disfagia</SD>
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<ID>05-0262067</ID>
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