MovDisordV3, PascalFrancis, Corpus, bibRecord, 001D49

Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure

Identifieur interne : 001D49 ( PascalFrancis/Corpus ); précédent : 001D48; suivant : 001D50

Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure

Auteurs : Atul Pathak ; Maryse Lapeyre-Mestre ; Jean-Louis Montastruc ; Jean-Michel Senard

Source :

Movement disorders [ 0885-3185 ] ; 2005.

RBID : Pascal:05-0492944

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Système nerveux autonome pathologie, Morbidité, Homme, Complication.

English descriptors

KwdEn :
- Complication, Diseases of the autonomic nervous system, Human, Morbidity, Nervous system diseases.

Abstract

We investigated the effects of high-external-temperature exposure on neurogenic orthostatic hypotension (OH). Thirty-one patients with autonomic failure (AF) and pharmacologically treated OH related to probable multiple-system atrophy (n = 7), Parkinson's disease (n = 10), pure autonomic failure (n = 7), and diffuse Lewy body disease (n = 7) and 26 parkinsonians without AF were included. Prevalence and severity of clinical events were studied during the August 2003 heat wave and the 2004 summer. The prevalence of OH-related events was significantly higher in 2003 [45.1 vs. 11.5%; P = 0.0052; OR = 6.31 (1.35-33.53)] and 2004 [42.3 vs. 12.0%; P = 0.014; OR = 5.40 (1.28-22.68)] in AF than in controls. The mean severity score for clinical events was significantly higher in AF than in controls during 2003 heat wave (1.2 ± 1.4 vs. 0.2 ± 0.5) but similar in summer 2004 (0.7 ± 1.0 vs. 0.1 ± 0.3). Severe events (unusual home care, assistance, or hospitalization) were only observed in AF patients. A non-statistically significant higher prevalence of clinical events was observed in AF patients prescribed fludrocortisone (66.7%) by comparison to heptaminol (42.9%), midodrine (45.5%), or midodrine plus fludrocortisone (28.6%). This study shows that AF patients have a poor clinical outcome when exposed to high temperatures and that heat exposure is a risk factor for OH worsening.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 20`
A06				`@2 9`
A08	`01`	`1`	`ENG`	`@1 Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure`
A11	`01`	`1`		`@1 PATHAK (Atul)`
A11	`02`	`1`		`@1 LAPEYRE-MESTRE (Maryse)`
A11	`03`	`1`		`@1 MONTASTRUC (Jean-Louis)`
A11	`04`	`1`		`@1 SENARD (Jean-Michel)`
A14	`01`			`@1 Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine @2 Toulouse @3 FRA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
A14	`02`			`@1 Club d'Etude du Système Nerveux Autonome, Faculté de Médecine @2 Toulouse @3 FRA @Z 1 aut. @Z 4 aut.`
A20				`@1 1213-1219`
A21				`@1 2005`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000131936030210`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 35 ref.`
A47	`01`	`1`		`@0 05-0492944`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 We investigated the effects of high-external-temperature exposure on neurogenic orthostatic hypotension (OH). Thirty-one patients with autonomic failure (AF) and pharmacologically treated OH related to probable multiple-system atrophy (n = 7), Parkinson's disease (n = 10), pure autonomic failure (n = 7), and diffuse Lewy body disease (n = 7) and 26 parkinsonians without AF were included. Prevalence and severity of clinical events were studied during the August 2003 heat wave and the 2004 summer. The prevalence of OH-related events was significantly higher in 2003 [45.1 vs. 11.5%; P = 0.0052; OR = 6.31 (1.35-33.53)] and 2004 [42.3 vs. 12.0%; P = 0.014; OR = 5.40 (1.28-22.68)] in AF than in controls. The mean severity score for clinical events was significantly higher in AF than in controls during 2003 heat wave (1.2 ± 1.4 vs. 0.2 ± 0.5) but similar in summer 2004 (0.7 ± 1.0 vs. 0.1 ± 0.3). Severe events (unusual home care, assistance, or hospitalization) were only observed in AF patients. A non-statistically significant higher prevalence of clinical events was observed in AF patients prescribed fludrocortisone (66.7%) by comparison to heptaminol (42.9%), midodrine (45.5%), or midodrine plus fludrocortisone (28.6%). This study shows that AF patients have a poor clinical outcome when exposed to high temperatures and that heat exposure is a risk factor for OH worsening.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17F`
C02	`03`	`X`		`@0 002B16B`
C03	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 01`
C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Système nerveux autonome pathologie @5 02`
C03	`02`	`X`	`ENG`	`@0 Diseases of the autonomic nervous system @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso autónomo patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Morbidité @5 09`
C03	`03`	`X`	`ENG`	`@0 Morbidity @5 09`
C03	`03`	`X`	`SPA`	`@0 Morbilidad @5 09`
C03	`04`	`X`	`FRE`	`@0 Homme @5 10`
C03	`04`	`X`	`ENG`	`@0 Human @5 10`
C03	`04`	`X`	`SPA`	`@0 Hombre @5 10`
C03	`05`	`X`	`FRE`	`@0 Complication @5 11`
C03	`05`	`X`	`ENG`	`@0 Complication @5 11`
C03	`05`	`X`	`SPA`	`@0 Complicación @5 11`
N21				`@1 346`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 05-0492944 INIST
ET :	Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure
AU :	PATHAK (Atul); LAPEYRE-MESTRE (Maryse); MONTASTRUC (Jean-Louis); SENARD (Jean-Michel)
AF :	Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine/Toulouse/France (1 aut., 2 aut., 3 aut., 4 aut.); Club d'Etude du Système Nerveux Autonome, Faculté de Médecine/Toulouse/France (1 aut., 4 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2005; Vol. 20; No. 9; Pp. 1213-1219; Bibl. 35 ref.
LA :	Anglais
EA :	We investigated the effects of high-external-temperature exposure on neurogenic orthostatic hypotension (OH). Thirty-one patients with autonomic failure (AF) and pharmacologically treated OH related to probable multiple-system atrophy (n = 7), Parkinson's disease (n = 10), pure autonomic failure (n = 7), and diffuse Lewy body disease (n = 7) and 26 parkinsonians without AF were included. Prevalence and severity of clinical events were studied during the August 2003 heat wave and the 2004 summer. The prevalence of OH-related events was significantly higher in 2003 [45.1 vs. 11.5%; P = 0.0052; OR = 6.31 (1.35-33.53)] and 2004 [42.3 vs. 12.0%; P = 0.014; OR = 5.40 (1.28-22.68)] in AF than in controls. The mean severity score for clinical events was significantly higher in AF than in controls during 2003 heat wave (1.2 ± 1.4 vs. 0.2 ± 0.5) but similar in summer 2004 (0.7 ± 1.0 vs. 0.1 ± 0.3). Severe events (unusual home care, assistance, or hospitalization) were only observed in AF patients. A non-statistically significant higher prevalence of clinical events was observed in AF patients prescribed fludrocortisone (66.7%) by comparison to heptaminol (42.9%), midodrine (45.5%), or midodrine plus fludrocortisone (28.6%). This study shows that AF patients have a poor clinical outcome when exposed to high temperatures and that heat exposure is a risk factor for OH worsening.
CC :	002B17; 002B17F; 002B16B
FD :	Système nerveux pathologie; Système nerveux autonome pathologie; Morbidité; Homme; Complication
ED :	Nervous system diseases; Diseases of the autonomic nervous system; Morbidity; Human; Complication
SD :	Sistema nervioso patología; Sistema nervioso autónomo patología; Morbilidad; Hombre; Complicación
LO :	INIST-20953.354000131936030210
ID :	05-0492944

Links to Exploration step

Pascal:05-0492944

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure</title>
<author><name sortKey="Pathak, Atul" sort="Pathak, Atul" uniqKey="Pathak A" first="Atul" last="Pathak">Atul Pathak</name>
<affiliation><inist:fA14 i1="01"><s1>Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Club d'Etude du Système Nerveux Autonome, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lapeyre Mestre, Maryse" sort="Lapeyre Mestre, Maryse" uniqKey="Lapeyre Mestre M" first="Maryse" last="Lapeyre-Mestre">Maryse Lapeyre-Mestre</name>
<affiliation><inist:fA14 i1="01"><s1>Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Montastruc, Jean Louis" sort="Montastruc, Jean Louis" uniqKey="Montastruc J" first="Jean-Louis" last="Montastruc">Jean-Louis Montastruc</name>
<affiliation><inist:fA14 i1="01"><s1>Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Senard, Jean Michel" sort="Senard, Jean Michel" uniqKey="Senard J" first="Jean-Michel" last="Senard">Jean-Michel Senard</name>
<affiliation><inist:fA14 i1="01"><s1>Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Club d'Etude du Système Nerveux Autonome, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0492944</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 05-0492944 INIST</idno>
<idno type="RBID">Pascal:05-0492944</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001D49</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure</title>
<author><name sortKey="Pathak, Atul" sort="Pathak, Atul" uniqKey="Pathak A" first="Atul" last="Pathak">Atul Pathak</name>
<affiliation><inist:fA14 i1="01"><s1>Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Club d'Etude du Système Nerveux Autonome, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lapeyre Mestre, Maryse" sort="Lapeyre Mestre, Maryse" uniqKey="Lapeyre Mestre M" first="Maryse" last="Lapeyre-Mestre">Maryse Lapeyre-Mestre</name>
<affiliation><inist:fA14 i1="01"><s1>Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Montastruc, Jean Louis" sort="Montastruc, Jean Louis" uniqKey="Montastruc J" first="Jean-Louis" last="Montastruc">Jean-Louis Montastruc</name>
<affiliation><inist:fA14 i1="01"><s1>Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Senard, Jean Michel" sort="Senard, Jean Michel" uniqKey="Senard J" first="Jean-Michel" last="Senard">Jean-Michel Senard</name>
<affiliation><inist:fA14 i1="01"><s1>Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Club d'Etude du Système Nerveux Autonome, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Complication</term>
<term>Diseases of the autonomic nervous system</term>
<term>Human</term>
<term>Morbidity</term>
<term>Nervous system diseases</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Système nerveux autonome pathologie</term>
<term>Morbidité</term>
<term>Homme</term>
<term>Complication</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We investigated the effects of high-external-temperature exposure on neurogenic orthostatic hypotension (OH). Thirty-one patients with autonomic failure (AF) and pharmacologically treated OH related to probable multiple-system atrophy (n = 7), Parkinson's disease (n = 10), pure autonomic failure (n = 7), and diffuse Lewy body disease (n = 7) and 26 parkinsonians without AF were included. Prevalence and severity of clinical events were studied during the August 2003 heat wave and the 2004 summer. The prevalence of OH-related events was significantly higher in 2003 [45.1 vs. 11.5%; P = 0.0052; OR = 6.31 (1.35-33.53)] and 2004 [42.3 vs. 12.0%; P = 0.014; OR = 5.40 (1.28-22.68)] in AF than in controls. The mean severity score for clinical events was significantly higher in AF than in controls during 2003 heat wave (1.2 ± 1.4 vs. 0.2 ± 0.5) but similar in summer 2004 (0.7 ± 1.0 vs. 0.1 ± 0.3). Severe events (unusual home care, assistance, or hospitalization) were only observed in AF patients. A non-statistically significant higher prevalence of clinical events was observed in AF patients prescribed fludrocortisone (66.7%) by comparison to heptaminol (42.9%), midodrine (45.5%), or midodrine plus fludrocortisone (28.6%). This study shows that AF patients have a poor clinical outcome when exposed to high temperatures and that heat exposure is a risk factor for OH worsening.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0>
</fA01>
<fA03 i2="1"><s0>Mov. disord.</s0>
</fA03>
<fA05><s2>20</s2>
</fA05>
<fA06><s2>9</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>PATHAK (Atul)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>LAPEYRE-MESTRE (Maryse)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>MONTASTRUC (Jean-Louis)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>SENARD (Jean-Michel)</s1>
</fA11>
<fA14 i1="01"><s1>Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Club d'Etude du Système Nerveux Autonome, Faculté de Médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA20><s1>1213-1219</s1>
</fA20>
<fA21><s1>2005</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000131936030210</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2005 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>35 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>05-0492944</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>We investigated the effects of high-external-temperature exposure on neurogenic orthostatic hypotension (OH). Thirty-one patients with autonomic failure (AF) and pharmacologically treated OH related to probable multiple-system atrophy (n = 7), Parkinson's disease (n = 10), pure autonomic failure (n = 7), and diffuse Lewy body disease (n = 7) and 26 parkinsonians without AF were included. Prevalence and severity of clinical events were studied during the August 2003 heat wave and the 2004 summer. The prevalence of OH-related events was significantly higher in 2003 [45.1 vs. 11.5%; P = 0.0052; OR = 6.31 (1.35-33.53)] and 2004 [42.3 vs. 12.0%; P = 0.014; OR = 5.40 (1.28-22.68)] in AF than in controls. The mean severity score for clinical events was significantly higher in AF than in controls during 2003 heat wave (1.2 ± 1.4 vs. 0.2 ± 0.5) but similar in summer 2004 (0.7 ± 1.0 vs. 0.1 ± 0.3). Severe events (unusual home care, assistance, or hospitalization) were only observed in AF patients. A non-statistically significant higher prevalence of clinical events was observed in AF patients prescribed fludrocortisone (66.7%) by comparison to heptaminol (42.9%), midodrine (45.5%), or midodrine plus fludrocortisone (28.6%). This study shows that AF patients have a poor clinical outcome when exposed to high temperatures and that heat exposure is a risk factor for OH worsening.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17F</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B16B</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Système nerveux autonome pathologie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Diseases of the autonomic nervous system</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso autónomo patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Morbidité</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Morbidity</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Morbilidad</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Homme</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Human</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Hombre</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Complication</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Complication</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Complicación</s0>
<s5>11</s5>
</fC03>
<fN21><s1>346</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 05-0492944 INIST</NO>
<ET>Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure</ET>
<AU>PATHAK (Atul); LAPEYRE-MESTRE (Maryse); MONTASTRUC (Jean-Louis); SENARD (Jean-Michel)</AU>
<AF>Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine/Toulouse/France (1 aut., 2 aut., 3 aut., 4 aut.); Club d'Etude du Système Nerveux Autonome, Faculté de Médecine/Toulouse/France (1 aut., 4 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2005; Vol. 20; No. 9; Pp. 1213-1219; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>We investigated the effects of high-external-temperature exposure on neurogenic orthostatic hypotension (OH). Thirty-one patients with autonomic failure (AF) and pharmacologically treated OH related to probable multiple-system atrophy (n = 7), Parkinson's disease (n = 10), pure autonomic failure (n = 7), and diffuse Lewy body disease (n = 7) and 26 parkinsonians without AF were included. Prevalence and severity of clinical events were studied during the August 2003 heat wave and the 2004 summer. The prevalence of OH-related events was significantly higher in 2003 [45.1 vs. 11.5%; P = 0.0052; OR = 6.31 (1.35-33.53)] and 2004 [42.3 vs. 12.0%; P = 0.014; OR = 5.40 (1.28-22.68)] in AF than in controls. The mean severity score for clinical events was significantly higher in AF than in controls during 2003 heat wave (1.2 ± 1.4 vs. 0.2 ± 0.5) but similar in summer 2004 (0.7 ± 1.0 vs. 0.1 ± 0.3). Severe events (unusual home care, assistance, or hospitalization) were only observed in AF patients. A non-statistically significant higher prevalence of clinical events was observed in AF patients prescribed fludrocortisone (66.7%) by comparison to heptaminol (42.9%), midodrine (45.5%), or midodrine plus fludrocortisone (28.6%). This study shows that AF patients have a poor clinical outcome when exposed to high temperatures and that heat exposure is a risk factor for OH worsening.</EA>
<CC>002B17; 002B17F; 002B16B</CC>
<FD>Système nerveux pathologie; Système nerveux autonome pathologie; Morbidité; Homme; Complication</FD>
<ED>Nervous system diseases; Diseases of the autonomic nervous system; Morbidity; Human; Complication</ED>
<SD>Sistema nervioso patología; Sistema nervioso autónomo patología; Morbilidad; Hombre; Complicación</SD>
<LO>INIST-20953.354000131936030210</LO>
<ID>05-0492944</ID>
</server>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PascalFrancis/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D49 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 001D49 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    PascalFrancis
   |étape=   Corpus
   |type=    RBID
   |clé=     Pascal:05-0492944
   |texte=   Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure

Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure

Source :

Descripteurs français

English descriptors

Abstract

Notice en format standard (ISO 2709)

Format Inist (serveur)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri