Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease
Identifieur interne : 001C79 ( PascalFrancis/Corpus ); précédent : 001C78; suivant : 001C80Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease
Auteurs : Katherine J. Schweitzer ; Rüdiger Hilker ; Uwe Walter ; Lothar Burghaus ; Daniela BergSource :
- Movement disorders [ 0885-3185 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Increased echogenic size (hyperechogenicity) of the substantia nigra (SN) is a characteristic transcranial sonography finding in patients with Parkinson's disease (PD). The SN echogenic size does not change in the course of the disease. In order to see whether this stable ultrasound marker may give any implications for the rate of PD progression, we sonographically investigated 16 PD patients in whom the rate of progression had been determined by serial 18-fluorodopa positron emission tomography over a follow-up period of 65.7 ± 26.7 months. We found a significant negative correlation between the right-to-left averaged SN echogenic size and the rate of disease progression in the caudate nucleus and in the putamen. There was a tendency towards a younger age at symptom onset in patients with SN hyperechogenicity. It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD.
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Format Inist (serveur)
NO : | PASCAL 06-0135503 INIST |
---|---|
ET : | Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease |
AU : | SCHWEITZER (Katherine J.); HILKER (Rüdiger); WALTER (Uwe); BURGHAUS (Lothar); BERG (Daniela) |
AF : | Hertie Institute of Clinical Brain Research, University of Tübingen/Tübingen/Allemagne (1 aut., 5 aut.); Department of Neurology, University Hospital/Cologne/Allemagne (2 aut., 4 aut.); Department of Neurology, University of Rostock/Rostock/Allemagne (3 aut.); Department of Medical Genetics, University of Tübingen/Tübingen/Allemagne (5 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 1; Pp. 94-98; Bibl. 23 ref. |
LA : | Anglais |
EA : | Increased echogenic size (hyperechogenicity) of the substantia nigra (SN) is a characteristic transcranial sonography finding in patients with Parkinson's disease (PD). The SN echogenic size does not change in the course of the disease. In order to see whether this stable ultrasound marker may give any implications for the rate of PD progression, we sonographically investigated 16 PD patients in whom the rate of progression had been determined by serial 18-fluorodopa positron emission tomography over a follow-up period of 65.7 ± 26.7 months. We found a significant negative correlation between the right-to-left averaged SN echogenic size and the rate of disease progression in the caudate nucleus and in the putamen. There was a tendency towards a younger age at symptom onset in patients with SN hyperechogenicity. It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD. |
CC : | 002B17; 002B17G; 002B17A03 |
FD : | Système nerveux pathologie; Parkinson maladie; Locus niger; Exploration ultrason |
FG : | Encéphale pathologie; Système nerveux central; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie |
ED : | Nervous system diseases; Parkinson disease; Locus niger; Sonography |
EG : | Cerebral disorder; Central nervous system; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Sistema nervioso patología; Parkinson enfermedad; Locus níger; Exploración ultrasonido |
LO : | INIST-20953.354000133169150170 |
ID : | 06-0135503 |
Links to Exploration step
Pascal:06-0135503Le document en format XML
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<front><div type="abstract" xml:lang="en">Increased echogenic size (hyperechogenicity) of the substantia nigra (SN) is a characteristic transcranial sonography finding in patients with Parkinson's disease (PD). The SN echogenic size does not change in the course of the disease. In order to see whether this stable ultrasound marker may give any implications for the rate of PD progression, we sonographically investigated 16 PD patients in whom the rate of progression had been determined by serial 18-fluorodopa positron emission tomography over a follow-up period of 65.7 ± 26.7 months. We found a significant negative correlation between the right-to-left averaged SN echogenic size and the rate of disease progression in the caudate nucleus and in the putamen. There was a tendency towards a younger age at symptom onset in patients with SN hyperechogenicity. It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD.</div>
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<ET>Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease</ET>
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<AF>Hertie Institute of Clinical Brain Research, University of Tübingen/Tübingen/Allemagne (1 aut., 5 aut.); Department of Neurology, University Hospital/Cologne/Allemagne (2 aut., 4 aut.); Department of Neurology, University of Rostock/Rostock/Allemagne (3 aut.); Department of Medical Genetics, University of Tübingen/Tübingen/Allemagne (5 aut.)</AF>
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<EA>Increased echogenic size (hyperechogenicity) of the substantia nigra (SN) is a characteristic transcranial sonography finding in patients with Parkinson's disease (PD). The SN echogenic size does not change in the course of the disease. In order to see whether this stable ultrasound marker may give any implications for the rate of PD progression, we sonographically investigated 16 PD patients in whom the rate of progression had been determined by serial 18-fluorodopa positron emission tomography over a follow-up period of 65.7 ± 26.7 months. We found a significant negative correlation between the right-to-left averaged SN echogenic size and the rate of disease progression in the caudate nucleus and in the putamen. There was a tendency towards a younger age at symptom onset in patients with SN hyperechogenicity. It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD.</EA>
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