Interaction between blood lead concentration and δ-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor
Identifieur interne : 001D45 ( PascalFrancis/Corpus ); précédent : 001D44; suivant : 001D46Interaction between blood lead concentration and δ-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor
Auteurs : Elan D. Louis ; Lakeisha Applegate ; Joseph H. Graziano ; Michael Parides ; Vesna Slavkovich ; Hari K. BhatSource :
- Movement disorders [ 0885-3185 ] ; 2005.
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Abstract
Blood lead (BPh) concentrations are elevated in essential tremor (ET) cases. The δ-amino-levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD-2 allele may be more susceptible to lead toxicily. The objective of this study was to test, using a case-control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD-2 allele (OR = 1.98; 95% Cl = 0.93-4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status X log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD-1 alleles (OR = 2.69; 95% Cl = 0.61-11.82). but in individuals with an ALAD-2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% Cl = 3.08-2,096.36). There was an interaction between BPh concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD-2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD-2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor.
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Format Inist (serveur)
| NO : | PASCAL 05-0493125 INIST |
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| ET : | Interaction between blood lead concentration and δ-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor |
| AU : | LOUIS (Elan D.); APPLEGATE (Lakeisha); GRAZIANO (Joseph H.); PARIDES (Michael); SLAVKOVICH (Vesna); BHAT (Hari K.) |
| AF : | Gertrude H. Sergievsky Center, Columbia University/New York, New Yolk/Etats-Unis (1 aut., 2 aut.); Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University/New York, New York/Etats-Unis (1 aut.); Department of Neurology, Columbia University/New York, New York/Etats-Unis (1 aut.); Department of Pharmacology, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (3 aut.); Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University/New York, New York/Etats-Unis (3 aut., 5 aut., 6 aut.); Department of Biostatistics, Mailman School of Public Health, Columbia University/New York, New York/Etats-Unis (4 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2005; Vol. 20; No. 9; Pp. 1170-1177; Bibl. 49 ref. |
| LA : | Anglais |
| EA : | Blood lead (BPh) concentrations are elevated in essential tremor (ET) cases. The δ-amino-levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD-2 allele may be more susceptible to lead toxicily. The objective of this study was to test, using a case-control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD-2 allele (OR = 1.98; 95% Cl = 0.93-4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status X log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD-1 alleles (OR = 2.69; 95% Cl = 0.61-11.82). but in individuals with an ALAD-2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% Cl = 3.08-2,096.36). There was an interaction between BPh concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD-2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD-2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor. |
| CC : | 002B17; 002B17G; 002B17A01 |
| FD : | Système nerveux pathologie; Tremblement; Interaction; Dehydratase; Polymorphisme; Epidémiologie; Etiologie |
| FG : | Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Mouvement involontaire; Trouble neurologique |
| ED : | Nervous system diseases; Tremor; Interaction; Dehydratase; Polymorphism; Epidemiology; Etiology |
| EG : | Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Involuntary movement; Neurological disorder |
| SD : | Sistema nervioso patología; Temblor; Interacción; Dehydratase; Polimorfismo; Epidemiología; Etiología |
| LO : | INIST-20953.354000131936030110 |
| ID : | 05-0493125 |
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Sergievsky Center, Columbia University</s1><s2>New York, New Yolk</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Neurology, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Applegate, Lakeisha" sort="Applegate, Lakeisha" uniqKey="Applegate L" first="Lakeisha" last="Applegate">Lakeisha Applegate</name><affiliation><inist:fA14 i1="01"><s1>Gertrude H. 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Bhat</name><affiliation><inist:fA14 i1="05"><s1>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0493125</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0493125 INIST</idno><idno type="RBID">Pascal:05-0493125</idno><idno type="wicri:Area/PascalFrancis/Corpus">001D45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Interaction between blood lead concentration and δ-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor</title><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation><inist:fA14 i1="01"><s1>Gertrude H. Sergievsky Center, Columbia University</s1><s2>New York, New Yolk</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Neurology, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Applegate, Lakeisha" sort="Applegate, Lakeisha" uniqKey="Applegate L" first="Lakeisha" last="Applegate">Lakeisha Applegate</name><affiliation><inist:fA14 i1="01"><s1>Gertrude H. Sergievsky Center, Columbia University</s1><s2>New York, New Yolk</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Graziano, Joseph H" sort="Graziano, Joseph H" uniqKey="Graziano J" first="Joseph H." last="Graziano">Joseph H. Graziano</name><affiliation><inist:fA14 i1="04"><s1>Department of Pharmacology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Parides, Michael" sort="Parides, Michael" uniqKey="Parides M" first="Michael" last="Parides">Michael Parides</name><affiliation><inist:fA14 i1="06"><s1>Department of Biostatistics, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Slavkovich, Vesna" sort="Slavkovich, Vesna" uniqKey="Slavkovich V" first="Vesna" last="Slavkovich">Vesna Slavkovich</name><affiliation><inist:fA14 i1="05"><s1>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bhat, Hari K" sort="Bhat, Hari K" uniqKey="Bhat H" first="Hari K." last="Bhat">Hari K. Bhat</name><affiliation><inist:fA14 i1="05"><s1>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dehydratase</term><term>Epidemiology</term><term>Etiology</term><term>Interaction</term><term>Nervous system diseases</term><term>Polymorphism</term><term>Tremor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Tremblement</term><term>Interaction</term><term>Dehydratase</term><term>Polymorphisme</term><term>Epidémiologie</term><term>Etiologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Blood lead (BPh) concentrations are elevated in essential tremor (ET) cases. The δ-amino-levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD-2 allele may be more susceptible to lead toxicily. The objective of this study was to test, using a case-control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD-2 allele (OR = 1.98; 95% Cl = 0.93-4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status X log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD-1 alleles (OR = 2.69; 95% Cl = 0.61-11.82). but in individuals with an ALAD-2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% Cl = 3.08-2,096.36). There was an interaction between BPh concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD-2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD-2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>20</s2></fA05><fA06><s2>9</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Interaction between blood lead concentration and δ-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor</s1></fA08><fA11 i1="01" i2="1"><s1>LOUIS (Elan D.)</s1></fA11><fA11 i1="02" i2="1"><s1>APPLEGATE (Lakeisha)</s1></fA11><fA11 i1="03" i2="1"><s1>GRAZIANO (Joseph H.)</s1></fA11><fA11 i1="04" i2="1"><s1>PARIDES (Michael)</s1></fA11><fA11 i1="05" i2="1"><s1>SLAVKOVICH (Vesna)</s1></fA11><fA11 i1="06" i2="1"><s1>BHAT (Hari K.)</s1></fA11><fA14 i1="01"><s1>Gertrude H. Sergievsky Center, Columbia University</s1><s2>New York, New Yolk</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></fA14><fA14 i1="02"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neurology, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Pharmacology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>3 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Biostatistics, Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>4 aut.</sZ></fA14><fA20><s1>1170-1177</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000131936030110</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>49 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0493125</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Blood lead (BPh) concentrations are elevated in essential tremor (ET) cases. The δ-amino-levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD-2 allele may be more susceptible to lead toxicily. The objective of this study was to test, using a case-control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD-2 allele (OR = 1.98; 95% Cl = 0.93-4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status X log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD-1 alleles (OR = 2.69; 95% Cl = 0.61-11.82). but in individuals with an ALAD-2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% Cl = 3.08-2,096.36). There was an interaction between BPh concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD-2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD-2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B17A01</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Tremblement</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Tremor</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Temblor</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Interaction</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Interaction</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Interacción</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Dehydratase</s0><s2>FE</s2><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Dehydratase</s0><s2>FE</s2><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Dehydratase</s0><s2>FE</s2><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Polymorphisme</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Polymorphism</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Polimorfismo</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Epidémiologie</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Epidemiology</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Epidemiología</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Etiologie</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Etiology</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Etiología</s0><s5>13</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Hydro-lyases</s0><s2>FE</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Hydro-lyases</s0><s2>FE</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Hydro-lyases</s0><s2>FE</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Carbon-oxygen lyases</s0><s2>FE</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Carbon-oxygen lyases</s0><s2>FE</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Carbon-oxygen lyases</s0><s2>FE</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Lyases</s0><s2>FE</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Lyases</s0><s2>FE</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Lyases</s0><s2>FE</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Enzyme</s0><s2>FE</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Enzyme</s0><s2>FE</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Enzima</s0><s2>FE</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Mouvement involontaire</s0><s5>37</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Involuntary movement</s0><s5>37</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Movimiento involuntario</s0><s5>37</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Trouble neurologique</s0><s5>38</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Neurological disorder</s0><s5>38</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Trastorno neurológico</s0><s5>38</s5></fC07><fN21><s1>346</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 05-0493125 INIST</NO><ET>Interaction between blood lead concentration and δ-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor</ET><AU>LOUIS (Elan D.); APPLEGATE (Lakeisha); GRAZIANO (Joseph H.); PARIDES (Michael); SLAVKOVICH (Vesna); BHAT (Hari K.)</AU><AF>Gertrude H. Sergievsky Center, Columbia University/New York, New Yolk/Etats-Unis (1 aut., 2 aut.); Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University/New York, New York/Etats-Unis (1 aut.); Department of Neurology, Columbia University/New York, New York/Etats-Unis (1 aut.); Department of Pharmacology, College of Physicians and Surgeons, Columbia University/New York, New York/Etats-Unis (3 aut.); Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University/New York, New York/Etats-Unis (3 aut., 5 aut., 6 aut.); Department of Biostatistics, Mailman School of Public Health, Columbia University/New York, New York/Etats-Unis (4 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2005; Vol. 20; No. 9; Pp. 1170-1177; Bibl. 49 ref.</SO><LA>Anglais</LA><EA>Blood lead (BPh) concentrations are elevated in essential tremor (ET) cases. The δ-amino-levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD-2 allele may be more susceptible to lead toxicily. The objective of this study was to test, using a case-control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD-2 allele (OR = 1.98; 95% Cl = 0.93-4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status X log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD-1 alleles (OR = 2.69; 95% Cl = 0.61-11.82). but in individuals with an ALAD-2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% Cl = 3.08-2,096.36). There was an interaction between BPh concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD-2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD-2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor.</EA><CC>002B17; 002B17G; 002B17A01</CC><FD>Système nerveux pathologie; Tremblement; Interaction; Dehydratase; Polymorphisme; Epidémiologie; Etiologie</FD><FG>Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Mouvement involontaire; Trouble neurologique</FG><ED>Nervous system diseases; Tremor; Interaction; Dehydratase; Polymorphism; Epidemiology; Etiology</ED><EG>Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Involuntary movement; Neurological disorder</EG><SD>Sistema nervioso patología; Temblor; Interacción; Dehydratase; Polimorfismo; Epidemiología; Etiología</SD><LO>INIST-20953.354000131936030110</LO><ID>05-0493125</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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