In vivo detection of iron and neuromelanin by transcranial sonography : A new approach for early detection of substantia nigra damage
Identifieur interne : 001D31 ( PascalFrancis/Corpus ); précédent : 001D30; suivant : 001D32In vivo detection of iron and neuromelanin by transcranial sonography : A new approach for early detection of substantia nigra damage
Auteurs : Luigi Zecca ; Daniela Berg ; Thomas Arzberger ; Petra Ruprecht ; Wolf D. Rausch ; Massimo Musicco ; Davide Tampellini ; Peter Riederer ; Manfred Gerlach ; Georg BeckerSource :
- Movement disorders [ 0885-3185 ] ; 2005.
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- Pascal (Inist)
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- KwdEn :
Abstract
Early diagnosis of Parkinson's disease (PD) in nonsymptomatic patients is a key issue. An increased echogenicity of the substantia nigra (SN) was found previously in Parkinsonian patients and in a low percentage of healthy adults. These nonsymptomatic subjects also showed a reduced 18F-dopa uptake in striatum, suggesting a preclinical injury of the nigrostriatal system that could later proceed into PD. To investigate the ability of ultrasonography to detect markers of SN degeneration, such as iron deposition and neuromelanin depletion, we scanned postmortem brains from normal subjects at different ages by ultrasound and measured the echogenic area of the SN. The SN was then dissected and used for histological examinations and determination of iron, ferritin, and neuromelanin content. A significant positive correlation was found between the echogenic area of the SN and the concentration of iron, H- and L-ferritins. Multivariate analysis carried out considering the iron content showed a significant negative correlation between echogenicity and neuromelanin content of the SN. In PD, a typical loss of neuromelanin and increase of iron is observed in this brain area. The finding of a positive correlation between iron and ferritin levels and a negative correlation of neuromelanin content with the area of echogenicity at the SN could therefore provide an interesting basis for diagnosis and therapeutic follow-up studies in PD.
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NO : | PASCAL 06-0001179 INIST |
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ET : | In vivo detection of iron and neuromelanin by transcranial sonography : A new approach for early detection of substantia nigra damage |
AU : | ZECCA (Luigi); BERG (Daniela); ARZBERGER (Thomas); RUPRECHT (Petra); RAUSCH (Wolf D.); MUSICCO (Massimo); TAMPELLINI (Davide); RIEDERER (Peter); GERLACH (Manfred); BECKER (Georg) |
AF : | Institute of Biomedical Technologies-CNR/Segrate (Milano)/Italie (1 aut., 6 aut., 7 aut.); Department of Medical Genetics and Hertie Institute for Clinical Brain Research/Tubingen/Allemagne (2 aut., 4 aut.); Department of Pathology, University of Würzhurg/Würzburg/Allemagne (3 aut.); Department of Neurology, Saarland University/Homburg/Allemagne (4 aut., 10 aut.); Institute of Medical Chemistry, Veterinary University/Wien/Autriche (5 aut.); Clinical Neurochemistry, Clinic and Policlinic for Psychiatry and Psychotherapy and NPF Center of Excellence Laboratories, University of Würzbürg/Würzburg/Allemagne (8 aut.); Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg/Würzburg/Allemagne (9 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2005; Vol. 20; No. 10; Pp. 1278-1285; Bibl. 52 ref. |
LA : | Anglais |
EA : | Early diagnosis of Parkinson's disease (PD) in nonsymptomatic patients is a key issue. An increased echogenicity of the substantia nigra (SN) was found previously in Parkinsonian patients and in a low percentage of healthy adults. These nonsymptomatic subjects also showed a reduced 18F-dopa uptake in striatum, suggesting a preclinical injury of the nigrostriatal system that could later proceed into PD. To investigate the ability of ultrasonography to detect markers of SN degeneration, such as iron deposition and neuromelanin depletion, we scanned postmortem brains from normal subjects at different ages by ultrasound and measured the echogenic area of the SN. The SN was then dissected and used for histological examinations and determination of iron, ferritin, and neuromelanin content. A significant positive correlation was found between the echogenic area of the SN and the concentration of iron, H- and L-ferritins. Multivariate analysis carried out considering the iron content showed a significant negative correlation between echogenicity and neuromelanin content of the SN. In PD, a typical loss of neuromelanin and increase of iron is observed in this brain area. The finding of a positive correlation between iron and ferritin levels and a negative correlation of neuromelanin content with the area of echogenicity at the SN could therefore provide an interesting basis for diagnosis and therapeutic follow-up studies in PD. |
CC : | 002B17; 002B17G; 002B05C02D |
FD : | Système nerveux pathologie; Parkinson maladie; Dépistage; Fer; Exploration ultrason; Voie abord; Locus niger; Ultrason; Ferritine |
FG : | Encéphale pathologie; Système nerveux central; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie |
ED : | Nervous system diseases; Parkinson disease; Medical screening; Iron; Sonography; Surgical approach; Locus niger; Ultrasound; Ferritin |
EG : | Cerebral disorder; Central nervous system; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Sistema nervioso patología; Parkinson enfermedad; Descubrimiento; Hierro; Exploración ultrasonido; Vía abordaje; Locus níger; Ultrasonido; Ferritina |
LO : | INIST-20953.354000135138750040 |
ID : | 06-0001179 |
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Early diagnosis of Parkinson's disease (PD) in nonsymptomatic patients is a key issue. An increased echogenicity of the substantia nigra (SN) was found previously in Parkinsonian patients and in a low percentage of healthy adults. These nonsymptomatic subjects also showed a reduced <sup>18</sup>
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<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Descubrimiento</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Fer</s0>
<s2>NC</s2>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Iron</s0>
<s2>NC</s2>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Hierro</s0>
<s2>NC</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Exploration ultrason</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Sonography</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Exploración ultrasonido</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Voie abord</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Surgical approach</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Vía abordaje</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Locus niger</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Locus niger</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Locus níger</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Ultrason</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Ultrasound</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Ultrasonido</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Ferritine</s0>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Ferritin</s0>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Ferritina</s0>
<s5>15</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>002</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 06-0001179 INIST</NO>
<ET>In vivo detection of iron and neuromelanin by transcranial sonography : A new approach for early detection of substantia nigra damage</ET>
<AU>ZECCA (Luigi); BERG (Daniela); ARZBERGER (Thomas); RUPRECHT (Petra); RAUSCH (Wolf D.); MUSICCO (Massimo); TAMPELLINI (Davide); RIEDERER (Peter); GERLACH (Manfred); BECKER (Georg)</AU>
<AF>Institute of Biomedical Technologies-CNR/Segrate (Milano)/Italie (1 aut., 6 aut., 7 aut.); Department of Medical Genetics and Hertie Institute for Clinical Brain Research/Tubingen/Allemagne (2 aut., 4 aut.); Department of Pathology, University of Würzhurg/Würzburg/Allemagne (3 aut.); Department of Neurology, Saarland University/Homburg/Allemagne (4 aut., 10 aut.); Institute of Medical Chemistry, Veterinary University/Wien/Autriche (5 aut.); Clinical Neurochemistry, Clinic and Policlinic for Psychiatry and Psychotherapy and NPF Center of Excellence Laboratories, University of Würzbürg/Würzburg/Allemagne (8 aut.); Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg/Würzburg/Allemagne (9 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2005; Vol. 20; No. 10; Pp. 1278-1285; Bibl. 52 ref.</SO>
<LA>Anglais</LA>
<EA>Early diagnosis of Parkinson's disease (PD) in nonsymptomatic patients is a key issue. An increased echogenicity of the substantia nigra (SN) was found previously in Parkinsonian patients and in a low percentage of healthy adults. These nonsymptomatic subjects also showed a reduced <sup>18</sup>
F-dopa uptake in striatum, suggesting a preclinical injury of the nigrostriatal system that could later proceed into PD. To investigate the ability of ultrasonography to detect markers of SN degeneration, such as iron deposition and neuromelanin depletion, we scanned postmortem brains from normal subjects at different ages by ultrasound and measured the echogenic area of the SN. The SN was then dissected and used for histological examinations and determination of iron, ferritin, and neuromelanin content. A significant positive correlation was found between the echogenic area of the SN and the concentration of iron, H- and L-ferritins. Multivariate analysis carried out considering the iron content showed a significant negative correlation between echogenicity and neuromelanin content of the SN. In PD, a typical loss of neuromelanin and increase of iron is observed in this brain area. The finding of a positive correlation between iron and ferritin levels and a negative correlation of neuromelanin content with the area of echogenicity at the SN could therefore provide an interesting basis for diagnosis and therapeutic follow-up studies in PD.</EA>
<CC>002B17; 002B17G; 002B05C02D</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Dépistage; Fer; Exploration ultrason; Voie abord; Locus niger; Ultrason; Ferritine</FD>
<FG>Encéphale pathologie; Système nerveux central; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Medical screening; Iron; Sonography; Surgical approach; Locus niger; Ultrasound; Ferritin</ED>
<EG>Cerebral disorder; Central nervous system; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Descubrimiento; Hierro; Exploración ultrasonido; Vía abordaje; Locus níger; Ultrasonido; Ferritina</SD>
<LO>INIST-20953.354000135138750040</LO>
<ID>06-0001179</ID>
</server>
</inist>
</record>
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