MovDisordV3, PascalFrancis, Corpus, bibRecord, 001B55

Plasticity of the motor cortex in Parkinson's disease patients On and Off therapy

Identifieur interne : 001B55 ( PascalFrancis/Corpus ); précédent : 001B54; suivant : 001B56

Plasticity of the motor cortex in Parkinson's disease patients On and Off therapy

Auteurs : Sergio Bagnato ; Rocco Agostino ; Nicola Modugno ; Angelo Quartarone ; Alfredo Berardelli

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0289029

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Plasticité, Cortex moteur, Homme, Traitement, Intégration, Stimulation magnétique transcrânienne.

English descriptors

KwdEn :
- Human, Integration, Motor cortex, Nervous system diseases, Parkinson disease, Plasticity, Transcranial magnetic stimulation, Treatment.

Abstract

We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`03`	`1`		`@1 MODUGNO (Nicola)`
A11	`04`	`1`		`@1 QUARTARONE (Angelo)`
A11	`05`	`1`		`@1 BERARDELLI (Alfredo)`
A14	`01`			`@1 Department of Neurological Sciences, University of Rome La Sapienza @2 Rome @3 ITA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut.`
A14	`02`			`@1 Istituto Neurologico Mediterraneo Neuromed, IRCCS @2 Pozzilli (IS) @3 ITA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut.`
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C01	`01`		`ENG`	@0 We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.
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C07	`03`	`X`	`FRE`	`@0 Voie motrice @5 39`
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Format Inist (serveur)

NO :	PASCAL 06-0289029 INIST
ET :	Plasticity of the motor cortex in Parkinson's disease patients On and Off therapy
AU :	BAGNATO (Sergio); AGOSTINO (Rocco); MODUGNO (Nicola); QUARTARONE (Angelo); BERARDELLI (Alfredo)
AF :	Department of Neurological Sciences, University of Rome La Sapienza/Rome/Italie (1 aut., 2 aut., 3 aut., 5 aut.); Istituto Neurologico Mediterraneo Neuromed, IRCCS/Pozzilli (IS)/Italie (1 aut., 2 aut., 3 aut., 5 aut.); Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina/Italie (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 5; Pp. 639-645; Bibl. 14 ref.
LA :	Anglais
EA :	We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.
CC :	002B17; 002B17G; 002B17F
FD :	Système nerveux pathologie; Parkinson maladie; Plasticité; Cortex moteur; Homme; Traitement; Intégration; Stimulation magnétique transcrânienne
FG :	Encéphale pathologie; Système nerveux central; Voie motrice; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Plasticity; Motor cortex; Human; Treatment; Integration; Transcranial magnetic stimulation
EG :	Cerebral disorder; Central nervous system; Motor pathway; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Plasticidad; Corteza motora; Hombre; Tratamiento; Integración
LO :	INIST-20953.354000142568210070
ID :	06-0289029

Links to Exploration step

Pascal:06-0289029

Le document en format XML

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<front><div type="abstract" xml:lang="en">We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.</div>
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<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Plasticité</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Plasticity</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Plasticidad</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Cortex moteur</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Motor cortex</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Corteza motora</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Human</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Traitement</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Treatment</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Intégration</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Integration</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Integración</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Stimulation magnétique transcrânienne</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Transcranial magnetic stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Voie motrice</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Motor pathway</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vía motora</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>42</s5>
</fC07>
<fN21><s1>184</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 06-0289029 INIST</NO>
<ET>Plasticity of the motor cortex in Parkinson's disease patients On and Off therapy</ET>
<AU>BAGNATO (Sergio); AGOSTINO (Rocco); MODUGNO (Nicola); QUARTARONE (Angelo); BERARDELLI (Alfredo)</AU>
<AF>Department of Neurological Sciences, University of Rome La Sapienza/Rome/Italie (1 aut., 2 aut., 3 aut., 5 aut.); Istituto Neurologico Mediterraneo Neuromed, IRCCS/Pozzilli (IS)/Italie (1 aut., 2 aut., 3 aut., 5 aut.); Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina/Italie (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2006; Vol. 21; No. 5; Pp. 639-645; Bibl. 14 ref.</SO>
<LA>Anglais</LA>
<EA>We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.</EA>
<CC>002B17; 002B17G; 002B17F</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Plasticité; Cortex moteur; Homme; Traitement; Intégration; Stimulation magnétique transcrânienne</FD>
<FG>Encéphale pathologie; Système nerveux central; Voie motrice; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Plasticity; Motor cortex; Human; Treatment; Integration; Transcranial magnetic stimulation</ED>
<EG>Cerebral disorder; Central nervous system; Motor pathway; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Plasticidad; Corteza motora; Hombre; Tratamiento; Integración</SD>
<LO>INIST-20953.354000142568210070</LO>
<ID>06-0289029</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Plasticity of the motor cortex in Parkinson's disease patients On and Off therapy

Plasticity of the motor cortex in Parkinson's disease patients On and Off therapy

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