MovDisordV3, PascalFrancis, Corpus, bibRecord, 001B58

Rasagiline improves quality of life in patients with early Parkinson's disease

Identifieur interne : 001B58 ( PascalFrancis/Corpus ); précédent : 001B57; suivant : 001B59

Rasagiline improves quality of life in patients with early Parkinson's disease

Auteurs : Kevin M. Biglan ; Steven Schwid ; Shirley Eberly ; Karen Blindauer ; Stanley Fahn ; Tamar Goren ; Karl Kieburtz ; David Oakes ; Sandra Plumb ; Andrew Siderowf ; Matthew Stern ; Ira Shoulson

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0289026

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Rasagiline, Qualité vie, Homme.

English descriptors

KwdEn :
- Human, Nervous system diseases, Parkinson disease, Quality of life, Rasagiline.

Abstract

The objective of this study was to determine the effects of rasagiline as monotherapy on quality of life (QOL) in patients with early Parkinson's disease (PD). Rasagiline, a potent, second-generation, irreversible, selective monoamine oxidase B inhibitor improves PD symptoms in patients with early PD. Patients with early untreated PD were randomly assigned to once-daily rasagiline I mg/day, rasagiline 2 mg/ day, or placebo in a 6-month, double-blind trial (n = 404). At the end of 6 months, patients entered the preplanned, active-treatment phase in which those receiving I mg/day and 2 mg/day of rasagiline continued on their previously assigned dosages and those receiving placebo switched to rasagiline 2 mg/day, while maintaining blinding to treatment assignments. QOL was measured with the Parkinson's Disease Quality of Life questionnaire (PDQUALIF) at 0, 14, 26, and 52 weeks after randomization. Analysis of the change in PDQUALIF scores from baseline to 6 months showed adjusted treatment effects (with 95% confidence interval) favoring rasagiline over placebo of -2.91 units (-5.19, -0.64, P = 0.01) for the 1 mg/day group and -2.74 units (-5.02, -0.45, P = 0.02) for the 2 mg/day. Subscore analysis attributed most of this benefit to the self-image/sexuality domain. At 12 months (n = 266), with all groups receiving rasagiline for at least 6 months, no significant differences in PDQUALIF scores were seen between groups. Rasagiline improved QOL compared with placebo. This QOL improvement appears to be accounted for primarily by the symptomatic benefit of rasagiline.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`05`	`1`		`@1 FAHN (Stanley)`
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A14	`03`			`@1 Department of Biostatistics, University of Rochester @2 New York @3 USA @Z 3 aut. @Z 8 aut.`
A14	`04`			`@1 Department of Neurology, Medical College of Wisconsin @2 Milwaukee, Wisconsin @3 USA @Z 4 aut.`
A14	`05`			`@1 Teva Pharmaceutical Industries, Ltd @2 Netanya @3 ISR @Z 6 aut.`
A14	`06`			`@1 Department of Neurology. University of Pennsylvania @2 Philadelphia, Pennsylvania @3 USA @Z 10 aut. @Z 11 aut.`
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C01	`01`		`ENG`	@0 The objective of this study was to determine the effects of rasagiline as monotherapy on quality of life (QOL) in patients with early Parkinson's disease (PD). Rasagiline, a potent, second-generation, irreversible, selective monoamine oxidase B inhibitor improves PD symptoms in patients with early PD. Patients with early untreated PD were randomly assigned to once-daily rasagiline I mg/day, rasagiline 2 mg/ day, or placebo in a 6-month, double-blind trial (n = 404). At the end of 6 months, patients entered the preplanned, active-treatment phase in which those receiving I mg/day and 2 mg/day of rasagiline continued on their previously assigned dosages and those receiving placebo switched to rasagiline 2 mg/day, while maintaining blinding to treatment assignments. QOL was measured with the Parkinson's Disease Quality of Life questionnaire (PDQUALIF) at 0, 14, 26, and 52 weeks after randomization. Analysis of the change in PDQUALIF scores from baseline to 6 months showed adjusted treatment effects (with 95% confidence interval) favoring rasagiline over placebo of -2.91 units (-5.19, -0.64, P = 0.01) for the 1 mg/day group and -2.74 units (-5.02, -0.45, P = 0.02) for the 2 mg/day. Subscore analysis attributed most of this benefit to the self-image/sexuality domain. At 12 months (n = 266), with all groups receiving rasagiline for at least 6 months, no significant differences in PDQUALIF scores were seen between groups. Rasagiline improved QOL compared with placebo. This QOL improvement appears to be accounted for primarily by the symptomatic benefit of rasagiline.
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C03	`03`	`X`	`ENG`	`@0 Rasagiline @2 NK @2 FR @5 09`
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C03	`04`	`X`	`ENG`	`@0 Quality of life @5 10`
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Format Inist (serveur)

NO :	PASCAL 06-0289026 INIST
ET :	Rasagiline improves quality of life in patients with early Parkinson's disease
AU :	BIGLAN (Kevin M.); SCHWID (Steven); EBERLY (Shirley); BLINDAUER (Karen); FAHN (Stanley); GOREN (Tamar); KIEBURTZ (Karl); OAKES (David); PLUMB (Sandra); SIDEROWF (Andrew); STERN (Matthew); SHOULSON (Ira)
AF :	Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (1 aut.); Department of Neurology, University of Rochester/Rochester, New York/Etats-Unis (2 aut., 5 aut., 7 aut., 8 aut., 9 aut., 12 aut.); Department of Biostatistics, University of Rochester/New York/Etats-Unis (3 aut., 8 aut.); Department of Neurology, Medical College of Wisconsin/Milwaukee, Wisconsin/Etats-Unis (4 aut.); Teva Pharmaceutical Industries, Ltd/Netanya/Israël (6 aut.); Department of Neurology. University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (10 aut., 11 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 5; Pp. 616-623; Bibl. 20 ref.
LA :	Anglais
EA :	The objective of this study was to determine the effects of rasagiline as monotherapy on quality of life (QOL) in patients with early Parkinson's disease (PD). Rasagiline, a potent, second-generation, irreversible, selective monoamine oxidase B inhibitor improves PD symptoms in patients with early PD. Patients with early untreated PD were randomly assigned to once-daily rasagiline I mg/day, rasagiline 2 mg/ day, or placebo in a 6-month, double-blind trial (n = 404). At the end of 6 months, patients entered the preplanned, active-treatment phase in which those receiving I mg/day and 2 mg/day of rasagiline continued on their previously assigned dosages and those receiving placebo switched to rasagiline 2 mg/day, while maintaining blinding to treatment assignments. QOL was measured with the Parkinson's Disease Quality of Life questionnaire (PDQUALIF) at 0, 14, 26, and 52 weeks after randomization. Analysis of the change in PDQUALIF scores from baseline to 6 months showed adjusted treatment effects (with 95% confidence interval) favoring rasagiline over placebo of -2.91 units (-5.19, -0.64, P = 0.01) for the 1 mg/day group and -2.74 units (-5.02, -0.45, P = 0.02) for the 2 mg/day. Subscore analysis attributed most of this benefit to the self-image/sexuality domain. At 12 months (n = 266), with all groups receiving rasagiline for at least 6 months, no significant differences in PDQUALIF scores were seen between groups. Rasagiline improved QOL compared with placebo. This QOL improvement appears to be accounted for primarily by the symptomatic benefit of rasagiline.
CC :	002B17; 002B17G; 002B17F
FD :	Système nerveux pathologie; Parkinson maladie; Rasagiline; Qualité vie; Homme
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Rasagiline; Quality of life; Human
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Rasagilina; Calidad vida; Hombre
LO :	INIST-20953.354000142568210040
ID :	06-0289026

Links to Exploration step

Pascal:06-0289026

Le document en format XML

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<author><name sortKey="Goren, Tamar" sort="Goren, Tamar" uniqKey="Goren T" first="Tamar" last="Goren">Tamar Goren</name>
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<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
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<author><name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name>
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<author><name sortKey="Plumb, Sandra" sort="Plumb, Sandra" uniqKey="Plumb S" first="Sandra" last="Plumb">Sandra Plumb</name>
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<author><name sortKey="Siderowf, Andrew" sort="Siderowf, Andrew" uniqKey="Siderowf A" first="Andrew" last="Siderowf">Andrew Siderowf</name>
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<author><name sortKey="Stern, Matthew" sort="Stern, Matthew" uniqKey="Stern M" first="Matthew" last="Stern">Matthew Stern</name>
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<author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Neurology, University of Rochester</s1>
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<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<series><title level="j" type="main">Movement disorders</title>
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<front><div type="abstract" xml:lang="en">The objective of this study was to determine the effects of rasagiline as monotherapy on quality of life (QOL) in patients with early Parkinson's disease (PD). Rasagiline, a potent, second-generation, irreversible, selective monoamine oxidase B inhibitor improves PD symptoms in patients with early PD. Patients with early untreated PD were randomly assigned to once-daily rasagiline I mg/day, rasagiline 2 mg/ day, or placebo in a 6-month, double-blind trial (n = 404). At the end of 6 months, patients entered the preplanned, active-treatment phase in which those receiving I mg/day and 2 mg/day of rasagiline continued on their previously assigned dosages and those receiving placebo switched to rasagiline 2 mg/day, while maintaining blinding to treatment assignments. QOL was measured with the Parkinson's Disease Quality of Life questionnaire (PDQUALIF) at 0, 14, 26, and 52 weeks after randomization. Analysis of the change in PDQUALIF scores from baseline to 6 months showed adjusted treatment effects (with 95% confidence interval) favoring rasagiline over placebo of -2.91 units (-5.19, -0.64, P = 0.01) for the 1 mg/day group and -2.74 units (-5.02, -0.45, P = 0.02) for the 2 mg/day. Subscore analysis attributed most of this benefit to the self-image/sexuality domain. At 12 months (n = 266), with all groups receiving rasagiline for at least 6 months, no significant differences in PDQUALIF scores were seen between groups. Rasagiline improved QOL compared with placebo. This QOL improvement appears to be accounted for primarily by the symptomatic benefit of rasagiline.</div>
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<s3>USA</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
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<ET>Rasagiline improves quality of life in patients with early Parkinson's disease</ET>
<AU>BIGLAN (Kevin M.); SCHWID (Steven); EBERLY (Shirley); BLINDAUER (Karen); FAHN (Stanley); GOREN (Tamar); KIEBURTZ (Karl); OAKES (David); PLUMB (Sandra); SIDEROWF (Andrew); STERN (Matthew); SHOULSON (Ira)</AU>
<AF>Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (1 aut.); Department of Neurology, University of Rochester/Rochester, New York/Etats-Unis (2 aut., 5 aut., 7 aut., 8 aut., 9 aut., 12 aut.); Department of Biostatistics, University of Rochester/New York/Etats-Unis (3 aut., 8 aut.); Department of Neurology, Medical College of Wisconsin/Milwaukee, Wisconsin/Etats-Unis (4 aut.); Teva Pharmaceutical Industries, Ltd/Netanya/Israël (6 aut.); Department of Neurology. University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (10 aut., 11 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 5; Pp. 616-623; Bibl. 20 ref.</SO>
<LA>Anglais</LA>
<EA>The objective of this study was to determine the effects of rasagiline as monotherapy on quality of life (QOL) in patients with early Parkinson's disease (PD). Rasagiline, a potent, second-generation, irreversible, selective monoamine oxidase B inhibitor improves PD symptoms in patients with early PD. Patients with early untreated PD were randomly assigned to once-daily rasagiline I mg/day, rasagiline 2 mg/ day, or placebo in a 6-month, double-blind trial (n = 404). At the end of 6 months, patients entered the preplanned, active-treatment phase in which those receiving I mg/day and 2 mg/day of rasagiline continued on their previously assigned dosages and those receiving placebo switched to rasagiline 2 mg/day, while maintaining blinding to treatment assignments. QOL was measured with the Parkinson's Disease Quality of Life questionnaire (PDQUALIF) at 0, 14, 26, and 52 weeks after randomization. Analysis of the change in PDQUALIF scores from baseline to 6 months showed adjusted treatment effects (with 95% confidence interval) favoring rasagiline over placebo of -2.91 units (-5.19, -0.64, P = 0.01) for the 1 mg/day group and -2.74 units (-5.02, -0.45, P = 0.02) for the 2 mg/day. Subscore analysis attributed most of this benefit to the self-image/sexuality domain. At 12 months (n = 266), with all groups receiving rasagiline for at least 6 months, no significant differences in PDQUALIF scores were seen between groups. Rasagiline improved QOL compared with placebo. This QOL improvement appears to be accounted for primarily by the symptomatic benefit of rasagiline.</EA>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Rasagiline improves quality of life in patients with early Parkinson's disease

Rasagiline improves quality of life in patients with early Parkinson's disease

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